{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:49:34Z","timestamp":1791575374230,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s11239-020-02116-5","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T09:02:29Z","timestamp":1587200549000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Predictors for layered coronary plaques: an optical coherence tomography study"],"prefix":"10.1007","volume":"50","author":[{"given":"Makoto","family":"Araki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Oh","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Thondapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunenari","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Higuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Kyung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"2116_CR1","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1093\/eurheartj\/ehx786","volume":"39","author":"RA Partida","year":"2018","unstructured":"Partida RA, Libby P, Crea F, Jang IK (2018) Plaque erosion: a new in vivo diagnosis and a potential major shift in the management of patients with acute coronary syndromes. Eur Heart J 39:2070\u20132076","journal-title":"Eur Heart J"},{"key":"2116_CR2","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/01.CIR.90.4.2126","volume":"90","author":"V Fuster","year":"1994","unstructured":"Fuster V, Lewis A (1994) Conner memorial lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 90:2126\u20132146","journal-title":"Circulation"},{"key":"2116_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0049-3848(96)00035-7","volume":"82","author":"MJ Davies","year":"1996","unstructured":"Davies MJ (1996) The contribution of thrombosis to the clinical expression of coronary atherosclerosis. Thromb Res 82:1\u201332","journal-title":"Thromb Res"},{"key":"2116_CR4","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1161\/ATVBAHA.108.179739","volume":"30","author":"AV Finn","year":"2010","unstructured":"Finn AV, Nakano M, Narula J, Kolodgie FD, Virmani R (2010) Concept of vulnerable\/unstable plaque. Arterioscler Thromb Vasc Biol 30:1282\u20131292","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2116_CR5","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1161\/01.ATV.20.5.1262","volume":"20","author":"R Virmani","year":"2000","unstructured":"Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20:1262\u20131275","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2116_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1136\/hrt.82.3.265","volume":"82","author":"J Mann","year":"1999","unstructured":"Mann J, Davies MJ (1999) Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart 82:265\u2013268","journal-title":"Heart"},{"key":"2116_CR7","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/01.CIR.103.7.934","volume":"103","author":"AP Burke","year":"2001","unstructured":"Burke AP, Kolodgie FD, Farb A et al (2001) Healed plaque ruptures and sudden coronary death evidence that subclinical rupture has a role in plaque progression. Circulation 103:934\u2013940","journal-title":"Circulation"},{"key":"2116_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2018.05.025","volume":"275","author":"A Shimokado","year":"2018","unstructured":"Shimokado A, Matsuo Y, Kubo T et al (2018) In vivo optical coherence tomography imaging and histopathology of healed coronary plaques. Atherosclerosis 275:35\u201342","journal-title":"Atherosclerosis"},{"key":"2116_CR9","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/j.jacc.2018.10.093","volume":"73","author":"F Fracassi","year":"2019","unstructured":"Fracassi F, Crea F, Sugiyama T et al (2019) Healed culprit plaques in patients with acute coronary syndromes. J Am Coll Cardiol 73:2253\u20132263","journal-title":"J Am Coll Cardiol"},{"key":"2116_CR10","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.jcmg.2013.05.004","volume":"6","author":"G Niccoli","year":"2013","unstructured":"Niccoli G, Stefanini GG, Capodanno D, Crea F, Ambrose JA, Berg R (2013) Are the culprit lesions severely stenotic? JACC Cardiovasc Imaging 6:1108\u20131114","journal-title":"JACC Cardiovasc Imaging"},{"key":"2116_CR11","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/01.CIR.78.2.486","volume":"78","author":"TJ Ryan","year":"1988","unstructured":"Ryan TJ, Faxon DP, Gunnar RM et al (1988) Guidelines for percutaneous transluminal coronary angioplasty. A report of the American College of Cardiology\/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee on Percutaneous Transluminal Coronary Angioplasty). Circulation 78:486\u2013502","journal-title":"Circulation"},{"key":"2116_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrcardio.2014.62","volume":"11","author":"F Otsuka","year":"2014","unstructured":"Otsuka F, Joner M, Prati F, Virmani R, Narula J (2014) Clinical classification of plaque morphology in coronary disease. Nat Rev Cardiol 11:379\u2013389","journal-title":"Nat Rev Cardiol"},{"key":"2116_CR13","doi-asserted-by":"publisher","first-page":"e006347","DOI":"10.1161\/CIRCIMAGING.117.006347","volume":"10","author":"MH Yamamoto","year":"2017","unstructured":"Yamamoto MH, Yamashita K, Matsumura M et al (2017) Serial 3-vessel optical coherence tomography and intravascular ultrasound analysis of changing morphologies associated with lesion progression in patients with stable angina pectoris. Circ Cardiovasc Imaging 10:e006347","journal-title":"Circ Cardiovasc Imaging"},{"key":"2116_CR14","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/01.CIR.0000029927.92825.F6","volume":"106","author":"H Yabushita","year":"2002","unstructured":"Yabushita H, Bouma BE, Houser SL et al (2002) Characterization of human atherosclerosis by optical coherence tomography. Circulation 106:1640\u20131645","journal-title":"Circulation"},{"key":"2116_CR15","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01175","author":"C Wang","year":"2019","unstructured":"Wang C, Hu S, Wu J et al (2019) Characteristics and significance of healed plaques in patients with acute coronary syndrome and stable angina: an in vivo OCT and IVUS study. EuroIntervention. https:\/\/doi.org\/10.4244\/EIJ-D-18-01175","journal-title":"EuroIntervention"},{"key":"2116_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez308","author":"M