{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:55:41Z","timestamp":1790560541951,"version":"4.1.0"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Thromb Thrombolysis"],"DOI":"10.1007\/s11239-026-03401-5","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:56:34Z","timestamp":1790513794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methodological Approaches in the Evaluation of Platelet Structure and Function: An Instrumental Perspective"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-190X","authenticated-orcid":false,"given":"Samir Kumar","family":"Beura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-0485","authenticated-orcid":false,"given":"Paresh P.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-6282","authenticated-orcid":false,"given":"Sunil Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"3401_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","volume":"16","author":"PEJ Van Der Meijden","year":"2019","unstructured":"Van Der Meijden PEJ, Heemskerk JWM (2019) Platelet biology and functions: new concepts and clinical perspectives. Nat Rev Cardiol 16:166\u2013179. https:\/\/doi.org\/10.1038\/s41569-018-0110-0","journal-title":"Nat Rev Cardiol"},{"key":"3401_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41577-023-00834-4","volume":"23","author":"M Scherlinger","year":"2023","unstructured":"Scherlinger M, Richez C, Tsokos GC, Boilard E, Blanco P (2023) The role of platelets in immune-mediated inflammatory diseases. Nat Rev Immunol 23:495\u2013510. https:\/\/doi.org\/10.1038\/s41577-023-00834-4","journal-title":"Nat Rev Immunol"},{"key":"3401_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/MOH.0b013e32833e7561","volume":"17","author":"R Grozovsky","year":"2010","unstructured":"Grozovsky R, Hoffmeister KM, Falet H (2010) Novel clearance mechanisms of platelets. Curr Opin Hematol 17:585\u2013589. https:\/\/doi.org\/10.1097\/MOH.0b013e32833e7561","journal-title":"Curr Opin Hematol"},{"key":"3401_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/456569","volume":"2014","author":"J-L Choi","year":"2014","unstructured":"Choi J-L, Li S, Han J-Y (2014) Platelet Function Tests: A Review of Progresses in Clinical Application. Biomed Res Int 2014:1\u20137. https:\/\/doi.org\/10.1155\/2014\/456569","journal-title":"Biomed Res Int"},{"key":"3401_CR5","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1007\/s12325-020-01453-4","volume":"37","author":"AD Kaye","year":"2020","unstructured":"Kaye AD, Jeha GM, Moll V, Ward CT, Watson MR, Wynn JT et al (2020) Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations. Adv Ther 37:3707\u20133722. https:\/\/doi.org\/10.1007\/s12325-020-01453-4","journal-title":"Adv Ther"},{"key":"3401_CR6","doi-asserted-by":"publisher","unstructured":"Paniccia R, Priora R, Alessandrello Liotta A, Abbate R Platelet function tests: a comparative review. VHRM 2015:133. https:\/\/doi.org\/10.2147\/VHRM.S44469","DOI":"10.2147\/VHRM.S44469"},{"key":"3401_CR7","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1055\/s-0042-1757898","volume":"49","author":"JB Larsen","year":"2023","unstructured":"Larsen JB, Hvas A-M, Hojbjerg JA (2023) Platelet Function Testing: Update and Future Directions. Semin Thromb Hemost 49:600\u2013608. https:\/\/doi.org\/10.1055\/s-0042-1757898","journal-title":"Semin Thromb Hemost"},{"key":"3401_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1055\/s-0036-1571307","volume":"42","author":"R Lassila","year":"2016","unstructured":"Lassila R (2016) Platelet Function Tests in Bleeding Disorders. Semin Thromb Hemost 42:185\u2013190. https:\/\/doi.org\/10.1055\/s-0036-1571307","journal-title":"Semin Thromb Hemost"},{"key":"3401_CR9","doi-asserted-by":"publisher","unstructured":"Boggio F, Giannotta JA, Lecchi A Automation in Platelet Function Testing: Current Challenges and Future Directions. Semin Thromb Hemost 2025:a-2622-3545. https:\/\/doi.org\/10.1055\/a-2622-3545","DOI":"10.1055\/a-2622-3545"},{"key":"3401_CR10","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3390\/biom14060714","volume":"14","author":"I Yoon","year":"2024","unstructured":"Yoon I, Han JH, Jeon H-J (2024) Advances in Platelet-Dysfunction Diagnostic Technologies. Biomolecules 14:714. https:\/\/doi.org\/10.3390\/biom14060714","journal-title":"Biomolecules"},{"key":"3401_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1542\/pir.2018-0359","volume":"41","author":"KM Haley","year":"2020","unstructured":"Haley KM (2020) Platelet Disorders. Pediatr Rev 41:224\u2013235. https:\/\/doi.org\/10.1542\/pir.2018-0359","journal-title":"Pediatr