{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:24:06Z","timestamp":1760984646248},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,9,16]],"date-time":"2012-09-16T00:00:00Z","timestamp":1347753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s11239-012-0807-6","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T14:59:51Z","timestamp":1347721191000},"page":"77-83","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin B12 level in peripheral arterial disease"],"prefix":"10.1007","volume":"36","author":[{"given":"Katalin S.","family":"Zs\u00f3ri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Csiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Katona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsnna","family":"Bereczky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir-Houshang","family":"Shemirani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,16]]},"reference":[{"key":"807_CR1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11239-011-0550-4","volume":"32","author":"F Cacciapuoti","year":"2011","unstructured":"Cacciapuoti F (2011) Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties. J Thromb Thrombolysis 32:82\u201388","journal-title":"J Thromb Thrombolysis"},{"key":"807_CR2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0021-9150(98)00156-7","volume":"141","author":"BJ Verhoeff","year":"1998","unstructured":"Verhoeff BJ, Trip MD, Prins MH, Kastelein JJ, Reitsma PH (1998) The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis. Atherosclerosis 141:161\u2013166","journal-title":"Atherosclerosis"},{"key":"807_CR3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0021-9150(99)00366-4","volume":"150","author":"FG Fowkes","year":"2000","unstructured":"Fowkes FG, Lee AJ, Hau CM, Cooke A, Connor JM, Lowe GD (2000) Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study. Atherosclerosis 150:179\u2013185","journal-title":"Atherosclerosis"},{"key":"807_CR4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2362.1999.00578.x","volume":"29","author":"L Todesco","year":"1999","unstructured":"Todesco L, Angst C, Litynski P, Loehrer F, Fowler B, Haefeli WE (1999) Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age. Eur J Clin Investig 29:1003\u20131009","journal-title":"Eur J Clin Investig"},{"key":"807_CR5","doi-asserted-by":"crossref","unstructured":"Santos ME, das CLESF, Gomes KB, Fernandes AP, Freitas FR, Faria MC, Mota AP, Carvalho MG (2011) Mutations in methylenetetrahydrofolate reductase and in cystathionine beta synthase: is there a link to homocysteine levels in peripheral arterial disease? Mol Biol Rep 38:3361\u20133366","DOI":"10.1007\/s11033-010-0443-1"},{"key":"807_CR6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/000331970005100302","volume":"51","author":"F Rassoul","year":"2000","unstructured":"Rassoul F, Richter V, Janke C, Purschwitz K, Klotzer B, Geisel J, Herrmann W (2000) Plasma homocysteine and lipoprotein profile in patients with peripheral arterial occlusive disease. Angiology 51:189\u2013196","journal-title":"Angiology"},{"key":"807_CR7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/ajcn\/82.2.335","volume":"82","author":"AM Gori","year":"2005","unstructured":"Gori AM, Corsi AM, Fedi S, Gazzini A, Sofi F, Bartali B, Bandinelli S, Gensini GF, Abbate R, Ferrucci L (2005) A proinflammatory state is associated with hyperhomocysteinemia in the elderly. Am J Clin Nutr 82:335\u2013341","journal-title":"Am J Clin Nutr"},{"key":"807_CR8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0895-4356(98)00122-X","volume":"51","author":"T Shinozaki","year":"1998","unstructured":"Shinozaki T, Hasegawa T, Yano E (1998) Ankle-arm index as an indicator of atherosclerosis: its application as a screening method. J Clin Epidemiol 51:1263\u20131269","journal-title":"J Clin Epidemiol"},{"key":"807_CR9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/145749690309200206","volume":"92","author":"S Matzke","year":"2003","unstructured":"Matzke S, Franckena M, Alback A, Railo M, Lepantalo M (2003) Ankle brachial index measurements in critical leg ischaemia\u2014the influence of experience on reproducibility. Scand J Surg 92:144\u2013147","journal-title":"Scand J Surg"},{"key":"807_CR10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1191\/1358863x03vm506ra","volume":"8","author":"RS Dieter","year":"2003","unstructured":"Dieter RS, Tomasson J, Gudjonsson T, Brown RL, Vitcenda M, Einerson J, McBride PE (2003) Lower extremity peripheral arterial disease in hospitalized patients with coronary artery disease. Vasc Med 8:233\u2013236","journal-title":"Vasc Med"},{"key":"807_CR11","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/clinchem\/45.5.694","volume":"45","author":"N Ahsen von","year":"1999","unstructured":"von Ahsen N, Schutz E, Armstrong VW, Oellerich M (1999) Rapid detection of prothrombotic mutations of prothrombin (G20210A), factor V (G1691A), and methylenetetrahydrofolate reductase (C677T) by real-time fluorescence PCR with the LightCycler. Clin Chem 45:694\u2013696","journal-title":"Clin Chem"},{"key":"807_CR12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2796.2000.00623.x","volume":"247","author":"EK Hoogeveen","year":"2000","unstructured":"Hoogeveen EK, Kostense PJ, Jakobs C, Rauwerda JA, Dekker JM, Nijpels G, Bouter LM, Heine RJ, Stehouwer CD (2000) Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: the Hoorn Study. J Intern Med 247:442\u2013448","journal-title":"J Intern Med"},{"key":"807_CR13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0002-9343(02)01258-5","volume":"113","author":"DG Bloemenkamp","year":"2002","unstructured":"Bloemenkamp DG, van den Bosch MA, Mali WP, Tanis BC, Rosendaal FR, Kemmeren JM, Algra A, Visseren FL, van der Graaf Y (2002) Novel risk factors for peripheral arterial disease in young women. Am J Med 113:462\u2013467","journal-title":"Am J Med"},{"key":"807_CR14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1046\/j.1365-2362.2003.01196.x","volume":"33","author":"H Darius","year":"2003","unstructured":"Darius H, Pittrow D, Haberl R, Trampisch HJ, Schuster A, Lange S, Tepohl HG, Allenberg JR, Diehm C (2003) Are elevated homocysteine plasma levels related to peripheral arterial disease? Results from a cross-sectional study of 6,880 primary care patients. Eur J Clin Investig 33:751\u2013757","journal-title":"Eur J Clin Investig"},{"key":"807_CR15","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1001\/jama.285.19.2481","volume":"285","author":"PM Ridker","year":"2001","unstructured":"Ridker PM, Stampfer MJ, Rifai N (2001) Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 285:2481\u20132485","journal-title":"JAMA"},{"key":"807_CR16","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1093\/jn\/133.9.2863","volume":"133","author":"AT Merchant","year":"2003","unstructured":"Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A (2003) The use of B vitamin supplements and peripheral arterial disease risk in men are inversely related. J Nutr 133:2863\u20132867","journal-title":"J Nutr"},{"key":"807_CR17","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jvs.2005.01.039","volume":"41","author":"T Mueller","year":"2005","unstructured":"Mueller T, Marschon R, Dieplinger B, Haidinger D, Gegenhuber A, Poelz W, Webersinke G, Haltmayer M (2005) Factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations are not associated with chronic limb ischemia: the Linz peripheral arterial disease (LIPAD) study. J Vasc Surg 41:808\u2013815","journal-title":"J Vasc Surg"},{"key":"807_CR18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/0003319710380681","volume":"62","author":"N Khandanpour","year":"2011","unstructured":"Khandanpour N, Jennings B, Armon MP, Wright A, Willis G, Clark A, Meyer FJ (2011) Do novel risk biomarkers reflect the severity of peripheral arterial disease? Angiology 62:126\u2013133","journal-title":"Angiology"},{"key":"807_CR19","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.CIR.95.8.2032","volume":"95","author":"H Morita","year":"1997","unstructured":"Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y (1997) Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 95:2032\u20132036","journal-title":"Circulation"},{"key":"807_CR20","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1161\/01.CIR.94.10.2410","volume":"94","author":"J Ma","year":"1996","unstructured":"Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willett WC, Rozen R (1996) Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 94:2410\u20132416","journal-title":"Circulation"},{"key":"807_CR21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","volume":"93","author":"PF Jacques","year":"1996","unstructured":"Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93:7\u20139","journal-title":"Circulation"},{"key":"807_CR22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0021-9150(96)05977-1","volume":"128","author":"R Brugada","year":"1997","unstructured":"Brugada R, Marian AJ (1997) A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis 128:107\u2013112","journal-title":"Atherosclerosis"},{"key":"807_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.thromres.2011.07.001","volume":"129","author":"E Balogh","year":"2012","unstructured":"Balogh E, Bereczky Z, Katona E, Koszegi Z, Edes I, Muszbek L, Czuriga I (2012) Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease\/myocardial infarction in women: a case-control study. Thromb Res 129:133\u2013138","journal-title":"Thromb Res"},{"key":"807_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwp094","volume":"170","author":"E Zintzaras","year":"2009","unstructured":"Zintzaras E, Zdoukopoulos N (2009) A field synopsis and meta-analysis of genetic association studies in peripheral arterial disease: the CUMAGAS-PAD database. Am J Epidemiol 170:1\u201311","journal-title":"Am J Epidemiol"},{"key":"807_CR25","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jvs.2008.10.004","volume":"49","author":"N Khandanpour","year":"2009","unstructured":"Khandanpour N, Willis G, Meyer FJ, Armon MP, Loke YK, Wright AJ, Finglas PM, Jennings BA (2009) Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: a case-control study and meta-analysis. J Vasc Surg 49:711\u2013718","journal-title":"J Vasc Surg"},{"key":"807_CR26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00001721-200109000-00007","volume":"12","author":"H Stricker","year":"2001","unstructured":"Stricker H, Soldati G, Balmelli T, Mombelli G (2001) Homocysteine, vitamins and gene mutations in peripheral arterial disease. Blood Coagul Fibrinolysis 12:469\u2013475","journal-title":"Blood Coagul