{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:20:38Z","timestamp":1771518038329,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2012\/05\/N\/NZ5\/00846"],"award-info":[{"award-number":["2012\/05\/N\/NZ5\/00846"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["N N402 383338"],"award-info":[{"award-number":["N N402 383338"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11239-018-1687-1","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T15:57:23Z","timestamp":1527782243000},"page":"193-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impaired fibrinolysis in degenerative mitral and aortic valve stenosis"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-1232","authenticated-orcid":false,"given":"Piotr","family":"Mazur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"My\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Natorska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Plens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Plicner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Grudzie\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142aw","family":"Kapelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"1687_CR1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","volume":"373","author":"BA Carabello","year":"2009","unstructured":"Carabello BA, Paulus WJ (2009) Aortic stenosis. Lancet 373:956\u2013966. https:\/\/doi.org\/10.1016\/S0140-6736(09)60211-7","journal-title":"Lancet"},{"key":"1687_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijcard.2009.03.108","volume":"135","author":"E Yetkin","year":"2009","unstructured":"Yetkin E, Waltenberger J (2009) Molecular and cellular mechanisms of aortic stenosis. Int J Cardiol 135:4\u201313. https:\/\/doi.org\/10.1016\/j.ijcard.2009.03.108","journal-title":"Int J Cardiol"},{"key":"1687_CR3","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/S0140-6736(16)00558-4","volume":"387","author":"RA Nishimura","year":"2016","unstructured":"Nishimura RA, Vahanian A, Eleid MF, Mack MJ (2016) Mitral valve disease\u2013current management and future challenges. Lancet 387:1324\u20131334. https:\/\/doi.org\/10.1016\/s0140-6736(16)00558-4","journal-title":"Lancet"},{"key":"1687_CR4","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.atherosclerosis.2010.08.072","volume":"213","author":"S Kanjanauthai","year":"2010","unstructured":"Kanjanauthai S, Nasir K, Katz R, Rivera JJ, Takasu J, Blumenthal RS, Eng J, Budoff MJ (2010) Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 213:558\u2013562. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2010.08.072","journal-title":"Atherosclerosis"},{"key":"1687_CR5","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1161\/CIRCULATIONAHA.115.020185","volume":"133","author":"K Sud","year":"2016","unstructured":"Sud K, Agarwal S, Parashar A, Raza MQ, Patel K, Min D, Rodriguez LL, Krishnaswamy A, Mick SL, Gillinov AM, Tuzcu EM, Kapadia SR (2016) Degenerative mitral stenosis: unmet need for percutaneous interventions. Circulation 133:1594\u20131604. https:\/\/doi.org\/10.1161\/circulationaha.115.020185","journal-title":"Circulation"},{"key":"1687_CR6","unstructured":"Society of Thoracic Surgeons Executive Summary Adult Cardiac Surgery Database for 2015. http:\/\/www.sts.org\/sites\/default\/files\/documents\/2015Harvest4_ExecutiveSummary.pdf"},{"key":"1687_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1160\/TH14-01-0032","volume":"112","author":"A Undas","year":"2014","unstructured":"Undas A (2014) Fibrin clot properties and their modulation in thrombotic disorders. Thromb Haemost 112:32\u201342. https:\/\/doi.org\/10.1160\/th14-01-0032","journal-title":"Thromb Haemost"},{"key":"1687_CR8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.atherosclerosis.2007.05.028","volume":"196","author":"A Undas","year":"2008","unstructured":"Undas A, Szuldrzynski K, Stepien E, Zalewski J, Godlewski J, Tracz W, Pasowicz M, Zmudka K (2008) Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress. Atherosclerosis 196:551\u2013557. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.05.028","journal-title":"Atherosclerosis"},{"key":"1687_CR9","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1161\/STROKEAHA.108.532812","volume":"40","author":"A Undas","year":"2009","unstructured":"Undas A, Podolec P, Zawilska K, Pieculewicz M, Jedlinski I, Stepien E, Konarska-Kuszewska E, Weglarz P, Duszynska M, Hanschke E, Przewlocki T, Tracz W (2009) Altered fibrin clot structure\/function in patients with cryptogenic ischemic stroke. Stroke 40:1499\u20131501. https:\/\/doi.org\/10.1161\/STROKEAHA.108.532812","journal-title":"Stroke"},{"key":"1687_CR10","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/jth.12122","volume":"11","author":"J Natorska","year":"2013","unstructured":"Natorska J, Wypasek E, Grudzien G, Sadowski J, Undas A (2013) Impaired fibrinolysis is associated with the severity of aortic stenosis in humans. J Thromb Haemost 11:733\u2013740. https:\/\/doi.org\/10.1111\/jth.12122","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"1687_CR11","first-page":"14","volume":"82","author":"TK Nordt","year":"1999","unstructured":"Nordt TK, Peter K, Ruef J, Kubler W, Bode C (1999) Plasminogen activator inhibitor type-1 (PAI-1) and its role in cardiovascular disease. Thromb Haemost 82(Suppl 1):14\u201318","journal-title":"Thromb Haemost"},{"key":"1687_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/658643","author":"N Kochtebane","year":"2014","unstructured":"Kochtebane N, Alzahrani AM, Bartegi A (2014) Expression of uPA, tPA, and PAI-1 in calcified aortic valves. Biochem Res Int. https:\/\/doi.org\/10.1155\/2014\/658643","journal-title":"Biochem Res Int"},{"key":"1687_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jjcc.2014.07.019","volume":"65","author":"R Kolasa-Trela","year":"2015","unstructured":"Kolasa-Trela R, Fil K, Wypasek E, Undas A (2015) Exercise stress testing enhances blood coagulation and impairs fibrinolysis in asymptomatic aortic valve stenosis. J Cardiol 65:501\u2013507. https:\/\/doi.org\/10.1016\/j.jjcc.2014.07.019","journal-title":"J Cardiol"},{"key":"1687_CR14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0002-9149(99)00749-3","volume":"85","author":"A Zaki","year":"2000","unstructured":"Zaki A, Salama M, El Masry M, Abou-Freikha M, Abou-Ammo D, Sweelum M, Mashhour E, Elhendy A (2000) Immediate effect of balloon valvuloplasty on hemostatic changes in mitral stenosis. Am J Cardiol 85:370\u2013375","journal-title":"Am J Cardiol"},{"key":"1687_CR15","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/S0002-9149(99)00453-1","volume":"84","author":"F Marin","year":"1999","unstructured":"Marin F, Roldan V, Monmeneu JV, Bodi V, Fernandez C, de Burgos FG, Marco P, Sogorb F (1999) Prothrombotic state and elevated levels of plasminogen activator inhibitor-1 in mitral stenosis with and without atrial fibrillation. Am J Cardiol 84:862\u2013864","journal-title":"Am J Cardiol"},{"key":"1687_CR16","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1093\/ejcts\/ezs455","volume":"42","author":"A Vahanian","year":"2012","unstructured":"Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Lung B, Lancellotti P, Pierard L, Price S, Schafers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M (2012) Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg 42:S1\u201344. https:\/\/doi.org\/10.1093\/ejcts\/ezs455","journal-title":"Eur J Cardiothorac Surg"},{"key":"1687_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12933-015-0207-2","volume":"14","author":"G Gajos","year":"2015","unstructured":"Gajos G, Konieczynska M, Zalewski J, Undas A (2015) Low fasting glucose is associated with enhanced thrombin generation and unfavorable fibrin clot properties in type 2 diabetic patients with high cardiovascular risk. Cardiovasc Diabetol 14:44. https:\/\/doi.org\/10.1186\/s12933-015-0207-2","journal-title":"Cardiovasc