{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:27:21Z","timestamp":1775251641603,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009232","name":"University of Debrecen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009232","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatments with different antithrombotic agents can affect micro-rheological variables, such as red blood cell (RBC) deformability and aggregation. Since the effect of dual antiplatelet and anticoagulant (APAC) treatment on micro-rheology is unknown, we aimed to investigate the effect of different intravenous doses of APAC on hematological and micro-rheological variables in a porcine model. Two groups were formed (APAC group, Control group), and blood was collected from the animals at preset intervals. Hematological variables, RBC deformability, and aggregation were measured. We observed an improvement in the RBC deformability measured at a low shear stress range (&lt;\u20093\u00a0Pa). However, after both doses, a decrease in the maximal elongation index of RBC values occurred in the APAC group. RBC aggregation increased after APAC bolus dose, while it gradually and dose-dependently decreased. Supposedly, the improvement in RBC deformability that was observed at a lower shear rate could facilitate aggregation. Administration of APAC and unfractionated heparin (UFH) caused comparable changes in hematological and hemorheological variables. Signs of thrombosis or bleeding did not occur. APAC and UFH had comparable micro-rheological effects.<\/jats:p>","DOI":"10.1007\/s11239-024-03040-8","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T19:02:16Z","timestamp":1725476536000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heparin-like effect of a dual antiplatelet and anticoagulant (APAC) agent on red blood cell deformability and aggregation in an experimental model"],"prefix":"10.1007","volume":"57","author":[{"given":"Adam Attila","family":"Matrai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Varga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bedocs-Barath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzsebet","family":"Vanyolos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Orban-Kalmandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Loczi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsa","family":"Bagoly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annukka","family":"Jouppila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Deak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"3040_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3233\/CH-2009-1178","volume":"41","author":"M Uyuklu","year":"2009","unstructured":"Uyuklu M, Cengiz M, Ulker P et al (2009) Effects of storage duration and temperature of human blood on red cell deformability and aggregation. Clin Hemorheol Microcirc 41:269\u2013278. https:\/\/doi.org\/10.3233\/CH-2009-1178","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3233\/CH-211118","volume":"78","author":"AA Matrai","year":"2021","unstructured":"Matrai AA, Varga G, Tanczos B et al (2021) In vitro effects of temperature on red blood cell deformability and membrane stability in human and various vertebrate species. Clin Hem-orheol Microcirc 78:291\u2013300. https:\/\/doi.org\/10.3233\/CH-211118","journal-title":"Clin Hem-orheol Microcirc"},{"key":"3040_CR3","first-page":"1","volume":"26","author":"M Singh","year":"2002","unstructured":"Singh M, Stoltz JF (2002) Influence of temperature variation from 5 degrees C to 37 degrees C on aggregation and deformability of erythrocytes. Clin Hemorheol Microcirc 26:1\u20137","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR4","first-page":"43","volume":"23","author":"OK Ba\u015fkurt","year":"2000","unstructured":"Ba\u015fkurt OK, Mat F (2000) Importance of measurement temperature in detecting the altera-tions of red blood cell aggregation and deformability studied by ektacytometry: a study on experimental sepsis in rats. Clin Hemorheol Microcirc 23:43\u201349","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s004240050195","volume":"432","author":"T Lecklin","year":"1996","unstructured":"Lecklin T, Egginton S, Nash GB (1996) Effect of temperature on the resistance of individual red blood cells to flow through capillary-sized apertures. Pflugers Arch 432:753\u2013759. https:\/\/doi.org\/10.1007\/s004240050195","journal-title":"Pflugers Arch"},{"key":"3040_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3233\/CH-1986-6208","volume":"6","author":"V Bartoli","year":"2016","unstructured":"Bartoli V, Albanese B, Manescalchi PG et al (2016) Influence of blood storage conditions and anticoagulants on results of blood cell filtration