{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:02:37Z","timestamp":1784829757511,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-026-03365-6","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:06:34Z","timestamp":1784826394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Platelet Destruction: A Mechanistic Understanding of Dengue Virus Non-Structural Proteins and Gene Regulatory Networks Driving Thrombocytopenia"],"prefix":"10.1007","author":[{"given":"Vishal","family":"Chanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuvashree","family":"Muralidaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9631-3508","authenticated-orcid":false,"given":"Prabhakar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"3365_CR1","doi-asserted-by":"publisher","first-page":"102943","DOI":"10.1016\/j.eclinm.2024.102943","volume":"78","author":"J Deng","year":"2024","unstructured":"Deng J, Zhang H, Wang Y, Liu Q, Du M, Yan W, Qin C, Zhang S, Chen W, Zhou L, Liu M, Niu B, Liu J (2024) Global, regional, and national burden of dengue infection in children and adolescents: an analysis of the Global Burden of Disease Study 2021. EClinicalMedicine 78:102943. https:\/\/doi.org\/10.1016\/j.eclinm.2024.102943","journal-title":"EClinicalMedicine"},{"issue":"10427","key":"3365_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/S0140-6736(23)02576-X","volume":"403","author":"G Paz-Bailey","year":"2024","unstructured":"Paz-Bailey G, Adams LE, Deen J, Anderson KB, Katzelnick LC (2024) Dengue. Lancet 403(10427):667\u2013682. https:\/\/doi.org\/10.1016\/S0140-6736(23)02576-X","journal-title":"Lancet"},{"key":"3365_CR3","doi-asserted-by":"publisher","unstructured":"Hossain MJ, Das M, Shahjahan M, Islam MW, Towhid ST (2025) Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital-Based Cross\u2010Sectional Study. Health Sci Rep 8(1). https:\/\/doi.org\/10.1002\/hsr2.70356","DOI":"10.1002\/hsr2.70356"},{"issue":"8","key":"3365_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3390\/tropicalmed10080233","volume":"10","author":"P Khamnuan","year":"2025","unstructured":"Khamnuan P, Pongpan S, Thanatrakolsri P, Vittaporn S, Daraswang P, Samsee S (2025) Prognostic Indicators of Severe Dengue Infection in Adult Patients in Thailand. Trop Med Infect Disease 10(8):233. https:\/\/doi.org\/10.3390\/tropicalmed10080233","journal-title":"Trop Med Infect Disease"},{"key":"3365_CR5","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1017\/erm.2024.18","volume":"26","author":"AS Khazali","year":"2024","unstructured":"Khazali AS, Hadrawi WH, Ibrahim F, Othman S, Nor Rashid N (2024) Thrombocytopenia in dengue infection: mechanisms and a potential application. Expert Rev Mol Med 26:e26. https:\/\/doi.org\/10.1017\/erm.2024.18","journal-title":"Expert Rev Mol Med"},{"issue":"11","key":"3365_CR6","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1371\/journal.ppat.0030183","volume":"3","author":"P Avirutnan","year":"2007","unstructured":"Avirutnan P, Zhang L, Punyadee N, Manuyakorn A, Puttikhunt C, Kasinrerk W, Malasit P, Atkinson JP, Diamond MS (2007) Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E. PLoS Pathog 3(11):e183. https:\/\/doi.org\/10.1371\/journal.ppat.0030183","journal-title":"PLoS Pathog"},{"issue":"4","key":"3365_CR7","doi-asserted-by":"publisher","first-page":"e1007625","DOI":"10.1371\/journal.ppat.1007625","volume":"15","author":"C-H Chao","year":"2019","unstructured":"Chao C-H, Wu W-C, Lai Y-C, Tsai P-J, Perng G-C, Lin Y-S, Yeh T-M (2019) Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathog 15(4):e1007625. https:\/\/doi.org\/10.1371\/journal.ppat.1007625","journal-title":"PLoS Pathog"},{"key":"3365_CR8","doi-asserted-by":"publisher","unstructured":"Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, Hume DA, Stacey KJ, Young PR (2015) Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Sci Transl Med 7(304). https:\/\/doi.org\/10.1126\/scitranslmed.aaa3863","DOI":"10.1126\/scitranslmed.aaa3863"},{"issue":"1","key":"3365_CR9","doi-asserted-by":"publisher","first-page":"19587","DOI":"10.1038\/s41598-020-76350-5","volume":"10","author":"A Banerjee","year":"2020","unstructured":"Banerjee A, Tripathi A, Duggal S, Banerjee A, Vrati S (2020) Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1. Sci Rep 10(1):19587. https:\/\/doi.org\/10.1038\/s41598-020-76350-5","journal-title":"Sci