{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:50:59Z","timestamp":1767862259674,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100018627","name":"Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China","doi-asserted-by":"publisher","award":["202003010399"],"award-info":[{"award-number":["202003010399"]}],"id":[{"id":"10.13039\/501100018627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-023-02835-5","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:02:08Z","timestamp":1686121328000},"page":"264-274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Procoagulant effect of extracellular vesicles in patients after transcatheter aortic valve replacement or transcatheter aortic valve replacement with percutaneous coronary intervention"],"prefix":"10.1007","volume":"56","author":[{"given":"Hang","family":"Chi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"2835_CR1","first-page":"125","volume":"6","author":"PP Hu","year":"2012","unstructured":"Hu PP (2012) TAVR and SAVR: current treatment of aortic stenosis. Clin Med Insights Cardiol 6:125\u2013139","journal-title":"Clin Med Insights Cardiol"},{"key":"2835_CR2","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","volume":"34","author":"KE Yutzey","year":"2014","unstructured":"Yutzey KE, Demer LL, Body SC et al (2014) Calcific aortic valve disease: a consensus summary from the Alliance of investigators on calcific aortic valve disease. Arterioscler Thromb Vasc Biol 34:2387\u20132393","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2835_CR3","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1007\/s00380-016-0804-3","volume":"31","author":"G Cappabianca","year":"2016","unstructured":"Cappabianca G, Ferrarese S, Musazzi A et al (2016) Predictive factors of long-term survival in the octogenarian undergoing surgical aortic valve replacement: 12-year single-centre follow-up. Heart Vessels 31:1798\u20131805","journal-title":"Heart Vessels"},{"key":"2835_CR4","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1002\/clc.22328","volume":"37","author":"I Mastoris","year":"2014","unstructured":"Mastoris I, Schoos MM, Dangas GD et al (2014) Stroke after transcatheter aortic valve replacement: incidence, risk factors, prognosis, and preventive strategies. Clin Cardiol 37:756\u2013764","journal-title":"Clin Cardiol"},{"key":"2835_CR5","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jacc.2016.05.065","volume":"68","author":"V Auffret","year":"2016","unstructured":"Auffret V, Regueiro A, Trigo MD et al (2016) Predictors of early cerebrovascular events in patients with aortic stenosis undergoing transcatheter aortic valve replacement. J Am Coll Cardiol 68:673\u2013684","journal-title":"J Am Coll Cardiol"},{"key":"2835_CR6","doi-asserted-by":"crossref","unstructured":"Yanagisawa R, Hayashida K, Yamada Y et al (2016) Incidence, predictors, and mid-term outcomes of possible leaflet thrombosis after TAVR. JACC Cardiovasc Imaging","DOI":"10.1016\/j.jcmg.2016.11.005"},{"key":"2835_CR7","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1056\/NEJMoa2017815","volume":"383","author":"J Brouwer","year":"2020","unstructured":"Brouwer J, Nijenhuis VJ, Delewi R et al (2020) Aspirin with or without Clopidogrel after Transcatheter aortic-valve implantation. N Engl J Med 383:1447\u20131457","journal-title":"N Engl J Med"},{"key":"2835_CR8","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1056\/NEJMoa1915152","volume":"382","author":"VJ Nijenhuis","year":"2020","unstructured":"Nijenhuis VJ, Brouwer J, Delewi R et al (2020) Anticoagulation with or without Clopidogrel after Transcatheter aortic-valve implantation. N Engl J Med 382:1696\u20131707","journal-title":"N Engl J Med"},{"key":"2835_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1126\/science.1152066","volume":"319","author":"T Yeung","year":"2008","unstructured":"Yeung T, Gilbert GE, Shi J et al (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science 319:210\u2013213","journal-title":"Science"},{"key":"2835_CR10","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1161\/CIRCRESAHA.110.233056","volume":"108","author":"AP Owens 3rd","year":"2011","unstructured":"Owens AP 3rd, Mackman N (2011) Microvesicles in hemostasis and thrombosis. Circ Res 108:1284\u20131297","journal-title":"Circ Res"},{"key":"2835_CR11","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1161\/ATVBAHA.107.141911","volume":"27","author":"N