test. Clin Hemorheol Microcirc 6:137\u2013149. https:\/\/doi.org\/10.3233\/CH-1986-6208","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3233\/BIR-1994-31307","volume":"31","author":"MV Kameneva","year":"1994","unstructured":"Kameneva MV, Antaki JF, Watach MJ et al (1994) Heparin effect on red blood cell aggregation. Biorheology 31:297\u2013304. https:\/\/doi.org\/10.3233\/BIR-1994-31307","journal-title":"Biorheology"},{"key":"3040_CR8","doi-asserted-by":"publisher","first-page":"5147","DOI":"10.3390\/jcm11175147","volume":"11","author":"S Rajsic","year":"2022","unstructured":"Rajsic S, Breitkopf R, Jadzic D et al (2022) Anticoagulation strategies during extracorporeal membrane oxygenation: a narrative review. J Clin Med 11:5147. https:\/\/doi.org\/10.3390\/jcm11175147","journal-title":"J Clin Med"},{"key":"3040_CR9","doi-asserted-by":"publisher","first-page":"19751","DOI":"10.1038\/s41598-022-24166-w","volume":"12","author":"M Bosek","year":"2022","unstructured":"Bosek M, Ziomkowska B, Pyskir J et al (2022) Relationship between red blood cell aggre-gation and dextran molecular mass. Sci Rep 12:19751. https:\/\/doi.org\/10.1038\/s41598-022-24166-w","journal-title":"Sci Rep"},{"key":"3040_CR10","doi-asserted-by":"publisher","first-page":"14952","DOI":"10.3390\/ijms241914952","volume":"24","author":"M Bosek","year":"2023","unstructured":"Bosek M, Wybranowski T, Napi\u00f3rkowska-Mastalerz M et al (2023) The impact of COVID-19 on cellular factors influencing red blood cell aggregation examined in dextran: possible causes and consequences. Int J Mol Sci 24:14952. https:\/\/doi.org\/10.3390\/ijms241914952","journal-title":"Int J Mol Sci"},{"key":"3040_CR11","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3324\/haematol.2008.005371","volume":"94","author":"J Tripette","year":"2009","unstructured":"Tripette J, Alexy T, Hardy-Dessources M-D et al (2009) Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sick-le cell anemia and sickle-hemoglobin C disease. Haematologica 94:1060\u20131065. https:\/\/doi.org\/10.3324\/haematol.2008.005371","journal-title":"Haematologica"},{"key":"3040_CR12","doi-asserted-by":"publisher","first-page":"20160157","DOI":"10.1515\/jmmm-2016-0157","volume":"1","author":"C Murali","year":"2017","unstructured":"Murali C, Nithiarasu P (2017) Red blood cell (RBC) aggregation and its influence on non-newtonian nature of blood in microvasculature. J Mech Mater Struct 1:20160157. https:\/\/doi.org\/10.1515\/jmmm-2016-0157","journal-title":"J Mech Mater Struct"},{"key":"3040_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.11.e113","author":"P Kauhanen","year":"2000","unstructured":"Kauhanen P, Kovanen PT, Lassila R (2000) Coimmobilized native macromolecular heparin proteoglycans strongly inhibit platelet-collagen interactions in flowing blood. Arterioscler Thromb Vasc Biol. https:\/\/doi.org\/10.1161\/01.ATV.20.11.e113. 20:","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3040_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1055\/s-0037-1612980","volume":"87","author":"E Olsson","year":"2002","unstructured":"Olsson E, Asko-Seljavaara S, Lassila R (2002) Topically administered macromolecular heparin proteoglycans inhibit thrombus growth in microvascular anastomoses. Thromb Haemost 87:245\u2013251","journal-title":"Thromb Haemost"},{"key":"3040_CR15","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1161\/01.ATV.17.12.3578","volume":"17","author":"R Lassila","year":"1997","unstructured":"Lassila R, Lindstedt K, Kovanen PT (1997) Native macromolecular heparin proteoglycans exocytosed from stimulated rat serosal mast cells strongly inhibit platelet-collagen inter-actions. Arterioscler Thromb Vasc Biol 17:3578\u20133587. https:\/\/doi.org\/10.1161\/01.ATV.17.12.3578","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3040_CR16","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1055\/s-0034-1395157","volume":"40","author":"R Lassila","year":"2014","unstructured":"Lassila R, Jouppila A (2014) Mast cell\u2013derived heparin proteoglycans as a model for a local antithrombotic. Semin Thromb Hemost 40:837\u2013844. https:\/\/doi.org\/10.1055\/s-0034-1395157","journal-title":"Semin Thromb Hemost"},{"key":"3040_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.01-0486fje","volume":"15","author":"E Tchougounova","year":"2001","unstructured":"Tchougounova E, Pejler G (2001) Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase. FASEB j 15:1\u201325. https:\/\/doi.org\/10.1096\/fj.01-0486fje","journal-title":"FASEB j"},{"key":"3040_CR18","doi-asserted-by":"publisher","first-page":"e46840","DOI":"10.7554\/eLife.46840","volume":"8","author":"T V\u00f6gtle","year":"2019","unstructured":"V\u00f6gtle T, Sharma S, Mori