Rev"},{"key":"3401_CR12","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.3390\/ijms22094521","volume":"22","author":"V Palma-Barqueros","year":"2021","unstructured":"Palma-Barqueros V, Revilla N, S\u00e1nchez A, Zamora C\u00e1novas A, Rodriguez-Al\u00e9n A, Mar\u00edn-Qu\u00edlez A et al (2021) Inherit Platelet Disorders: Updated Overv IJMS 22:4521. https:\/\/doi.org\/10.3390\/ijms22094521","journal-title":"Inherit Platelet Disorders: Updated Overv IJMS"},{"key":"3401_CR13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1515\/labmed-2020-0007","volume":"44","author":"C Robier","year":"2020","unstructured":"Robier C (2020) Platelet morphology. J Lab Med 44:231\u2013239. https:\/\/doi.org\/10.1515\/labmed-2020-0007","journal-title":"J Lab Med"},{"key":"3401_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/ijlh.12213","volume":"36","author":"K Freson","year":"2014","unstructured":"Freson K, Wijgaerts A, Van Geet C (2014) Update on the causes of platelet disorders and functional consequences. Int J Lab Hematol 36:313\u2013325. https:\/\/doi.org\/10.1111\/ijlh.12213","journal-title":"Int J Lab Hematol"},{"key":"3401_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12959-021-00283-w","volume":"19","author":"M Nagy","year":"2021","unstructured":"Nagy M, Fazaeli S, Van Oerle R, Ten Cate H, Schemmann M, Sherry J et al (2021) Evaluation of the analytical performance of the PC100 platelet counter. Thromb J 19:29. https:\/\/doi.org\/10.1186\/s12959-021-00283-w","journal-title":"Thromb J"},{"key":"3401_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/diagnostics12010068","volume":"12","author":"H Kim","year":"2021","unstructured":"Kim H, Hur M, Lee G-H, Kim S-W, Moon H-W, Yun Y-M (2021) Performance of Platelet Counting in Thrombocytopenic Samples: Comparison between Mindray BC-6800Plus and Sysmex XN-9000. Diagnostics 12:68. https:\/\/doi.org\/10.3390\/diagnostics12010068","journal-title":"Diagnostics"},{"key":"3401_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1423-0410.2011.01467.x","volume":"101","author":"S Panzer","year":"2011","unstructured":"Panzer S, Jilma P (2011) Methods for testing platelet function for transfusion medicine. Vox Sang 101:1\u20139. https:\/\/doi.org\/10.1111\/j.1423-0410.2011.01467.x","journal-title":"Vox Sang"},{"key":"3401_CR18","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1080\/19336918.2016.1173803","volume":"10","author":"S Sorrentino","year":"2016","unstructured":"Sorrentino S, Studt J-D, Horev MB, Medalia O, Sapra KT (2016) Toward correlating structure and mechanics of platelets. Cell Adhes Migr 10:568\u2013575. https:\/\/doi.org\/10.1080\/19336918.2016.1173803","journal-title":"Cell Adhes Migr"},{"key":"3401_CR19","doi-asserted-by":"publisher","first-page":"2467383","DOI":"10.1080\/09537104.2025.2467383","volume":"36","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Wang Z, Zhou P, Zhang H (2025) From reticulated platelets to immature platelet fraction: structure, function, and clinical applications. Platelets 36:2467383. https:\/\/doi.org\/10.1080\/09537104.2025.2467383","journal-title":"Platelets"},{"key":"3401_CR20","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1111\/trf.14886","volume":"58","author":"K Hummel","year":"2018","unstructured":"Hummel K, Sachse M, Hoffmann JJML, Van Dun LPJM (2018) Comparative evaluation of platelet counts in two hematology analyzers and potential effects on prophylactic platelet transfusion decisions. Transfusion 58:2301\u20132308. https:\/\/doi.org\/10.1111\/trf.14886","journal-title":"Transfusion"},{"key":"3401_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1053\/j.tcam.2011.02.001","volume":"26","author":"DB DeNicola","year":"2011","unstructured":"DeNicola DB (2011) Advances in Hematology Analyzers. Top Companion Anim Med 26:52\u201361. https:\/\/doi.org\/10.1053\/j.tcam.2011.02.001","journal-title":"Top Companion Anim Med"},{"key":"3401_CR22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28327","author":"N Sahu","year":"2022","unstructured":"Sahu N, Mohanty M, Adhya AK (2022) Estimation of Total Platelet Count From Peripheral Blood Smear Needs a Correction Factor. Cureus. https:\/\/doi.org\/10.7759\/cureus.28327","journal-title":"Cureus"},{"key":"3401_CR23","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1080\/09537104.2020.1763939","volume":"31","author":"M Tomaiuolo","year":"2020","unstructured":"Tomaiuolo M, Litvinov RI, Weisel JW, Stalker TJ (2020) Use of electron microscopy to study platelets and thrombi. Platelets 31:580\u2013588. https:\/\/doi.org\/10.1080\/09537104.2020.1763939","journal-title":"Platelets"},{"key":"3401_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1055\/s-0029-1220329","volume":"35","author":"S