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Weitz: Honoraria from Bayer Pharma AG, Boehringer-Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Ionis, Janssen, Merck, Portola, Pfizer, Servier, Novartis, Anthos, and Tetherex. Sylvia Haas: Honoraria from Aspen, Bayer Pharma AG, Bristol Myers Squibb, Daiichi-Sankyo, Portola, Sanofi. Walter Ageno: Honoraria from Boehringer Ingelheim, Bayer Pharma AG, Bristol Myers Squibb, Pfizer and Daiichi-Sankyo. Research support from Bayer Pharma AG and Boehringer-Ingelheim. Samuel Z. Goldhaber: Grants from BiO2 Medical, Boehringer-Ingelheim, Bristol Meyers Squibb, BTG EKOS, Daiichi-Sankyo, National Heart Lung and Blood Institute of the National Institutes of Health and Janssen. Personal fees from Bayer Pharma AG, Boehringer-Ingelheim, Bristol Meyers Squibb, Daiichi-Sankyo, Janssen, Portola, Zafgen. Alexander G. G. Turpie: Personal fees from Bayer Pharma AG and Janssen. Henri Bounameaux: Honoraria from Bayer Pharma AG. Shinya Goto: Research funding from Ono, Bristol Myers Squibb, Sanofi, and Pfizer. J\u00f8rn Dalsgaard Nielsen: Honoraria from Bayer Pharma AG, Boehringer-Ingelheim, Bristol Myers Squibb, Leo Pharma and Pfizer. Sebastian Schellong: Speaker fees from Bayer Pharma AG, Boehringer-Ingelheim, Bristol Meyer Squibb, Daiichi-Sankyo, Sanofi Aventis and Pfizer. Consultancy fees from Bayer Pharma AG, Boehringer-Ingelheim, Daiichi-Sankyo, Sanofi Aventis and Pfizer. Lorenzo Mantovani: Grants and personal fees from Bayer Pharma AG, Boehringer-Ingelheim, Pfizer and Daiichi-Sankyo. Paolo Prandoni: Personal fees from Bayer Pharma AG, Pfizer, Daiichi-Sankyo and Sanofi. Professor Ajay K. Kakkar: Research grants from Bayer Pharma AG, personal fees from Bayer Pharma AG, Boehringer-Ingelheim, Daiichi-Sankyo Europe, Sanofi SA and Janssen. Pantep Angchaisuksiri, Henrik Fryk and Gloria Kayani declare that they have no conflicts of interest in the research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Independent ethics committee and hospital-based institutional review board approvals were obtained, as necessary, for the registry protocol.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}