{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:24:42Z","timestamp":1792797882047,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s11248-016-9986-9","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T09:49:20Z","timestamp":1477302560000},"page":"51-64","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phenotypic characterization of a novel HO-1 depletion model in the rat"],"prefix":"10.1007","volume":"26","author":[{"given":"Vassilios","family":"Atsaves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Detsika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpida","family":"Poulaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hara","family":"Gakiopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A.","family":"Lianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"9986_CR1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1681\/ASN.V115965","volume":"11","author":"A Agarwal","year":"2000","unstructured":"Agarwal A, Nick HS (2000) Renal response to tissue injury: lessons from heme oxygenase-1 Gene Ablation and expression. J Am Soc Nephrol 11:965\u2013973","journal-title":"J Am Soc Nephrol"},{"key":"9986_CR2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.171.3.1148","volume":"171","author":"P Aichele","year":"2003","unstructured":"Aichele P, Zinke J, Grode L, Schwendener RA, Kaufmann SH, Seiler P (2003) Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses. J Immunol 171:1148\u20131155","journal-title":"J Immunol"},{"key":"9986_CR3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000020667","volume":"8","author":"H Anders","year":"2000","unstructured":"Anders H, Schlondorff D (2000) Murine models of renal disease: possibilities and problems in studies using mutant mice. Exp Nephrol 8:181\u2013193","journal-title":"Exp Nephrol"},{"key":"9986_CR4","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1152\/ajplung.00236.2013","volume":"306","author":"AC Anyanwu","year":"2014","unstructured":"Anyanwu AC et al (2014) Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide. Am J Physiol Lung Cell Mol Physiol 306:749\u2013763. doi: 10.1152\/ajplung.00236.2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9986_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13079","author":"V Atsaves","year":"2014","unstructured":"Atsaves V et al (2014) The oncogenic JUNB\/CD30 axis contributes to cell cycle deregulation in ALK\u00a0+\u00a0anaplastic large cell lymphoma. Br J Haematol. doi: 10.1111\/bjh.13079","journal-title":"Br J Haematol"},{"key":"9986_CR6","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1093\/ndt\/gft071","volume":"28","author":"GJ Becker","year":"2013","unstructured":"Becker GJ, Hewitson TD (2013) Animal models of chronic kidney disease: useful but not perfect. Nephrol Dial Transplant 28:2432\u20132438. doi: 10.1093\/ndt\/gft071","journal-title":"Nephrol Dial Transplant"},{"key":"9986_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1161\/hypertensionaha.112.193805","volume":"60","author":"J Cao","year":"2012","unstructured":"Cao J et al (2012) Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet. Hypertension 60:467\u2013475. doi: 10.1161\/hypertensionaha.112.193805","journal-title":"Hypertension"},{"key":"9986_CR8","doi-asserted-by":"publisher","first-page":"F660","DOI":"10.1152\/ajprenal.00437.2004","volume":"289","author":"AV Cybulsky","year":"2005","unstructured":"Cybulsky AV, Quigg RJ, Salant DJ (2005) Experimental membranous nephropathy redux. Am J Physiol Renal Physiol 289:F660\u2013F671. doi: 10.1152\/ajprenal.00437.2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"9986_CR9","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1172\/jci71195","volume":"124","author":"I Daehn","year":"2014","unstructured":"Daehn I et al (2014) Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. J Clin Investig 124:1608\u20131621. doi: 10.1172\/jci71195","journal-title":"J Clin Investig"},{"key":"9986_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3109\/01913123.2011.584657","volume":"35","author":"S Darouich","year":"2011","unstructured":"Darouich S, Goucha R, Jaafoura MH, Zekri S, Ben Maiz H, Kheder A (2011) Clinicopathological characteristics of obesity-associated focal segmental glomerulosclerosis. Ultrastruct Pathol 35:176\u2013182. doi: 10.3109\/01913123.2011.584657","journal-title":"Ultrastruct Pathol"},{"key":"9986_CR11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1159\/000446859","volume":"43","author":"MG Detsika","year":"2016","unstructured":"Detsika MG et al (2016) Effect of heme oxygenase-1 deficiency on glomerular proteomics. Am J