Clauser","year":"2009","unstructured":"Clauser S, Cramer-Bord\u00e9 E (2009) Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders. Semin Thromb Hemost 35:213\u2013223. https:\/\/doi.org\/10.1055\/s-0029-1220329","journal-title":"Semin Thromb Hemost"},{"key":"3401_CR25","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1309\/AJCP58INTITVGQZI","volume":"140","author":"S Marionneaux","year":"2013","unstructured":"Marionneaux S, Francisco N, Chan V, Hanenberg J, Rafael J, Chua C et al (2013) Comparison of Automated Platelet Counts and Potential Effect on Transfusion Decisions in Cancer Patients. Am J Clin Pathol 140:747\u2013754. https:\/\/doi.org\/10.1309\/AJCP58INTITVGQZI","journal-title":"Am J Clin Pathol"},{"key":"3401_CR26","doi-asserted-by":"publisher","first-page":"808","DOI":"10.3390\/jcm9030808","volume":"9","author":"V Baccini","year":"2020","unstructured":"Baccini V, Genevi\u00e8ve F, Jacqmin H, Chatelain B, Girard S, Wuilleme S et al (2020) Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC). JCM 9:808. https:\/\/doi.org\/10.3390\/jcm9030808","journal-title":"JCM"},{"key":"3401_CR27","doi-asserted-by":"publisher","first-page":"434","DOI":"10.18203\/2320-6012.ijrms20190348","volume":"7","author":"VT Anchinmane","year":"2019","unstructured":"Anchinmane VT, Sankhe SV (2019) Utility of peripheral blood smear in platelet count estimation. Int J Res Med Sci 7:434. https:\/\/doi.org\/10.18203\/2320-6012.ijrms20190348","journal-title":"Int J Res Med Sci"},{"key":"3401_CR28","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/cbin.12192","volume":"48","author":"P Yadav","year":"2024","unstructured":"Yadav P, Beura SK, Panigrahi AR, Kulkarni PP, Yadav MK, Munshi A et al (2024) Lysophosphatidylcholine induces oxidative stress and calcium-mediated cell death in human blood platelets. Cell Biol Int 48:1266\u20131284. https:\/\/doi.org\/10.1002\/cbin.12192","journal-title":"Cell Biol Int"},{"key":"3401_CR29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.tmrv.2007.05.005","volume":"21","author":"E Maurer-Spurej","year":"2007","unstructured":"Maurer-Spurej E, Chipperfield K (2007) Past and Future Approaches to Assess the Quality of Platelets for Transfusion. Transfus Med Rev 21:295\u2013306. https:\/\/doi.org\/10.1016\/j.tmrv.2007.05.005","journal-title":"Transfus Med Rev"},{"key":"3401_CR30","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.blre.2014.04.002","volume":"28","author":"T Burnouf","year":"2014","unstructured":"Burnouf T, Goubran HA, Chou M-L, Devos D, Radosevic M (2014) Platelet microparticles: Detection and assessment of their paradoxical functional roles in disease and regenerative medicine. Blood Rev 28:155\u2013166. https:\/\/doi.org\/10.1016\/j.blre.2014.04.002","journal-title":"Blood Rev"},{"key":"3401_CR31","doi-asserted-by":"publisher","first-page":"2300494","DOI":"10.1002\/lpor.202300494","volume":"18","author":"A Sdobnov","year":"2024","unstructured":"Sdobnov A, Piavchenko G, Bykov A, Meglinski I (2024) Advances in Dynamic Light Scattering Imaging of Blood Flow. Laser Photonics Rev 18:2300494. https:\/\/doi.org\/10.1002\/lpor.202300494","journal-title":"Laser Photonics Rev"},{"key":"3401_CR32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000350362","volume":"40","author":"A Labrie","year":"2013","unstructured":"Labrie A, Marshall A, Bedi H, Maurer-Spurej E (2013) Characterization of Platelet Concentrates Using Dynamic Light Scattering. Transfus Med Hemother 40:93\u2013100. https:\/\/doi.org\/10.1159\/000350362","journal-title":"Transfus Med Hemother"},{"key":"3401_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nnano.2017.45","volume":"12","author":"YF Dufr\u00eane","year":"2017","unstructured":"Dufr\u00eane YF, Ando T, Garcia R, Alsteens D, Martinez-Martin D, Engel A et al (2017) Imaging modes of atomic force microscopy for application in molecular and cell biology. Nat Nanotech 12:295\u2013307. https:\/\/doi.org\/10.1038\/nnano.2017.45","journal-title":"Nat Nanotech"},{"key":"3401_CR34","doi-asserted-by":"publisher","first-page":"114764","DOI":"10.1016\/j.colsurfb.2025.114764","volume":"253","author":"X Yan","year":"2025","unstructured":"Yan X, Zhang X, Yue K, Wang A, Zhong W, Zhang G (2025) Characterization of platelet adhesion forces by atomic force microscope under magneto-thermal conditions. Colloids Surf B 253:114764. https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114764","journal-title":"Colloids Surf B"},{"key":"3401_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/17474086.2019.1562333","volume":"12","author":"P Gresele","year":"2019","unstructured":"Gresele P, Bury