Mackman","year":"2007","unstructured":"Mackman N, Tilley RE, Key NS (2007) Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 27:1687\u20131693","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2835_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/cyto.a.20354","volume":"71","author":"S Perez-Pujol","year":"2007","unstructured":"Perez-Pujol S, Marker PH, Key NS (2007) Platelet microvesicles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytometry A 71:38\u201345","journal-title":"Cytometry A"},{"key":"2835_CR13","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1016\/j.jacc.2020.09.595","volume":"76","author":"JD Carroll","year":"2020","unstructured":"Carroll JD, Mack MJ, Vemulapalli S et al (2020) STS-ACC TVT Registry of Transcatheter aortic valve replacement. J Am Coll Cardiol 76:2492\u20132516","journal-title":"J Am Coll Cardiol"},{"key":"2835_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s00380-016-0885-z","volume":"32","author":"C Jung","year":"2017","unstructured":"Jung C, Lichtenauer M, Figulla H-R et al (2017) Microvesicles in patients undergoing transcatheter aortic valve implantation (TAVI). Heart Vessels 32:458\u2013466","journal-title":"Heart Vessels"},{"key":"2835_CR15","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3892\/etm.2016.3060","volume":"11","author":"B Zhou","year":"2016","unstructured":"Zhou B, Li J, Chen S et al (2016) Time course of various cell origin circulating microvesicles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention. Exp Ther Med 11:1481\u20131486","journal-title":"Exp Ther Med"},{"key":"2835_CR16","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.jacbts.2022.05.002","volume":"7","author":"RG Jung","year":"2022","unstructured":"Jung RG, Duchez A, Simard T et al (2022) Plasminogen activator inhibitor-1-Positive platelet-derived extracellular vesicles predicts MACE and the Proinflammatory SMC phenotype. JACC Basic Transl Sci 7:985\u2013997","journal-title":"JACC Basic Transl Sci"},{"key":"2835_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.amjmed.2016.10.005","volume":"130","author":"J Joseph","year":"2017","unstructured":"Joseph J, Naqvi SY, Giri J et al (2017) Aortic stenosis: pathophysiology, diagnosis, and Therapy. Am J Med 130:253\u2013263","journal-title":"Am J Med"},{"key":"2835_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bbamem.2004.09.006","volume":"1667","author":"J Shi","year":"2004","unstructured":"Shi J, Heegaard CW, Rasmussen JT et al (2004) Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta 1667:82\u201390","journal-title":"Biochim Biophys Acta"},{"key":"2835_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12952-016-0051-2","volume":"15","author":"JF Marchini","year":"2016","unstructured":"Marchini JF, Miyakawa AA, Tarasoutchi F et al (2016) Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement. J Negat Results Biomed 15:7","journal-title":"J Negat Results Biomed"},{"key":"2835_CR20","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1160\/TH15-09-0710","volume":"115","author":"Z He","year":"2016","unstructured":"He Z, Si Y, Jiang T et al (2016) Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease. Thromb Haemost 115:738\u2013751","journal-title":"Thromb Haemost"},{"key":"2835_CR21","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.4244\/EIJY14M10_02","volume":"10","author":"P Horn","year":"2015","unstructured":"Horn P, Stern D, Veulemans V et al (2015) Improved endothelial function and decreased levels of endothelium-derived microvesicles after transcatheter aortic valve implantation. EuroIntervention 10:1456\u20131463","journal-title":"EuroIntervention"},{"key":"2835_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1161\/CIRCULATIONAHA.109.927764","volume":"122","author":"G Petrov","year":"2010","unstructured":"Petrov G, Regitz-Zagrosek V, Lehmkuhl E et al (2010) Regression of myocardial hypertrophy after aortic valve replacement: faster in women? Circulation 122:23\u201328","journal-title":"Circulation"},{"key":"2835_CR23","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11239-020-02342-x","volume":"51","author":"J Li","year":"2021","unstructured":"Li J, Tong D, Chen F et al (2021) Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension. J Thromb Thrombolysis 51:933\u2013940","journal-title":"J Thromb Thrombolysis"},{"key":"2835_CR24","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12872-019-1148-6","volume":"19","author":"HU