{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:46:28Z","timestamp":1791744388832,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82460061"],"award-info":[{"award-number":["82460061"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-026-03330-3","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T16:58:46Z","timestamp":1779641926000},"page":"1711-1727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Time- and risk-dependent effects of dual antiplatelet therapy targeting the P2Y12 receptor after CABG: A network meta-analysis of graft permeability and clinical outcomes"],"prefix":"10.1007","volume":"59","author":[{"given":"Yuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runwei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"issue":"3","key":"3330_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41569-021-00612-6","volume":"19","author":"FJ Beerkens","year":"2022","unstructured":"Beerkens FJ, Claessen BE, Mahan M et al (2022) Contemporary coronary artery bypass graft surgery and subsequent percutaneous revascularization[J]. Nat Reviews Cardiol 19(3):195\u2013208","journal-title":"Nat Reviews Cardiol"},{"issue":"9","key":"3330_CR2","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1161\/CIRCULATIONAHA.120.052163","volume":"144","author":"I Xenogiannis","year":"2021","unstructured":"Xenogiannis I, Zenati M, Bhatt DL et al (2021) Saphenous vein graft failure: from pathophysiology to prevention and treatment strategies[J]. Circulation 144(9):728\u2013745","journal-title":"Circulation"},{"issue":"5","key":"3330_CR3","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1161\/ATVBAHA.123.318239","volume":"44","author":"JM Szafron","year":"2024","unstructured":"Szafron JM, Heng EE, Boyd J, Humphrey JD, Marsden AL (2024) Hemodynamics and wall mechanics of vascular graft failure. Arterioscler Thromb Vasc Biol 44(5):1065\u20131085. https:\/\/doi.org\/10.1161\/ATVBAHA.123.318239","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"23","key":"3330_CR4","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa2508026","volume":"393","author":"A Jeppsson","year":"2025","unstructured":"Jeppsson A, James S, Moller CH et al (2025) Ticagrelor and aspirin or aspirin alone after coronary surgery for acute coronary syndrome[J]. N Engl J Med 393(23):2313\u20132323","journal-title":"N Engl J Med"},{"issue":"10","key":"3330_CR5","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.jacc.2024.06.027","volume":"84","author":"MP Bonaca","year":"2024","unstructured":"Bonaca MP, Barnes GD, Bauersachs R et al (2024) Antithrombotic Strategies for Patients With Peripheral Artery Disease: JACC Scientific Statement[J]. J Am Coll Cardiol 84(10):936\u2013952","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"3330_CR6","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/eurheartj\/ehab642","volume":"43","author":"TF L\u00fcscher","year":"2022","unstructured":"L\u00fcscher TF, Davies A, Beer JH et al (2022) Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum[J]. Eur Heart J 43(10):940\u2013958","journal-title":"Eur Heart J"},{"key":"3330_CR7","doi-asserted-by":"crossref","unstructured":"Jain K, Tyagi T, Gu SX et al (2025) Demographic diversity in platelet function and response to antiplatelet therapy[J]. Trends in Pharmacological Sciences","DOI":"10.1016\/j.tips.2024.11.005"},{"issue":"8","key":"3330_CR8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/01410768221113196","volume":"115","author":"A Lee","year":"2022","unstructured":"Lee A (2022) The development of network meta-analysis[J]. J R Soc Med 115(8):313\u2013321","journal-title":"J R Soc Med"},{"issue":"4","key":"3330_CR9","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1177\/02676591231159513","volume":"39","author":"SU Hasan","year":"2024","unstructured":"Hasan