{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:40:10Z","timestamp":1790779210193,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s11248-010-9384-7","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T08:49:42Z","timestamp":1269334182000},"page":"1109-1117","source":"Crossref","is-referenced-by-count":27,"title":["Chemokine CXCL14\/BRAK transgenic mice suppress growth of carcinoma cell xenografts"],"prefix":"10.1007","volume":"19","author":[{"given":"Kazuhito","family":"Izukuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiro","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu-Ichiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"9384_CR1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI0215970","volume":"109","author":"RJ Akhurst","year":"2002","unstructured":"Akhurst RJ (2002) TGF-\u03b2 antagonists: why suppress a tumor suppressor? J Clin Invest 109:1533\u20131536","journal-title":"J Clin Invest"},{"key":"9384_CR2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2004.06.010","volume":"6","author":"M Allinen","year":"2004","unstructured":"Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K (2004) Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6:17\u201332","journal-title":"Cancer Cell"},{"key":"9384_CR3","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1073\/pnas.0813144106","volume":"106","author":"M Augsten","year":"2009","unstructured":"Augsten M, Hagglof C, Olsson E, Stolz C, Tsagozis P, Levchenko T, Frederick MJ, Borg A, Micke P, Egevad L, Ostman A (2009) CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth. Proc Natl Acad Sci USA 106:3414\u20133419","journal-title":"Proc Natl Acad Sci USA"},{"key":"9384_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.68.1.1","volume":"68","author":"JA Belperio","year":"2000","unstructured":"Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD, Strieter RM (2000) CXC chemokines in angiogenesis. J Leukoc Biol 68:1\u20138","journal-title":"J Leukoc Biol"},{"key":"9384_CR5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/nar\/gkm1046","volume":"36","author":"P Benatti","year":"2008","unstructured":"Benatti P, Basile V, Merico D, Fantoni LI, Tagliafico E, Imbriano C (2008) A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response. Nucleic Acids Res 36:1415\u20131428","journal-title":"Nucleic Acids Res"},{"key":"9384_CR6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/35094059","volume":"1","author":"MJ Bissell","year":"2001","unstructured":"Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev Cancer 1:46\u201354","journal-title":"Nat Rev Cancer"},{"key":"9384_CR7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccr.2009.01.021","volume":"15","author":"JM Ebos","year":"2009","unstructured":"Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15:232\u2013239","journal-title":"Cancer Cell"},{"key":"9384_CR8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nm1764","volume":"14","author":"G Finak","year":"2008","unstructured":"Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu G, Meterissian S, Omeroglu A, Hallett M, Park M (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nature Med 14:518\u2013527","journal-title":"Nature Med"},{"key":"9384_CR9","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0002-9440(10)65067-5","volume":"156","author":"MJ Frederick","year":"2000","unstructured":"Frederick MJ, Henderson Y, Xu X, Deavers MT, Sahin AA, Wu H, Lewis DE, El-Naggar AK, Clayman GL (2000) In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am J Pathol 156:1937\u20131950","journal-title":"Am J Pathol"},{"key":"9384_CR10","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1073\/pnas.77.12.7380","volume":"77","author":"JW Gordon","year":"1980","unstructured":"Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77:7380\u20137384","journal-title":"Proc Natl Acad Sci USA"},{"key":"9384_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57\u201370","journal-title":"Cell"},{"key":"9384_CR12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1006\/bbrc.1999.0257","volume":"255","author":"R Hromas","year":"1999","unstructured":"Hromas R, Broxmeyer HE, Kim C, Nakshatri H, Christopherson K II, Azam M, Hou YH (1999) Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. Biochem Biophys Res Commun 255:703\u2013706","journal-title":"Biochem Biophys Res Commun"},{"key":"9384_CR50","doi-asserted-by":"crossref","unstructured":"Izukuri K, Ito S, Nozaki N, Yajima N, Iwamiya M, Kawahara S, Suzuki K, Kubota E, Hata R (2010) Determination of serum BRAK\/CXCL14 level in healthy volunteers. LabMedicine (in press)","DOI":"10.1309\/LMQOXCQEF7ZXIIUK"},{"key":"9384_CR13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1189\/jlb.1105633","volume":"79","author":"T