Nephrol 43:441\u2013450. doi: 10.1159\/000446859","journal-title":"Am J Nephrol"},{"key":"9986_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.trre.2014.05.002","volume":"28","author":"BM Doorschodt","year":"2014","unstructured":"Doorschodt BM, Teubner A, Kobayashi E, Tolba RH (2014) Promising future for the transgenic rat in transplantation research. Transplant Rev 28:155\u2013162. doi: 10.1016\/j.trre.2014.05.002","journal-title":"Transplant Rev"},{"key":"9986_CR13","doi-asserted-by":"publisher","first-page":"473709","DOI":"10.1155\/2011\/473709","volume":"2011","author":"ST Fraser","year":"2011","unstructured":"Fraser ST, Midwinter RG, Berger BS, Stocker R (2011) Heme oxygenase-1: a critical link between iron metabolism, erythropoiesis, and development. Adv Hematol 2011:473709. doi: 10.1155\/2011\/473709","journal-title":"Adv Hematol"},{"key":"9986_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/978-1-60327-389-3_15","volume":"597","author":"AM Geurts","year":"2010","unstructured":"Geurts AM et al (2010) Generation of gene-specific mutated rats using zinc-finger nucleases. Methods Mol Biol 597:211\u2013225. doi: 10.1007\/978-1-60327-389-3_15","journal-title":"Methods Mol Biol"},{"key":"9986_CR15","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.tig.2010.08.006","volume":"26","author":"HJ Jacob","year":"2010","unstructured":"Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM (2010) Gene targeting in the rat: advances and opportunities. Trends Genet 26:510\u2013518. doi: 10.1016\/j.tig.2010.08.006","journal-title":"Trends Genet"},{"key":"9986_CR16","doi-asserted-by":"publisher","first-page":"26003","DOI":"10.1074\/jbc.M111.223164","volume":"286","author":"H Kato","year":"2011","unstructured":"Kato H et al (2011) Wnt\/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 286:26003\u201326015. doi: 10.1074\/jbc.M111.223164","journal-title":"J Biol Chem"},{"key":"9986_CR17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/hupa.2002.30217","volume":"33","author":"A Kawashima","year":"2002","unstructured":"Kawashima A, Oda Y, Yachie A, Koizumi S, Nakanishi I (2002) Heme oxygenase-1 deficiency: the first autopsy case. Hum Pathol 33:125\u2013130","journal-title":"Hum Pathol"},{"key":"9986_CR18","doi-asserted-by":"publisher","first-page":"L707","DOI":"10.1152\/ajplung.00145.2014","volume":"307","author":"FM Konrad","year":"2014","unstructured":"Konrad FM, Braun S, Ngamsri KC, Vollmer I, Reutershan J (2014) Heme oxygenase-1 attenuates acute pulmonary inflammation by decreasing the release of segmented neutrophils from the bone marrow. Am J Physiol Lung Cell Mol Physiol 307:L707\u2013L717. doi: 10.1152\/ajplung.00145.2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9986_CR19","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1182\/blood-2010-03-272138","volume":"116","author":"G Kovtunovych","year":"2010","unstructured":"Kovtunovych G, Eckhaus MA, Ghosh MC, Ollivierre-Wilson H, Rouault TA (2010) Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Blood 116:6054\u20136062. doi: 10.1182\/blood-2010-03-272138","journal-title":"Blood"},{"key":"9986_CR20","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1182\/blood-2014-02-554162","volume":"124","author":"G Kovtunovych","year":"2014","unstructured":"Kovtunovych G et al (2014) Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice. Blood 124:1522\u20131530. doi: 10.1182\/blood-2014-02-554162","journal-title":"Blood"},{"key":"9986_CR21","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6659","author":"JM Lever","year":"2016","unstructured":"Lever JM, Boddu R, George JF, Agarwal A (2016) Heme oxygenase-1 in kidney health and disease. Antioxid Redox Signal. doi: 10.1089\/ars.2016.6659","journal-title":"Antioxid Redox Signal"},{"key":"9986_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. doi: 10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"9986_CR23","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.bbrc.2005.08.121","volume":"338","author":"MD Maines","year":"2005","unstructured":"Maines MD, Gibbs PE (2005) 30 some years of heme oxygenase: from a \u201cmolecular wrecking ball\u201d to a \u201cmesmerizing\u201d trigger of cellular events. Biochem Biophys Res Commun 338:568\u2013577. doi: 10.1016\/j.bbrc.2005.08.121","journal-title":"Biochem Biophys Res Commun"},{"key":"9986_CR24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ajcp\/58.2.135","volume":"58","author":"RP Misra","year":"1972","unstructured":"Misra RP (1972) Isolation of glomeruli from mammalian kidneys by graded sieving. Am J Clin Pathol 58:135\u2013139","journal-title":"Am