{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:28Z","timestamp":1761513448119},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s11248-014-9799-7","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T09:54:14Z","timestamp":1397555654000},"page":"631-641","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Generation of mice encoding a conditional null allele of Gcm2"],"prefix":"10.1007","volume":"23","author":[{"given":"Ziqiang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan E.","family":"Opas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakravarthy","family":"Vrikshajanani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Libutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,16]]},"reference":[{"issue":"25","key":"9799_CR1","doi-asserted-by":"crossref","first-page":"14912","DOI":"10.1073\/pnas.93.25.14912","volume":"93","author":"Y Akiyama","year":"1996","unstructured":"Akiyama Y, Hosoya T, Poole AM, Hotta Y (1996) The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc Natl Acad Sci USA 93(25):14912\u201314916","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2\u20133","key":"9799_CR2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-5793(96)00890-3","volume":"393","author":"Y Altshuller","year":"1996","unstructured":"Altshuller Y, Copeland NG, Gilbert DJ, Jenkins NA, Frohman MA (1996) Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett 393(2\u20133):201\u2013204","journal-title":"FEBS Lett"},{"issue":"5","key":"9799_CR3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jmg.2004.026898","volume":"42","author":"L Baumber","year":"2005","unstructured":"Baumber L, Tufarelli C, Patel S, King P, Johnson CA, Maher ER, Trembath RC (2005) Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism. J Med Genet 42(5):443\u2013448","journal-title":"J Med Genet"},{"issue":"1","key":"9799_CR4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/humu.20827","volume":"30","author":"L Canaff","year":"2009","unstructured":"Canaff L, Zhou X, Mosesova I, Cole DE, Hendy GN (2009) Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism. Hum Mutat 30(1):85\u201392. doi: 10.1002\/humu.20827","journal-title":"Hum Mutat"},{"issue":"2","key":"9799_CR5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuron.2005.09.019","volume":"48","author":"C Chotard","year":"2005","unstructured":"Chotard C, Leung W, Salecker I (2005) Glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Neuron 48(2):237\u2013251","journal-title":"Neuron"},{"issue":"1\u20133","key":"9799_CR6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0014-5793(02)03257-X","volume":"528","author":"SX Cohen","year":"2002","unstructured":"Cohen SX, Moulin M, Schilling O, Meyer-Klaucke W, Schreiber J, Wegner M, Muller CW (2002) The GCM domain is a Zn-coordinating DNA-binding domain. FEBS Lett 528(1\u20133):95\u2013100","journal-title":"FEBS Lett"},{"issue":"8","key":"9799_CR7","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/emboj\/cdg182","volume":"22","author":"SX Cohen","year":"2003","unstructured":"Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Muller CW (2003) Structure of the GCM domain\u2013DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition. EMBO J 22(8):1835\u20131845","journal-title":"EMBO J"},{"issue":"11","key":"9799_CR8","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1359\/JBMR.050718","volume":"20","author":"MT Collins","year":"2005","unstructured":"Collins MT, Lindsay JR, Jain A, Kelly MH, Cutler CM, Weinstein LS, Liu J, Fedarko NS, Winer KK (2005) Fibroblast growth factor-23 is regulated by 1alpha,25-dihydroxyvitamin D. J Bone Miner Res 20(11):1944\u20131950","journal-title":"J Bone Miner Res"},{"issue":"8","key":"9799_CR9","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI200113180","volume":"108","author":"C Ding","year":"2001","unstructured":"Ding C, Buckingham B, Levine MA (2001) Familial isolated hypoparathyroidism caused by a mutation in the gene for the transcription factor GCMB. J Clin Invest 108(8):1215\u20131220","journal-title":"J Clin Invest"},{"issue":"7\u20138","key":"9799_CR10","first-page":"741","volume":"25","author":"D Doyle","year":"2012","unstructured":"Doyle D, Kirwin SM, Sol-Church K, Levine MA (2012) A novel mutation in the GCM2 gene causing severe congenital