Kakinuma","year":"2006","unstructured":"Kakinuma T, Hwang ST (2006) Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79:639\u2013651","journal-title":"J Leukoc Biol"},{"key":"9384_CR14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.semcancer.2008.10.011","volume":"19","author":"C Krieg","year":"2009","unstructured":"Krieg C, Boyman O (2009) The role of chemokines in cancer immune surveillance by the adaptive immune system. Semin Cancer Biol 19:76\u201383","journal-title":"Semin Cancer Biol"},{"key":"9384_CR15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.194.6.855","volume":"194","author":"I Kurth","year":"2001","unstructured":"Kurth I, Willimann K, Schaerli P, Hunziker T, Clark-Lewis I, Moser B (2001) Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development. J Exp Med 194:855\u2013861","journal-title":"J Exp Med"},{"key":"9384_CR16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cyto.2008.08.009","volume":"44","author":"S Meuter","year":"2008","unstructured":"Meuter S, Moser B (2008) Constitutive expression of CXCL14 in healthy human and murine epithelial tissues. Cytokine 44:248\u2013255","journal-title":"Cytokine"},{"key":"9384_CR17","doi-asserted-by":"crossref","first-page":"30794","DOI":"10.1074\/jbc.M700412200","volume":"282","author":"N Nara","year":"2007","unstructured":"Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T (2007) Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem 282:30794\u201330803","journal-title":"J Biol Chem"},{"key":"9384_CR18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1349-7006.2000.tb00905.x","volume":"91","author":"G Nishimura","year":"2000","unstructured":"Nishimura G, Yanoma S, Satake K, Ikeda Y, Taguchi T, Nakamura Y, Hirose F, Tsukuda M (2000) An experimental model of tumor dormancy therapy for advanced head and neck carcinoma. Jpn J Cancer Res 91:1199\u20131203","journal-title":"Jpn J Cancer Res"},{"key":"9384_CR19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","volume":"108","author":"H Niwa","year":"1991","unstructured":"Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193\u2013199","journal-title":"Gene"},{"key":"9384_CR20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2006.07.070","volume":"348","author":"S Ozawa","year":"2006","unstructured":"Ozawa S, Kato Y, Komori R, Maehata Y, Kubota E, Hata R (2006) BRAK\/CXCL14 expression suppresses tumor growth in vivo in human oral carcinoma cells. Biochem Biophys Res Commun 348:406\u2013412","journal-title":"Biochem Biophys Res Commun"},{"key":"9384_CR21","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1111\/j.1349-7006.2009.01281.x","volume":"100","author":"S Ozawa","year":"2009","unstructured":"Ozawa S, Kato Y, Ito S, Komori R, Shiiki N, Tsukinoki K, Ozono S, Maehata Y, Taguchi T, Imagawa-Ishiguro Y, Tsukuda M, Kubota E, Hata RI (2009a) Restoration of BRAK\/CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma. Cancer Sci 100:2202\u20132209","journal-title":"Cancer Sci"},{"key":"9384_CR22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2220\/biomedres.30.315","volume":"30","author":"S Ozawa","year":"2009","unstructured":"Ozawa S, Kato Y, Kubota E, Hata R (2009b) BRAK\/CXCL14 expression in oral carcinoma cells completely suppresses tumor cell xenografts in SCID mouse. Biomed Res 30:315\u2013318","journal-title":"Biomed Res"},{"key":"9384_CR23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ccr.2009.01.027","volume":"15","author":"M Paez-Ribes","year":"2009","unstructured":"Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, Inoue M, Bergers G, Hanahan D, Casanovas O (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15:220\u2013231","journal-title":"Cancer Cell"},{"key":"9384_CR24","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1158\/0008-5472.CAN-08-3359","volume":"69","author":"H Pelicano","year":"2009","unstructured":"Pelicano H, Lu W, Zhou Y, Zhang W, Chen Z, Hu Y, Huang P (2009) Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res 69:2375\u20132383","journal-title":"Cancer Res"},{"key":"9384_CR25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.canlet.2007.05.013","volume":"256","author":"D Raman","year":"2007","unstructured":"Raman D, Baugher PJ, Thu YM, Richmond A (2007) Role of chemokines in tumor growth. Cancer Lett 256:137\u2013165","journal-title":"Cancer Lett"},{"key":"9384_CR26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/157488408784293705","volume":"3","author":"JM Roodhart","year":"2008","unstructured":"Roodhart JM, Langenberg MH, Witteveen E, Voest EE (2008) The molecular basis of class side effects due to treatment with inhibitors of the VEGF\/VEGFR pathway. Curr Clin Pharmacol 3:132\u2013143","journal-title":"Curr Clin Pharmacol"},{"key":"9384_CR27","doi-asserted-by":"crossref","unstructured":"Sato