{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:38:27Z","timestamp":1790379507983,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI056273"],"award-info":[{"award-number":["AI056273"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s11239-015-1298-z","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T15:15:37Z","timestamp":1447686937000},"page":"671-677","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG)"],"prefix":"10.1007","volume":"41","author":[{"given":"Akram A.","family":"Da\u2019dara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle M.","family":"de Laforcade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Skelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"1298_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/00001432-200410000-00009","volume":"17","author":"BJ Vennervald","year":"2004","unstructured":"Vennervald BJ, Dunne DW (2004) Morbidity in schistosomiasis: an update. Curr Opin Infect Dis 17:439\u2013447","journal-title":"Curr Opin Infect Dis"},{"key":"1298_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1177\/1742395307084407","volume":"4","author":"CH King","year":"2008","unstructured":"King CH, Dangerfield-Cha M (2008) The unacknowledged impact of chronic schistosomiasis. Chronic Illn 4:65\u201379","journal-title":"Chronic Illn"},{"key":"1298_CR3","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","volume":"383","author":"DG Colley","year":"2014","unstructured":"Colley DG, Bustinduy AL, Secor WE, King CH (2014) Human schistosomiasis. Lancet 383:2253\u20132264","journal-title":"Lancet"},{"issue":"6","key":"1298_CR4","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1645\/GE-864R.1","volume":"92","author":"J Keating","year":"2006","unstructured":"Keating J, Wilson R, Skelly P (2006) No overt cellular inflammation around intravascular schistosomes in vivo. J Parasitol 92(6):1365\u20131369","journal-title":"J Parasitol"},{"key":"1298_CR5","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1111\/j.1538-7836.2007.02725.x","volume":"5","author":"YP Wu","year":"2007","unstructured":"Wu YP, Lenting PJ, Tielens AG, de Groot PG, van Hellemond JJ (2007) Differential platelet adhesion to distinct life-cycle stages of the parasitic helminth Schistosoma mansoni. J Thromb Haemost 5:2146\u20132148","journal-title":"J Thromb Haemost"},{"key":"1298_CR6","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/B978-012369367-9\/50802-8","volume-title":"Platelets","author":"M Yeaman","year":"2007","unstructured":"Yeaman M, Bayer A (2007) Antimicrobial host defense. In: Michelson A (ed) Platelets, 2nd edn. Academic Press, Burlington, pp 727\u2013755","edition":"2"},{"key":"1298_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tmrv.2011.07.005","volume":"26","author":"D Bolliger","year":"2012","unstructured":"Bolliger D, Seeberger MD, Tanaka KA (2012) Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev 26:1\u201313","journal-title":"Transfus Med Rev"},{"key":"1298_CR8","doi-asserted-by":"crossref","unstructured":"Tucker MS, Karunaratne LB, Lewis FA, Freitas TC, Liang YS. Schistosomiasis. Current protocols in immunology\/ed Coligan JE et al. 2013;103:Unit 19 1","DOI":"10.1002\/0471142735.im1901s103"},{"key":"1298_CR9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1055\/s-0030-1265288","volume":"36","author":"SG MacDonald","year":"2010","unstructured":"MacDonald SG, Luddington RJ (2010) Critical factors contributing to the thromboelastography trace. Semin Thromb Hemost 36:712\u2013722","journal-title":"Semin Thromb Hemost"},{"key":"1298_CR10","doi-asserted-by":"publisher","first-page":"e2314","DOI":"10.1371\/journal.pntd.0002314","volume":"7","author":"LA Leite","year":"2013","unstructured":"Leite LA, Pimenta Filho AA, Martins da Fonseca CS, Santana dos Santos B, Ferreira Rde C, Montenegro SM et al (2013) Hemostatic dysfunction is increased in patients with hepatosplenic schistosomiasis mansoni and advanced periportal fibrosis. PLoS Negl Trop Dis 7:e2314","journal-title":"PLoS Negl Trop Dis"},{"key":"1298_CR11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/00001721-199110000-00012","volume":"2","author":"SA Omran","year":"1991","unstructured":"Omran SA, Amer AM, el-Kaliouby AH, Eldin AA (1991) Study of contact activation in endemic hepatosplenomegaly. Blood Coagul Fibrinolysis 2:659\u2013662","journal-title":"Blood