isolated hypoparathyroidism. J Pediatr Endocrinol Metab 25(7\u20138):741\u2013746","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"5","key":"9799_CR11","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1210\/endo-127-5-2517","volume":"127","author":"RA Fraser","year":"1990","unstructured":"Fraser RA, Kronenberg HM, Pang PK, Harvey S (1990) Parathyroid hormone messenger ribonucleic acid in the rat hypothalamus. Endocrinology 127(5):2517\u20132522","journal-title":"Endocrinology"},{"issue":"11","key":"9799_CR12","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1210\/en.2005-0681","volume":"146","author":"EL Germain-Lee","year":"2005","unstructured":"Germain-Lee EL, Schwindinger W, Crane JL, Zewdu R, Zweifel LS, Wand G, Huso DL, Saji M, Ringel MD, Levine MA (2005) A mouse model of Albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene. Endocrinology 146(11):4697\u20134709","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"9799_CR13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0925-4773(01)00333-1","volume":"103","author":"J Gordon","year":"2001","unstructured":"Gordon J, Bennett AR, Blackburn CC, Manley NR (2001) Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Mech Dev 103(1\u20132):141\u2013143","journal-title":"Mech Dev"},{"issue":"6","key":"9799_CR14","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1172\/JCI42021","volume":"120","author":"IV Grigorieva","year":"2010","unstructured":"Grigorieva IV, Mirczuk S, Gaynor KU, Nesbit MA, Grigorieva EF, Wei Q, Ali A, Fairclough RJ, Stacey JM, Stechman MJ, Mihai R, Kurek D, Fraser WD, Hough T, Condie BG, Manley N, Grosveld F, Thakker RV (2010) Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest 120(6):2144\u20132155","journal-title":"J Clin Invest"},{"issue":"6792","key":"9799_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35018111","volume":"406","author":"T Gunther","year":"2000","unstructured":"Gunther T, Chen ZF, Kim J, Priemel M, Rueger JM, Amling M, Moseley JM, Martin TJ, Anderson DJ, Karsenty G (2000) Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 406(6792):199\u2013203","journal-title":"Nature"},{"issue":"9","key":"9799_CR16","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1210\/jc.2004-0724","volume":"89","author":"A Gupta","year":"2004","unstructured":"Gupta A, Winer K, Econs MJ, Marx SJ, Collins MT (2004) FGF-23 is elevated by chronic hyperphosphatemia. J Clin Endocrinol Metab 89(9):4489\u20134492","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"9799_CR17","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.200406097","volume":"166","author":"S Hashemolhosseini","year":"2004","unstructured":"Hashemolhosseini S, Wegner M (2004) Impacts of a new transcription factor family: mammalian GCM proteins in health and disease. J Cell Biol 166(6):765\u2013768","journal-title":"J Cell Biol"},{"issue":"8","key":"9799_CR18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nn.2875","volume":"14","author":"S Hitoshi","year":"2011","unstructured":"Hitoshi S, Ishino Y, Kumar A, Jasmine S, Tanaka KF, Kondo T, Kato S, Hosoya T, Hotta Y, Ikenaka K (2011) Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells. Nat Neurosci 14(8):957\u2013964","journal-title":"Nat Neurosci"},{"issue":"6","key":"9799_CR19","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(95)90281-3","volume":"82","author":"T Hosoya","year":"1995","unstructured":"Hosoya T, Takizawa K, Nitta K, Hotta Y (1995) Glial cells missing: a binary switch between neuronal and glial determination in Drosophila. Cell 82(6):1025\u20131036","journal-title":"Cell"},{"issue":"6","key":"9799_CR20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0092-8674(95)90280-5","volume":"82","author":"BW Jones","year":"1995","unstructured":"Jones BW, Fetter RD, Tear G, Goodman CS (1995) Glial cells missing: a genetic switch that controls glial versus neuronal fate. Cell 82(6):1013\u20131023","journal-title":"Cell"},{"issue":"10","key":"9799_CR21","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1002\/jbmr.458","volume":"26","author":"A Kamitani-Kawamoto","year":"2011","unstructured":"Kamitani-Kawamoto A, Hamada M, Moriguchi T, Miyai M, Saji F, Hatamura I, Nishikawa K, Takayanagi H, Hitoshi S, Ikenaka K, Hosoya T, Hotta Y, Takahashi S, Kataoka K (2011) MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development. J Bone Miner Res 26(10):2463\u20132472","journal-title":"J Bone Miner Res"},{"issue":"1\u20132","key":"9799_CR22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000015210","volume":"84","author":"M Kammerer","year":"1999","unstructured":"Kammerer M, Pirola B, Giglio S, Giangrande A (1999) GCMB, a second human homolog of the fly glide\/gcm gene. Cytogenet Cell Genet 84(1\u20132):43\u201347","journal-title":"Cytogenet Cell Genet"},{"key":"9799_CR23","doi-asserted-by":"crossref","first-page":"12364","DOI":"10.1073\/pnas.95.21.12364","volume":"95","author":"J Kim","year":"1998","unstructured":"Kim J, Jones BW, Zock C, Chen Z, Wang H, Goodman CS, Anderson DJ (1998) Isolation and characterization of mammalian homologs of the drosophila gene glial cells missing. Proc Natl Acad Sci USA 95:12364\u201312369","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"9799_CR24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ydbio.2007.02.014","volume":"305","author":"Z Liu","year":"2007","unstructured":"Liu Z, Yu S, Manley NR (2007) Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid\/thymus primordia. Dev Biol 305(1):333\u2013346","journal-title":"Dev Biol"},{"issue":"12","key":"9799_CR25","doi-asserted-by":"crossref","first-page":"e1001251","DOI":"10.1371\/journal.pgen.1001251","volume":"6","author":"Z Liu","year":"2010","unstructured":"Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, Manley NR (2010) Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genet 6(12):e1001251","journal-title":"PLoS Genet"},{"issue":"9","key":"9799_CR26","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1210\/jc.2007-2167","volume":"93","author":"M Mannstadt","year":"2008","unstructured":"Mannstadt M, Bertrand G, Muresan M, Weryha G, Leheup B, Pulusani SR, Grandchamp B, Juppner H, Silve C (2008) Dominant-negative GCMB mutations cause an autosomal dominant form of hypoparathyroidism. J Clin Endocrinol Metab 93(9):3568\u20133576","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9799_CR27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1210\/jc.2003-030733","volume":"89","author":"A Maret","year":"2004","unstructured":"Maret A, Bourdeau I, Ding C, Kadkol SS, Westra WH, Levine MA (2004) Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin. J Clin Endocrinol Metab 89(1):8\u201312","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"9799_CR28","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1210\/jc.2007-1783","volume":"93","author":"A Maret","year":"2008","unstructured":"Maret A, Ding C, Kornfield SL, Levine MA (2008) Analysis of the GCM2 gene in isolated hypoparathyroidism: a molecular and biochemical study. J Clin Endocrinol Metab 93(4):1426\u20131432","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"9799_CR29","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1210\/jc.2009-2532","volume":"95","author":"SM Mirczuk","year":"2010","unstructured":"Mirczuk SM, Bowl MR, Nesbit MA, Cranston T, Fratter C, Allgrove J, Brain C, Thakker RV (2010) A missense glial cells missing homolog B (GCMB) mutation, Asn502His, causes autosomal dominant hypoparathyroidism. J Clin Endocrinol Metab 95(7):3512\u20133516","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"9799_CR30","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1210\/endo.136.12.7588314","volume":"136","author":"MT Nutley","year":"1995","unstructured":"Nutley MT, Parimi SA, Harvey S (1995) Sequence analysis of hypothalamic parathyroid hormone messenger ribonucleic acid. Endocrinology 136(12):5600\u20135607","journal-title":"Endocrinology"},{"issue":"5329","key":"9799_CR31","first-page":"1025","volume":"277","author":"S O\u2019Gorman","year":"1997","unstructured":"O\u2019Gorman S, Wahl GM (1997) Mouse engineering. Science 277(5329):1025","journal-title":"Science"},{"issue":"26","key":"9799_CR32","doi-asserted-by":"crossref","first-page":"14602","DOI":"10.1073\/pnas.94.26.14602","volume":"94","author":"S O\u2019Gorman","year":"1997","unstructured":"O\u2019Gorman S, Dagenais NA, Qian M, Marchuk Y (1997) Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci USA 94(26):14602\u201314607","journal-title":"Proc Natl Acad Sci