SU, Pervez A, Shah AA et al (2024) Safety outcomes of anti-platelet therapy post coronary artery bypass graft surgery: A systematic review and network meta-analysis of randomized control trials[J]. Perfusion 39(4):684\u2013697","journal-title":"Perfusion"},{"issue":"12","key":"3330_CR10","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.1111\/jocs.17149","volume":"37","author":"B Hwang","year":"2022","unstructured":"Hwang B, Williams ML, Tian DH et al (2022) Coronary artery bypass surgery for acute coronary syndrome: A network meta-analysis of on\u2010pump cardioplegic arrest, off\u2010pump, and on\u2010pump beating heart strategies[J]. J Card Surg 37(12):5290\u20135299","journal-title":"J Card Surg"},{"issue":"4","key":"3330_CR11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/bmjebm-2022-112102","volume":"28","author":"E Flemyng","year":"2023","unstructured":"Flemyng E, Moore TH, Boutron I et al (2023) Using Risk of Bias 2 to assess results from randomised controlled trials: guidance from Cochrane[J]. BMJ Evidence-Based Med 28(4):260\u2013266","journal-title":"BMJ Evidence-Based Med"},{"key":"3330_CR12","doi-asserted-by":"publisher","first-page":"108602","DOI":"10.1016\/j.envint.2024.108602","volume":"186","author":"JPT Higgins","year":"2024","unstructured":"Higgins JPT, Morgan RL, Rooney AA et al (2024) A tool to assess risk of bias in non-randomized follow-up studies of exposure effects (ROBINS-E)[J]. Environ Int 186:108602","journal-title":"Environ Int"},{"issue":"4","key":"3330_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S2468-1253(21)00470-2","volume":"7","author":"M Li","year":"2022","unstructured":"Li M, Yao L, Wang Q et al (2022) Ranking treatments in the network meta-analysis should consider the certainty of evidence[J]. Lancet Gastroenterol Hepatol 7(4):287\u2013288","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"25","key":"3330_CR14","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1161\/CIRCULATIONAHA.110.978007","volume":"122","author":"A Kulik","year":"2010","unstructured":"Kulik A, Le May MR, Voisine P, Tardif JC, Delarochelliere R, Naidoo S, Wells GA, Mesana TG, Ruel M (2010) Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial. Circulation 122(25):2680\u20132687. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.978007. Epub 2010 Dec 6. PMID: 21135365","journal-title":"Circulation"},{"key":"3330_CR15","doi-asserted-by":"publisher","unstructured":"Sun JC, Teoh KH, Lamy A, Sheth T, Ellins ML, Jung H, Yusuf S, Anand S, Connolly S, Whitlock RP, Eikelboom JW (2010) Randomized trial of aspirin and clopidogrel versus aspirin alone for the prevention of coronary artery bypass graft occlusion: the Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting study. Am Heart J. ;160(6):1178-84. https:\/\/doi.org\/10.1016\/j.ahj.2010.07.035. PMID: 21146675","DOI":"10.1016\/j.ahj.2010.07.035"},{"key":"3330_CR16","doi-asserted-by":"publisher","unstructured":"Gao G, Zheng Z, Pi Y, Lu B, Lu J, Hu S (2010) Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial. J Am Coll Cardiol. ;56(20):1639-43. https:\/\/doi.org\/10.1016\/j.jacc.2010.03.104. PMID: 21050973","DOI":"10.1016\/j.jacc.2010.03.104"},{"issue":"1","key":"3330_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jtcvs.2017.06.039","volume":"155","author":"A Hage","year":"2018","unstructured":"Hage A, Voisine P, Erthal F, Larose \u00c9, Glineur D, Chow B, Tremblay H, Fortier J, Ko G, Une D, Farkouh M, Mesana TG, LeMay M, Kulik A, Ruel M (2018) Eight-year follow-up of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial. J Thorac Cardiovasc Surg 155(1):212\u2013222e2. https:\/\/doi.org\/10.1016\/j.jtcvs.2017.06.039. Epub 2017 Jun 24. PMID: 