L, Mezzasoma AM, Falcinelli E (2019) Platelet function assays in diagnosis: an update. Expert Rev Hematol 12:29\u201346. https:\/\/doi.org\/10.1080\/17474086.2019.1562333","journal-title":"Expert Rev Hematol"},{"key":"3401_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.blre.2004.05.002","volume":"19","author":"P Harrison","year":"2005","unstructured":"Harrison P (2005) Platelet function analysis. Blood Rev 19:111\u2013123. https:\/\/doi.org\/10.1016\/j.blre.2004.05.002","journal-title":"Blood Rev"},{"key":"3401_CR37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1476-4431.2011.00707.x","volume":"22","author":"KE Jandrey","year":"2012","unstructured":"Jandrey KE (2012) Assessment of platelet function. J Vet Emergen Crit Care 22:81\u201398. https:\/\/doi.org\/10.1111\/j.1476-4431.2011.00707.x","journal-title":"J Vet Emergen Crit Care"},{"key":"3401_CR38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.neuroscience.2024.09.015","volume":"559","author":"SK Beura","year":"2024","unstructured":"Beura SK, Yadav P, Ramachandra Panigrahi A, Sahoo G, Kumar Singh S (2024) Impact of 6-hydroxydopamine on agonist-induced human platelet functional parameters: An explanation for platelet impairment in Parkinson\u2019s disease. Neuroscience 559:237\u2013248. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.09.015","journal-title":"Neuroscience"},{"key":"3401_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.transci.2011.03.006","volume":"44","author":"SM Picker","year":"2011","unstructured":"Picker SM (2011) In-vitro assessment of platelet function. Transfus Apheres Sci 44:305\u2013319. https:\/\/doi.org\/10.1016\/j.transci.2011.03.006","journal-title":"Transfus Apheres Sci"},{"key":"3401_CR40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1161\/ATVBAHA.107.150474","volume":"28","author":"D Varga-Szabo","year":"2008","unstructured":"Varga-Szabo D, Pleines I, Nieswandt B (2008) Cell Adhesion Mechanisms in Platelets. ATVB 28:403\u2013412. https:\/\/doi.org\/10.1161\/ATVBAHA.107.150474","journal-title":"ATVB"},{"key":"3401_CR41","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","volume":"30","author":"Z Li","year":"2010","unstructured":"Li Z, Delaney MK, O\u2019Brien KA, Du X (2010) Signaling During Platelet Adhesion and Activation. ATVB 30:2341\u20132349. https:\/\/doi.org\/10.1161\/ATVBAHA.110.207522","journal-title":"ATVB"},{"key":"3401_CR42","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1161\/01.RES.0000267878.97021.ab","volume":"100","author":"ZM Ruggeri","year":"2007","unstructured":"Ruggeri ZM, Mendolicchio GL (2007) Adhesion Mechanisms in Platelet Function. Circul Res 100:1673\u20131685. https:\/\/doi.org\/10.1161\/01.RES.0000267878.97021.ab","journal-title":"Circul Res"},{"key":"3401_CR43","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1080\/10739680802651477","volume":"16","author":"ZM Ruggeri","year":"2009","unstructured":"Ruggeri ZM (2009) Platelet Adhesion under Flow. Microcirculation 16:58\u201383. https:\/\/doi.org\/10.1080\/10739680802651477","journal-title":"Microcirculation"},{"key":"3401_CR44","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1161\/hq0202.104122","volume":"22","author":"M Kuwahara","year":"2002","unstructured":"Kuwahara M, Sugimoto M, Tsuji S, Matsui H, Mizuno T, Miyata S et al (2002) Platelet Shape Changes and Adhesion Under High Shear Flow. ATVB 22:329\u2013334. https:\/\/doi.org\/10.1161\/hq0202.104122","journal-title":"ATVB"},{"key":"3401_CR45","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1039\/D0LC00756K","volume":"21","author":"SM Rahman","year":"2021","unstructured":"Rahman SM, Hlady V (2021) Microfluidic assay of antiplatelet agents for inhibition of shear-induced platelet adhesion and activation. Lab Chip 21:174\u2013183. https:\/\/doi.org\/10.1039\/D0LC00756K","journal-title":"Lab Chip"},{"key":"3401_CR46","doi-asserted-by":"publisher","unstructured":"Michelson AD (2009) Methods for the Measurement of Platelet Function. Am J Cardiol 103. https:\/\/doi.org\/10.1016\/j.amjcard.2008.11.019. :20A-26A","DOI":"10.1016\/j.amjcard.2008.11.019"},{"key":"3401_CR47","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1586\/14779072.5.5.955","volume":"5","author":"AM Zeidan","year":"2007","unstructured":"Zeidan AM, Kouides PA, Tara MA, Fricke WA (2007) Platelet function testing: state of the art. Expert Rev Cardiovasc Ther 5:955\u2013967. https:\/\/doi.org\/10.1586\/14779072.5.5.955","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"3401_CR48","doi-asserted-by":"publisher","first-page":"e002094","DOI":"10.1161\/JAHA.115.002094","volume":"4","author":"DA Gorog","year":"2015","unstructured":"Gorog