Rep"},{"key":"3365_CR10","doi-asserted-by":"publisher","unstructured":"Lahon A, Arya RP, Banerjea AC (2021) Dengue Virus Dysregulates Master Transcription Factors and PI3K\/AKT\/mTOR Signaling Pathway in Megakaryocytes. Front Cell Infect Microbiol 11. https:\/\/doi.org\/10.3389\/fcimb.2021.715208","DOI":"10.3389\/fcimb.2021.715208"},{"key":"3365_CR11","doi-asserted-by":"publisher","unstructured":"Noisakran S, Onlamoon N, Songprakhon P, Hsiao H-M, Chokephaibulkit K, Perng GC (2010) Cells in Dengue Virus Infection In Vivo. Advances in Virology, 2010, 1\u201315. https:\/\/doi.org\/10.1155\/2010\/164878","DOI":"10.1155\/2010\/164878"},{"issue":"10","key":"3365_CR12","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1111\/jth.15431","volume":"19","author":"N Garc\u00eda-Larragoiti","year":"2021","unstructured":"Garc\u00eda-Larragoiti N, Kim YC, L\u00f3pez\u2010Camacho C, Cano\u2010M\u00e9ndez A, L\u00f3pez\u2010Castaneda S, Hern\u00e1ndez\u2010Hern\u00e1ndez D, Vargas\u2010Ruiz \u00c1G, V\u00e1zquez\u2010Garcidue\u00f1as MS, Reyes\u2010Sandoval A, Viveros\u2010Sandoval ME (2021) Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains. J Thromb Haemost 19(10):2572\u20132582. https:\/\/doi.org\/10.1111\/jth.15431","journal-title":"J Thromb Haemost"},{"issue":"20","key":"3365_CR13","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1182\/blood-2013-05-504449","volume":"122","author":"ED Hottz","year":"2013","unstructured":"Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Poian D, Weyrich AT, Zimmerman AS, Bozza GA, F. A., Bozza PT (2013) Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood 122(20):3405\u20133414. https:\/\/doi.org\/10.1182\/blood-2013-05-504449","journal-title":"Blood"},{"key":"3365_CR14","doi-asserted-by":"publisher","unstructured":"Lien T-S, Chan H, Sun D-S, Wu J-C, Lin Y-Y, Lin G-L, Chang H-H (2021) Exposure of Platelets to Dengue Virus and Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent Platelet Cell Death and Thrombocytopenia in Mice. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.616394","DOI":"10.3389\/fimmu.2021.616394"},{"issue":"2","key":"3365_CR15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO;2-L","volume":"63","author":"C-F Lin","year":"2001","unstructured":"Lin C-F, Lei H-Y, Liu C-C, Liu H-S, Yeh T-M, Wang S-T, Yang T-I, Sheu F-C, Kuo C-F, Lin Y-S (2001) Generation of IgM anti-platelet autoantibody in dengue patients. J Med Virol 63(2):143\u2013149. https:\/\/doi.org\/10.1002\/1096-9071(20000201)63:2%3C143::AID-JMV1009%3E3.0.CO;2-L","journal-title":"J Med Virol"},{"issue":"03","key":"3365_CR16","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1160\/th15-06-0498","volume":"115","author":"S-W Wan","year":"2016","unstructured":"Wan S-W, Yang Y-W, Chu Y-T, Lin C-F, Chang C-P, Yeh T-M, Anderson R, Lin Y-S (2016) Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages. Thromb Haemost 115(03):646\u2013656. https:\/\/doi.org\/10.1160\/th15-06-0498","journal-title":"Thromb Haemost"},{"issue":"3","key":"3365_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/imm.12748","volume":"151","author":"GN Malavige","year":"2017","unstructured":"Malavige GN, Ogg GS (2017) Pathogenesis of vascular leak in dengue virus infection. Immunology 151(3):261\u2013269. https:\/\/doi.org\/10.1111\/imm.12748","journal-title":"Immunology"},{"issue":"2","key":"3365_CR18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/infdis\/jiz331","volume":"221","author":"H Puerta-Guardo","year":"2020","unstructured":"Puerta-Guardo H, Tabata T, Petitt M, Dimitrova M, Glasner DR, Pereira L, Harris E (2020) Zika Virus Nonstructural Protein 1 Disrupts Glycosaminoglycans and Causes Permeability in Developing Human Placentas. J Infect Dis 221(2):313\u2013324. https:\/\/doi.org\/10.1093\/infdis\/jiz331","journal-title":"J Infect Dis"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03365-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-026-03365-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03365-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:06:34Z","timestamp":1784826394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-026-03365-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":18,"alternative-id":["3365"],"URL":"https:\/\/doi.org\/10.1007\/s11239-026-03365-6","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"13 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}