Coagul Fibrinolysis"},{"key":"1298_CR12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/00001721-199803000-00011","volume":"9","author":"NE El-Bassiouni","year":"1998","unstructured":"El-Bassiouni NE, El Bassiouny AE, Hussein NA, El-Sayed HH, Ibrahim IM, Lotfy MG et al (1998) The coagulation profile in hepatosplenic schistosomiasis. Blood Coagul Fibrinolysis 9:189\u2013194","journal-title":"Blood Coagul Fibrinolysis"},{"key":"1298_CR13","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1023\/A:1005535808464","volume":"45","author":"MR Souza","year":"2000","unstructured":"Souza MR, Toledo CF, Borges DR (2000) Thrombocytemia as a predictor of portal hypertension in schistosomiasis. Dig Dis Sci 45:1964\u20131970","journal-title":"Dig Dis Sci"},{"key":"1298_CR14","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/0035-9203(87)90444-5","volume":"81","author":"JR Ngaiza","year":"1987","unstructured":"Ngaiza JR, Doenhoff MJ (1987) Schistosoma mansoni-induced thrombocytopenia in mice. Trans R Soc Trop Med Hyg 81:655\u2013656","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"1298_CR15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0166-6851(93)90042-V","volume":"58","author":"EG Vasconcelos","year":"1993","unstructured":"Vasconcelos EG, Nascimento PS, Meirelles MN, Verjovski-Almeida S, Ferreira ST (1993) Characterization and localization of an ATP-diphosphohydrolase on the external surface of the tegument of Schistosoma mansoni. Mol Biochem Parasitol 58:205\u2013214","journal-title":"Mol Biochem Parasitol"},{"key":"1298_CR16","doi-asserted-by":"publisher","first-page":"22139","DOI":"10.1074\/jbc.271.36.22139","volume":"271","author":"EG Vasconcelos","year":"1996","unstructured":"Vasconcelos EG, Ferreira ST, Carvalho TM, Souza W, Kettlun AM, Mancilla M et al (1996) Partial purification and immunohistochemical localization of ATP diphosphohydrolase from Schistosoma mansoni. Immunological cross-reactivities with potato apyrase and Toxoplasma gondii nucleoside triphosphate hydrolase. J Biol Chem 271:22139\u201322145","journal-title":"J Biol Chem"},{"key":"1298_CR17","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.7717\/peerj.316","volume":"2","author":"AA Da\u2019dara","year":"2014","unstructured":"Da\u2019dara AA, Bhardwaj R, Ali YBM, Skelly P (2014) Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ. 2:e316. doi:\n                    10.7717\/peerj.316","journal-title":"PeerJ."},{"key":"1298_CR18","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.pt.2009.03.004","volume":"25","author":"R Bhardwaj","year":"2009","unstructured":"Bhardwaj R, Skelly PJ (2009) Purinergic signaling and immune modulation at the schistosome surface? Trends Parasitol 25:256\u2013260","journal-title":"Trends Parasitol"},{"key":"1298_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.molbiopara.2006.01.012","volume":"147","author":"YL Lin","year":"2006","unstructured":"Lin YL, He S (2006) Sm22.6 antigen is an inhibitor to human thrombin. Mol Biochem Parasitol 147:95\u2013100","journal-title":"Mol Biochem Parasitol"},{"key":"1298_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0166-6851(94)90003-5","volume":"63","author":"RE Blanton","year":"1994","unstructured":"Blanton RE, Licate LS, Aman RA (1994) Characterization of a native and recombinant Schistosoma haematobium serine protease inhibitor gene product. Mol Biochem Parasitol 63:1\u201311","journal-title":"Mol Biochem Parasitol"},{"key":"1298_CR21","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1074\/mcp.M500287-MCP200","volume":"5","author":"S Braschi","year":"2006","unstructured":"Braschi S, Wilson RA (2006) Proteins exposed at the adult schistosome surface revealed by biotinylation. Mol Cell Proteomics 5:347\u2013356","journal-title":"Mol Cell Proteomics"},{"key":"1298_CR22","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1002\/pmic.200500368","volume":"6","author":"S Braschi","year":"2006","unstructured":"Braschi S, Curwen RS, Ashton PD, Verjovski-Almeida S, Wilson A (2006) The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction. Proteomics 6:1471\u20131482","journal-title":"Proteomics"},{"issue":"Suppl 1","key":"1298_CR23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1590\/S0074-02762006000900032","volume":"101","author":"S Braschi","year":"2006","unstructured":"Braschi S, Borges