DA, Jeong Y (2015) Platelet Function Tests: Why They Fail to Guide Personalized Antithrombotic Medication. JAHA 4:e002094. https:\/\/doi.org\/10.1161\/JAHA.115.002094","journal-title":"JAHA"},{"key":"3401_CR49","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1073\/pnas.0509397103","volume":"103","author":"S Marcondes","year":"2006","unstructured":"Marcondes S, Cardoso MHM, Morganti RP, Thomazzi SM, Lilla S, Murad F et al (2006) Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: A role for \u03b1-actinin nitration. Proc Natl Acad Sci USA 103:3434\u20133439. https:\/\/doi.org\/10.1073\/pnas.0509397103","journal-title":"Proc Natl Acad Sci USA"},{"key":"3401_CR50","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/jth.13270","volume":"14","author":"SM Baker-Groberg","year":"2016","unstructured":"Baker-Groberg SM, Lattimore S, Recht M, McCarty OJT, Haley KM (2016) Assessment of neonatal platelet adhesion, activation, and aggregation. J Thromb Haemost 14:815\u2013827. https:\/\/doi.org\/10.1111\/jth.13270","journal-title":"J Thromb Haemost"},{"key":"3401_CR51","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/s25020491","volume":"25","author":"YY Tan","year":"2025","unstructured":"Tan YY, Liu J, Su QP (2025) Advancing Platelet Research Through Live-Cell Imaging: Challenges, Techniques, and Insights. Sensors 25:491. https:\/\/doi.org\/10.3390\/s25020491","journal-title":"Sensors"},{"key":"3401_CR52","doi-asserted-by":"publisher","first-page":"e23747","DOI":"10.1002\/jbt.23747","volume":"38","author":"SK Beura","year":"2024","unstructured":"Beura SK, Sahoo G, Yadav S, Yadav P, Panigrahi AR, Singh SK (2024) Investigating the role of rotenone on human blood platelets: Molecular insights into abnormal platelet functions in Parkinson\u2019s disease. J Biochem Mol Tox 38:e23747. https:\/\/doi.org\/10.1002\/jbt.23747","journal-title":"J Biochem Mol Tox"},{"key":"3401_CR53","doi-asserted-by":"publisher","first-page":"13104","DOI":"10.1038\/s41598-020-70162-3","volume":"10","author":"MN Barrachina","year":"2020","unstructured":"Barrachina MN, Mor\u00e1n LA, Izquierdo I, Casanueva FF, Pardo M, Garc\u00eda \u00c1 (2020) Analysis of platelets from a diet-induced obesity rat model: elucidating platelet dysfunction in obesity. Sci Rep 10:13104. https:\/\/doi.org\/10.1038\/s41598-020-70162-3","journal-title":"Sci Rep"},{"key":"3401_CR54","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12035-021-02587-4","volume":"59","author":"SK Beura","year":"2022","unstructured":"Beura SK, Panigrahi AR, Yadav P, Agrawal S, Singh SK (2022) Role of Neurons and Glia Cells in Wound Healing as a Novel Perspective Considering Platelet as a Conventional Player. Mol Neurobiol 59:137\u2013160. https:\/\/doi.org\/10.1007\/s12035-021-02587-4","journal-title":"Mol Neurobiol"},{"key":"3401_CR55","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.3390\/ijms26072944","volume":"26","author":"B Winskel-Wood","year":"2025","unstructured":"Winskel-Wood B, Marks DC, Johnson L (2025) Storage Temperature Affects Platelet Activation and Degranulation in Response to Stimuli. IJMS 26:2944. https:\/\/doi.org\/10.3390\/ijms26072944","journal-title":"IJMS"},{"key":"3401_CR56","doi-asserted-by":"publisher","first-page":"101681","DOI":"10.1016\/j.arr.2022.101681","volume":"80","author":"SK Beura","year":"2022","unstructured":"Beura SK, Panigrahi AR, Yadav P, Singh SK (2022) Role of platelet in Parkinson\u2019s disease: Insights into pathophysiology & theranostic solutions. Ageing Res Rev 80:101681. https:\/\/doi.org\/10.1016\/j.arr.2022.101681","journal-title":"Ageing Res Rev"},{"key":"3401_CR57","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.jtha.2023.01.006","volume":"21","author":"I De Simone","year":"2023","unstructured":"De Simone I, Baaten CCFMJ, Gibbins JM, Ten Cate H, Heemskerk JWM, Jones CI et al (2023) Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. J Thromb Haemost 21:1289\u20131306. https:\/\/doi.org\/10.1016\/j.jtha.2023.01.006","journal-title":"J Thromb Haemost"},{"key":"3401_CR58","doi-asserted-by":"publisher","first-page":"102701","DOI":"10.1016\/j.bcmd.2022.102701","volume":"98","author":"P Yadav","year":"2023","unstructured":"Yadav P, Beura SK, Panigrahi AR, Bhardwaj T, Giri R, Singh SK (2023) Platelet-derived microvesicles activate human platelets via intracellular calcium mediated reactive oxygen species release. Blood Cells Molecules Dis 98:102701. https:\/\/doi.org\/10.1016\/j.bcmd.2022.102701","journal-title":"Blood Cells Molecules Dis"},{"key":"3401_CR59","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1111\/j.1538-7836.2006.01932.x","volume":"4","author":"M