{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:02:52Z","timestamp":1762542172101},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,3,30]],"date-time":"2013-03-30T00:00:00Z","timestamp":1364601600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s11248-013-9707-6","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T15:33:45Z","timestamp":1364571225000},"page":"1231-1239","source":"Crossref","is-referenced-by-count":9,"title":["Generation of c-Myc transgenic pigs for autosomal dominant polycystic kidney disease"],"prefix":"10.1007","volume":"22","author":[{"given":"Jianhua","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,30]]},"reference":[{"issue":"3","key":"9707_CR1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1128\/MCB.10.3.1192","volume":"10","author":"R Al-Shawi","year":"1990","unstructured":"Al-Shawi R, Kinnaird J, Burke J, Bishop JO (1990) Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. Mol Cell Biol 10(3):1192\u20131198","journal-title":"Mol Cell Biol"},{"issue":"11","key":"9707_CR2","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1681\/ASN.2008040435","volume":"20","author":"AP Bastos","year":"2009","unstructured":"Bastos AP, Piontek K, Silva AM, Martini D, Menezes LF, Fonseca JM, Fonseca II, Germino GG, Onuchic LF (2009) Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia\/reperfusion. J Am Soc Nephrol JASN 20(11):2389\u20132402. doi: 10.1681\/ASN.2008040435","journal-title":"J Am Soc Nephrol JASN"},{"issue":"5","key":"9707_CR3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1681\/ASN.2010050526","volume":"22","author":"PD Bell","year":"2011","unstructured":"Bell PD, Fitzgibbon W, Sas K, Stenbit AE, Amria M, Houston A, Reichert R, Gilley S, Siegal GP, Bissler J, Bilgen M, Chou PC, Guay-Woodford L, Yoder B, Haycraft CJ, Siroky B (2011) Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis. J Am Soc Nephrol JASN 22(5):839\u2013848. doi: 10.1681\/ASN.2010050526","journal-title":"J Am Soc Nephrol JASN"},{"issue":"5","key":"9707_CR4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nbt0510-436","volume":"28","author":"JV Bonventre","year":"2010","unstructured":"Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F (2010) Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 28(5):436\u2013440. doi: 10.1038\/nbt0510-436","journal-title":"Nat Biotechnol"},{"issue":"2","key":"9707_CR5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI119147","volume":"99","author":"JL Brasier","year":"1997","unstructured":"Brasier JL, Henske EP (1997) Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis. J Clin Investig 99(2):194\u2013199. doi: 10.1172\/JCI119147","journal-title":"J Clin Investig"},{"issue":"4","key":"9707_CR6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/ndt\/gfm763","volume":"23","author":"S Burtey","year":"2008","unstructured":"Burtey S, Riera M, Ribe E, Pennekamp P, Passage E, Rance R, Dworniczak B, Fontes M (2008) Overexpression of PKD2 in the mouse is associated with renal tubulopathy. Nephrol Dial Transplant 23(4):1157\u20131165. doi: 10.1093\/ndt\/gfm763","journal-title":"Nephrol Dial Transplant"},{"issue":"23","key":"9707_CR7","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1073\/pnas.84.23.8394","volume":"84","author":"BD Cowley Jr","year":"1987","unstructured":"Cowley BD Jr, Smardo FL Jr, Grantham JJ, Calvet JP (1987) Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc Natl Acad Sci USA 84(23):8394\u20138398","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"9707_CR8","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1681\/ASN.V181048","volume":"1","author":"BD Cowley Jr","year":"1991","unstructured":"Cowley BD Jr, Chadwick LJ, Grantham JJ, Calvet JP (1991) Elevated proto-oncogene expression in polycystic kidneys of the C57BL\/6J (cpk) mouse. J Am Soc Nephrol JASN 1(8):1048\u20131053","journal-title":"J Am Soc Nephrol JASN"},{"key":"9707_CR9","doi-asserted-by":"crossref","unstructured":"Cuppen E (2010) DNA isolation from rat tail or ear. Cold Spring Harb Protoc (5): pdb prot5434. doi: 10.1101\/pdb.prot5434","DOI":"10.1101\/pdb.prot5434"},{"issue":"1","key":"9707_CR10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nm812","volume":"9","author":"B Dekel","year":"2003","unstructured":"Dekel B, Burakova T, Arditti