J et al (2019) Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. eLife 8:e46840. https:\/\/doi.org\/10.7554\/eLife.46840","journal-title":"eLife"},{"key":"3040_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.thromres.2018.07.026","volume":"169","author":"J Chen","year":"2018","unstructured":"Chen J, Verni CC, Jouppila A et al (2018) Dual antiplatelet and anticoagulant (APAC) heparin proteoglycan mimetic with shear-dependent effects on platelet-collagen binding and thrombin generation. Thromb Res 169:143\u2013151. https:\/\/doi.org\/10.1016\/j.thromres.2018.07.026","journal-title":"Thromb Res"},{"key":"3040_CR20","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.ejvs.2019.05.019","volume":"58","author":"KA Barreiro","year":"2019","unstructured":"Barreiro KA, Tulamo R, Jouppila A et al (2019) Novel locally acting dual antiplatelet and anticoagulant (APAC) targets multiple sites of vascular injury in an experimental porcine model. Eur J Vasc Endovasc Surg 58:903\u2013911. https:\/\/doi.org\/10.1016\/j.ejvs.2019.05.019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"3040_CR21","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s10157-016-1308-2","volume":"21","author":"R Tuuminen","year":"2017","unstructured":"Tuuminen R, Jouppila A, Salvail D et al (2017) Dual antiplatelet and anticoagulant APAC prevents experimental ischemia\u2013reperfusion-induced acute kidney injury. Clin Exp Nephrol 21:436\u2013445. https:\/\/doi.org\/10.1007\/s10157-016-1308-2","journal-title":"Clin Exp Nephrol"},{"key":"3040_CR22","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4103\/0972-5229.76083","volume":"14","author":"P Sikka","year":"2010","unstructured":"Sikka P, Bindra VK (2010) Newer antithrombotic drugs. Indian J Crit Care M 14:188\u2013195. https:\/\/doi.org\/10.4103\/0972-5229.76083","journal-title":"Indian J Crit Care M"},{"key":"3040_CR23","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1136\/bmj.325.7376.1348","volume":"325","author":"RDS Watson","year":"2002","unstructured":"Watson RDS (2002) ABC of antithrombotic therapy: antithrombotic therapy in acute coronary syndromes. Br Med J 325:1348\u20131351. https:\/\/doi.org\/10.1136\/bmj.325.7376.1348","journal-title":"Br Med J"},{"key":"3040_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jacc.2009.03.044","volume":"54","author":"DR Holmes","year":"2009","unstructured":"Holmes DR, Kereiakes DJ, Kleiman NS et al (2009) Combining antiplatelet and anticoagulant therapies. J Am Coll Cardiol 54:95\u2013109. https:\/\/doi.org\/10.1016\/j.jacc.2009.03.044","journal-title":"J Am Coll Cardiol"},{"key":"3040_CR25","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1161\/CIRCULATIONAHA.112.114967","volume":"126","author":"M Lamberts","year":"2012","unstructured":"Lamberts M, Olesen JB, Ruwald MH et al (2012) Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study. Circ 126:1185\u20131193. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.114967","journal-title":"Circ"},{"key":"3040_CR26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/FJC.0000000000001080","volume":"78","author":"S Craige","year":"2021","unstructured":"Craige S, Jouppila A, Humphries B, Lassila R (2021) Safety and functional pharmacokinetic profile of APAC, a novel intravascular antiplatelet and anticoagulant. J Cardiovasc Pharm 78:453\u2013462. https:\/\/doi.org\/10.1097\/FJC.0000000000001080","journal-title":"J Cardiovasc Pharm"},{"key":"3040_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/CH-2009-1202","volume":"42","author":"OK Baskurt","year":"2009","unstructured":"Baskurt OK, Boynard M, Cokelet GC et al (2009) New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 42:75\u201397. https:\/\/doi.org\/10.3233\/CH-2009-1202","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR28","first-page":"242","volume-title":"Handbook of hemorheology and hemodynamics","author":"M Hardeman","year":"2007","unstructured":"Hardeman M, Goedhart P, Shin S (2007) Methods in hemorheology. In: Baskurt OK, Har-deman MR, Rampling MW, Meiselman HJ (eds) Handbook of hemorheology and hemodynamics. IOS, Amsterdam, The Netherlands, pp 242\u2013266"},{"key":"3040_CR29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3109\/00365510903266069","volume":"69","author":"OK Baskurt","year":"2009","unstructured":"Baskurt OK, Hardeman MR, Uyuklu M et al (2009) Parameterization of red blood cell elongation index \u2013 shear stress curves obtained by ektacytometry. Scand J Clin Lab Invest 69:777\u2013788. https:\/\/doi.org\/10.3109\/00365510903266069","journal-title":"Scand J Clin Lab Invest"},{"key":"3040_CR30","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1002\/9781119500537.ch113","volume-title":"Schalm\u2019s Veterinary