{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:34:43Z","timestamp":1786970083364,"version":"build-2736575974"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"DIPAS","award":["S&T(A)\/22-23\/DIP-276"],"award-info":[{"award-number":["S&T(A)\/22-23\/DIP-276"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-024-02947-6","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:03:35Z","timestamp":1708704215000},"page":"699-709","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic implication of MicroRNA-320a antagonist in attenuating blood clots formed during venous thrombosis"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-0255","authenticated-orcid":false,"given":"Swati","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iti","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjana","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"10","key":"2947_CR1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1111\/jth.12698","volume":"12","author":"ISTH Steering Committee for World Thrombosis Day","year":"2014","unstructured":"ISTH Steering Committee for World Thrombosis Day (2014) Thrombosis: a major contributor to the global disease burden. J Thromb Haemost 12(10):1580\u20131590. https:\/\/doi.org\/10.1111\/jth.12698","journal-title":"J Thromb Haemost"},{"issue":"4","key":"2947_CR2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","volume":"5","author":"IA Naess","year":"2007","unstructured":"Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstr\u00f8m J (2007) Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost 5(4):692\u2013699. https:\/\/doi.org\/10.1111\/j.1538-7836.2007.02450.x","journal-title":"J Thromb Haemost"},{"issue":"4","key":"2947_CR3","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/j.1538-7836.2006.01795.x","volume":"4","author":"S Schulman","year":"2006","unstructured":"Schulman S, Lindmarker P, Holmstr\u00f6m M, L\u00e4rfars G, Carlsson A, Nicol P, Svensson E, Ljungberg B, Viering S, Nordlander S, Leijd B, Jahed K, Hjorth M, Linder O, Beckman M (2006) Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months. J Thromb Haemost 4(4):734\u2013742. https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01795.x","journal-title":"J Thromb Haemost"},{"key":"2947_CR4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/ATVBAHA.111.244608","volume":"32","author":"JA Diaz","year":"2012","unstructured":"Diaz JA, Obi A, Myers DD, Wrobleski SK, Henke PK, Mackman N, Wakefield TW (2012) Critical review of mouse models of venous thrombosis. Arterioscler Thromb Vasc Biol 32:556\u2013562","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2947_CR5","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1001\/archinte.162.11.1245","volume":"162","author":"JA Heit","year":"2002","unstructured":"Heit JA, O\u2019Fallon WM, Petterson TM, Lohse CM, Silverstein MD, Mohr DN, Melton LJ (2002) Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 162:1245\u20131248","journal-title":"Arch Intern Med"},{"key":"2947_CR6","doi-asserted-by":"publisher","first-page":"6830","DOI":"10.1158\/1078-0432.CCR-09-0371","volume":"15","author":"I Zwicker","year":"2009","unstructured":"Zwicker I et al (2009) Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res 15:6830\u20136840","journal-title":"Clin Cancer Res"},{"key":"2947_CR7","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.amjmed.2010.05.021","volume":"123","author":"X Zhou","year":"2010","unstructured":"Zhou X et al (2010) Incidence and risk factors of venous thromboembolic events in lymphoma. Am J Med 123:935\u2013941","journal-title":"Am J Med"},{"key":"2947_CR8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/archinte.158.1.47","volume":"158","author":"C Demers","year":"1998","unstructured":"Demers C et al (1998) Incidence of venographically proved deep vein thrombosis after knee