FD, Reich-Zeliger S, Milstein O, Aviel-Ronen S, Rechavi G, Friedman N, Kaminski N, Passwell JH, Reisner Y (2003) Human and porcine early kidney precursors as a new source for transplantation. Nat Med 9(1):53\u201360. doi: 10.1038\/nm812","journal-title":"Nat Med"},{"issue":"3","key":"9707_CR11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.meatsci.2004.04.010","volume":"68","author":"JJ Dooley","year":"2004","unstructured":"Dooley JJ, Paine KE, Garrett SD, Brown HM (2004) Detection of meat species using TaqMan real-time PCR assays. Meat Sci 68(3):431\u2013438. doi: 10.1016\/j.meatsci.2004.04.010","journal-title":"Meat Sci"},{"issue":"3","key":"9707_CR12","first-page":"226","volume":"3","author":"WR Douglas","year":"1972","unstructured":"Douglas WR (1972) Of pigs and men and research: a review of applications and analogies of the pig, Sus scrofa, in human medical research. Space Life Sci 3(3):226\u2013234","journal-title":"Space Life Sci"},{"issue":"5","key":"9707_CR13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1056\/NEJM199307293290508","volume":"329","author":"PA Gabow","year":"1993","unstructured":"Gabow PA (1993) Autosomal dominant polycystic kidney disease. New Engl J Med 329(5):332\u2013342. doi: 10.1056\/NEJM199307293290508","journal-title":"New Engl J Med"},{"issue":"14","key":"9707_CR14","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1056\/NEJMcp0804458","volume":"359","author":"JJ Grantham","year":"2008","unstructured":"Grantham JJ (2008) Clinical practice. Autosomal dominant polycystic kidney disease. New Engl J Med 359(14):1477\u20131485. doi: 10.1056\/NEJMcp0804458","journal-title":"New Engl J Med"},{"issue":"14","key":"9707_CR15","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/hmg\/ddp190","volume":"18","author":"H Happe","year":"2009","unstructured":"Happe H, Leonhard WN, van der Wal A, van de Water B, Lantinga-van Leeuwen IS, Breuning MH, de Heer E, Peters DJ (2009) Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet 18(14):2532\u20132542. doi: 10.1093\/hmg\/ddp190","journal-title":"Hum Mol Genet"},{"key":"9707_CR16","doi-asserted-by":"crossref","unstructured":"Harlow E, Lane D (2006) Immunoblotting: submerged electrophoretic transfer of proteins from gels to membranes. CSH Protoc (1). doi: 10.1101\/pdb.prot4302","DOI":"10.1101\/pdb.prot4302"},{"issue":"7","key":"9707_CR17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1681\/ASN.2010030328","volume":"21","author":"PC Harris","year":"2010","unstructured":"Harris PC (2010) What is the role of somatic mutation in autosomal dominant polycystic kidney disease? J Am Soc Nephrol 21(7):1073\u20131076. doi: 10.1681\/ASN.2010030328","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"9707_CR18","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1161\/ATVBAHA.107.149252","volume":"27","author":"S Hassane","year":"2007","unstructured":"Hassane S, Claij N, Lantinga-van Leeuwen IS, Van Munsteren JC, Van Lent N, Hanemaaijer R, Breuning MH, Peters DJ, DeRuiter MC (2007) Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model. Arterioscler Thromb Vasc Biol 27(10):2177\u20132183. doi: 10.1161\/ATVBAHA.107.149252","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1\u20132","key":"9707_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.gene.2011.08.027","volume":"490","author":"J He","year":"2011","unstructured":"He J, Wang Q, Ye J, Hu X, Li N (2011) Identification of porcine polycystic kidney disease 1 (PKD1) gene: molecular cloning, expression profile, and implication in disease model. Gene 490(1\u20132):37\u201346. doi: 10.1016\/j.gene.2011.08.027","journal-title":"Gene"},{"issue":"11","key":"9707_CR20","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI64313","volume":"122","author":"K Hopp","year":"2012","unstructured":"Hopp K, Ward CJ, Hommerding CJ, Nasr SH, Tuan HF, Gainullin VG, Rossetti S, Torres VE, Harris PC (2012) Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity. J Clin Investig 122(11):4257\u20134273. doi: 10.1172\/JCI64313","journal-title":"J Clin Investig"},{"issue":"4 Pt 2","key":"9707_CR21","first-page":"F599","volume":"277","author":"P Igarashi","year":"1999","unstructured":"Igarashi P, Shashikant CS, Thomson RB, Whyte DA, Liu-Chen S, Ruddle FH, Aronson PS (1999) Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice. Am