USA"},{"issue":"51","key":"9799_CR33","doi-asserted-by":"crossref","first-page":"17716","DOI":"10.1073\/pnas.0406116101","volume":"101","author":"M Okabe","year":"2004","unstructured":"Okabe M, Graham A (2004) The origin of the parathyroid gland. Proc Natl Acad Sci USA 101(51):17716\u201317719","journal-title":"Proc Natl Acad Sci USA"},{"key":"9799_CR34","doi-asserted-by":"crossref","unstructured":"Quinn SJ, Thomsen AR, Pang JL, Kantham L, Brauner-Osborne H, Pollak M, Goltzman D, Brown EM (2013) Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab 304(3):E310\u2013E320","DOI":"10.1152\/ajpendo.00460.2012"},{"issue":"10","key":"9799_CR35","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1093\/nar\/26.10.2337","volume":"26","author":"J Schreiber","year":"1998","unstructured":"Schreiber J, Enderich J, Wegner M (1998) Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res 26(10):2337\u20132343","journal-title":"Nucleic Acids Res"},{"key":"9799_CR36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/978-1-4614-0887-1_6","volume":"728","author":"J Silver","year":"2012","unstructured":"Silver J, Naveh-Many T (2012) FGF23 and the parathyroid. Adv Exp Med Biol 728:92\u201399","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"9799_CR37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1359\/jbmr.090825","volume":"25","author":"CS Simmonds","year":"2010","unstructured":"Simmonds CS, Karsenty G, Karaplis AC, Kovacs CS (2010) Parathyroid hormone regulates fetal-placental mineral homeostasis. J Bone Miner Res 25(3):594\u2013605","journal-title":"J Bone Miner Res"},{"issue":"3","key":"9799_CR38","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.mehy.2006.01.062","volume":"67","author":"H Sticht","year":"2006","unstructured":"Sticht H, Hashemolhosseini S (2006) A common structural mechanism underlying GCMB mutations that cause hypoparathyroidism. Med Hypotheses 67(3):482\u2013487","journal-title":"Med Hypotheses"},{"issue":"5","key":"9799_CR39","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1210\/jc.2004-2450","volume":"90","author":"C Thomee","year":"2005","unstructured":"Thomee C, Schubert SW, Parma J, Le PQ, Hashemolhosseini S, Wegner M, Abramowicz MJ (2005) GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone. J Clin Endocrinol Metab 90(5):2487\u20132492","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"9799_CR40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0168-9525(01)02275-2","volume":"17","author":"M Wegner","year":"2001","unstructured":"Wegner M, Riethmacher D (2001) Chronicles of a switch hunt: gcm genes in development. Trends Genet 17(5):286\u2013290","journal-title":"Trends Genet"},{"issue":"3","key":"9799_CR41","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1507\/endocrj.K06-156","volume":"54","author":"H Yamashita","year":"2007","unstructured":"Yamashita H, Yamazaki Y, Hasegawa H, Yamashita T, Fukumoto S, Shigematsu T, Kazama JJ, Fukagawa M, Noguchi S (2007) Fibroblast growth factor-23 (FGF23) in patients with transient hypoparathyroidism: its important role in serum phosphate regulation. Endocr J 54(3):465\u2013470","journal-title":"Endocr J"},{"key":"9799_CR42","doi-asserted-by":"crossref","unstructured":"Yuan Q, Jiang Y, Zhao X, Sato T, Densmore M, Schuler C, Erben RG, McKee MD, Lanske B (2013) Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice. J Bone Miner Res. 29(3):693\u2013704","DOI":"10.1002\/jbmr.2079"},{"issue":"4","key":"9799_CR43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MNH.0b013e328304651c","volume":"17","author":"JD Zajac","year":"2008","unstructured":"Zajac JD, Danks JA (2008) The development of the parathyroid gland: from fish to human. Curr Opin Nephrol Hypertens 17(4):353\u2013356","journal-title":"Curr Opin Nephrol Hypertens"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-014-9799-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-014-9799-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-014-9799-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T14:48:26Z","timestamp":1565362106000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-014-9799-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,16]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["9799"],"URL":"https:\/\/doi.org\/10.1007\/s11248-014-9799-7","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,16]]}}}