{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:11Z","timestamp":1787496851013,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-025-03217-9","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T19:47:24Z","timestamp":1766260044000},"page":"1031-1035","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Full-dose heparin anticoagulation as prevention for COVID-19 disease progression in non-critically ill patients: An up-to-date brief meta-analysis"],"prefix":"10.1007","volume":"59","author":[{"given":"Eros","family":"Pilia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Belletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Finco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"3217_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.51893\/2020.2.pov2","volume":"22","author":"F Ciceri","year":"2020","unstructured":"Ciceri F, Beretta L, Scandroglio AM et al (2020) Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc 22:95\u201397. https:\/\/doi.org\/10.51893\/2020.2.pov2","journal-title":"Crit Care Resusc"},{"key":"3217_CR2","doi-asserted-by":"publisher","DOI":"10.22514\/sv.2023.117","author":"Z Tanriverdi","year":"2024","unstructured":"Tanriverdi Z, Ture HS, Beckmann Y et al (2024) Acute ischemic stroke as a major neurologic complication of SARS-CoV-2 infection. Signa Vitae. https:\/\/doi.org\/10.22514\/sv.2023.117","journal-title":"Signa Vitae"},{"key":"3217_CR3","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2025.07.017","author":"A Bottussi","year":"2025","unstructured":"Bottussi A, Ciceri F, Landoni G (2025) MicroCLOTS: immunothrombotic culprit of atypical acute respiratory distress syndrome. J Cardiothorac Vasc Anesth S. https:\/\/doi.org\/10.1053\/j.jvca.2025.07.017. 1053-0770(25)00579\u20138","journal-title":"J Cardiothorac Vasc Anesth S"},{"key":"3217_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3138\/jammi-2023-12-07","volume":"8","author":"JM Grant","year":"2024","unstructured":"Grant JM, Lam J, Goyal SV et al (2024) AMMI Canada practice point: updated recommendations for treatment of adults with symptomatic COVID-19 in 2023\u20132024. J Assoc Med Microbiol Infect Dis Can 8:245\u2013252. https:\/\/doi.org\/10.3138\/jammi-2023-12-07","journal-title":"J Assoc Med Microbiol Infect Dis Can"},{"key":"3217_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00408-023-00599-6","volume":"201","author":"E Pilia","year":"2023","unstructured":"Pilia E, Belletti A, Fresilli S et al (2023) The effect of heparin Full-Dose anticoagulation on survival of Hospitalized, Non-critically ill COVID-19 patients: A Meta-analysis of high quality studies. Lung 201:135\u2013147. https:\/\/doi.org\/10.1007\/s00408-023-00599-6","journal-title":"Lung"},{"key":"3217_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.02.011","author":"S Schulman","year":"2024","unstructured":"Schulman S, Arnold DM, Bradbury CA et al (2024) 2023 ISTH update of the 2022 ISTH guidelines for antithrombotic treatment in COVID-19. J Thromb Haemost S. https:\/\/doi.org\/10.1016\/j.jtha.2024.02.011. 1538-7836(24)00113\u20132","journal-title":"J Thromb Haemost S"},{"key":"3217_CR7","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.jacc.2023.02.041","volume":"81","author":"GW Stone","year":"2023","unstructured":"Stone GW, Farkouh ME, Lala A et al (2023) Randomized trial of anticoagulation strategies for noncritically ill patients hospitalized with COVID-19. J Am Coll Cardiol 81:1747\u20131762. https:\/\/doi.org\/10.1016\/j.jacc.2023.02.041","journal-title":"J Am Coll Cardiol"},{"key":"3217_CR8","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1001\/jamainternmed.2023.0456","volume":"183","author":"V Labb\u00e9","year":"2023","unstructured":"Labb\u00e9 V, Contou D, Heming N et al (2023) Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and therapeutic anticoagulation in patients with hypoxemic COVID-19 pneumonia: the ANTICOVID randomized clinical trial. JAMA Intern Med 183:520\u2013531. https:\/\/doi.org\/10.1001\/jamainternmed.2023.0456","journal-title":"JAMA Intern Med"},{"key":"3217_CR9","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"3217_CR10","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions https:\/\/training.cochrane.org\/handbook. Accessed 20 Jan 2024"},{"key":"3217_CR11","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"3217_CR12","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924\u2013926. https:\/\/doi.org\/10.1136\/bmj.39489.470347.AD","journal-title":"BMJ"},{"key":"3217_CR13","doi-asserted-by":"publisher","first-page":"EVIDoa2200293","DOI":"10.1056\/EVIDoa2200293","volume":"2","author":"ZK McQuilten","year":"2023","unstructured":"McQuilten ZK, Venkatesh B, Jha V et al (2023) Anticoagulation strategies in Non-Critically ill patients