{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:55:34Z","timestamp":1770962134677,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s11248-005-1772-z","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T15:42:34Z","timestamp":1133192554000},"page":"845-857","source":"Crossref","is-referenced-by-count":8,"title":["The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach"],"prefix":"10.1007","volume":"14","author":[{"given":"P.S.","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nielen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.T.J.","family":"van der Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Colenbrander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.P.","family":"Heesterbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M. Fentener","family":"van Vlissingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1772_CR1","first-page":"179","volume-title":"Practical Statistics for Medical Research. Chapter 9","author":"DG Altman","year":"1991"},{"key":"1772_CR2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/em.1033","volume":"37","author":"R Amiram","year":"2001","journal-title":"Environ Mol Mutagen"},{"key":"1772_CR3","unstructured":"Baal JBJM van and Verkerk A, The Animal Management System (AMS). Web site http:\/\/www.eur.nl\/fgg\/ch1\/ams (lower case) Rotterdam, The Netherlands"},{"key":"1772_CR4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0303-7207(99)00060-X","volume":"151","author":"WM Baarends","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"1772_CR5","first-page":"33","volume":"54","author":"M Berneburg","year":"2003","journal-title":"Hautarzt"},{"key":"1772_CR6","first-page":"197","volume-title":"Principles of Laboratory Animal Science","author":"AC Beynen","year":"2001"},{"key":"1772_CR7","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.1070174","volume":"296","author":"J Boer de","year":"2002","journal-title":"Science"},{"key":"1772_CR8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0300-9084(99)80045-5","volume":"81","author":"J Boer de","year":"1999","journal-title":"Biochimie"},{"key":"1772_CR9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/carcin\/21.3.453","volume":"21","author":"J Boer de","year":"2000","journal-title":"Carcinogenesis"},{"key":"1772_CR10","first-page":"677","volume-title":"The Metabolic and Molecular Bases of Inherited Disease. vol. 1","author":"D Bootsma","year":"2001"},{"key":"1772_CR11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1530\/jrf.0.0150427","volume":"15","author":"DP Boshier","year":"1968","journal-title":"J Reprod Fertil"},{"key":"1772_CR12","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0960-9822(02)70794-X","volume":"6","author":"DL Cheo","year":"1996","journal-title":"Curr Biol"},{"key":"1772_CR13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mce.2003.10.076","volume":"216","author":"TG. Cooper","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"1772_CR14","unstructured":"European Union (1986) Directive 86\/ 609\/ EEC on the protection of animals used for experimental and other scientific purposes. Web site http:\/\/europa.eu.int"},{"key":"1772_CR15","first-page":"89","volume-title":"Humane Endpoints in Animal Experiments for Biomedical Research","author":"JM Fentener Vlissingen van","year":"1999"},{"key":"1772_CR16","first-page":"393","volume":"91","author":"MFW Festing","year":"1993","journal-title":"Mouse Genome"},{"key":"1772_CR17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0303-7207(98)00183-X","volume":"145","author":"JA Grootegoed","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"1772_CR18","first-page":"1","volume-title":"Manipulating the Mouse Embryo \u2013 A Laboratory Manual","author":"B Hogan","year":"1994"},{"key":"1772_CR19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80223-8","volume":"89","author":"GTJ Horst van der","year":"1997","journal-title":"Cell"},{"key":"1772_CR20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1568-7864(01)00010-6","volume":"1","author":"GTJ Horst van der","year":"2002","journal-title":"DNA Repair"},{"key":"1772_CR21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0960-9822(02)01050-3","volume":"12","author":"A Lehmann","year":"2002","journal-title":"Curr Biol"},{"key":"1772_CR22","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"MF Lyon","year":"1989","edition":"2"},{"key":"1772_CR23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1012244404020","volume":"10","author":"M Meer van der","year":"2001","journal-title":"Trans Res"},{"key":"1772_CR24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ajmg.1320420115","volume":"42","author":"MA Nance","year":"1992","journal-title":"Am J Med Genet"},{"key":"1772_CR25","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1128\/MCB.22.4.1233-1245.2002","volume":"22","author":"JM Ng","year":"2002","journal-title":"Mol Cell Biol"},{"key":"1772_CR26","doi-asserted-by":"crossref","DOI":"10.1787\/9789264162389-en","volume-title":"Why Mice Matter: Novel Systems for the Study of Human Disease: From Basic Research to Applications","author":"OECD","year":"1998"},{"key":"1772_CR27","first-page":"39","volume-title":"Guidance Document on the Recognition, Assessment, and use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation. OECD Environmental Health and Safety Publications, Series on Testing and assessment, 19","author":"OECD","year":"2000"},{"key":"1772_CR28","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.2527\/1992.7061661x","volume":"70","author":"K Osoro","year":"1992","journal-title":"J Anim Sci"},{"key":"1772_CR29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/300611a0","volume":"300","author":"RD Palmiter","year":"1982","journal-title":"Nature"},{"key":"1772_CR30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1258\/0023677021912334","volume":"36","author":"AG Peters","year":"2002","journal-title":"Lab Anim"},{"key":"1772_CR31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1469-7580.2000.19610111.x","volume":"196","author":"K Shimizu","year":"2000","journal-title":"J Anat"},{"key":"1772_CR32","first-page":"190","volume-title":"Non-parametric Statistics for the Behavioral Sciences. vol. 1","author":"S Siegel","year":"1988","edition":"2"},{"key":"1772_CR33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0303-7207(98)00169-5","volume":"145","author":"ER Simpson","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"1772_CR34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/377169a0","volume":"377","author":"A Vries de","year":"1995","journal-title":"Nature"},{"key":"1772_CR35","first-page":"129","volume-title":"Principles of Laboratory Animal Science","author":"LFM Zutphen van","year":"2001"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-005-1772-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-005-1772-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-005-1772-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T07:29:09Z","timestamp":1559374149000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-005-1772-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["1772"],"URL":"https:\/\/doi.org\/10.1007\/s11248-005-1772-z","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}