WC, Wilson RA (2006) Proteomic analysis of the schistosome tegument and its surface membranes. Mem Inst Oswaldo Cruz 101(Suppl 1):205\u2013212","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"1298_CR24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0305-0491(85)90245-7","volume":"82","author":"NP Robertson","year":"1985","unstructured":"Robertson NP, Cain GD (1985) Isolation and characterization of glycosaminoglycans from Schistosoma mansoni. Comp Biochem Physiol B 82:299\u2013306","journal-title":"Comp Biochem Physiol B"},{"key":"1298_CR25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0014-4894(87)90048-8","volume":"64","author":"B Salafsky","year":"1987","unstructured":"Salafsky B, Fusco AC (1987) Schistosoma mansoni: a comparison of secreted vs nonsecreted eicosanoids in developing schistosomulae and adults. Exp Parasitol 64:361\u2013367","journal-title":"Exp Parasitol"},{"key":"1298_CR26","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.193.10.1135","volume":"193","author":"V Angeli","year":"2001","unstructured":"Angeli V, Faveeuw C, Roye O, Fontaine J, Teissier E, Capron A et al (2001) Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J Exp Med 193:1135\u20131147","journal-title":"J Exp Med"},{"key":"1298_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0049-3848(74)90168-6","volume":"5","author":"JB Smith","year":"1974","unstructured":"Smith JB, Silver MJ, Ingerman CM, Kocsis JJ (1974) Prostaglandin D2 inhibits the aggregation of human platelets. Thromb Res 5:291\u2013299","journal-title":"Thromb Res"},{"key":"1298_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.exppara.2006.07.003","volume":"115","author":"A Ramajo-Hernandez","year":"2007","unstructured":"Ramajo-Hernandez A, Perez-Sanchez R, Ramajo-Martin V, Oleaga A (2007) Schistosoma bovis: plasminogen binding in adults and the identification of plasminogen-binding proteins from the worm tegument. Exp Parasitol 115:83\u201391","journal-title":"Exp Parasitol"},{"key":"1298_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.vetpar.2010.06.011","volume":"173","author":"E de la Torre-Escudero","year":"2010","unstructured":"de la Torre-Escudero E, Manzano-Roman R, Perez-Sanchez R, Siles-Lucas M, Oleaga A (2010) Cloning and characterization of a plasminogen-binding surface-associated enolase from Schistosoma bovis. Vet Parasitol 173:76\u201384","journal-title":"Vet Parasitol"},{"key":"1298_CR30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.vetpar.2011.08.013","volume":"184","author":"E de la Torre-Escudero","year":"2012","unstructured":"de la Torre-Escudero E, Manzano-Roman R, Siles-Lucas M, Perez-Sanchez R, Moyano JC, Barrera I et al (2012) Molecular and functional characterization of a Schistosoma bovis annexin: fibrinolytic and anticoagulant activity. Vet Parasitol 184:25\u201336","journal-title":"Vet Parasitol"},{"issue":"Pt 4","key":"1298_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1017\/S0031182098003175","volume":"117","author":"WS Carvalho","year":"1998","unstructured":"Carvalho WS, Lopes CT, Juliano L, Coelho PM, Cunha-Melo JR, Beraldo WT et al (1998) Purification and partial characterization of kininogenase activity from Schistosoma mansoni adult worms. Parasitology 117(Pt 4):311\u2013319","journal-title":"Parasitology"},{"key":"1298_CR32","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1111\/j.1398-9995.2011.02686.x","volume":"66","author":"M Maurer","year":"2011","unstructured":"Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M et al (2011) New topics in bradykinin research. Allergy 66:1397\u20131406","journal-title":"Allergy"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-015-1298-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11239-015-1298-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-015-1298-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-015-1298-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T07:57:06Z","timestamp":1589702226000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11239-015-1298-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,16]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1298"],"URL":"https:\/\/doi.org\/10.1007\/s11239-015-1298-z","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,16]]},"assertion":[{"value":"16 November 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}