with Covid-19. NEJM Evid 2:EVIDoa2200293. https:\/\/doi.org\/10.1056\/EVIDoa2200293","journal-title":"NEJM Evid"},{"key":"3217_CR14","doi-asserted-by":"publisher","first-page":"n2400","DOI":"10.1136\/bmj.n2400","volume":"375","author":"M Sholzberg","year":"2021","unstructured":"Sholzberg M, Tang GH, Rahhal H et al (2021) Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial. BMJ 375:n2400. https:\/\/doi.org\/10.1136\/bmj.n2400","journal-title":"BMJ"},{"key":"3217_CR15","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1001\/jamainternmed.2021.6203","volume":"181","author":"AC Spyropoulos","year":"2021","unstructured":"Spyropoulos AC, Goldin M, Giannis D et al (2021) Efficacy and safety of therapeutic-Dose heparin vs standard prophylactic or Intermediate-Dose heparins for thromboprophylaxis in High-risk hospitalized patients with COVID-19: the HEP-COVID randomized clinical trial. JAMA Intern Med 181:1612\u20131620. https:\/\/doi.org\/10.1001\/jamainternmed.2021.6203","journal-title":"JAMA Intern Med"},{"key":"3217_CR16","doi-asserted-by":"publisher","first-page":"5632","DOI":"10.3390\/jcm11195632","volume":"11","author":"N Mu\u00f1oz-Rivas","year":"2022","unstructured":"Mu\u00f1oz-Rivas N, Aibar J, Gabara-Xanc\u00f3 C et al (2022) Efficacy and safety of Tinzaparin in Prophylactic, intermediate and therapeutic doses in Non-Critically ill patients hospitalized with COVID-19: the PROTHROMCOVID randomized controlled trial. J Clin Med 11:5632. https:\/\/doi.org\/10.3390\/jcm11195632","journal-title":"J Clin Med"},{"key":"3217_CR17","doi-asserted-by":"publisher","first-page":"e12712","DOI":"10.1002\/rth2.12712","volume":"6","author":"M Blondon","year":"2022","unstructured":"Blondon M, Cereghetti S, Pugin J et al (2022) Therapeutic anticoagulation to prevent thrombosis, coagulopathy, and mortality in severe COVID-19: the Swiss COVID-HEP randomized clinical trial. Res Pract Thromb Haemost 6:e12712. https:\/\/doi.org\/10.1002\/rth2.12712","journal-title":"Res Pract Thromb Haemost"},{"key":"3217_CR18","doi-asserted-by":"publisher","unstructured":"ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators et al (2021) Therapeutic anticoagulation with heparin in noncritically ill patients with Covid-19. N Engl J Med 385:790\u2013802. https:\/\/doi.org\/10.1056\/NEJMoa2105911","DOI":"10.1056\/NEJMoa2105911"},{"key":"3217_CR19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1055\/a-1667-7534","volume":"122","author":"M Marcos-Jubilar","year":"2022","unstructured":"Marcos-Jubilar M, Carmona-Torre F, Vidal R et al (2022) Therapeutic versus prophylactic Bemiparin in hospitalized patients with nonsevere COVID-19 pneumonia (BEMICOP Study): an Open-Label, Multicenter, Randomized, controlled trial. Thromb Haemost 122:295\u2013299. https:\/\/doi.org\/10.1055\/a-1667-7534","journal-title":"Thromb Haemost"},{"key":"3217_CR20","unstructured":"Luo P, Onlinemeta Available from: https:\/\/smuonco.shinyapps.io\/Onlinemeta\/. [Last accessed on 2025 Nov 09]"},{"key":"3217_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4103\/jfmpc.jfmpc_839_21","volume":"11","author":"M Pustake","year":"2022","unstructured":"Pustake M, Tambolkar I, Giri P, Gandhi C (2022) SARS, MERS and CoVID-19: an overview and comparison of clinical, laboratory and radiological features. J Family Med Prim Care 11:10\u201317. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_839_21","journal-title":"J Family Med Prim Care"},{"key":"3217_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10877-010-9228-2","volume":"24","author":"S Efrati","year":"2010","unstructured":"Efrati S, Deutsch I, Antonelli M et al (2010) Ventilator-associated pneumonia: current status and future recommendations. J Clin Monit Comput 24:161\u2013168. https:\/\/doi.org\/10.1007\/s10877-010-9228-2","journal-title":"J Clin Monit Comput"},{"key":"3217_CR23","doi-asserted-by":"publisher","DOI":"10.22514\/sv.2023.041","author":"L Pasin","year":"2023","unstructured":"Pasin L, Dagna L, Consonni M et al (2023) Prone positioning in awake COVID-19 patients: a systematic review and meta-analysis. Signa Vitae. https:\/\/doi.org\/10.22514\/sv.2023.041","journal-title":"Signa Vitae"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-025-03217-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-025-03217-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-025-03217-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:32:39Z","timestamp":1781339559000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-025-03217-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["3217"],"URL":"https:\/\/doi.org\/10.1007\/s11239-025-03217-9","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]},"assertion":[{"value":"2 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}