J Physiol 277(4 Pt 2):F599\u2013F610","journal-title":"Am J Physiol"},{"issue":"1\u20132","key":"9707_CR22","first-page":"15","volume":"104","author":"T Jackson","year":"1991","unstructured":"Jackson T, Allard MF, Sreenan CM, Doss LK, Bishop SP, Swain JL (1991) Transgenic animals as a tool for studying the effect of the c-myc proto-oncogene on cardiac development. Mol Cell Biochem 104(1\u20132):15\u201319","journal-title":"Mol Cell Biochem"},{"issue":"46","key":"9707_CR23","doi-asserted-by":"crossref","first-page":"31559","DOI":"10.1074\/jbc.M805452200","volume":"283","author":"I Kim","year":"2008","unstructured":"Kim I, Li C, Liang D, Chen XZ, Coffy RJ, Ma J, Zhao P, Wu G (2008) Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin. J Biol Chem 283(46):31559\u201331566. doi: 10.1074\/jbc.M805452200","journal-title":"J Biol Chem"},{"issue":"3","key":"9707_CR24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/hmg\/8.3.509","volume":"8","author":"M Koptides","year":"1999","unstructured":"Koptides M, Hadjimichael C, Koupepidou P, Pierides A, Constantinou Deltas C (1999) Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease. Hum Mol Genet 8(3):509\u2013513. doi: 10.1093\/hmg\/8.3.509","journal-title":"Hum Mol Genet"},{"issue":"7","key":"9707_CR25","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/hmg\/ddp588","volume":"19","author":"A Kurbegovic","year":"2010","unstructured":"Kurbegovic A, Cote O, Couillard M, Ward CJ, Harris PC, Trudel M (2010) Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes. Hum Mol Genet 19(7):1174\u20131189. doi: 10.1093\/hmg\/ddp588","journal-title":"Hum Mol Genet"},{"issue":"6","key":"9707_CR26","first-page":"1153","volume":"13","author":"J Lanoix","year":"1996","unstructured":"Lanoix J, D\u2019Agati V, Szabolcs M, Trudel M (1996) Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD). Oncogene 13(6):1153\u20131160","journal-title":"Oncogene"},{"issue":"24","key":"9707_CR27","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/hmg\/ddh336","volume":"13","author":"IS Lantinga-van Leeuwen","year":"2004","unstructured":"Lantinga-van Leeuwen IS, Dauwerse JG, Baelde HJ, Leonhard WN, van de Wal A, Ward CJ, Verbeek S, Deruiter MC, Breuning MH, de Heer E, Peters DJ (2004) Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. Hum Mol Genet 13(24):3069\u20133077. doi: 10.1093\/hmg\/ddh336","journal-title":"Hum Mol Genet"},{"issue":"24","key":"9707_CR28","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/hmg\/ddm299","volume":"16","author":"IS Lantinga-van Leeuwen","year":"2007","unstructured":"Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A, Breuning MH, de Heer E, Peters DJ (2007) Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet 16(24):3188\u20133196. doi: 10.1093\/hmg\/ddm299","journal-title":"Hum Mol Genet"},{"issue":"2","key":"9707_CR29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11248-011-9536-4","volume":"21","author":"S Liu","year":"2012","unstructured":"Liu S, Li X, Lu D, Shang S, Wang M, Zheng M, Zhang R, Tang B, Li Q, Dai Y, Li N (2012) High-level expression of bioactive recombinant human lysozyme in the milk of transgenic mice using a modified human lactoferrin BAC. Transgenic Res 21(2):407\u2013414. doi: 10.1007\/s11248-011-9536-4","journal-title":"Transgenic Res"},{"issue":"7","key":"9707_CR30","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1006\/jmcc.1997.0427","volume":"29","author":"N Machida","year":"1997","unstructured":"Machida N, Brissie N, Sreenan C, Bishop SP (1997) Inhibition of cardiac myocyte division in c-myc transgenic mice. J Mol Cell Cardiol 29(7):1895\u20131902. doi: 10.1006\/jmcc.1997.0427","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"9707_CR31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0011-5029(05)80007-0","volume":"41","author":"JR Martinez","year":"1995","unstructured":"Martinez JR, Grantham JJ (1995) Polycystic kidney disease: etiology, pathogenesis, and treatment. Dis Month DM 41(11):693\u2013765","journal-title":"Dis Month DM"},{"issue":"12","key":"9707_CR32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nrc2231","volume":"8","author":"N Meyer","year":"2008","unstructured":"Meyer N, Penn LZ (2008) Reflecting on 25\u00a0years with MYC. Nat Rev Cancer 