Diabetol"},{"key":"1687_CR18","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1161\/ATVBAHA.109.194936","volume":"30","author":"A Undas","year":"2010","unstructured":"Undas A, Zalewski J, Krochin M, Siudak Z, Sadowski M, Pregowski J, Dudek D, Janion M, Witkowski A, Zmudka K (2010) Altered plasma fibrin clot properties are associated with in-stent thrombosis. Arterioscler Thromb Vasc Biol 30:276\u2013282. https:\/\/doi.org\/10.1161\/atvbaha.109.194936","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1687_CR19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/MBC.0b013e32835a083c","volume":"24","author":"M Zabczyk","year":"2013","unstructured":"Zabczyk M, Hondo L, Krzek M, Undas A (2013) High-density cholesterol and apolipoprotein AI as modifiers of plasma fibrin clot properties in apparently healthy individuals. Blood Coagul Fibrinolysis 24:50\u201354. https:\/\/doi.org\/10.1097\/MBC.0b013e32835a083c","journal-title":"Blood Coagul Fibrinolysis"},{"key":"1687_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.thromres.2012.11.033","volume":"131","author":"K Gronostaj","year":"2013","unstructured":"Gronostaj K, Richter P, Nowak W, Undas A (2013) Altered plasma fibrin clot properties in patients with digestive tract cancers: links with the increased thrombin generation. Thromb Res 131:262\u2013267. https:\/\/doi.org\/10.1016\/j.thromres.2012.11.033","journal-title":"Thromb Res"},{"key":"1687_CR21","doi-asserted-by":"publisher","first-page":"873","DOI":"10.20452\/pamw.4165","volume":"127","author":"M Z\u0105bczyk","year":"2017","unstructured":"Z\u0105bczyk M, Undas A (2017) Plasma fibrin clot structure and thromboembolism: clinical implications. Pol Arch Intern Med 127:873\u2013881. https:\/\/doi.org\/10.20452\/pamw.4165","journal-title":"Pol Arch Intern Med"},{"key":"1687_CR22","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/S0195-668X(03)00239-2","volume":"24","author":"V Roldan","year":"2003","unstructured":"Roldan V, Marin F, Blann AD, Garcia A, Marco P, Sogorb F, Lip GY (2003) Interleukin-6, endothelial activation and thrombogenesis in chronic atrial fibrillation. Eur Heart J 24:1373\u20131380","journal-title":"Eur Heart J"},{"key":"1687_CR23","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1053\/euhj.2000.2531","volume":"22","author":"FL Li-Saw-Hee","year":"2001","unstructured":"Li-Saw-Hee FL, Blann AD, Gurney D, Lip GY (2001) Plasma von Willebrand factor, fibrinogen and soluble P-selectin levels in paroxysmal, persistent and permanent atrial fibrillation. Effects of cardioversion and return of left atrial function. Eur Heart J 22:1741\u20131747. https:\/\/doi.org\/10.1053\/euhj.2000.2531","journal-title":"Eur Heart J"},{"key":"1687_CR24","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.thromres.2015.05.028","volume":"136","author":"L Drabik","year":"2015","unstructured":"Drabik L, Wolkow P, Undas A (2015) Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: association with thrombin generation, endothelial injury and platelet activation. Thromb Res 136:408\u2013414. https:\/\/doi.org\/10.1016\/j.thromres.2015.05.028","journal-title":"Thromb Res"},{"key":"1687_CR25","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1160\/TH14-07-0591","volume":"113","author":"M Zabczyk","year":"2015","unstructured":"Zabczyk M, Blomback M, Majewski J, Karkowski G, Wallen HN, Undas A, He S (2015) Assays of fibrin network properties altered by VKAs in atrial fibrillation - importance of using an appropriate coagulation trigger. Thromb Haemost 113:851\u2013861. https:\/\/doi.org\/10.1160\/th14-07-0591","journal-title":"Thromb Haemost"},{"key":"1687_CR26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.20452\/pamw.1101","volume":"121","author":"M Zabczyk","year":"2011","unstructured":"Zabczyk M, Majewski J, Lelakowski J (2011) Thromboembolic events are associated with prolonged clot lysis time in patients with permanent