{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:49:46Z","timestamp":1786981786326,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00191"],"award-info":[{"award-number":["PI16\/00191"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-022-02737-y","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T11:10:58Z","timestamp":1670497858000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of intravenous lysine acetylsalicylate versus oral aspirin on platelet responsiveness in patients with ST-segment elevation myocardial infarction: the ECCLIPSE-STEMI trial"],"prefix":"10.1007","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nct02929888","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"David","family":"Vivas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Julio","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mart\u00edn-Asenjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Aranzazu","family":"Ortega-Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"G\u00f3mez-Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidre","family":"Vilacosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"P\u00e9rez-Villacast\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fern\u00e1ndez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"2737_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1056\/NEJMra043430","volume":"352","author":"GK Hansson","year":"2005","unstructured":"Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352:1685\u20131695","journal-title":"N Engl J Med"},{"key":"2737_CR2","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMra071014","volume":"357","author":"G Davi","year":"2007","unstructured":"Davi G, Patrono C (2007) Platelet activation and atherothrombosis. New Engl J Med 357:2482\u20132494","journal-title":"New Engl J Med"},{"key":"2737_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1253\/circj.CJ-09-0982","volume":"74","author":"DJ Angiolillo","year":"2010","unstructured":"Angiolillo DJ, Ueno M, Goto S (2010) Basic principles of platelet biology and clinical implications. Circ J 74:597\u2013607","journal-title":"Circ J"},{"key":"2737_CR4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2165\/11537670-000000000-00000","volume":"10","author":"D Vivas","year":"2010","unstructured":"Vivas D, Angiolillo DJ (2010) Platelet P2Y12 receptor inhibition: an update on clinical drug development. Am J Cardiovasc Drugs 10:217\u2013226","journal-title":"Am J Cardiovasc Drugs"},{"key":"2737_CR5","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1161\/CIR.0b013e3182742c84","volume":"127","author":"PT O \u0301Gara","year":"2013","unstructured":"O \u0301Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, CF\/AHA Task Force et al (2013) 2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American college of cardiology foundation\/American heart association task force on practice guidelines. Circulation 127:529\u2013555","journal-title":"Circulation"},{"key":"2737_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2018","unstructured":"Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European society of cardiology (ESC). Eur Heart J 39:119\u2013177","journal-title":"Eur Heart J"},{"key":"2737_CR7","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.jacc.2006.11.044","volume":"49","author":"DJ Angiolillo","year":"2007","unstructured":"Angiolillo DJ, Fern\u00e1ndez-Ortiz A, Bernardo E, Alfonso F, Macaya C, Bass TA et al (2007) Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 49:1505\u20131516","journal-title":"J Am Coll Cardiol"},{"key":"2737_CR8","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1161\/01.CIR.0000130846.46168.03","volume":"109","author":"S Matetzky","year":"2004","unstructured":"Matetzky S, Shenkman B, Guetta V, Shechter M, Beinart R, Goldenberg I et al (2004) Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 109:3171\u20133175","journal-title":"Circulation"},{"key":"2737_CR9","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.jacc.2007.05.049","volume":"50","author":"DJ Angiolillo","year":"2007","unstructured":"Angiolillo DJ, Bernardo E, Sabat\u00e9 M, Jimenez-Quevedo P, Costa MA, Palazuelos J et al (2007) Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 50:1541\u20131547","journal-title":"J Am Coll Cardiol"},{"key":"2737_CR10","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1056\/NEJMoa0706482","volume":"357","author":"SD Wiviott","year":"2007","unstructured":"Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, TRITON-TIMI 38 Investigators et al (2007) Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357:2001\u20132015","journal-title":"N Engl J Med"},{"key":"2737_CR11","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","volume":"361","author":"L Wallentin","year":"2009","unstructured":"Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C et al (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045\u20131057","journal-title":"N Engl J Med"},{"key":"2737_CR12","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1056\/NEJM198411083111902","volume":"311","author":"AK Pedersen","year":"1984","unstructured":"Pedersen AK, FitzGerald GA (1984) Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med 311:1206\u20131211","journal-title":"N Engl J Med"},{"key":"2737_CR13","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1023\/A:1015978104017","volume":"6","author":"L Aarons","year":"1989","unstructured":"Aarons L, Hopkins K, Rowland M, Brossel S, Thiercelin JF (1989) Route of administration and sex differences in the pharmacokinetics of aspirin, administered as its lysine salt. Pharm Res 6:660\u2013666","journal-title":"Pharm Res"},{"key":"2737_CR14","first-page":"28","volume":"8","author":"JF Bretagne","year":"1984","unstructured":"Bretagne JF, Feuillu A, Gosselin M, Gastard J (1984) Aspirin and gastroduodenal toxicity. A double-blind endoscopic study of the effects of placebo, aspirin and lysine acetylsalicylate in healthy subjects. Gastroenterol Clin Biol 8:28\u201332","journal-title":"Gastroenterol Clin Biol"},{"key":"2737_CR15","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/clc.4960230912","volume":"23","author":"EP