{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T16:39:11Z","timestamp":1751906351852,"version":"3.37.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T00:00:00Z","timestamp":1264550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s11248-010-9361-1","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T06:22:05Z","timestamp":1264486925000},"page":"829-840","source":"Crossref","is-referenced-by-count":11,"title":["Functional evaluation of therapeutic response for a mouse model of medulloblastoma"],"prefix":"10.1007","volume":"19","author":[{"given":"Aislynn K.","family":"Samano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ohshima-Hosoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Whitney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh I.","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoife","family":"Kilcoyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Nelon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inkyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent M.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy Q.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,1,27]]},"reference":[{"key":"9361_CR15","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1101\/gad.1207204","volume":"18","author":"BR Arenkiel","year":"2004","unstructured":"Arenkiel BR, Tvrdik P, Gaufo GO, Capecchi MR (2004) Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev 18:1539\u20131552","journal-title":"Genes Dev"},{"key":"9361_CR1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0091-3057(77)90036-3","volume":"6","author":"LL Coughenour","year":"1977","unstructured":"Coughenour LL, McLean JR, Parker RB (1977) A new device for the rapid measurement of impaired motor function in mice. Pharmacol Biochem Behav 6:351\u2013353","journal-title":"Pharmacol Biochem Behav"},{"key":"9361_CR2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S1474-4422(07)70289-2","volume":"6","author":"JR Crawford","year":"2007","unstructured":"Crawford JR, MacDonald TJ, Packer RJ (2007) Medulloblastoma in childhood: new biological advances. Lancet Neurol 6:1073\u20131085","journal-title":"Lancet Neurol"},{"key":"9361_CR3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0022-3565(25)11126-9","volume":"261","author":"M Facklam","year":"1992","unstructured":"Facklam M, Schoch P, Bonetti EP, Jenck F, Martin JR, Moreau JL et al (1992) Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies. J Pharmacol Exp Ther 261:1113\u20131121","journal-title":"J Pharmacol Exp Ther"},{"key":"9361_CR16","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1158\/1078-0432.CCR-06-0438","volume":"12","author":"EI Fomchenko","year":"2006","unstructured":"Fomchenko EI, Holland EC (2006) Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res 12:5288\u20135297","journal-title":"Clin Cancer Res"},{"key":"9361_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1470-2045(04)01424-X","volume":"5","author":"RJ Gilbertson","year":"2004","unstructured":"Gilbertson RJ (2004) Medulloblastoma: signaling a change in treatment. Lancet Oncol 5:209\u2013218","journal-title":"Lancet Oncol"},{"key":"9361_CR5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199503303321302","volume":"332","author":"SR Hamilton","year":"1995","unstructured":"Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM et al (1995) The molecular basis of Turcot\u2019s syndrome. N Engl J Med 332:839\u2013847","journal-title":"N Engl J Med"},{"key":"9361_CR6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.1994.11.187","volume":"11","author":"RJ Hamm","year":"1994","unstructured":"Hamm RJ, Pike BR, O\u2019Dell DM, Lyeth BG, Jenkins LW (1994) The Rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma 11:187\u2013196","journal-title":"J Neurotrauma"},{"key":"9361_CR7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0955-0674(00)00283-0","volume":"13","author":"B Hann","year":"2001","unstructured":"Hann B, Balmain A (2001) Building \u2018validated\u2019 mouse models of human cancer. Curr Opin Cell Biol 13:778\u2013784","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"9361_CR8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1634\/theoncologist.2008-0193","volume":"14","author":"L Lafay-Cousin","year":"2009","unstructured":"Lafay-Cousin L, Strother D (2009) Current treatment approaches for infants with malignant central nervous system tumors. Oncologist 14(4):433\u2013444","journal-title":"Oncologist"},{"key":"9361_CR17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncponc0794","volume":"4","author":"WR Polkinghorn","year":"2007","unstructured":"Polkinghorn WR, Tarbell NJ (2007) Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification. Nat Clin Pract Oncol 4:295\u2013304","journal-title":"Nat Clin Pract Oncol"},{"key":"9361_CR9","first-page":"291","volume":"2","author":"T Sakakibara","year":"1996","unstructured":"Sakakibara T, Xu Y, Bumpers HL, Chen FA, Bankert RB, Arredondo MA et al (1996) Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice. Cancer J Sci Am 2:291\u2013300","journal-title":"Cancer J Sci Am"},{"key":"9361_CR10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0360-3016(03)01574-8","volume":"58","author":"WH St Clair","year":"2004","unstructured":"St Clair WH, Adams JA, Bues M, Fullerton BC, La Shell S, Kooy HM et al (2004) Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma. Int J Radiat Oncol Biol Phys 58:727\u2013734","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"9361_CR11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/pbc.21968","volume":"52","author":"E Taniguchi","year":"2009","unstructured":"Taniguchi E, Cho MJ, Arenkiel BR, Hansen MS, Rivera OJ, McCleish AT et al (2009) Bortezomib reverses a post-translational mechanism of tumor genesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer 52(2):136\u2013144","journal-title":"Pediatr Blood Cancer"},{"key":"9361_CR12","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nm1298","volume":"11","author":"M Waza","year":"2005","unstructured":"Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F et al (2005) 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med 11:1088\u20131095","journal-title":"Nat Med"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-010-9361-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-010-9361-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-010-9361-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T23:38:28Z","timestamp":1739749108000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-010-9361-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,27]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["9361"],"URL":"https:\/\/doi.org\/10.1007\/s11248-010-9361-1","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"type":"print","value":"0962-8819"},{"type":"electronic","value":"1573-9368"}],"subject":[],"published":{"date-parts":[[2010,1,27]]}}}