atrial fibrillation. Pol Arch Med Wewn 121:400\u2013407","journal-title":"Pol Arch Med Wewn"},{"key":"1687_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-018-0490-9","author":"O Konigsbrugge","year":"2018","unstructured":"Konigsbrugge O, Weigel G, Quehenberger P, Pabinger I, Ay C (2018) Plasma clot formation and clot lysis to compare effects of different anticoagulation treatments on hemostasis in patients with atrial fibrillation. Clin Exp Med. https:\/\/doi.org\/10.1007\/s10238-018-0490-9","journal-title":"Clin Exp Med"},{"key":"1687_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2253-12-27","volume":"12","author":"A Ozolina","year":"2012","unstructured":"Ozolina A, Strike E, Jaunalksne I, Krumina A, Bjertnaes LJ, Vanags I (2012) PAI-1 and t-PA\/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass. BMC Anesthesiol 12:27. https:\/\/doi.org\/10.1186\/1471-2253-12-27","journal-title":"BMC Anesthesiol"},{"key":"1687_CR29","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1056\/NEJMoa022831","volume":"349","author":"A Vincentelli","year":"2003","unstructured":"Vincentelli A, Susen S, Le Tourneau T, Six I, Fabre O, Juthier F, Bauters A, Decoene C, Goudemand J, Prat A, Jude B (2003) Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med 349:343\u2013349. https:\/\/doi.org\/10.1056\/NEJMoa022831","journal-title":"N Engl J Med"},{"key":"1687_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.thromres.2016.01.016","volume":"139","author":"J Natorska","year":"2016","unstructured":"Natorska J, Mazur P, Undas A (2016) Increased bleeding risk in patients with aortic valvular stenosis: from new mechanisms to new therapies. Thromb Res 139:85\u201389. https:\/\/doi.org\/10.1016\/j.thromres.2016.01.016","journal-title":"Thromb Res"},{"key":"1687_CR31","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.ejcts.2010.10.003","volume":"39","author":"A Vuylsteke","year":"2011","unstructured":"Vuylsteke A, Pagel C, Gerrard C, Reddy B, Nashef S, Aldam P, Utley M (2011) The Papworth Bleeding Risk Score: a stratification scheme for identifying cardiac surgery patients at risk of excessive early postoperative bleeding. Eur J Cardiothorac Surg 39:924\u2013930. https:\/\/doi.org\/10.1016\/j.ejcts.2010.10.003","journal-title":"Eur J Cardiothorac Surg"},{"key":"1687_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.atherosclerosis.2005.01.036","volume":"181","author":"M Verschuur","year":"2005","unstructured":"Verschuur M, Jellema A, Bladbjerg EM, EJ MF, Mensink RP, Moller L, Vos HL, de Maat MP (2005) The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals. Atherosclerosis 181:275\u2013284. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.01.036","journal-title":"Atherosclerosis"},{"key":"1687_CR33","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1055\/s-0037-1615366","volume":"80","author":"LO Mosnier","year":"1998","unstructured":"Mosnier LO, von dem Borne PA, Meijers JC, Bouma BN (1998) Plasma TAFI levels influence the clot lysis time in healthy individuals in the presence of an intact intrinsic pathway of coagulation. Thromb Haemost 80:829\u2013835","journal-title":"Thromb Haemost"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11239-018-1687-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-018-1687-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-018-1687-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T22:27:19Z","timestamp":1751668039000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11239-018-1687-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1687"],"URL":"https:\/\/doi.org\/10.1007\/s11239-018-1687-1","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,31]]},"assertion":[{"value":"31 May 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were in accordance with the ethical standards of the institutional ethical committee and with the 1964 Helsinki declaration and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}