28734623","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"8","key":"3330_CR18","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1080\/09537104.2017.1280147","volume":"28","author":"S Rafiq","year":"2017","unstructured":"Rafiq S, Johansson PI, Kofoed KF, Lund JT, Olsen PS, Bentsen S, Steinbr\u00fcchel DA (2017) Thrombelastographic hypercoagulability and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): a randomized controlled trial. Platelets 28(8):786\u2013793 Epub 2017 Feb 22. PMID: 28277060","journal-title":"Platelets"},{"key":"3330_CR19","doi-asserted-by":"publisher","unstructured":"Gao C, Ren C, Li D, Li L (2009) Clopidogrel and aspirin versus clopidogrel alone on graft patency after coronary artery bypass grafting. Ann Thorac Surg. ;88(1):59\u201362. https:\/\/doi.org\/10.1016\/j.athoracsur.2009.04.024. PMID: 19559191","DOI":"10.1016\/j.athoracsur.2009.04.024"},{"issue":"10","key":"3330_CR20","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1136\/heartjnl-2015-308691","volume":"102","author":"J Saw","year":"2016","unstructured":"Saw J, Wong GC, Mayo J, Bernstein V, Mancini GB, Ye J, Skarsgard P, Starovoytov A, Cairns J (2016) Ticagrelor and aspirin for the prevention of cardiovascular events after coronary artery bypass graft surgery. Heart 102(10):763\u2013769. https:\/\/doi.org\/10.1136\/heartjnl-2015-308691. Epub 2016 Feb 18. PMID: 26891756","journal-title":"Heart"},{"issue":"1","key":"3330_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.athoracsur.2013.08.058","volume":"97","author":"R Ebrahimi","year":"2014","unstructured":"Ebrahimi R, Bakaeen FG, Uberoi A, Ardehali A, Baltz JH, Hattler B, Almassi GH, Wagner TH, Collins JF, Grover FL, Shroyer AL (2014) Effect of clopidogrel use post coronary artery bypass surgery on graft patency. Ann Thorac Surg 97(1):15\u201321 Epub 2013 Nov 6. PMID: 24206971","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"3330_CR22","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.athoracsur.2022.10.040","volume":"115","author":"HH Kim","year":"2023","unstructured":"Kim HH, Yoo KJ, Youn YN (2023) A Randomized Trial of Clopidogrel vs Ticagrelor After Off-Pump Coronary Bypass. Ann Thorac Surg 115(5):1127\u20131134. https:\/\/doi.org\/10.1016\/j.athoracsur.2022.10.040. Epub 2022 Nov 14. PMID: 36395875","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"3330_CR23","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1111\/jocs.16492","volume":"37","author":"A Kulik","year":"2022","unstructured":"Kulik A, Abreu AM, Boronat V, Kouchoukos NT, Ruel M (2022) Ticagrelor versus aspirin 2 years after coronary bypass: Observational analysis from the TARGET trial. J Card Surg 37(7):1969\u20131977. https:\/\/doi.org\/10.1111\/jocs.16492. Epub 2022 Apr 9. PMID: 35397138","journal-title":"J Card Surg"},{"issue":"16","key":"3330_CR24","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1001\/jama.2018.3197","volume":"319","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Zhu Y, Xu Z, Cheng Z, Mei J, Chen X, Wang X (2018) Effect of Ticagrelor Plus Aspirin, Ticagrelor Alone, or Aspirin Alone on Saphenous Vein Graft Patency 1 Year After Coronary Artery Bypass Grafting: A Randomized Clinical Trial. JAMA 319(16):1677\u20131686. https:\/\/doi.org\/10.1001\/jama.2018.3197. PMID: 29710164; PMCID: PMC5933396","journal-title":"JAMA"},{"key":"3330_CR25","doi-asserted-by":"publisher","unstructured":"Lamy A, Eikelboom J, Sheth T, Connolly S, Bosch J, Fox KAA, Zhu J, Lonn E, Dagenais G, Widimsky P, Branch KRH, Bhatt DL, Zheng Z, Straka Z, Dagenais F, Kong Y, Marsden T, Lee SF, Copland I, Yusuf S (2019) Rivaroxaban, Aspirin, or Both to Prevent Early Coronary Bypass Graft Occlusion: The COMPASS-CABG Study. J Am Coll Cardiol. ;73(2):121\u2013130. https:\/\/doi.org\/10.1016\/j.jacc.2018.10.048. PMID: 