arthroscopy. Arch Intern Med 158:47\u201350","journal-title":"Arch Intern Med"},{"key":"2947_CR9","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1161\/CIRCULATIONAHA.108.778837","volume":"118","author":"MY Chan","year":"2008","unstructured":"Chan MY, Andreotti F, Becker RC (2008) Hypercoagulable states in cardiovascular disease. Circulation 118:2286\u20132297","journal-title":"Circulation"},{"issue":"4","key":"2947_CR10","first-page":"197","volume":"14","author":"AC Anand","year":"2001","unstructured":"Anand AC, Jha SK, Saha A, Sharma V, Adya CM (2001) Thrombosis as a complication of extended stay at high altitude. Natl Med J India 14(4):197\u2013201","journal-title":"Natl Med J India"},{"key":"2947_CR11","first-page":"7","volume":"20","author":"KF Khalil","year":"2010","unstructured":"Khalil KF, Saeed W (2010) Pulmonary embolism in soldiers serving at high altitude. J Coll Physicians Surg Pak 20:7","journal-title":"J Coll Physicians Surg Pak"},{"key":"2947_CR12","first-page":"84","volume":"68","author":"S Kumar","year":"2006","unstructured":"Kumar S (2006) High altitude induced deep venous thrombosis: a study of 28 cases. Indian J Surg 68:84\u201388","journal-title":"Indian J Surg"},{"key":"2947_CR13","first-page":"26","volume-title":"Textbook of environmental emergencies","author":"KS Rao","year":"2006","unstructured":"Rao KS (2006) Other medical illnesses aggravated by high altitude. In: Anand AC, Narula AS, Kakkar R, Kalra R (eds) Textbook of environmental emergencies. Department of Internal Medicine Armed Forces Medical College, Pune, pp 26\u201329"},{"key":"2947_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/hrt.34.6.611","volume":"34","author":"I Singh","year":"1972","unstructured":"Singh I, Chohan IS (1972) Blood coagulation changes at high altitude predisposing to pulmonary hypertension. Br Heart J 34:611\u2013617","journal-title":"Br Heart J"},{"key":"2947_CR15","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","volume":"117","author":"A Brill","year":"2011","unstructured":"Brill A, Fuchs TA, Chauhan AK et al (2011) von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood 117:1400\u20131407. https:\/\/doi.org\/10.1182\/blood-2010-05-287623","journal-title":"Blood"},{"key":"2947_CR16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.6_supplement.640s","author":"EF Mammen","year":"1992","unstructured":"Mammen EF (1992) Pathogenesis of venous thrombosis. Chest. https:\/\/doi.org\/10.1378\/chest.102.6_supplement.640s","journal-title":"Chest"},{"key":"2947_CR17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1136\/jcp.27.7.517","volume":"27","author":"S Sevitt","year":"1974","unstructured":"Sevitt S (1974) The structure and growth of valve-pocket thrombi in femoral veins. J Clin Pathol 27:517\u2013528. https:\/\/doi.org\/10.1136\/jcp.27.7.517","journal-title":"J Clin Pathol"},{"key":"2947_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1084\/jem.20112322","volume":"209","author":"MLV Br\u00fchl","year":"2012","unstructured":"Br\u00fchl MLV, Stark K, Steinhart A et al (2012) Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209:819\u2013835. https:\/\/doi.org\/10.1084\/jem.20112322","journal-title":"J Exp Med"},{"key":"2947_CR19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s00772-016-0227-6","volume":"22","author":"T Sch\u00f6nfelder","year":"2017","unstructured":"Sch\u00f6nfelder T, J\u00e4ckel S, Wenzel P (2017) Mouse models of deep vein thrombosis. Gefasschirurgie 22:28\u201333. https:\/\/doi.org\/10.1007\/s00772-016-0227-6","journal-title":"Gefasschirurgie"},{"key":"2947_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281\u2013297","journal-title":"Cell"},{"issue":"11","key":"2947_CR21","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.tcb.2015.07.011","volume":"25","author":"HO Iwakawa","year":"2015","unstructured":"Iwakawa