8(12):976\u2013990. doi: 10.1038\/nrc2231","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"9707_CR33","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1046\/j.1523-1755.1999.00370.x","volume":"55","author":"NS Murcia","year":"1999","unstructured":"Murcia NS, Sweeney WE Jr, Avner ED (1999) New insights into the molecular pathophysiology of polycystic kidney disease. Kidney Int 55(4):1187\u20131197. doi: 10.1046\/j.1523-1755.1999.00370.x","journal-title":"Kidney Int"},{"issue":"6","key":"9707_CR34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ccr.2008.10.018","volume":"14","author":"DJ Murphy","year":"2008","unstructured":"Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA, Brown-Swigart L, Johnson L, Evan GI (2008) Distinct thresholds govern Myc\u2019s biological output in vivo. Cancer Cell 14(6):447\u2013457. doi: 10.1016\/j.ccr.2008.10.018","journal-title":"Cancer Cell"},{"issue":"7","key":"9707_CR35","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1681\/ASN.V571462","volume":"5","author":"T Nadasdy","year":"1995","unstructured":"Nadasdy T, Laszik Z, Lajoie G, Blick KE, Wheeler DE, Silva FG (1995) Proliferative activity of cyst epithelium in human renal cystic diseases. J Am Soc Nephrol 5(7):1462\u20131468","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"9707_CR36","doi-asserted-by":"crossref","first-page":"e1002573","DOI":"10.1371\/journal.pgen.1002573","volume":"8","author":"LM Nilsson","year":"2012","unstructured":"Nilsson LM, Forshell TZ, Rimpi S, Kreutzer C, Pretsch W, Bornkamm GW, Nilsson JA (2012) Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet 8(3):e1002573. doi: 10.1371\/journal.pgen.1002573","journal-title":"PLoS Genet"},{"issue":"7","key":"9707_CR37","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1681\/ASN.V1071524","volume":"10","author":"Y Pei","year":"1999","unstructured":"Pei Y, Watnick T, He N, Wang K, Liang Y, Parfrey P, Germino G, St George-Hyslop P (1999) Somatic PKD2 mutations in individual kidney and liver cysts support a \u201ctwo-hit\u201d model of cystogenesis in type 2 autosomal dominant polycystic kidney disease. J Am Soc Nephrol 10(7):1524\u20131529","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"9707_CR38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2011.12.021","volume":"21","author":"Y Pei","year":"2012","unstructured":"Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ (2012) An animal model of MYC-driven medulloblastoma. Cancer Cell 21(2):155\u2013167. doi: 10.1016\/j.ccr.2011.12.021","journal-title":"Cancer Cell"},{"issue":"12","key":"9707_CR39","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","volume":"13","author":"K Piontek","year":"2007","unstructured":"Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG (2007) A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13(12):1490\u20131495. doi: 10.1038\/nm1675","journal-title":"Nat Med"},{"issue":"18","key":"9707_CR40","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/hmg\/9.18.2617","volume":"9","author":"L Pritchard","year":"2000","unstructured":"Pritchard L, Sloane-Stanley JA, Sharpe JA, Aspinwall R, Lu W, Buckle V, Strmecki L, Walker D, Ward CJ, Alpers CE, Zhou J, Wood WG, Harris PC (2000) A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Hum Mol Genet 9(18):2617\u20132627","journal-title":"Hum Mol Genet"},{"issue":"6","key":"9707_CR41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","volume":"87","author":"F Qian","year":"1996","unstructured":"Qian F, Watnick TJ, Onuchic LF, Germino GG (1996) The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 87(6):979\u2013987. doi: 10.1016\/S0092-8674(00)81793-6","journal-title":"Cell"},{"issue":"3","key":"9707_CR42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1365-2052.1999.00447.x","volume":"30","author":"G Reiner","year":"1999","unstructured":"Reiner G, Hecht W, Leeb T, Brenig B, Robic A, Dzapo V (1999) Isolation and characterization of the porcine c-myc proto-oncogene and chromosomal assignment to SSC 4p13. Anim Genet 30(3):204\u2013206","journal-title":"Anim Genet"},{"issue":"9","key":"9707_CR43","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMoa0907419","volume":"363","author":"AL Serra","year":"2010","unstructured":"Serra AL, Poster D, Kistler AD, Krauer F, Raina S, Young J, Rentsch