Gurfinkel","year":"2000","unstructured":"Gurfinkel EP, Altman R, Scazziota A, Heguilen R, Mautner B (2000) Fast platelet suppression by lysine acetylsalicylate in chronic stable coronary patients. Potential clinical impact over regular aspirin for coronary syndromes. Clin Cardiol 23:697\u2013700","journal-title":"Clin Cardiol"},{"key":"2737_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/09537100500438156","volume":"17","author":"A Majluf-Cruz","year":"2006","unstructured":"Majluf-Cruz A, Chavez-Ochoa AR, Majluf-Cruz K, Coria-Ramirez E, Pineda Del Aguila I, Trevi\u00f1o-Perez S et al (2006) Effect of combined administration of clopidogrel and lysine acetylsalicylate versus clopidogrel and aspirin on platelet aggregation and activated GPIIb\/IIIa expression in healthy volunteers. Platelets 17:105\u2013107","journal-title":"Platelets"},{"key":"2737_CR17","doi-asserted-by":"publisher","first-page":"e002281","DOI":"10.1161\/CIRCINTERVENTIONS.114.002281","volume":"8","author":"D Vivas","year":"2015","unstructured":"Vivas D, Mart\u00edn A, Bernardo E, Ortega-Pozzi MA, Tirado G, Fern\u00e1ndez C et al (2015) Impact of intravenous lysine acetylsalicylate versus oral aspirin on prasugrel-inhibited platelets: results of a prospective, randomized, crossover study (the ECCLIPSE trial). Circ Cardiovasc Interv 8:e002281. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.114.002281","journal-title":"Circ Cardiovasc Interv"},{"key":"2737_CR18","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1001\/jama.294.10.1224","volume":"294","author":"MS Sabatine","year":"2005","unstructured":"Sabatine MS, Cannon CP, Gibson CM, L\u00f3pez-Send\u00f3n JL, Montalescot G, Theroux P, Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators et al (2005) Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA 294:1224\u20131232","journal-title":"JAMA"},{"key":"2737_CR19","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0140-6736(09)60441-4","volume":"373","author":"G Montalescot","year":"2009","unstructured":"Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabe CH, TRITON-TIMI 38 Investigators et al (2009) Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomized controlled trial. Lancet 373:723\u2013731","journal-title":"Lancet"},{"key":"2737_CR20","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1161\/CIRCULATIONAHA.109.927582","volume":"122","author":"PG Steg","year":"2010","unstructured":"Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, Plato Study Group et al (2010) Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a platelet inhibition and patient outcomes (PLATO) trial subgroup analysis. Circulation 122:2131\u20132141","journal-title":"Circulation"},{"key":"2737_CR21","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association Declaration of Helsinki","year":"2013","unstructured":"World Medical Association Declaration of Helsinki (2013) Ethical principles for medical research involving human subjects. JAMA 310:2191\u20132194","journal-title":"JAMA"},{"key":"2737_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1160\/TH07-07-0478","volume":"99","author":"D Sibbing","year":"2008","unstructured":"Sibbing D, Braun S, Jawansky S, Vogt W, Mehilli J, Sch\u00f6mig A et al (2008) Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thromb Haemost 99:121\u2013126","journal-title":"Thromb Haemost"},{"key":"2737_CR23","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/CIRCULATIONAHA.106.667741","volume":"115","author":"DJ Angiolillo","year":"2007","unstructured":"Angiolillo DJ, Shoemaker SB, Desai B, Yuan H, Charlton RK, Bernardo E et al (2007) A randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the OPTIMUS (optimizing anti-platelet therapy in diabetes mellitus) study. Circulation 115:708\u2013716","journal-title":"Circulation"},{"key":"2737_CR24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1160\/TH16-08-0650","volume":"117","author":"U Zeymer","year":"2017","unstructured":"Zeymer U, Hohlfeld T, Vom Dahl J, Erbel R, Munzel T, Zahn R et al (2017) Prospective, randomised trial of the time dependent antiplatelet effects of 500 mg and 250 mg acetylsalicylic acid i. v. and 300 mg p. o. in ACS (ACUTE). Thromb Haemost 117:625\u2013635","journal-title":"Thromb Haemost"},{"key":"2737_CR25","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1016\/j.jacc.2009.11.091","volume":"55","author":"JM ten Berg","year":"2010","unstructured":"ten Berg JM, van \u2019t Hof AWJ, Dill T, Heestermans T, van Werkum JW, Mosterd A et al (2010) Effect of early, pre-hospital initiation of high bolus dose tirofiban in patients with ST- segment elevation myocardial infarction on short- and long-term clinical out- come. J Am Coll Cardiol 55:2446\u20132455","journal-title":"J Am Coll Cardiol"},{"key":"2737_CR26","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1056\/NEJMoa0908629","volume":"361","author":"DL Bhatt","year":"2009","unstructured":"Bhatt DL, Lincoff AM, Gibson CM, Stone GW, McNulty S, Montalescot G, CHAMPION PLATFORM Investigators et al (2009) Intravenous platelet blockade with cangrelor during PCI. N Engl J Med 361:2330\u20132341","journal-title":"N Engl J Med"},{"key":"2737_CR27","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1056\/NEJMoa1300815","volume":"368","author":"DL Bhatt","year":"2013","unstructured":"Bhatt DL, Stone GW, Mahaffey KW, Gibson CM, Steg PG, Hamm CW, CHAMPION PHOENIX Investigators et al (2013) Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med 368:1303\u20131313","journal-title":"N Engl J Med"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-022-02737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-022-02737-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-022-02737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T10:57:44Z","timestamp":1744196264000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-022-02737-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["2737"],"URL":"https:\/\/doi.org\/10.1007\/s11239-022-02737-y","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"20 November 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}