Fouassier","year":"2006","unstructured":"Fouassier M, Bourgerette E, Libert F, Pouplard C, Marques-Verdier A (2006) Determination of serotonin release from platelets by HPLC and ELISA in the diagnosis of heparin\u2010induced thrombocytopenia: comparison with reference method by [14\u00a0C]\u2010serotonin release assay. J Thromb Haemost 4:1136\u20131139. https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01932.x","journal-title":"J Thromb Haemost"},{"key":"3401_CR60","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1159\/000350294","volume":"40","author":"M Von Papen","year":"2013","unstructured":"Von Papen M, Gambaryan S, Sch\u00fctz C, Geiger J (2013) Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay. Transfus Med Hemother 40:109\u2013116. https:\/\/doi.org\/10.1159\/000350294","journal-title":"Transfus Med Hemother"},{"key":"3401_CR61","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1055\/s-0029-1220325","volume":"35","author":"D McGlasson","year":"2009","unstructured":"McGlasson D, Fritsma G (2009) Whole Blood Platelet Aggregometry and Platelet Function Testing. Semin Thromb Hemost 35:168\u2013180. https:\/\/doi.org\/10.1055\/s-0029-1220325","journal-title":"Semin Thromb Hemost"},{"key":"3401_CR62","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.peptides.2015.04.012","volume":"72","author":"S Aydin","year":"2015","unstructured":"Aydin S (2015) A short history, principles, and types of ELISA, and our laboratory experience with peptide\/protein analyses using ELISA. Peptides 72:4\u201315. https:\/\/doi.org\/10.1016\/j.peptides.2015.04.012","journal-title":"Peptides"},{"key":"3401_CR63","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1160\/TH09-07-0505","volume":"104","author":"I Salles","year":"2010","unstructured":"Salles I, Broos K, Fontayne A, Sz\u00e1nt\u00f3 T, Ruan C, Nurden A et al (2010) Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood. Thromb Haemost 104:392\u2013401. https:\/\/doi.org\/10.1160\/TH09-07-0505","journal-title":"Thromb Haemost"},{"key":"3401_CR64","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1164\/rccm.201109-1712OC","volume":"185","author":"MW Johansson","year":"2012","unstructured":"Johansson MW, Han S-T, Gunderson KA, Busse WW, Jarjour NN, Mosher DF (2012) Platelet Activation, P-Selectin, and Eosinophil \u03b21 -Integrin Activation in Asthma. Am J Respir Crit Care Med 185:498\u2013507. https:\/\/doi.org\/10.1164\/rccm.201109-1712OC","journal-title":"Am J Respir Crit Care Med"},{"key":"3401_CR65","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0304-3940(03)00573-1","volume":"346","author":"G D\u2019Andrea","year":"2003","unstructured":"D\u2019Andrea G, Terrazzino S, Fortin D, Farruggio A, Rinaldi L, Leon A (2003) HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leukocytes. Neurosci Lett 346:89\u201392. https:\/\/doi.org\/10.1016\/S0304-3940(03)00573-1","journal-title":"Neurosci Lett"},{"key":"3401_CR66","doi-asserted-by":"publisher","first-page":"102156","DOI":"10.1016\/j.rpth.2023.102156","volume":"7","author":"E Aranda","year":"2023","unstructured":"Aranda E, Iha S, Solari S, Rodr\u00edguez D, Romero V, Villarroel L et al (2023) Serotonin secretion by blood platelets: accuracy of high-performance liquid chromatography-electrochemical technique compared with the isotopic test and use in a clinical laboratory. Res Pract Thromb Haemostasis 7:102156. https:\/\/doi.org\/10.1016\/j.rpth.2023.102156","journal-title":"Res Pract Thromb Haemostasis"},{"key":"3401_CR67","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.3390\/ijms18081803","volume":"18","author":"K Koltai","year":"2017","unstructured":"Koltai K, Kesmarky G, Feher G, Tibold A, Toth K (2017) Platelet Aggregometry Testing: Molecular Mechanisms, Techniques and Clinical Implications. IJMS 18:1803. https:\/\/doi.org\/10.3390\/ijms18081803","journal-title":"IJMS"},{"key":"3401_CR68","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mex.2018.12.012","volume":"6","author":"A Tsoupras","year":"2019","unstructured":"Tsoupras A, Zabetakis I, Lordan R (2019) Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro. MethodsX 6:63\u201370. https:\/\/doi.org\/10.1016\/j.mex.2018.12.012","journal-title":"MethodsX"},{"key":"3401_CR69","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1111\/jth.13784","volume":"15","author":"R Al Ghaithi","year":"2017","unstructured":"Al Ghaithi R, Drake S, Watson SP, Morgan NV, Harrison P (2017) Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders. J Thromb Haemost 15:2045\u20132052. https:\/\/doi.org\/10.1111\/jth.13784","journal-title":"J Thromb