J Clin Pathol"},{"key":"9986_CR25","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/S0002-9440(10)65024-9","volume":"156","author":"KA Nath","year":"2000","unstructured":"Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, Alam J (2000) The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol 156:1527\u20131535. doi: 10.1016\/S0002-9440(10)65024-9","journal-title":"Am J Pathol"},{"key":"9986_CR26","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.redox.2014.09.001","volume":"2","author":"JF Ndisang","year":"2014","unstructured":"Ndisang JF, Tiwari S (2014) Mechanisms by which heme oxygenase rescue renal dysfunction in obesity. Redox Biol 2:1029\u20131037. doi: 10.1016\/j.redox.2014.09.001","journal-title":"Redox Biol"},{"key":"9986_CR27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1292\/jvms.10-0144","volume":"72","author":"T Nishino","year":"2010","unstructured":"Nishino T, Sasaki N, Nagasaki K, Ahmad Z, Agui T (2010) Genetic background strongly influences the severity of glomerulosclerosis in mice. J Vet Med Sci\/Jpn Soc Vet Sci 72:1313\u20131318","journal-title":"J Vet Med Sci\/Jpn Soc Vet Sci"},{"key":"9986_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbrc.2010.04.069","volume":"396","author":"J Patrakka","year":"2010","unstructured":"Patrakka J, Tryggvason K (2010) Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun 396:164\u2013169. doi: 10.1016\/j.bbrc.2010.04.069","journal-title":"Biochem Biophys Res Commun"},{"key":"9986_CR29","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","volume":"94","author":"KD Poss","year":"1997","unstructured":"Poss KD, Tonegawa S (1997) Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 94:10919\u201310924","journal-title":"Proc Natl Acad Sci USA"},{"key":"9986_CR30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/MPH.0b013e3181fd2aae","volume":"33","author":"N Radhakrishnan","year":"2011","unstructured":"Radhakrishnan N et al (2011) Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia. J Pediatr Hematol\/Oncol 33:74\u201378. doi: 10.1097\/MPH.0b013e3181fd2aae","journal-title":"J Pediatr Hematol\/Oncol"},{"key":"9986_CR31","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/2063","volume":"4","author":"MP Soares","year":"1998","unstructured":"Soares MP et al (1998) Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med 4:1073\u20131077. doi: 10.1038\/2063","journal-title":"Nat Med"},{"key":"9986_CR32","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/scrt176","volume":"4","author":"L Vanella","year":"2013","unstructured":"Vanella L et al (2013) Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade. Stem Cell Res Ther 4:28. doi: 10.1186\/scrt176","journal-title":"Stem Cell Res Ther"},{"key":"9986_CR33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2353\/jmoldx.2009.080144","volume":"11","author":"K Voskarides","year":"2009","unstructured":"Voskarides K, Deltas C (2009) Screening for mutations in kidney-related genes using SURVEYOR nuclease for cleavage at heteroduplex mismatches. J Mol Diagn 11:311\u2013318. doi: 10.2353\/jmoldx.2009.080144","journal-title":"J Mol Diagn"},{"key":"9986_CR34","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3748\/wjg.v8.i6.1123","volume":"8","author":"ZW Xia","year":"2002","unstructured":"Xia ZW et al (2002) Analysis of heme oxygenase isomers in rat. World J Gastroenterol 8:1123\u20131128","journal-title":"World J Gastroenterol"},{"key":"9986_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/jci4165","volume":"103","author":"A Yachie","year":"1999","unstructured":"Yachie A et al (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Investig 103:129\u2013135. doi: 10.1172\/jci4165","journal-title":"J Clin Investig"},{"key":"9986_CR36","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.redox.2013.01.013","volume":"1","author":"G Yang","year":"2013","unstructured":"Yang G et al (2013) Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: role of beta-catenin\/hnRNPK signaling. Redox Biol 1:234\u2013243. doi: 10.1016\/j.redox.2013.01.013","journal-title":"Redox Biol"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-016-9986-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-016-9986-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-016-9986-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T02:28:33Z","timestamp":1657506513000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-016-9986-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["9986"],"URL":"https:\/\/doi.org\/10.1007\/s11248-016-9986-9","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}