HO, Tomari Y (2015) The functions of microRNAs: mRNA decay and translational repression. Trends Cell Biol 25(11):651\u2013665","journal-title":"Trends Cell Biol"},{"issue":"39","key":"2947_CR22","doi-asserted-by":"publisher","first-page":"65218","DOI":"10.18632\/oncotarget.18060","volume":"8","author":"W Zhu","year":"2017","unstructured":"Zhu W, Qian J, Ma L, Ma P, Yang F, Shu Y (2017) MiR-346 suppresses cell proliferation through SMYD3 dependent approach in hepatocellular carcinoma. Oncotarget 8(39):65218\u201365229. https:\/\/doi.org\/10.18632\/oncotarget.18060","journal-title":"Oncotarget"},{"key":"2947_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215\u2013233","journal-title":"Cell"},{"key":"2947_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1515\/bmc-2017-0002","volume":"8","author":"V Armand-Labit","year":"2017","unstructured":"Armand-Labit V, Pradines A (2017) Circulating cell-free MicroRNAs as clinical cancer biomarkers. Biomol Concepts 8:61\u201381","journal-title":"Biomol Concepts"},{"key":"2947_CR25","doi-asserted-by":"publisher","first-page":"586","DOI":"10.4254\/wjh.v9.i12.586","volume":"9","author":"SH Loosen","year":"2017","unstructured":"Loosen SH, Schueller F, Trautwein C et al (2017) Role of circulating microRNAs in liver diseases. World J Hepatol 9:586\u2013594","journal-title":"World J Hepatol"},{"key":"2947_CR26","first-page":"812","volume":"60","author":"K Rayner","year":"2014","unstructured":"Rayner K, Dimmeler S, Calin GA et al (2014) Novel biomarkers for acute myocardial infarction: is microRNA the new kid on the block? ClinChem 60:812\u2013817","journal-title":"ClinChem"},{"key":"2947_CR27","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1161\/CIRCRESAHA.108.185363","volume":"104","author":"X Liu","year":"2009","unstructured":"Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C (2009) A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 104:476\u2013487","journal-title":"Circ Res"},{"key":"2947_CR28","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1159\/000445588","volume":"38","author":"M Tan","year":"2016","unstructured":"Tan M, Yan HB, Li JN et al (2016) Thrombin stimulated platelet-derived exosomes inhibit platelet-derived growth factor receptor-beta expression vascular smooth muscle cells. Cell Physiol Biochem 38:2348\u20132365","journal-title":"Cell Physiol Biochem"},{"key":"2947_CR29","doi-asserted-by":"publisher","first-page":"950","DOI":"10.2174\/138945010791591377","volume":"11","author":"C Weber","year":"2010","unstructured":"Weber C, Schober A, Zernecke A (2010) Micrornas in arterial remodelling, inflammation and atherosclerosis. Curr Drug Targets 11:950\u2013956","journal-title":"Curr Drug Targets"},{"key":"2947_CR30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cca.2020.01.034","volume":"504","author":"AA Hembrom","year":"2020","unstructured":"Hembrom AA, Srivastava S, Garg I, Kumar B (2020) MicroRNAs in venous thrombo-embolism. Clin Chim Acta 504:66\u201372. https:\/\/doi.org\/10.1016\/j.cca.2020.01.034","journal-title":"Clin Chim Acta"},{"issue":"1","key":"2947_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.14429\/dlsj.7.17185","volume":"7","author":"AA Hembrom","year":"2022","unstructured":"Hembrom AA, Ghosh N, Kumar V, Garg I, Ganju L, Srivastava S (2022) Panel of regulatory miRNAs for blood coagulation under normoxic and hypoxic conditions. Def Life Sci J 7(1):17\u201326","journal-title":"Def Life Sci J"},{"key":"2947_CR32","doi-asserted-by":"publisher","first-page":"100550","DOI":"10.1016\/j.genrep.2019.100550","volume":"17","author":"S Srivastava","year":"2019","unstructured":"Srivastava S, Garg I, Kumari B, Rai C, Singh Y, Kumar V, Yanamandra U, Singh J, Bansal A, Kumar B (2019) Diagnostic potential of circulating micro RNA hsa-miR-320 in patients of high altitude induced deep vein thrombosis: an Indian study. Gene Rep. 17:100550","journal-title":"Gene Rep."