KM, Spanaus KS, Senn O, Kristanto P, Scheffel H, Weishaupt D, Wuthrich RP (2010) Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. New Engl J Med 363(9):820\u2013829. doi: 10.1056\/NEJMoa0907419","journal-title":"New Engl J Med"},{"issue":"7","key":"9707_CR44","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1097\/01.ASN.0000016443.50138.CD","volume":"13","author":"X Shao","year":"2002","unstructured":"Shao X, Johnson JE, Richardson JA, Hiesberger T, Igarashi P (2002) A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract. J Am Soc Nephrol 13(7):1824\u20131836","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"9707_CR45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.gde.2009.11.001","volume":"20","author":"L Soucek","year":"2010","unstructured":"Soucek L, Evan GI (2010) The ups and downs of Myc biology. Curr Opin Genet Dev 20(1):91\u201395. doi: 10.1016\/j.gde.2009.11.001","journal-title":"Curr Opin Genet Dev"},{"key":"9707_CR46","volume-title":"Swine as models in biomedical research","author":"MM Swindle","year":"1992","unstructured":"Swindle MM, Moody DC, Phillips LD (1992) Swine as models in biomedical research, 1st edn. Iowa State University Press, Ames","edition":"1"},{"issue":"12","key":"9707_CR47","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1681\/ASN.2007101139","volume":"19","author":"A Takakura","year":"2008","unstructured":"Takakura A, Contrino L, Beck AW, Zhou J (2008) Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol 19(12):2351\u20132363. doi: 10.1681\/ASN.2007101139","journal-title":"J Am Soc Nephrol"},{"issue":"14","key":"9707_CR48","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1093\/hmg\/ddp147","volume":"18","author":"A Takakura","year":"2009","unstructured":"Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD, Zhou J (2009) Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet 18(14):2523\u20132531. doi: 10.1093\/hmg\/ddp147","journal-title":"Hum Mol Genet"},{"issue":"9569","key":"9707_CR49","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","volume":"369","author":"VE Torres","year":"2007","unstructured":"Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369(9569):1287\u20131301. doi: 10.1016\/S0140-6736(07)60601-1","journal-title":"Lancet"},{"issue":"4","key":"9707_CR50","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ki.1991.80","volume":"39","author":"M Trudel","year":"1991","unstructured":"Trudel M, D\u2019Agati V, Costantini F (1991) C-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int 39(4):665\u2013671","journal-title":"Kidney Int"},{"issue":"3","key":"9707_CR51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00352345","volume":"5","author":"M Trudel","year":"1994","unstructured":"Trudel M, Chretien N, D\u2019Agati V (1994) Disappearance of polycystic kidney disease in revertant c-myc transgenic mice. Mamm Genome 5(3):149\u2013152","journal-title":"Mamm Genome"},{"issue":"1","key":"9707_CR52","first-page":"219","volume":"152","author":"M Trudel","year":"1998","unstructured":"Trudel M, Barisoni L, Lanoix J, D\u2019Agati V (1998) Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. Am J Pathol 152(1):219\u2013229","journal-title":"Am J Pathol"},{"issue":"1","key":"9707_CR53","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nm.2068","volume":"16","author":"F Verdeguer","year":"2010","unstructured":"Verdeguer F, Le Corre S, Fischer E, Callens C, Garbay S, Doyen A, Igarashi P, Terzi F, Pontoglio M (2010) A mitotic transcriptional switch in polycystic kidney disease. Nat Med 16(1):106\u2013110. doi: 10.1038\/nm.2068","journal-title":"Nat Med"},{"issue":"9","key":"9707_CR54","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMoa1003491","volume":"363","author":"G Walz","year":"2010","unstructured":"Walz G, Budde K, Mannaa M, Nurnberger J, Wanner C, Sommerer C, Kunzendorf U, Banas B, Horl WH, Obermuller N, Arns W, Pavenstadt H, Gaedeke J, Buchert M, May C, Gschaidmeier H, Kramer S, Eckardt KU (2010) Everolimus in patients with autosomal dominant polycystic kidney disease. New Engl J Med 363(9):830\u2013840. doi: 10.1056\/NEJMoa1003491","journal-title":"New Engl J Med"},{"issue":"2","key":"9707_CR55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1097-2765(00)80135-5","volume":"2","author":"TJ Watnick","year":"1998","unstructured":"Watnick TJ, Torres VE, Gandolph MA, Qian F, Onuchic LF, Klinger KW, Landes G, Germino GG (1998) Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease. Mol Cell 2(2):247\u2013251. doi: 10.1016\/S1097-2765(00)80135-5","journal-title":"Mol Cell"},{"issue":"2","key":"9707_CR56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1262\/jrd.19167","volume":"55","author":"HX Wei","year":"2009","unstructured":"Wei HX, Zhang K, Ma YF, Li Y, Li QY, Dai YP, Li N (2009) Stage-dependent effect of leptin on development of porcine embryos derived from parthenogenetic activation and transgenic somatic cell nuclear transfer. J Reprod Dev 55(2):99\u2013104","journal-title":"J Reprod Dev"},{"issue":"5","key":"9707_CR57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1681\/ASN.2011030284","volume":"22","author":"T Weimbs","year":"2011","unstructured":"Weimbs T (2011) Third-hit signaling in renal cyst formation. J Am Soc Nephrol 22(5):793\u2013795. doi: 10.1681\/ASN.2011030284","journal-title":"J Am Soc Nephrol"},{"issue":"4 Pt 2","key":"9707_CR58","first-page":"F587","volume":"277","author":"DA Whyte","year":"1999","unstructured":"Whyte DA, Li C, Thomson RB, Nix SL, Zanjani R, Karp SL, Aronson PS, Igarashi P (1999) Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity. Am J Physiol 277(4 Pt 2):F587\u2013F598","journal-title":"Am J Physiol"},{"issue":"2","key":"9707_CR59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","volume":"350","author":"PD Wilson","year":"2004","unstructured":"Wilson PD (2004) Polycystic kidney disease. New Engl J Med 350(2):151\u2013164. doi: 10.1056\/NEJMra022161","journal-title":"New Engl J Med"},{"issue":"12","key":"9707_CR60","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/hh2401.100742","volume":"89","author":"G Xiao","year":"2001","unstructured":"Xiao G, Mao S, Baumgarten G, Serrano J, Jordan MC, Roos KP, Fishbein MC, MacLellan WR (2001) Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. Circ Res 89(12):1122\u20131129. doi: 10.1161\/hh2401.100742","journal-title":"Circ Res"},{"issue":"2","key":"9707_CR61","first-page":"44","volume":"20","author":"WC-w Yu Shu-min","year":"2003","unstructured":"Yu Shu-min WC-w, Zhao De-ming, Zhang Qing-cai, Pei De-zhi (2003) Raising and pathogen purification of Chinese experimental mini-pig. Lab Anim Sci Manag 20(2):44\u201346","journal-title":"Lab Anim Sci Manag"},{"issue":"2","key":"9707_CR62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2011.12.015","volume":"15","author":"MO Yuneva","year":"2012","unstructured":"Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Mates JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM (2012) The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 15(2):157\u2013170. doi: 10.1016\/j.cmet.2011.12.015","journal-title":"Cell Metab"},{"issue":"12","key":"9707_CR63","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1097\/00007890-199806270-00008","volume":"65","author":"A Zaidi","year":"1998","unstructured":"Zaidi A, Schmoeckel M, Bhatti F, Waterworth P, Tolan M, Cozzi E, Chavez G, Langford G, Thiru S, Wallwork J, White D, Friend P (1998) Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. Transplantation 65(12):1584\u20131590","journal-title":"Transplantation"},{"issue":"2","key":"9707_CR64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11427-006-0164-9","volume":"49","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Pan D, Sun X, Sun G, Wang X, Liu X, Li Y, Dai Y, Li N (2006) Production of porcine cloned transgenic embryos expressing green fluorescent protein by somatic cell nuclear transfer. Sci China Ser C Life Sci Chin Acad Sci 49(2):164\u2013171","journal-title":"Sci China Ser C Life Sci Chin Acad Sci"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-013-9707-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-013-9707-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-013-9707-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T18:03:50Z","timestamp":1644689030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-013-9707-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,30]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["9707"],"URL":"https:\/\/doi.org\/10.1007\/s11248-013-9707-6","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,30]]}}}