30654882","DOI":"10.1016\/j.jacc.2018.10.048"},{"issue":"11","key":"3330_CR26","doi-asserted-by":"publisher","first-page":"e020413","DOI":"10.1161\/JAHA.120.020413","volume":"10","author":"J Qu","year":"2021","unstructured":"Qu J, Zhang H, Rao C, Chen S, Zhao Y, Sun H, Song Y, Liu S, Wang L, Feng W, Wang S, Hu S, Zheng Z (2021) Dual Antiplatelet Therapy with Clopidogrel and Aspirin Versus Aspirin Monotherapy in Patients Undergoing Coronary Artery Bypass Graft Surgery. J Am Heart Assoc 10(11):e020413 Epub 2021 May 15. PMID: 33998246; PMCID: PMC8483527","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"3330_CR27","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1136\/heartjnl-2012-302449","volume":"98","author":"VA Mannacio","year":"2012","unstructured":"Mannacio VA, Di Tommaso L, Antignan A, De Amicis V, Vosa C (2012) Aspirin plus clopidogrel for optimal platelet inhibition following off-pump coronary artery bypass surgery: results from the CRYSSA (prevention of Coronary arteRY bypaSS occlusion After off-pump procedures) randomised study. Heart 98(23):1710\u20131715. https:\/\/doi.org\/10.1136\/heartjnl-2012-302449. Epub 2012 Sep 2. PMID: 22942294","journal-title":"Heart"},{"key":"3330_CR28","doi-asserted-by":"publisher","unstructured":"Une D, Al-Atassi T, Kulik A, Voisine P, Le May M, Ruel M (2014) Impact of clopidogrel plus aspirin versus aspirin alone on the progression of native coronary artery disease after bypass surgery: analysis from the Clopidogrel After Surgery for Coronary Artery DiseasE (CASCADE) randomized trial. Circulation. ;130(11 Suppl 1):S12-8. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.008227. PMID: 25200049","DOI":"10.1161\/CIRCULATIONAHA.113.008227"},{"issue":"29","key":"3330_CR29","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1093\/eurheartj\/ehz185","volume":"40","author":"H Schunkert","year":"2019","unstructured":"Schunkert H, Boening A, von Scheidt M et al (2019) Randomized trial of ticagrelor vs. aspirin in patients after coronary artery bypass grafting: the TiCAB trial. Eur Heart J 40(29):2432\u20132440. https:\/\/doi.org\/10.1093\/eurheartj\/ehz185","journal-title":"Eur Heart J"},{"issue":"19","key":"3330_CR30","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1161\/CIRCULATIONAHA.120.050749","volume":"142","author":"LM Willemsen","year":"2020","unstructured":"Willemsen LM, Janssen PWA, Peper J et al (2020) Effect of Adding Ticagrelor to Standard Aspirin on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting (POPular CABG): A Randomized, Double-Blind, Placebo-Controlled Trial. Circulation 142(19):1799\u20131807. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.050749","journal-title":"Circulation"},{"issue":"10","key":"3330_CR31","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/j.amjcard.2014.02.024","volume":"113","author":"H Gasparovic","year":"2014","unstructured":"Gasparovic H, Petricevic M, Kopjar T, Djuric Z, Svetina L, Biocina B (2014) Impact of dual antiplatelet therapy on outcomes among aspirin-resistant patients following coronary artery bypass grafting. Am J Cardiol 113(10):1660\u20131667. https:\/\/doi.org\/10.1016\/j.amjcard.2014.02.024","journal-title":"Am J Cardiol"},{"issue":"3","key":"3330_CR32","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1093\/ejcts\/ezx075","volume":"52","author":"U Benedetto","year":"2017","unstructured":"Benedetto U, Altman DG, Gerry S et al (2017) Impact of dual antiplatelet therapy after coronary artery bypass surgery on 1-year outcomes in the Arterial Revascularization Trial. Eur J Cardiothorac Surg 52(3):456\u2013461. https:\/\/doi.org\/10.1093\/ejcts\/ezx075","journal-title":"Eur J Cardiothorac Surg"},{"issue":"10","key":"3330_CR33","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jacc.2010.09.069","volume":"57","author":"R