Haemost"},{"key":"3401_CR70","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/MBC.0000000000000941","volume":"31","author":"H Mansouritorghabeh","year":"2020","unstructured":"Mansouritorghabeh H, De Laat B, Roest M (2020) Current methods of measuring platelet activity: pros and cons. Blood Coagul Fibrinolysis 31:426\u2013433. https:\/\/doi.org\/10.1097\/MBC.0000000000000941","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3401_CR71","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s11239-005-0341-x","volume":"18","author":"MM White","year":"2004","unstructured":"White MM, Krishnan R, Kueter TJ, Jacoski MV, Jennings LK (2004) The Use of the Point of Care Helena ICHOR\/Plateletworks\u00ae and the Accumetrics Ultegra\u00ae RPFA for Assessment of Platelet Function with GPIIb-IIIa Antagonists. J Thromb Thrombolysis 18:163\u2013169. https:\/\/doi.org\/10.1007\/s11239-005-0341-x","journal-title":"J Thromb Thrombolysis"},{"key":"3401_CR72","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1751-553X.2011.01356.x","volume":"34","author":"JA Milburn","year":"2012","unstructured":"Milburn JA, Ford I, Cassar K, Fluck N, Brittenden J (2012) Platelet activation, coagulation activation and C-reactive protein in simultaneous samples from the vascular access and peripheral veins of haemodialysis patients. Int J Lab Hematol 34:52\u201358. https:\/\/doi.org\/10.1111\/j.1751-553X.2011.01356.x","journal-title":"Int J Lab Hematol"},{"key":"3401_CR73","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/ijlh.13710","volume":"44","author":"P Yadav","year":"2022","unstructured":"Yadav P, Beura SK, Panigrahi AR, Singh SK (2022) Quantification and optimization of clot retraction in washed human platelets by Sonoclot coagulation analysis. Int J Lab Hematol 44:177\u2013185. https:\/\/doi.org\/10.1111\/ijlh.13710","journal-title":"Int J Lab Hematol"},{"key":"3401_CR74","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/biomedicines9081064","volume":"9","author":"EE Jansen","year":"2021","unstructured":"Jansen EE, Hartmann M (2021) Clot Retraction: Cellular Mechanisms and Inhibitors, Measuring Methods, and Clinical Implications. Biomedicines 9:1064. https:\/\/doi.org\/10.3390\/biomedicines9081064","journal-title":"Biomedicines"},{"key":"3401_CR75","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/MBC.0b013e3283456c68","volume":"22","author":"NJ White","year":"2011","unstructured":"White NJ, Martin EJ, Brophy DF, Ward KR (2011) Examining platelet\u2013fibrin interactions during traumatic shock in a swine model using platelet contractile force and clot elastic modulus. Blood Coagul Fibrinolysis 22:379\u2013387. https:\/\/doi.org\/10.1097\/MBC.0b013e3283456c68","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3401_CR76","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1365-2516.2007.01524.x","volume":"13","author":"DF Brophy","year":"2007","unstructured":"Brophy DF, Martin EJ, Nolte ME, Kuhn JG, Carr ME Jr (2007) Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients. Haemophilia 13:533\u2013541. https:\/\/doi.org\/10.1111\/j.1365-2516.2007.01524.x","journal-title":"Haemophilia"},{"key":"3401_CR77","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.resuscitation.2011.02.034","volume":"82","author":"NJ White","year":"2011","unstructured":"White NJ, Leong BS-H, Brueckner J, Martin EJ, Brophy DF, Peberdy MA et al (2011) Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation. Resuscitation 82:925\u2013931. https:\/\/doi.org\/10.1016\/j.resuscitation.2011.02.034","journal-title":"Resuscitation"},{"key":"3401_CR78","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/SHK.0b013e3182787122","volume":"39","author":"JN Harr","year":"2013","unstructured":"Harr JN, Moore EE, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, FUNCTIONAL FIBRINOGEN ASSAY INDICATES THAT FIBRINOGEN IS CRITICAL IN CORRECTING ABNORMAL CLOT STRENGTH FOLLOWING TRAUMA et al (2013) Shock 39:45\u201349. https:\/\/doi.org\/10.1097\/SHK.0b013e3182787122","journal-title":"Shock"},{"key":"3401_CR79","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ajh.23599","volume":"89","author":"D Whiting","year":"2014","unstructured":"Whiting D, DiNardo JA (2014) TEG and ROTEM: Technology and clinical applications. Am J Hematol 89:228\u2013232. https:\/\/doi.org\/10.1002\/ajh.23599","journal-title":"Am J Hematol"},{"key":"3401_CR80","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/01.mbc.0000169225.31173.19","volume":"16","author":"T Lang","year":"2005","unstructured":"Lang T, Bauters A, Braun SL, P\u00f6tzsch B, Von Pape K-W, Kolde H-J et al (2005) Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 