{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:25:18Z","timestamp":1786116318592,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uterine leiomyomas are the most common benign gynaecological tumours and a major cause of heavy menstrual bleeding, frequently resulting in iron deficiency anaemia. However, the long-term cardiovascular and thromboembolic consequences of fibroid-related anaemia remain poorly understood. We conducted a retrospective cohort study using the TriNetX health research network (~\u2009160\u00a0million patients). Women with uterine fibroids undergoing surgical management were identified and stratified by the presence or absence of anaemia within three years before surgery. Propensity score matching (1:1) was applied to balance demographics and comorbidities. Twelve-month outcomes included all-cause mortality, myocardial infarction, stroke, atrial fibrillation\/flutter, heart failure, and venous thromboembolism. Risk ratios (RR) with 95% confidence intervals (CI) were calculated. From 83,319 eligible patients, 9,581 anaemic and 9,581 non-anaemic women were well matched. At one year, the presence of anaemia was associated with higher risks of mortality (RR 1.93, 95% CI 1.04\u20133.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), stroke (RR 1.65, 1.05\u20132.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02), atrial fibrillation\/flutter (RR 1.60, 1.03\u20132.48,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), heart failure (RR 1.97, 1.43\u20132.70,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), and venous thromboembolism (RR 2.15, 1.67\u20132.80,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). No significant difference was observed for myocardial infarction (RR 1.44, 0.80\u20132.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.22). The composite cardiovascular outcome was significantly elevated (HR 1.74, 95% CI 1.44\u20132.09,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Preoperative anaemia in women undergoing fibroid surgery independently predicts adverse cardiovascular and thromboembolic events and nearly doubled 12-month mortality. Early recognition and optimisation of anaemia may improve clinical outcomes.\n                  <\/jats:p>","DOI":"10.1007\/s11239-026-03326-z","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T14:47:09Z","timestamp":1779547629000},"page":"1659-1666","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anaemia and long-term outcomes after surgical treatment of uterine fibroids: evidence from real-world data"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-2582","authenticated-orcid":false,"given":"Hani","family":"Essa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-0150","authenticated-orcid":false,"given":"Dharani K.","family":"Hapangama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-8798","authenticated-orcid":false,"given":"Ingeborg","family":"Welters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"3326_CR1","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/1471-0528.14640","volume":"124","author":"EA Stewart","year":"2017","unstructured":"Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R (2017) Epidemiology of uterine fibroids: a systematic review. BJOG 124:1501\u20131512","journal-title":"BJOG"},{"key":"3326_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.fertnstert.2022.08.850","volume":"118","author":"F Petraglia","year":"2022","unstructured":"Petraglia F, Dolmans MM (2022) Iron deficiency anemia: Impact on women\u2019s reproductive health. Fertil Steril 118:605\u2013606","journal-title":"Fertil Steril"},{"key":"3326_CR3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1515\/jbcpp-2022-0219","volume":"34","author":"A Ahmad","year":"2023","unstructured":"Ahmad A, Kumar M, Bhoi NR et al (2023) Diagnosis and management of uterine fibroids: current trends and future strategies. J Basic Clin Physiol Pharmacol 34:291\u2013310","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"3326_CR4","doi-asserted-by":"publisher","first-page":"38e31","DOI":"10.1016\/j.ajog.2013.09.038","volume":"210","author":"K Puri","year":"2014","unstructured":"Puri K, Famuyide AO, Erwin PJ, Stewart EA, Laughlin-Tommaso SK (2014) Submucosal fibroids and the relation to heavy menstrual bleeding and anemia. 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No AI tools were used for data analysis, interpretation, or drafting of the scientific content.","order":2,"name":"Ethics","label":"Generative AI Use","group":{"name":"EthicsHeading","label":"Declarations"}}]}}