S\u00f8rensen","year":"2011","unstructured":"S\u00f8rensen R, Abildstr\u00f8m SZ, Hansen PR et al (2011) Efficacy of post-operative clopidogrel treatment in patients revascularized with coronary artery bypass grafting after myocardial infarction. J Am Coll Cardiol 57(10):1202\u20131209. https:\/\/doi.org\/10.1016\/j.jacc.2010.09.069","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"3330_CR34","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.21037\/jtd-20-3407","volume":"13","author":"Y Tang","year":"2021","unstructured":"Tang Y, Fan X, Zhang B et al (2021) Aspirin plus ticagrelor or clopidogrel on graft patency one year after coronary bypass grafting: a single-center, randomized, controlled trial. J Thorac Dis 13(3):1697\u20131705. https:\/\/doi.org\/10.21037\/jtd-20-3407","journal-title":"J Thorac Dis"},{"key":"3330_CR35","doi-asserted-by":"publisher","first-page":"e075707","DOI":"10.1136\/bmj-2023-075707","volume":"385","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Zhang W, Dimagli A et al (2024) Antiplatelet therapy after coronary artery bypass surgery: five year follow-up of randomised DACAB trial. BMJ 385:e075707 Published 2024 Jun 11. https:\/\/doi.org\/10.1136\/bmj-2023-075707","journal-title":"BMJ"},{"issue":"23","key":"3330_CR36","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa2508026","volume":"393","author":"A Jeppsson","year":"2025","unstructured":"Jeppsson A, James S, Moller CH et al (2025) Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome. N Engl J Med 393(23):2313\u20132323. https:\/\/doi.org\/10.1056\/NEJMoa2508026","journal-title":"N Engl J Med"},{"issue":"2","key":"3330_CR37","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jtcvs.2018.10.032","volume":"158","author":"F Xu","year":"2019","unstructured":"Xu F, Feng W, Zhou Z et al (2019) Antiplatelet effects of ticagrelor versus clopidogrel after coronary artery bypass graft surgery: A single-center randomized controlled trial. J Thorac Cardiovasc Surg 158(2):430\u2013437e4. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.10.032","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"3330_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/BJMMR\/2016\/24386","volume":"14","author":"A Slim","year":"2016","unstructured":"Slim A, Fentanes E, Thomas D et al (2016) ASpirin and Plavix following Coronary Artery Bypass Grafting (ASAP-CABG): A randomized, double-blind, placebo-controlled pilot trial[J]. Br J Med Med Res 14(3):1\u201310","journal-title":"Br J Med Med Res"},{"issue":"6","key":"3330_CR39","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jacc.2010.10.029","volume":"57","author":"C Held","year":"2011","unstructured":"Held C, Asenblad N, Bassand JP et al (2011) Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol 57(6):672\u2013684. https:\/\/doi.org\/10.1016\/j.jacc.2010.10.029","journal-title":"J Am Coll Cardiol"},{"key":"3330_CR40","doi-asserted-by":"publisher","first-page":"1461370","DOI":"10.3389\/fcvm.2025.1461370","volume":"12","author":"W Wang","year":"2025","unstructured":"Wang W, Chi Q, Gao F et al (2025) Ticagrelor combined with aspirin may improve patency of vein graft one year after off-pump coronary artery bypass grafting: a single-center, randomized double-blinded clinical controlled trial. Front Cardiovasc Med 12:1461370 Published 2025 May 9. https:\/\/doi.org\/10.3389\/fcvm.2025.1461370","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"3330_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12055-020-01052-6","volume":"37","author":"PK Varma","year":"2021","unstructured":"Varma PK, Ahmed H, Krishna N et al (2021) Bleeding complications after dual antiplatelet therapy with ticagrelor versus dual antiplatelet therapy with clopidogrel-a propensity-matched comparative study of two antiplatelet