},{"issue":"1","key":"2947_CR33","first-page":"1","volume":"6","author":"S Srivastava","year":"2019","unstructured":"Srivastava S, Garg I, Kumar B (2019) An In-Silico argument for Micro-RNAs showing pivotal role in susceptibility towards high altitude induced venous thrombo-embolism (HA-VTE). Int J Gen Sci 6(1):1\u201311","journal-title":"Int J Gen Sci"},{"key":"2947_CR34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ebiom.2017.11.022","volume":"26","author":"A Sahu","year":"2017","unstructured":"Sahu A, Jha PK, Prabhakar A, Singh HD, Gupta N, Chatterjee T, Tyagi T, Sharma S, Kumari B, Singh S, Nair V, Goel S, Ashraf MZ (2017) MicroRNA-145 impedes thrombus formation via targeting tissue factor in venous thrombosis. EBioMedicine 26:175\u2013186","journal-title":"EBioMedicine"},{"key":"2947_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ebiom.2017.11.022","volume":"26","author":"A Sahu","year":"2017","unstructured":"Sahu A, Jha PK, Prabhakar A, Singh HD, Gupta N, Chatterjee T, Tyagi T, Sharma S, Kumari B, Singh S et al (2017) MicroRNA-145 impedes thrombus formation via targeting tissue factor in venous thrombosis. EBioMedicine 26:175\u2013186","journal-title":"EBioMedicine"},{"key":"2947_CR36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501924","author":"T Tyagi","year":"2013","unstructured":"Tyagi T, Ahmad S, Gupta N, Sahu A, Ahmad Y, Nair V, Chatterjee T, Bajaj N, Sengupta S, Ganju L, Singh SB, Ashraf MZ (2013) Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood. https:\/\/doi.org\/10.1182\/blood-2013-05-501924","journal-title":"Blood"},{"issue":"18","key":"2947_CR37","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1073\/pnas.1620458114","volume":"114","author":"N Gupta","year":"2017","unstructured":"Gupta N, Sahu A, Prabhakar A, Chatterjee T, Tyagi T, Kumari B, Khan N, Nair V, Bajaj N, Sharma M, Ashraf MZ (2017) Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci U S A 114(18):4763\u20134768. https:\/\/doi.org\/10.1073\/pnas.1620458114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2947_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mvr.2018.10.003","volume":"123","author":"W Wang","year":"2019","unstructured":"Wang W, Zhu X, Du X, Xu A, Yuan X, Zhan Y, Liu M, Wang S (2019) MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1. Microvasc Res 123:35\u201341","journal-title":"Microvasc Res"},{"key":"2947_CR39","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13148-019-0627-z","volume":"11","author":"X Wang","year":"2019","unstructured":"Wang X, Sundquist K, Svensson PJ et al (2019) Association of recurrent venous thromboembolism and circulating microRNAs. Clin Epigenet 11:28","journal-title":"Clin Epigenet"},{"key":"2947_CR40","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1161\/ATVBAHA.120.314092","volume":"40","author":"A Rodriguez-Rius","year":"2020","unstructured":"Rodriguez-Rius A, Lopez S, Martinez-Perez A, Souto JC, Soria JM (2020) Identification of a plasma MicroRNA Profile associated with venous thrombosis. Arterioscler, Thromb, Vasc Biol 40:1392\u20131399","journal-title":"Arterioscler, Thromb, Vasc Biol"},{"issue":"5","key":"2947_CR41","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1161\/ATVBAHA.120.314092","volume":"40","author":"A Rodriguez-Rius","year":"2020","unstructured":"Rodriguez-Rius A, Lopez S, Martinez-Perez A, Souto JC, Soria JM (2020) Identification of a plasma MicroRNA profile associated with venous thrombosis. Arterioscler Thromb Vasc Biol 40(5):1392\u20131399. https:\/\/doi.org\/10.1161\/ATVBAHA.120.314092","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"2947_CR42","doi-asserted-by":"publisher","first-page":"E1915","DOI":"10.3390\/cells9081915","volume":"9","author":"M Mussbacher","year":"2020","unstructured":"Mussbacher