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Thrombophilia screening requires a targeted patient with specific indication, in which a finding would have implications. Carrying out a thrombophilia examination in the physician\u2019s practice is often a cause of uncertainty and concern. The concerns begin in choosing the right patient to be examined, are associated with the time of investigation, with the choice of analysis, the test-material and with the correct interpretation of the results. Difficulties, which can influence the results, can occur with both organization and blood sampling. As common for any analysis, pre-analytical, analytical and post-analytical factors should be considered, as well as the possibility of false positive or false negative results. Finally, recommendation of correct therapeutic and prophylactic measures for the patient and his relatives is an additional focus. In this article we want to provide\u2014on the basis of the evidence and personal experience\u2014the theory of thrombophilia-investigation, the indications for testing, as well as practical recommendations for treatment options.<\/jats:p>","DOI":"10.1007\/s11239-020-02090-y","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T12:02:26Z","timestamp":1586001746000},"page":"618-629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Thrombophilia screening revisited: an issue of personalized medicine"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2379-8751","authenticated-orcid":false,"given":"Giuseppe","family":"Colucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios A.","family":"Tsakiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"issue":"2 Suppl","key":"2090_CR1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/CCM.0b013e3181c9cbd9","volume":"38","author":"I Martinelli","year":"2010","unstructured":"Martinelli I, Bucciarelli P, Mannucci PM (2010) Thrombotic risk factors: basic pathophysiology. 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