Fibrinolysis"},{"key":"807_CR27","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1111\/j.1538-7836.2003.00500.x","volume":"1","author":"E Ciccarone","year":"2003","unstructured":"Ciccarone E, Di Castelnuovo A, Assanelli D, Archetti S, Ruggeri G, Salcuni N, Donati MB, Capani F, Iacoviello L (2003) Homocysteine levels are associated with the severity of peripheral arterial disease in type 2 diabetic patients. J Thromb Haemost 1:2540\u20132547","journal-title":"J Thromb Haemost"},{"key":"807_CR28","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/ajcn\/59.4.940","volume":"59","author":"N Pancharuniti","year":"1994","unstructured":"Pancharuniti N, Lewis CA, Sauberlich HE, Perkins LL, Go RC, Alvarez JO, Macaluso M, Acton RT, Copeland RB, Cousins AL et al (1994) Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. Am J Clin Nutr 59:940\u2013948","journal-title":"Am J Clin Nutr"},{"key":"807_CR29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/eurheartj\/ehn515","volume":"30","author":"C Antoniades","year":"2009","unstructured":"Antoniades C, Antonopoulos AS, Tousoulis D, Marinou K, Stefanadis C (2009) Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 30:6\u201315","journal-title":"Eur Heart J"},{"key":"807_CR30","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","volume":"274","author":"CJ Boushey","year":"1995","unstructured":"Boushey CJ, Beresford SA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274:1049\u20131057","journal-title":"JAMA"},{"key":"807_CR31","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.1997.03540460039030","volume":"277","author":"IM Graham","year":"1997","unstructured":"Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, Palma-Reis RJ, Boers GH, Sheahan RG, Israelsson B, Uiterwaal CS, Meleady R, McMaster D, Verhoef P, Witteman J, Rubba P, Bellet H, Wautrecht JC, de Valk HW, Sales Luis AC, Parrot-Rouland FM, Tan KS, Higgins I, Garcon D, Andria G et al (1997) Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 277:1775\u20131781","journal-title":"JAMA"},{"issue":"A1008","key":"807_CR32","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0002-9149(00)01137-1","volume":"86","author":"TJ Cleophas","year":"2000","unstructured":"Cleophas TJ, Hornstra N, van Hoogstraten B, van der Meulen J (2000) Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis. Am J Cardiol 86(A1008):1005\u20131009","journal-title":"Am J Cardiol"},{"key":"807_CR33","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/jn\/135.9.2253","volume":"135","author":"V Ganji","year":"2005","unstructured":"Ganji V, Kafai MR (2005) Population references for plasma total homocysteine concentrations for U.S. children and adolescents in the post-folic acid fortification era. J Nutr 135:2253\u20132256","journal-title":"J Nutr"},{"key":"807_CR34","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1161\/01.CIR.103.23.2788","volume":"103","author":"S Friso","year":"2001","unstructured":"Friso S, Jacques PF, Wilson PW, Rosenberg IH, Selhub J (2001) Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 103:2788\u20132791","journal-title":"Circulation"},{"key":"807_CR35","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0002-9149(99)00491-9","volume":"84","author":"LE Rohde","year":"1999","unstructured":"Rohde LE, Hennekens CH, Ridker PM (1999) Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men. Am J Cardiol 84:1018\u20131022","journal-title":"Am J Cardiol"},{"key":"807_CR36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0021-9150(03)00161-8","volume":"169","author":"AR Folsom","year":"2003","unstructured":"Folsom AR, Desvarieux M, Nieto FJ, Boland LL, Ballantyne CM, Chambless LE (2003) B vitamin status and inflammatory markers. Atherosclerosis 169:169\u2013174","journal-title":"Atherosclerosis"},{"key":"807_CR37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.exger.2003.11.005","volume":"39","author":"G Ravaglia","year":"2004","unstructured":"Ravaglia G, Forti P, Maioli F, Servadei L, Martelli M, Arnone G, Talerico T, Zoli M, Mariani E (2004) Plasma homocysteine and inflammation in elderly patients with cardiovascular disease and dementia. Exp Gerontol 39:443\u2013450","journal-title":"Exp Gerontol"},{"key":"807_CR38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.97.5.425","volume":"97","author":"PM Ridker","year":"1998","unstructured":"Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1998) Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 97:425\u2013428","journal-title":"Circulation"},{"key":"807_CR39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/07315724.1998.10718790","volume":"17","author":"PW Siri","year":"1998","unstructured":"Siri PW, Verhoef P, Kok FJ (1998) Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis. J Am Coll Nutr 17:435\u2013441","journal-title":"J Am Coll Nutr"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-012-0807-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11239-012-0807-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-012-0807-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T21:24:54Z","timestamp":1594675494000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11239-012-0807-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,16]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["807"],"URL":"https:\/\/doi.org\/10.1007\/s11239-012-0807-6","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,16]]}}}