regimes in off-pump coronary artery bypass grafting. Indian J Thorac Cardiovasc Surg 37(1):27\u201337. https:\/\/doi.org\/10.1007\/s12055-020-01052-6","journal-title":"Indian J Thorac Cardiovasc Surg"},{"issue":"4","key":"3330_CR42","doi-asserted-by":"publisher","first-page":"ezad128","DOI":"10.1093\/ejcts\/ezad128","volume":"63","author":"JS Kim","year":"2023","unstructured":"Kim JS, Kang Y, Sohn SH, Hwang HY (2023) Comparative effectiveness of clopidogrel versus aspirin as a maintenance monotherapy 1 year after coronary artery bypass grafting. Eur J Cardiothorac Surg 63(4):ezad128. https:\/\/doi.org\/10.1093\/ejcts\/ezad128","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"3330_CR43","doi-asserted-by":"publisher","first-page":"598","DOI":"10.21470\/1678-9741-2022-0133","volume":"37","author":"GA Guida","year":"2022","unstructured":"Guida GA, Angelini GD (2022) Pathophysiology and mechanisms of saphenous vein graft failure. Braz J Cardiovasc Surg 37(4):598\u2013607. https:\/\/doi.org\/10.21470\/1678-9741-2022-0133","journal-title":"Braz J Cardiovasc Surg"},{"issue":"12","key":"3330_CR44","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.3390\/jcm11123285","volume":"11","author":"S Soh","year":"2022","unstructured":"Soh S, Shin YR, Song JW et al (2022) Platelet reactivity and outcomes after off-pump coronary surgery in acute coronary syndrome patients. J Clin Med 11(12):3285. https:\/\/doi.org\/10.3390\/jcm11123285","journal-title":"J Clin Med"},{"issue":"Suppl 2","key":"3330_CR45","doi-asserted-by":"publisher","first-page":"P040","DOI":"10.1186\/cc1929","volume":"7","author":"K Masayuki","year":"2003","unstructured":"Masayuki K, Kikuchi T, Sunanaga J et al (2003) Measurement of endotoxin, IL-6, IL-8 and blood lactate after cardiac surgery: re-evaluation of the systemic inflammatory response induced by cardiopulmonary bypass[J]. Crit Care 7(Suppl 2):P040","journal-title":"Crit Care"},{"issue":"15","key":"3330_CR46","doi-asserted-by":"publisher","first-page":"7150","DOI":"10.3390\/ijms26157150","volume":"26","author":"DV Scripcariu","year":"2025","unstructured":"Scripcariu DV, Huzum B, Mircea C et al (2025) Systemic impact of platelet activation in abdominal surgery: from oxidative and inflammatory pathways to postoperative complications[J]. Int J Mol Sci 26(15):7150","journal-title":"Int J Mol Sci"},{"issue":"10508","key":"3330_CR47","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0140-6736(25)01562-4","volume":"406","author":"M Valgimigli","year":"2025","unstructured":"Valgimigli M, Choi KH, Giacoppo D et al (2025) Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis. Lancet 406(10508):1091\u20131102. https:\/\/doi.org\/10.1016\/S0140-6736(25)01562-4","journal-title":"Lancet"},{"key":"3330_CR48","doi-asserted-by":"publisher","first-page":"e082561","DOI":"10.1136\/bmj-2024-082561","volume":"389","author":"D Giacoppo","year":"2025","unstructured":"Giacoppo D, Gragnano F, Watanabe H et al (2025) P2Y12 inhibitor or aspirin after percutaneous coronary intervention: individual patient data meta-analysis of randomised clinical trials. BMJ 389:e082561 Published 2025 Jun 4. https:\/\/doi.org\/10.1136\/bmj-2024-082561","journal-title":"BMJ"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03330-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-026-03330-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03330-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:36:53Z","timestamp":1791743813000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-026-03330-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["3330"],"URL":"https:\/\/doi.org\/10.1007\/s11239-026-03330-3","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agreed to publish this article.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}