M, Krammer TL, Heber S et al (2020) Impact of anticoagulation and sample processing on the quantification of human blood-derived microRNA signatures. Cells 9(8):E1915. https:\/\/doi.org\/10.3390\/cells9081915","journal-title":"Cells"},{"issue":"24","key":"2947_CR43","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.12659\/MSM.906596","volume":"6","author":"Z Jiang","year":"2018","unstructured":"Jiang Z, Ma J, Wang Q, Wu F, Ping J, Ming L (2018) Combination of circulating miRNA-320a\/b and D-dimer improves diagnostic accuracy in deep vein thrombosis patients. Med Sci Monit 6(24):2031\u20132037","journal-title":"Med Sci Monit"},{"issue":"3","key":"2947_CR44","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.thromres.2015.07.005","volume":"136","author":"I Starikova","year":"2015","unstructured":"Starikova I, Jamaly S, Sorrentino A, Blondal T, Latysheva N, Sovershaev M, Hansen JB (2015) Differential expression of plasma miRNAs in patients with unprovoked venous thromboembolism and healthy control individuals. Thromb Res 136(3):566\u2013572","journal-title":"Thromb Res"},{"issue":"1","key":"2947_CR45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/pro.421","volume":"31","author":"PD Thomas","year":"2022","unstructured":"Thomas PD, Ebert D, Muruganujan A, Mushayahama T, Albou L-P, Mi H (2022) PANTHER: making genome-scale phylogenetics accessible to all. Protein Soc 31(1):8\u201322. https:\/\/doi.org\/10.1002\/pro.421","journal-title":"Protein Soc"},{"key":"2947_CR46","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.devcel.2006.09.009","volume":"11","author":"WP Kloosterman","year":"2006","unstructured":"Kloosterman WP, Plasterk RH (2006) The diverse functions of microRNAs in animal development and disease. Dev Cell 11:441\u2013450. https:\/\/doi.org\/10.1016\/j.devcel.2006.09.009","journal-title":"Dev Cell"},{"key":"2947_CR47","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1002\/jcp.25854","volume":"233","author":"P Paul","year":"2018","unstructured":"Paul P, Chakraborty A, Sarkar D, Langthasa M, Rahman M, Bari M, Singha RS, Malakar AK, Chakraborty S (2018) Interplay between miRNAs and human diseases. J Cell Physiol 233:2007\u20132018. https:\/\/doi.org\/10.1002\/jcp.25854","journal-title":"J Cell Physiol"},{"key":"2947_CR48","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack FJ (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16:203\u2013222. https:\/\/doi.org\/10.1038\/nrd.2016.246","journal-title":"Nat Rev Drug Discov"},{"key":"2947_CR49","doi-asserted-by":"publisher","first-page":"851","DOI":"10.15252\/emmm.201100899","volume":"6","author":"E Van Rooij","year":"2014","unstructured":"Van Rooij E, Kauppinen S (2014) Development of microRNA therapeutics is coming of age. EMBO Mol Med 6:851\u2013864. https:\/\/doi.org\/10.15252\/emmm.201100899","journal-title":"EMBO Mol Med"},{"issue":"7","key":"2947_CR50","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.3390\/ijms21072602","volume":"21","author":"VM Morelli","year":"2020","unstructured":"Morelli VM, Br\u00e6kkan SK, Hansen JB (2020) Role of microRNAs in venous thromboembolism. Int J Mol Sci 21(7):2602","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2947_CR51","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1681\/ASN.2013010072","volume":"25","author":"L Denby","year":"2014","unstructured":"Denby L, Ramdas V, Lu R, Conway BR, Grant JS, Dickinson B, Aurora AB, McClure JD, Kipgen D, Delles C, van Rooij E, Baker AH (2014) MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol 25(1):65\u201380","journal-title":"J Am Soc Nephrol"},{"key":"2947_CR52","first-page":"5356","volume":"17","author":"H Zhang","year":"2018","unstructured":"Zhang H, Qu Y, Wang A (2018) Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-\u03baB pathway. Mol Med Rep 17:5356\u20135361","journal-title":"Mol