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MF Mart\u00ednez has received financial support from Bayer and Daiichi Sankyo for various scientific activities. A Santamar\u00eda has participated in Advisory Boards for Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Shire, Roche, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo, Werfen and Ferrer. A Santamar\u00eda has received travel support from Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Bayer, Shire, Roche, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo and Werfen. A Santamar\u00eda has received Research Support: Rovi, Shire, Bayer, LEO Pharma, BMS, Pfizer. A Santamar\u00eda has done consultancy for Bayer, Pfizer, MS and Rovi. A Santamar\u00eda has received honoraria per conferences from Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Shire, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo, Werfen and Ferrer. G. Oristrell declares that he has no conflict of interest. N. Palmer declares that he has no conflict of interest. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflic of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}