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It is a common condition, but its management remains debated. We conducted a survey distributed by email to the members of the French Society of Vascular Medicine, Thrombosis Canada, the Swiss Society of Angiology and INVENT-VTE research networks; Our objectives were to determine how healthcare professionals specialized in thrombosis manage iDDVT and to obtain experts input on the design of a future clinical trial. Participants were asked how they diagnosed and managed iDDVT and what should be the treatment arms of a future clinical trial on iDDVT management. 472 thrombosis specialists answered the questionnaire, mainly from France (<jats:italic>n<\/jats:italic>\u2009=\u2009337), Canada (<jats:italic>n<\/jats:italic>\u2009=\u200961) and Switzerland (<jats:italic>n<\/jats:italic>\u2009=\u200928). Overall, 87.9% (<jats:italic>n<\/jats:italic>\u2009=\u2009405) of respondents stated that their center always performed whole leg ultrasound in case of suspected DVT and that they managed patients with iDDVT usually at least once a week in 50.3% (<jats:italic>n<\/jats:italic>\u2009=\u2009229) of cases. In 91.0% (<jats:italic>n<\/jats:italic>\u2009=\u2009415) of cases respondents treated patients with iDDVT with anticoagulation more than 75% of time, with therapeutic doses and for a duration of 3 months in 90.2% (<jats:italic>n<\/jats:italic>\u2009=\u2009406) and 74.7% (<jats:italic>n<\/jats:italic>\u2009=\u2009334) of cases respectively. Most respondent managed muscular and deep-calf vein DVT similarly. More than 60% of respondents favored future trials comparing prophylactic versus therapeutic anticoagulation. Our real-world, international, practice survey of healthcare professionals shows that almost all respondents always conduct whole leg ultrasonography in case of suspected DVT and that they treat iDDVT with therapeutic anticoagulation usually for 3 months.<\/jats:p>","DOI":"10.1007\/s11239-025-03091-5","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T20:35:46Z","timestamp":1744403746000},"page":"657-662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of isolated distal deep vein thrombosis: an international survey of healthcare professionals"],"prefix":"10.1007","volume":"58","author":[{"given":"Ilia","family":"Makedonov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Kapitanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Giai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Vermorel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Chevrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Le\u00a0Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Khider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Antoinette","family":"Sevestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameel","family":"Abdulrehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Bosson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Righini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Galanaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"issue":"5","key":"3091_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/MOH.0000000000000670","volume":"28","author":"I Makedonov","year":"2021","unstructured":"Makedonov I, Galanaud JP, Kahn SR (2021) Significance and management of isolated distal deep vein thrombosis. 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