{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:15Z","timestamp":1792251195533,"version":"4.4.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09225"],"award-info":[{"award-number":["18K09225"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09799"],"award-info":[{"award-number":["19K09799"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03823"],"award-info":[{"award-number":["20H03823"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s11239-021-02513-4","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T14:04:42Z","timestamp":1625580282000},"page":"208-212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory effects of amniotic fluid on the activated protein C anticoagulation system in maternal plasma"],"prefix":"10.1007","volume":"53","author":[{"given":"Divyanu","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-4318","authenticated-orcid":false,"given":"Tomoaki","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Horikoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Narumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kohmura-Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Furuta-Isomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Yaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunao","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"2513_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11239-013-0941-9","volume":"37","author":"E Conti","year":"2014","unstructured":"Conti E, Zezza L, Ralli E, Comito C, Sada L, Passerini J, Caserta D, Rubattu S, Autore C, Moscarini M, Volpe M (2014) Pulmonary embolism in pregnancy. J Thromb Thrombolysis 37:251\u2013270. https:\/\/doi.org\/10.1007\/s11239-013-0941-9","journal-title":"J Thromb Thrombolysis"},{"key":"2513_CR2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1253\/circj.72.753","volume":"72","author":"T Kobayashi","year":"2008","unstructured":"Kobayashi T, Nakabayashi M, Ishikawa M, Adachi T, Kobashi G, Maeda M, Ikenoue T (2008) Pulmonary thromboembolism in obstetrics and gynecology increased by 6.5-fold over the past decade in Japan. Circ J 72:753\u2013756","journal-title":"Circ J"},{"key":"2513_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/1933719107309646","volume":"15","author":"AS Leong","year":"2008","unstructured":"Leong AS, Norman JE, Smith R (2008) Vascular and myometrial changes in the human uterus at term. Reprod Sci 15:59\u201365. https:\/\/doi.org\/10.1177\/1933719107309646","journal-title":"Reprod Sci"},{"key":"2513_CR4","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/0002-9378(86)90334-0","volume":"155","author":"W Lee","year":"1986","unstructured":"Lee W, Ginsburg KA, Cotton DB, Kaufman RH (1986) Squamous and trophoblastic cells in the maternal pulmonary circulation identified by invasive hemodynamic monitoring during the peripartum period. Am J Obstet Gynecol 155:999\u20131001","journal-title":"Am J Obstet Gynecol"},{"key":"2513_CR5","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1111\/j.1538-7836.2007.02767.x","volume":"5","author":"K Boer","year":"2007","unstructured":"Boer K, den Hollander IA, Meijers JC, Levi M (2007) Tissue factor-dependent blood coagulation is enhanced following delivery irrespective of the mode of delivery. J Thromb Haemost 5:2415\u20132420. https:\/\/doi.org\/10.1111\/j.1538-7836.2007.02767.x","journal-title":"J Thromb Haemost"},{"key":"2513_CR6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.thromres.2018.11.001","volume":"172","author":"T Oda","year":"2018","unstructured":"Oda T, Tamura N, Shen Y, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Uchida T, Suzuki K, Itoh H, Kanayama N (2018) Amniotic fluid as a potent activator of blood coagulation and platelet aggregation: study with rotational thromboelastometry. Thromb Res 172:142\u2013149. https:\/\/doi.org\/10.1016\/j.thromres.2018.11.001","journal-title":"Thromb Res"},{"key":"2513_CR7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1046\/j.1365-2141.1995.00271.x","volume":"92","author":"F Mathonnet","year":"1996","unstructured":"Mathonnet F, de Mazancourt P, Bastenaire B, Morot M, Benattar N, Beufe S, Borg JY, Giudicelli Y (1996) Activated protein C sensitivity ratio in pregnant women at delivery. Br J Haematol 92:244\u2013246. https:\/\/doi.org\/10.1046\/j.1365-2141.1995.00271.x","journal-title":"Br J Haematol"},{"key":"2513_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000322880","volume":"72","author":"K Hirai","year":"2011","unstructured":"Hirai K, Sugimura M, Ohashi R, Suzuki K, Itoh H, Sugihara K, Kanayama N (2011) A rapid activated protein C sensitivity test as a diagnostic marker for a suspected venous thromboembolism in pregnancy and puerperium. Gynecol Obstet Investig 72:55\u201362. https:\/\/doi.org\/10.1159\/000322880","journal-title":"Gynecol Obstet Investig"},{"key":"2513_CR9","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/humrep\/det092","volume":"28","author":"R Chaireti","year":"2013","unstructured":"Chaireti R, Gustafsson KM, Bystrom B, Bremme K, Lindahl TL (2013) Endogenous thrombin potential is higher during the luteal phase than during the follicular phase of a normal menstrual cycle. Hum Reprod 28:1846\u20131852. https:\/\/doi.org\/10.1093\/humrep\/det092","journal-title":"Hum Reprod"},{"key":"2513_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1055\/s-2007-994957","volume":"25","author":"M Sugimura","year":"1999","unstructured":"Sugimura M, Kobayashi T, Kanayama N, Terao T (1999) Detection of decreased response to activated protein C during pregnancy by an endogenous thrombin potential-based assay. Semin Thromb Hemost 25:497\u2013502. https:\/\/doi.org\/10.1055\/s-2007-994957","journal-title":"Semin Thromb Hemost"},{"key":"2513_CR11","first-page":"34","volume":"45","author":"S Guibaud","year":"1975","unstructured":"Guibaud S, Bonnet M, Thoulon JM, Dumont M (1975) Alpha 1-antitrypsin in amniotic fluid. Obstet Gynecol 45:34\u201338","journal-title":"Obstet Gynecol"},{"key":"2513_CR12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0049-3848(91)90002-e","volume":"64","author":"F Espa\u00f1a","year":"1991","unstructured":"Espa\u00f1a F, Gilabert J, Estell\u00e9s A, Romeu A, Aznar J, Cabo A (1991) Functionally active protein C inhibitor\/plasminogen activator inhibitor-3 (PCI\/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb Res 64:309\u2013320. https:\/\/doi.org\/10.1016\/0049-3848(91)90002-e","journal-title":"Thromb Res"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-021-02513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-021-02513-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-021-02513-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T14:05:23Z","timestamp":1643205923000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-021-02513-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["2513"],"URL":"https:\/\/doi.org\/10.1007\/s11239-021-02513-4","relation":{},"ISSN":["0929-5305","1573-742X"],"issn-type":[{"value":"0929-5305","type":"print"},{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"assertion":[{"value":"12 June 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The present study was approved by the Institutional Review Board of Hamamatsu University School of Medicine (No. 16-165).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}