K, Ozawa S, Izukuri K, Kato Y, Hata R (2010) Expression of tumor-suppressing chemokine BRAK\/CXCL14 reduces cell migration rate of HSC-3 tongue carcinoma cells and stimulates attachment to collagen and formation of elongated focal adhesions in vitro. Cell Biol Int (in press).","DOI":"10.1042\/CBI20090108"},{"key":"9384_CR28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2005.08.012","volume":"23","author":"P Schaerli","year":"2005","unstructured":"Schaerli P, Willimann K, Ebert LM, Walz A, Moser B (2005) Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity 23:331\u2013342","journal-title":"Immunity"},{"key":"9384_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/pros.20215","volume":"64","author":"SR Schwarze","year":"2005","unstructured":"Schwarze SR, Luo J, Isaacs WB, Jarrard DF (2005) Modulation of CXCL14 (BRAK) expression in prostate cancer. Prostate 64:67\u201374","journal-title":"Prostate"},{"key":"9384_CR30","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1158\/0008-5472.CAN-04-2056","volume":"64","author":"TD Shellenberger","year":"2004","unstructured":"Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, Ioannides CG, Efferson CL, El-Naggar AK, Roberts D, Clayman GL, Frederick MJ (2004) CXCL14\/BRAK is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res 64:8262\u20138270","journal-title":"Cancer Res"},{"key":"9384_CR31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrc755","volume":"2","author":"D Sidransky","year":"2002","unstructured":"Sidransky D (2002) Emerging molecular markers of cancer. Nat Rev Cancer 2:210\u2013219","journal-title":"Nat Rev Cancer"},{"key":"9384_CR32","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.exphem.2006.05.015","volume":"34","author":"T Starnes","year":"2006","unstructured":"Starnes T, Rasila KK, Robertson MJ, Brahmi Z, Dahl R, Christopherson K, Hromas R (2006) The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy. Exp Hematol 34:1101\u20131105","journal-title":"Exp Hematol"},{"key":"9384_CR33","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","volume":"270","author":"RM Strieter","year":"1995","unstructured":"Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D, Chan S-Y, Roczniak S, Shanafel AB (1995) The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348\u201327357","journal-title":"J Biol Chem"},{"key":"9384_CR34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S1074-7613(00)00068-6","volume":"13","author":"K Suzuki","year":"2000","unstructured":"Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H (2000) Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis. Immunity 13:691\u2013702","journal-title":"Immunity"},{"key":"9384_CR35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM198809013190901","volume":"319","author":"B Vogelstein","year":"1988","unstructured":"Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525\u2013532","journal-title":"N Engl J Med"},{"key":"9384_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-1759(98)00128-8","volume":"220","author":"JM Wang","year":"1998","unstructured":"Wang JM, Deng X, Gong W, Su S (1998) Chemokines and their role in tumor growth and metastasis. J Immunol Methods 220:1\u201317","journal-title":"J Immunol Methods"},{"key":"9384_CR37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.canlet.2007.10.021","volume":"259","author":"MN Wente","year":"2008","unstructured":"Wente MN, Mayer C, Gaida MM, Michalski CW, Giese T, Bergmann F, Giese NA, Buchler MW, Friess H (2008) CXCL14 expression and potential function in pancreatic cancer. Cancer Lett 259:209\u2013217","journal-title":"Cancer Lett"},{"key":"9384_CR38","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1073\/pnas.84.24.9233","volume":"84","author":"T Yoshimura","year":"1987","unstructured":"Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA 84:9233\u20139237","journal-title":"Proc Natl Acad Sci USA"},{"key":"9384_CR39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/gb-2006-7-12-243","volume":"7","author":"A Zlotnik","year":"2006","unstructured":"Zlotnik A, Yoshie O, Nomiyama H (2006) The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol 7:243","journal-title":"Genome Biol"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-010-9384-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-010-9384-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-010-9384-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:48:25Z","timestamp":1685508505000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-010-9384-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,24]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["9384"],"URL":"https:\/\/doi.org\/10.1007\/s11248-010-9384-7","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,24]]}}}