Atmaca","year":"2019","unstructured":"Atmaca HU, Akbas F, Aral H (2019) Relationship between circulating microvesicles and hypertension and other cardiac disease biomarkers in the elderly. BMC Cardiovasc Disord 19:164","journal-title":"BMC Cardiovasc Disord"},{"key":"2835_CR25","doi-asserted-by":"publisher","first-page":"6556","DOI":"10.1074\/jbc.M607973200","volume":"282","author":"AW Shaw","year":"2007","unstructured":"Shaw AW, Pureza VS, Sligar SG et al (2007) The local phospholipid environment modulates the activation of blood clotting. J Biol Chem 282:6556\u20136563","journal-title":"J Biol Chem"},{"key":"2835_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.thromres.2012.02.021","volume":"129","author":"LVM Rao","year":"2012","unstructured":"Rao LVM, Kothari H, Pendurthi UR (2012) Tissue factor encryption and decryption: facts and controversies. Thromb Res 129:13\u201317","journal-title":"Thromb Res"},{"key":"2835_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.thromres.2021.07.018","volume":"206","author":"S Koganti","year":"2021","unstructured":"Koganti S, Eleftheriou D, Gurung R et al (2021) Persistent circulating platelet and endothelial derived microparticle signature may explain on-going pro-thrombogenicity after acute coronary syndrome. Thromb Res 206:60\u201365","journal-title":"Thromb Res"},{"key":"2835_CR28","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1253\/circj.CJ-12-0068","volume":"76","author":"LM Biasucci","year":"2012","unstructured":"Biasucci LM, Porto I, Di Vito L et al (2012) Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circ J 76:2174\u20132182","journal-title":"Circ J"},{"key":"2835_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.thromres.2012.02.025","volume":"129","author":"R Lacroix","year":"2012","unstructured":"Lacroix R, Dignat-George F (2012) Microvesicles as a circulating source of procoagulant and fibrinolytic activities in the circulation. Thromb Res 129:27\u201329","journal-title":"Thromb Res"},{"key":"2835_CR30","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.3324\/haematol.2012.066167","volume":"97","author":"R Lacroix","year":"2012","unstructured":"Lacroix R, Plawinski L, Robert S et al (2012) Leukocyte- and endothelial-derived microvesicles: a circulating source for fibrinolysis. Haematologica 97:1864\u20131872","journal-title":"Haematologica"},{"key":"2835_CR31","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.112.300818","volume":"112","author":"AC Vion","year":"2013","unstructured":"Vion AC, Ramkhelawon B, Loyer X et al (2013) Shear stress regulates endothelial microparticle release. Circ Res 112:1323\u20131333","journal-title":"Circ Res"},{"key":"2835_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0021-9150(01)00433-6","volume":"158","author":"S Nomura","year":"2001","unstructured":"Nomura S, Tandon NN, Nakamura T et al (2001) High-shear-stress-induced activation of platelets and microvesicles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis 158:277\u2013287","journal-title":"Atherosclerosis"},{"key":"2835_CR33","first-page":"927","volume":"45","author":"S Nomura","year":"1997","unstructured":"Nomura S, Komiyama Y (1997) Shear stress and platelet-derived microvesicles. Rinsho Byori 45:927\u2013933","journal-title":"Rinsho Byori"},{"key":"2835_CR34","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/aor.12438","volume":"39","author":"J Ding","year":"2015","unstructured":"Ding J, Chen Z, Niu S et al (2015) Quantification of Shear-Induced platelet activation: high shear stresses for short exposure time. Artif Organs 39:576\u2013583","journal-title":"Artif Organs"},{"key":"2835_CR35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12933-021-01267-w","volume":"20","author":"A Giannella","year":"2021","unstructured":"Giannella A, Ceolotto G, Radu CM et al (2021) PAR-4\/Ca(2+)-calpain pathway activation stimulates platelet-derived microvesicles in hyperglycemic type 2 diabetes. Cardiovasc Diabetol 20:77","journal-title":"Cardiovasc Diabetol"},{"key":"2835_CR36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0049-3848(00)00186-9","volume":"98","author":"S Nomura","year":"2000","unstructured":"Nomura S, Imamura A, Okuno M et al (2000) Platelet-derived microvesicles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines. Thromb Res 98:257\u2013268","journal-title":"Thromb