Russo","year":"2019","unstructured":"Russo M, Kim HO, Kurihara O et al (2019) Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque. Eur Heart J Cardiovasc Imaging. https:\/\/doi.org\/10.1093\/ehjci\/jez308","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2116_CR17","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.0275","author":"R Vergallo","year":"2019","unstructured":"Vergallo R, Porto I, D'Amario D et al (2019) Coronary atherosclerotic phenotype and plaque healing in patients with recurrent acute coronary syndromes compared with patients with long-term clinical stability: an in vivo optical coherence tomography study. JAMA Cardiol. https:\/\/doi.org\/10.1001\/jamacardio.2019.0275","journal-title":"JAMA Cardiol"},{"key":"2116_CR18","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.jacc.2014.11.041","volume":"65","author":"A Arbab-Zadeh","year":"2015","unstructured":"Arbab-Zadeh A, Fuster V (2015) The myth of the \"vulnerable plaque\": transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment. J Am Coll Cardiol 65:846\u2013855","journal-title":"J Am Coll Cardiol"},{"key":"2116_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2012.07.064","volume":"61","author":"F Crea","year":"2013","unstructured":"Crea F, Liuzzo G (2013) Pathogenesis of acute coronary syndromes. J Am Coll Cardiol 61:1\u201311","journal-title":"J Am Coll Cardiol"},{"key":"2116_CR20","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1056\/NEJM198711263172201","volume":"317","author":"JB Kruskal","year":"1987","unstructured":"Kruskal JB, Commerford PJ, Franks JJ, Kirsch RE (1987) Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease. N Engl J Med 317:1361\u20131365","journal-title":"N Engl J Med"},{"key":"2116_CR21","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1161\/01.CIR.83.5.1685","volume":"83","author":"A Zalewski","year":"1991","unstructured":"Zalewski A, Shi Y, Nardone D et al (1991) Evidence for reduced fibrinolytic activity in unstable angina at rest. Clinical, biochemical, and angiographic correlates. Circulation 83:1685\u20131691","journal-title":"Circulation"},{"issue":"12","key":"2116_CR22","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1253\/circj.CJ-19-0640","volume":"83","author":"H Okamoto","year":"2019","unstructured":"Okamoto H, Kume T, Yamada R et al (2019) Prevalence and clinical significance of layered plaque in patients with stable angina pectoris- evaluation with histopathology and optical coherence tomography. Circ J 83(12):2452\u20132459","journal-title":"Circ J"},{"key":"2116_CR23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1001\/jamacardio.2017.5234","volume":"3","author":"T Sugiyama","year":"2018","unstructured":"Sugiyama T, Yamamoto E, Bryniarski K et al (2018) Nonculprit plaque characteristics in patients with acute coronary syndrome caused by plaque erosion vs plaque rupture: a 3-Vessel optical coherence tomography study. JAMA Cardiol 3:207\u2013214","journal-title":"JAMA Cardiol"},{"key":"2116_CR24","first-page":"488","volume":"314","author":"IK Jang","year":"2017","unstructured":"Jang IK (2017) Plaque progression slow linear or rapid stepwise? Circ Cardiovasc Imag 314:488\u2013500","journal-title":"Circ Cardiovasc Imag"},{"key":"2116_CR25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1378\/chest.94.4.731","volume":"94","author":"JI Haft","year":"1988","unstructured":"Haft JI, Haik BJ, Goldstein JE, Brodyn NE (1988) Development of significant coronary artery lesions in areas of minimal disease. A common mechanism for coronary disease progression. Chest 94:731\u2013736","journal-title":"Chest"},{"key":"2116_CR26","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/0735-1097(93)90429-5","volume":"22","author":"EL Alderman","year":"1993","unstructured":"Alderman EL, Corley SD, Fisher LD et al (1993) Five-year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 22:1141\u20131154","journal-title":"J Am Coll Cardiol"},{"key":"2116_CR27","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/MCA.0000000000000420","volume":"27","author":"Z Xie","year":"2016","unstructured":"Xie Z, Hou J, Yu H et al (2016) Patterns of coronary plaque progression: phasic versus gradual. A combined optical coherence tomography and intravascular ultrasound study. Coron Artery Dis 27:658\u2013666","journal-title":"Coron Artery Dis"},{"key":"2116_CR28","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/CIRCIMAGING.112.973701","volume":"5","author":"K Kato","year":"2012","unstructured":"Kato K, Yonetsu T, Kim SJ et al (2012) Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study. Circ Cardiovasc Imag 5:433\u2013440","journal-title":"Circ Cardiovasc Imag"},{"key":"2116_CR29","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1161\/01.CIR.0000158435.98035.8D","volume":"111","author":"J Johnson","year":"2005","unstructured":"Johnson J, Carson K, Williams H et al (2005) Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment. Circulation 111:1422\u20131430","journal-title":"Circulation"},{"key":"2116_CR30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/CIRCRESAHA.113.301562","volume":"113","author":"YC Chen","year":"2013","unstructured":"Chen YC, Bui AV, Diesch J et al (2013) A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic\/therapeutic discoveries using gene and microRNA expression profiling. Circ Res 113:252\u2013265","journal-title":"Circ Res"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-020-02116-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-020-02116-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-020-02116-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T23:22:09Z","timestamp":1618701729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-020-02116-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,18]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["2116"],"URL":"https:\/\/doi.org\/10.1007\/s11239-020-02116-5","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,18]]},"assertion":[{"value":"18 April 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Ik-Kyung Jang has received educational grants from Abbott Vascular. They had no role in the design or conduct of this research. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}