{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:07:48Z","timestamp":1792080468053,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s11239-018-1690-6","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T06:25:37Z","timestamp":1528093537000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Non-recommended dosing of direct oral anticoagulants in the treatment of acute pulmonary embolism is related to an increased rate of adverse events"],"prefix":"10.1007","volume":"46","author":[{"given":"Romain","family":"Chopard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Serzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Falvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Morel-Aleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Napporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Kalbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Obert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Degano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Cappelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Schiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meneveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"issue":"9","key":"1690_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/archinternmed.2011.178","volume":"171","author":"RS Wiener","year":"2011","unstructured":"Wiener RS, Schwartz LM, Woloshin S (2011) Time trends in pulmonary embolism in the United States: evidence of overdiagnosis. Arch Intern Med 171(9):831\u2013837. \n                    https:\/\/doi.org\/10.1001\/archinternmed.2011.178","journal-title":"Arch Intern Med"},{"issue":"9828","key":"1690_CR2","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1016\/S0140-6736(11)61904-1","volume":"379","author":"SZ Goldhaber","year":"2012","unstructured":"Goldhaber SZ, Bounameaux H (2012) Pulmonary embolism and deep vein thrombosis. Lancet 379(9828):1835\u20131846. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(11)61904-1","journal-title":"Lancet"},{"issue":"2","key":"1690_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","volume":"149","author":"C Kearon","year":"2016","unstructured":"Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, Huisman M, King CS, Morris TA, Sood N, Stevens SM, Vintch JRE, Wells P, Woller SC, Moores L (2016) Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest 149(2):315\u2013352. \n                    https:\/\/doi.org\/10.1016\/j.chest.2015.11.026","journal-title":"Chest"},{"issue":"8","key":"1690_CR4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJMoa1207541","volume":"368","author":"G Agnelli","year":"2013","unstructured":"Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI, Investigators A-E (2013) Apixaban for extended treatment of venous thromboembolism. N Engl J Med 368(8):699\u2013708. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1207541","journal-title":"N Engl J Med"},{"issue":"15","key":"1690_CR5","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1056\/NEJMoa1306638","volume":"369","author":"VTEI Hokusai","year":"2013","unstructured":"Hokusai VTEI., Buller HR, Decousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P (2013) Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 369(15):1406\u20131415. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1306638","journal-title":"N Engl J Med"},{"issue":"14","key":"1690_CR6","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1056\/NEJMoa1113572","volume":"366","author":"E-P Investigators","year":"2012","unstructured":"Investigators E-P, Buller HR, Prins MH, Lensin AW, Decousus H, Jacobson BF, Minar E, Chlumsky J, Verhamme P, Wells P, Agnelli G, Cohen A, Berkowitz SD, Bounameaux H, Davidson BL, Misselwitz F, Gallus AS, Raskob GE, Schellong S, Segers A (2012) Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 366(14):1287\u20131297. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1113572","journal-title":"N Engl J Med"},{"issue":"24","key":"1690_CR7","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","volume":"361","author":"S Schulman","year":"2009","unstructured":"Schulman S, Kearon C, Kakkar AK, Mismetti P, Schellong S, Eriksson H, Baanstra D, Schnee J, Goldhaber SZ, Group R-CS (2009) Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 361(24):2342\u20132352. \n                    https:\/\/doi.org\/10.1056\/NEJMoa0906598","journal-title":"N Engl J Med"},{"issue":"9921","key":"1690_CR8","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, Camm AJ, Weitz JI, Lewis BS, Parkhomenko A, Yamashita T, Antman EM (2014) Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 383(9921):955\u2013962. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(13)62343-0","journal-title":"Lancet"},{"issue":"2","key":"1690_CR9","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1160\/TH16-07-0494","volume":"117","author":"J Trujillo-Santos","year":"2017","unstructured":"Trujillo-Santos J, Di Micco P, Dentali F, Douketis J, Diaz-Peromingo JA, Nunez MJ, Canas I, Mastroiacovo D, Saraiva de Sousa M, Monreal M, Investigators R (2017) Real-life treatment of venous thromboembolism with direct oral anticoagulants: the influence of recommended dosing and regimens. Thromb Haemost 117(2):382\u2013389. \n                    https:\/\/doi.org\/10.1160\/TH16-07-0494","journal-title":"Thromb Haemost"},{"issue":"11","key":"1690_CR10","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.amjmed.2016.05.041","volume":"129","author":"ME Barra","year":"2016","unstructured":"Barra ME, Fanikos J, Connors JM, Sylvester KW, Piazza G, Goldhaber SZ (2016) Evaluation of dose-reduced direct oral anticoagulant therapy. Am J Med 129(11):1198\u20131204. \n                    https:\/\/doi.org\/10.1016\/j.amjmed.2016.05.041","journal-title":"Am J Med"},{"issue":"4","key":"1690_CR11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s11239-017-1487-z","volume":"43","author":"E Tran","year":"2017","unstructured":"Tran E, Duckett A, Fisher S, Bohm N (2017) Appropriateness of direct oral anticoagulant dosing for venous thromboembolism treatment. J Thromb Thrombolysis 43(4):505\u2013513. \n                    https:\/\/doi.org\/10.1007\/s11239-017-1487-z","journal-title":"J Thromb Thrombolysis"},{"issue":"4","key":"1690_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/jcpt.12288","volume":"40","author":"KB Tellor","year":"2015","unstructured":"Tellor KB, Patel S, Armbruster AL, Daly MW (2015) Evaluation of the appropriateness of dosing, indication and safety of rivaroxaban in a community hospital. J Clin Pharm Ther 40(4):447\u2013451. \n                    https:\/\/doi.org\/10.1111\/jcpt.12288","journal-title":"J Clin Pharm Ther"},{"issue":"4","key":"1690_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.respe.2010.04.005","volume":"58","author":"P Tuppin","year":"2010","unstructured":"Tuppin P, de Roquefeuil L, Weill A, Ricordeau P, Merliere Y (2010) French national health insurance information system and the permanent beneficiaries sample. Rev Epidemiol Sante Publique 58(4):286\u2013290. \n                    https:\/\/doi.org\/10.1016\/j.respe.2010.04.005","journal-title":"Rev Epidemiol Sante Publique"},{"issue":"4","key":"1690_CR14","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"S Schulman","year":"2005","unstructured":"Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 3 (4):692\u2013694. \n                    https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01204.x","journal-title":"J Thromb Haemost"},{"issue":"1","key":"1690_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","volume":"37","author":"N Galie","year":"2016","unstructured":"Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M, Aboyans V, Vaz Carneiro A, Achenbach S, Agewall S, Allanore Y, Asteggiano R, Paolo Badano L, Albert Barbera J, Bouvaist H, Bueno H, Byrne RA, Carerj S, Castro G, Erol C, Falk V, Funck-Brentano C, Gorenflo M, Granton J, Iung B, Kiely DG, Kirchhof P, Kjellstrom B, Landmesser U, Lekakis J, Lionis C, Lip GY, Orfanos SE, Park MH, Piepoli MF, Ponikowski P, Revel MP, Rigau D, Rosenkranz S, Voller H, Luis Zamorano J (2016) 2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 37(1):67\u2013119. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehv317","journal-title":"Eur Heart J"},{"issue":"45","key":"1690_CR16","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1093\/eurheartj\/ehu393","volume":"35","author":"SV Konstantinides","year":"2014","unstructured":"Konstantinides SV (2014) 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J 35(45):3145\u20133146. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehu393","journal-title":"Eur Heart J"},{"issue":"23","key":"1690_CR17","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1016\/j.jacc.2017.03.600","volume":"69","author":"X Yao","year":"2017","unstructured":"Yao X, Shah ND, Sangaralingham LR, Gersh BJ, Noseworthy PA (2017) Non-vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction. J Am Coll Cardiol 69(23):2779\u20132790. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2017.03.600","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"1690_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.joa.2016.11.003","volume":"33","author":"Y Okumura","year":"2017","unstructured":"Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Matsumoto M, Kojima T, Hanada S, Nomoto K, Arima K, Takahashi F, Kotani T, Ikeya Y, Fukushima S, Itoh S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A, The SAKURA AF Registry Investigators (2017) Current use of direct oral anticoagulants for atrial fibrillation in Japan: findings from the SAKURA AF Registry. J Arrhythm 33(4):289\u2013296. \n                    https:\/\/doi.org\/10.1016\/j.joa.2016.11.003","journal-title":"J Arrhythm"},{"issue":"5","key":"1690_CR19","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","volume":"138","author":"R Pisters","year":"2010","unstructured":"Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY (2010) A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 138(5):1093\u20131100. \n                    https:\/\/doi.org\/10.1378\/chest.10-0134","journal-title":"Chest"},{"issue":"16","key":"1690_CR20","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1001\/archinternmed.2010.271","volume":"170","author":"ML Hansen","year":"2010","unstructured":"Hansen ML, Sorensen R, Clausen MT, Fog-Petersen ML, Raunso J, Gadsboll N, Gislason GH, Folke F, Andersen SS, Schramm TK, Abildstrom SZ, Poulsen HE, Kober L, Torp-Pedersen C (2010) Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med 170(16):1433\u20131441. \n                    https:\/\/doi.org\/10.1001\/archinternmed.2010.271","journal-title":"Arch Intern Med"},{"issue":"16","key":"1690_CR21","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.jacc.2014.01.058","volume":"63","author":"A Muriel","year":"2014","unstructured":"Muriel A, Jimenez D, Aujesky D, Bertoletti L, Decousus H, Laporte S, Mismetti P, Munoz FJ, Yusen R, Monreal M, Investigators R (2014) Survival effects of inferior vena cava filter in patients with acute symptomatic venous thromboembolism and a significant bleeding risk. J Am Coll Cardiol 63(16):1675\u20131683. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2014.01.058","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"1690_CR22","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1161\/CIRCULATIONAHA.117.028513","volume":"137","author":"N Bennaghmouch","year":"2018","unstructured":"Bennaghmouch N, de Veer A, Bode K, Mahmoodi BK, Dewilde WJM, Lip GYH, Brueckmann M, Kleine E, Ten Berg JM (2018) Efficacy and safety of the use of non-vitamin K antagonist oral anticoagulants in patients with non-valvular atrial fibrillation and concomitant aspirin therapy: a meta-analysis of randomized trials. Circulation 137(11):1117\u20131129. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.028513","journal-title":"Circulation"},{"issue":"1","key":"1690_CR23","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/CIRCULATIONAHA.115.015086","volume":"133","author":"DM Dudzinski","year":"2016","unstructured":"Dudzinski DM, Piazza G (2016) Multidisciplinary pulmonary embolism response teams. Circulation 133(1):98\u2013103. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.015086","journal-title":"Circulation"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11239-018-1690-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-018-1690-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-018-1690-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T19:14:27Z","timestamp":1559589267000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11239-018-1690-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["1690"],"URL":"https:\/\/doi.org\/10.1007\/s11239-018-1690-6","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]},"assertion":[{"value":"4 June 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Chopard has received research grant support from the French Federation of Cardiology, the Burgundy Franche-Comte region, and Edwards Lifesciences. Dr. Francois Schiele declares research grants from GlaxoSmithKline, St. Jude Medical, Sanofi-Aventis, Servier, Daiichi-Sankyo\/Lilly. Dr. Nicolas Meneveau declares receipt of consultancy agreements Bayer Healthcare, BMS-Pfizer. Drs. Serzian, Humbert, Falvo, Morel-Aleton, Bonnet, Napporn, Kalbacher, Obert, Degano, Cappelier, Cottin have no relevant financial disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research involved human participants. The study was conducted in accordance with the Declaration of Helsinki. Institutional Review Board approval was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from each study participant.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}