Res"},{"key":"2835_CR37","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1161\/CIRCULATIONAHA.108.816710","volume":"119","author":"AS Leroyer","year":"2009","unstructured":"Leroyer AS, Ebrahimian TG, Cochain C et al (2009) Microvesicles from ischemic muscle promotes postnatal vasculogenesis. Circulation 119:2808\u20132817","journal-title":"Circulation"},{"key":"2835_CR38","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1074\/jbc.M508915200","volume":"281","author":"B Karten","year":"2006","unstructured":"Karten B, Campenot RB, Vance DE et al (2006) Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J Biol Chem 281:4049\u20134057","journal-title":"J Biol Chem"},{"key":"2835_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12968-021-00771-y","volume":"23","author":"H Komoriyama","year":"2021","unstructured":"Komoriyama H, Kimiya K, Nagai T et al (2021) Blood flow dynamics with four-dimensional flow cardiovascular magnetic resonance in patients with aortic stenosis before and after transcatheter aortic valve replacement. J Cardiovasc Magn Reson 23:81","journal-title":"J Cardiovasc Magn Reson"},{"key":"2835_CR40","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jacc.2006.10.053","volume":"49","author":"AS Leroyer","year":"2007","unstructured":"Leroyer AS, Isobe H, Leseche G et al (2007) Cellular origins and thrombogenic activity of microvesicles isolated from human atherosclerotic plaques. J Am Coll Cardiol 49:772\u2013777","journal-title":"J Am Coll Cardiol"},{"key":"2835_CR41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jash.2012.06.003","volume":"6","author":"AJ Viera","year":"2012","unstructured":"Viera AJ, Mooberry M, Key NS (2012) Microvesicles in cardiovascular disease pathophysiology and outcomes. J Am Soc Hypertens 6:243\u2013252","journal-title":"J Am Soc Hypertens"},{"key":"2835_CR42","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jacc.2016.05.054","volume":"68","author":"O Barth\u00e9l\u00e9my","year":"2016","unstructured":"Barth\u00e9l\u00e9my O, Collet JP, Montalescot G (2016) Cerebral embolism: a silent iatrogenic complication of TAVR that needs voiced consideration. J Am Coll Cardiol 68:600\u2013602","journal-title":"J Am Coll Cardiol"},{"key":"2835_CR43","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1161\/CIRCULATIONAHA.112.110981","volume":"126","author":"L Nombela-Franco","year":"2012","unstructured":"Nombela-Franco L, Webb JG, Jaegere PP et al (2012) Timing, predictive factors, and prognostic value of cerebrovascular events in a large cohort of patients undergoing transcatheter aortic valve implantation. Circulation 126:3041\u20133053","journal-title":"Circulation"},{"key":"2835_CR44","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/CIRCINTERVENTIONS.112.000429","volume":"6","author":"A Ghanem","year":"2013","unstructured":"Ghanem A, Kocurek J, Sinning J-M et al (2013) Cognitive trajectory after transcatheter aortic valve implantation. Circ Cardiovasc Interv 6:615\u2013624","journal-title":"Circ Cardiovasc Interv"},{"key":"2835_CR45","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1093\/eurheartj\/ehv526","volume":"37","author":"G Pache","year":"2016","unstructured":"Pache G, Schoechlin S, Blanke P et al (2016) Early hypo-attenuated leaflet thickening in balloon-expandable transcatheter aortic heart valves. Eur Heart J 37:2263\u20132271","journal-title":"Eur Heart J"},{"key":"2835_CR46","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.jacc.2012.01.001","volume":"59","author":"DR Holmes Jr","year":"2012","unstructured":"Holmes DR Jr, Mack MJ, Kaul S et al (2012) 2012 ACCF\/AATS\/SCAI\/STS expert consensus document on transcatheter aortic valve replacement. J Am Coll Cardiol 59:1200\u20131254","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-023-02835-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-023-02835-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-023-02835-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T04:03:33Z","timestamp":1689134613000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-023-02835-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["2835"],"URL":"https:\/\/doi.org\/10.1007\/s11239-023-02835-5","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"19 May 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors, HC, YS, FX, GZ, JZ, GJ, DT and JL declare to have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}