16:301\u2013310. https:\/\/doi.org\/10.1097\/01.mbc.0000169225.31173.19","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3401_CR81","doi-asserted-by":"publisher","unstructured":"Mihalko E, Abdullah A, Hoteit L, Akinbode D, Shea S, Neal MD Microfluidics in Assessing Platelet Function. JoVE 2024:67214. https:\/\/doi.org\/10.3791\/67214","DOI":"10.3791\/67214"},{"key":"3401_CR82","doi-asserted-by":"publisher","first-page":"766513","DOI":"10.3389\/fcvm.2021.766513","volume":"8","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Ramasundara SDZ, Preketes-tardiani RE, Cheng V, Lu H, Ju LA (2021) Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems. Front Cardiovasc Med 8:766513. https:\/\/doi.org\/10.3389\/fcvm.2021.766513","journal-title":"Front Cardiovasc Med"},{"key":"3401_CR83","doi-asserted-by":"publisher","first-page":"8605","DOI":"10.3390\/ijms22168605","volume":"22","author":"J Sikora","year":"2021","unstructured":"Sikora J, Karczmarska-W\u00f3dzka A, Bugieda J, Sobczak P (2021) The Use of Total Thrombus Formation Analysis System as a Tool to Assess Platelet Function in Bleeding and Thrombosis Risk\u2014A. Syst Rev IJMS 22:8605. https:\/\/doi.org\/10.3390\/ijms22168605","journal-title":"Syst Rev IJMS"},{"key":"3401_CR84","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/ijlh.14403","volume":"47","author":"H Mansouritorghabeh","year":"2025","unstructured":"Mansouritorghabeh H, Monard A, Heubel-Moenen F, Leentjens J, Stroobants A, Henskens Y (2025) The Utility of Total Thrombus\u2010Formation Analysis System (T\u2010 TAS) in the Thrombosis and Hemostasis Field: A Scoping Review. Int J Lab Hematol 47:201\u2013211. https:\/\/doi.org\/10.1111\/ijlh.14403","journal-title":"Int J Lab Hematol"},{"key":"3401_CR85","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/17474086.2017.1315302","volume":"10","author":"AE Knight","year":"2017","unstructured":"Knight AE, Gomez K, Cutler DF (2017) Super-resolution microscopy in the diagnosis of platelet granule disorders. Expert Rev Hematol 10:375\u2013381. https:\/\/doi.org\/10.1080\/17474086.2017.1315302","journal-title":"Expert Rev Hematol"},{"key":"3401_CR86","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.bios.2017.11.058","volume":"102","author":"D Long","year":"2018","unstructured":"Long D, Shang Y, Qiu Y, Zhou B, Yang P (2018) A single-cell analysis platform for electrochemiluminescent detection of platelets adhesion to endothelial cells based on Au@DL-ZnCQDs nanoprobes. Biosens Bioelectron 102:553\u2013559. https:\/\/doi.org\/10.1016\/j.bios.2017.11.058","journal-title":"Biosens Bioelectron"},{"key":"3401_CR87","doi-asserted-by":"publisher","first-page":"114273","DOI":"10.1016\/j.bios.2022.114273","volume":"209","author":"K Wu","year":"2022","unstructured":"Wu K, Yao C, Yang D, Liu D (2022) A functional DNA nanosensor for highly sensitive and selective imaging of ClO\u2009\u2013\u2009in atherosclerotic plaques. Biosens Bioelectron 209:114273. https:\/\/doi.org\/10.1016\/j.bios.2022.114273","journal-title":"Biosens Bioelectron"},{"key":"3401_CR88","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1055\/s-0039-1697949","volume":"46","author":"A Mishra","year":"2020","unstructured":"Mishra A, Ashraf MZ (2020) Using Artificial Intelligence to Manage Thrombosis Research, Diagnosis, and Clinical Management. Semin Thromb Hemost 46:410\u2013418. https:\/\/doi.org\/10.1055\/s-0039-1697949","journal-title":"Semin Thromb Hemost"},{"key":"3401_CR89","doi-asserted-by":"publisher","first-page":"4018","DOI":"10.1182\/blood.V106.11.4018.4018","volume":"106","author":"AM Dyszkiewicz-Korpanty","year":"2005","unstructured":"Dyszkiewicz-Korpanty AM, Kim A, Burner JD, Frenkel EP, Sarode R (2005) Comparison of Rapid Platelet Function Assay with Whole Blood Platelet Impedance Aggregometry for the Definition of Aspirin Resistance. Blood 106:4018\u20134018. https:\/\/doi.org\/10.1182\/blood.V106.11.4018.4018","journal-title":"Blood"}],"container-title":["Journal of Thrombosis and Thrombolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11239-026-03401-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11239-026-03401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:01:58Z","timestamp":1790557318000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11239-026-03401-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":89,"alternative-id":["3401"],"URL":"https:\/\/doi.org\/10.1007\/s11239-026-03401-5","relation":{},"ISSN":["1573-742X"],"issn-type":[{"value":"1573-742X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"13 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical Consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}