Hematology","author":"CE Thorn","year":"2022","unstructured":"Thorn CE, Bowman AS, Eckersall D (2022) Hematology of pigs. In: Brooks MB, Harr KE, Seelig DM et al (eds) Schalm\u2019s Veterinary Hematology, 7th edn. Wiley, Ho-boken, NJ, USA, pp 1019\u20131025. https:\/\/doi.org\/10.1002\/9781119500537.ch113","edition":"7"},{"key":"3040_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00701-024-06017-x","volume":"166","author":"F Denorme","year":"2024","unstructured":"Denorme F, Fr\u00f6sen J, Jouppila A et al (2024) Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia\u2013reperfusion injury in a mouse model of temporary middle cerebral artery occlusion\u2014implications for neurovascular procedures. Acta Neurochir 166:137. https:\/\/doi.org\/10.1007\/s00701-024-06017-x","journal-title":"Acta Neurochir"},{"key":"3040_CR32","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1159\/000186772","volume":"60","author":"H Druid","year":"1992","unstructured":"Druid H, Rammer L (1992) Protective effect on postischemic renal edema by anticoagulation. Nephron 60:319\u2013323. https:\/\/doi.org\/10.1159\/000186772","journal-title":"Nephron"},{"key":"3040_CR33","first-page":"143","volume":"38","author":"G Feher","year":"2008","unstructured":"Feher G, Koltai K, Kesmarky G, Toth K (2008) Hemorheological background of acetylsalicylic acid resistance. Clin Hemorheol Microcirc 38:143\u2013152","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.59566\/IJBS.2012.8188","volume":"8","author":"MA Elblbesy","year":"2012","unstructured":"Elblbesy MA, Hereba ARM, Shawki MM (2012) Effects of aspirin on rheological properties of erythrocytes in vitro. Int J Biomed Sci 8:188\u2013193","journal-title":"Int J Biomed Sci"},{"key":"3040_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3233\/CH-211109","volume":"78","author":"B Barath","year":"2021","unstructured":"Barath B, Somogyi V, Tanczos B et al (2021) Examination of the relation between red blood cell aggregation and hematocrit in human and various experimental animals. Clin Hemorheol Microcirc 78:187\u2013198. https:\/\/doi.org\/10.3233\/CH-211109","journal-title":"Clin Hemorheol Microcirc"},{"key":"3040_CR36","doi-asserted-by":"publisher","first-page":"H2644","DOI":"10.1152\/ajpheart.00534.2004","volume":"287","author":"O Yalcin","year":"2004","unstructured":"Yalcin O, Uyuklu M, Armstrong JK et al (2004) Graded alterations of RBC aggregation influence in vivo blood flow resistance. Am J Physiol Heart Circ Physiol 287:H2644\u2013H2650. https:\/\/doi.org\/10.1152\/ajpheart.00534.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3040_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1201\/b11221-5","volume-title":"Red blood cell aggregation","author":"OK Baskurt","year":"2011","unstructured":"Baskurt OK, Neu B, Meiselman HJ (2011) Measurement of red blood cell aggregation. In: Baskurt OK, Neu B, Meiselman HJ (eds) Red blood cell aggregation, 1st edn. CRC, Boca Raton, Fla, pp 63\u2013132","edition":"1"},{"key":"3040_CR38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1201\/b11221-9","volume-title":"Red blood cell aggregation","author":"OK Baskurt","year":"2011","unstructured":"Baskurt OK, Neu B, Meiselman HJ (2011) Alterations in red blood cell aggregation. In: Baskurt OK, Neu B, Meiselman HJ (eds) Red blood cell aggregation, 1st edn. CRC, Boca Raton, Fla, pp 223\u2013267","edition":"1"},{"key":"3040_CR39","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1055\/s-2003-44551","volume":"29","author":"OK Baskurt","year":"2003","unstructured":"Baskurt OK, Meiselman HJ (2003) Blood rheology and hemodynamics. Semin Thromb Hemost 29:435\u2013450. https:\/\/doi.org\/10.1055\/s-2003-44551","journal-title":"Semin Thromb Hemost"},{"key":"3040_CR40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1021\/ba-1980-0188.ch009","volume-title":"Bioelectrochemistry: ions, surfaces, membranes","author":"KM Jan","year":"1980","unstructured":"Jan KM (1980) Electrochemical basis of heparin-induced red blood cell aggregation. In: Blank M (ed) Bioelectrochemistry: ions, surfaces, membranes. American Chemical Society, Washington, D. C., pp 143\u2013149"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-024-03040-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-024-03040-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-024-03040-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T17:04:14Z","timestamp":1734109454000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-024-03040-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3040"],"URL":"https:\/\/doi.org\/10.1007\/s11239-024-03040-8","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"25 August 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}