Med Rep"},{"issue":"5","key":"2947_CR53","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s40265-021-01474-5","volume":"81","author":"C Hum","year":"2021","unstructured":"Hum C, Loiselle J, Ahmed N, Shaw TA, Toudic C, Pezacki JP (2021) MicroRNA mimics or inhibitors as antiviral therapeutic approaches against COVID-19. Drugs 81(5):517\u2013531","journal-title":"Drugs"},{"issue":"15","key":"2947_CR54","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025575","volume":"100","author":"L Sun","year":"2021","unstructured":"Sun L, Li X, Li Q, Wang L, Li J, Shu C (2021) Multiple arterial and venous thromboembolism in a male patient with hereditary protein C deficiency. Medicine (Baltimore) 100(15):e25575. https:\/\/doi.org\/10.1097\/MD.0000000000025575","journal-title":"Medicine (Baltimore)"},{"key":"2947_CR55","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s12967-019-2015-z","volume":"17","author":"X Du","year":"2019","unstructured":"Du X, Hong L, Sun L, Sang H, Qian A, Li W, Zhuang H, Liang H, Song D, Li C et al (2019) miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis. J Transl Med 17:270","journal-title":"J Transl Med"},{"key":"2947_CR56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.thromres.2015.12.020","volume":"138","author":"L Kong","year":"2016","unstructured":"Kong L, Du X, Hu N, Li W, Wang W, Wei S, Zhuang H, Li X, Li C (2016) Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG. Thromb Res 138:30\u201336","journal-title":"Thromb Res"},{"key":"2947_CR57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12967-016-0775-2","volume":"14","author":"L Kong","year":"2016","unstructured":"Kong L, Hu N, Du X, Wang W, Chen H, Li W, Wei S, Zhuang H, Li X, Li C (2016) Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF. J Transl Med 14:23","journal-title":"J Transl Med"},{"key":"2947_CR58","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/jcb.25115","volume":"116","author":"Q Meng","year":"2015","unstructured":"Meng Q, Wang W, Yu X, Li W, Kong L, Qian A, Li C, Li X (2015) Upregulation of MicroRNA-126 contributes to endothelial progenitor cell function in deep vein thrombosis via its target PIK3R2. J Cell Biochem 116:1613\u20131623. https:\/\/doi.org\/10.1002\/jcb.25115","journal-title":"J Cell Biochem"},{"key":"2947_CR59","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.thromres.2013.12.038","volume":"133","author":"W Wang","year":"2014","unstructured":"Wang W, Li C, Li W, Kong L, Qian A, Hu N, Meng Q, Li X (2014) MiR-150 enhances the motility of EPCs in vitro and promotes EPCs homing and thrombus resolving in vivo. Thromb Res 133:590\u2013598","journal-title":"Thromb Res"},{"issue":"3","key":"2947_CR60","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/iub.2168","volume":"72","author":"S Sun","year":"2020","unstructured":"Sun S, Chai S, Zhang F, Lu L (2020) Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. IUBMB Life 72(3):492\u2013504. https:\/\/doi.org\/10.1002\/iub.2168","journal-title":"IUBMB Life"},{"key":"2947_CR61","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/iub.2168","volume":"72","author":"S Sun","year":"2020","unstructured":"Sun S, Chai S, Zhang F, Lu L (2020) Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. IUBMB Life 72:492\u2013504. https:\/\/doi.org\/10.1002\/iub.2168","journal-title":"IUBMB Life"},{"key":"2947_CR62","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1161\/ATVBAHA.119.313137","volume":"40","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhang Z, Wei R, Miao X, Sun S, Liang G, Chu C, Zhao L, Zhu X, Guo Q et al (2020) IL (Interleukin)-6 contributes to deep vein thrombosis and is negatively regulated by miR-338-5p. Arterioscler Thromb Vasc Biol 40:323\u2013334","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2947_CR63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176596","volume":"12","author":"J McCreight","year":"2017","unstructured":"McCreight J, Schneider S, Wilburn D, Swanson W (2017) Evolution of microRNA in primates. PLoS ONE 12:e0176596. https:\/\/doi.org\/10.1371\/journal.pone.0176596","journal-title":"PLoS ONE"},{"key":"2947_CR64","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13578-020-00439-7","volume":"10","author":"X Chen","year":"2020","unstructured":"Chen X, Gao S, Zhao Z, Liang G, Kong J, Feng X (2020) MicroRNA-320d regulates tumor growth and invasion by promoting FoxM1 and predicts poor outcome in gastric cardiac adenocarcinoma. Cell Biosci 10:80. https:\/\/doi.org\/10.1186\/s13578-020-00439-7","journal-title":"Cell Biosci"},{"key":"2947_CR65","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13046-015-0198-6","volume":"34","author":"Z Fang","year":"2015","unstructured":"Fang Z, Tang J, Bai Y, Lin H, You H, Jin H, Lin L, You P, Li J, Dai Z et al (2015) Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma. J Exp Clin Cancer Res 34:86. https:\/\/doi.org\/10.1186\/s13046-015-0198-6","journal-title":"J Exp Clin Cancer Res"},{"key":"2947_CR66","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/s41419-019-2183-z","volume":"10","author":"H Hong","year":"2019","unstructured":"Hong H, Zhu H, Zhao S, Wang K, Zhang N, Tian Y, Li Y, Wang Y, Lv X, Wei T et al (2019) The novel circCLK3\/miR-320a\/FoxM1 axis promotes cervical cancer progression. Cell Death Dis 10:950. https:\/\/doi.org\/10.1038\/s41419-019-2183-z","journal-title":"Cell Death Dis"},{"key":"2947_CR67","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3892\/or.2017.5762","volume":"38","author":"Q Lv","year":"2017","unstructured":"Lv Q, Du H, Liu Y, Huang Y, Wang G, Zhang X, Chen S, Zhou H (2017) Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncol Rep 38:959\u2013966. https:\/\/doi.org\/10.3892\/or.2017.5762","journal-title":"Oncol Rep"},{"issue":"Suppl C","key":"2947_CR68","doi-asserted-by":"publisher","first-page":"C34","DOI":"10.1093\/eurheartj\/suaa008","volume":"22","author":"F Thibord","year":"2020","unstructured":"Thibord F, Munsch G, Perret C, Suchon P, Roux M, Ibrahim-Kosta M, Goumidi L, Deleuze JF, Morange PE, Tr\u00e9gou\u00ebt DA (2020) Bayesian network analysis of plasma microRNA sequencing data in patients with venous thrombosis. Eur Heart J Suppl 22(Suppl C):C34\u2013C45","journal-title":"Eur Heart J Suppl"},{"issue":"6","key":"2947_CR69","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.tig.2022.02.006","volume":"38","author":"C Diener","year":"2022","unstructured":"Diener C, Keller A, Meese E (2022) Emerging concepts of miRNA therapeutics: from cells to clinic. Trends Genet 38(6):613\u2013626","journal-title":"Trends Genet"},{"issue":"19","key":"2947_CR70","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1182\/blood-2010-09-299719","volume":"117","author":"S Nagalla","year":"2011","unstructured":"Nagalla S, Shaw C, Kong X et al (2011) Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood 117(19):5189\u20135197. https:\/\/doi.org\/10.1182\/blood-2010-09-299719","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-024-02947-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-024-02947-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-024-02947-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T13:12:11Z","timestamp":1713445931000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-024-02947-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":70,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["2947"],"URL":"https:\/\/doi.org\/10.1007\/s11239-024-02947-6","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"31 December 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript has been read and approved for submission by all authors. No potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}