{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:20:53Z","timestamp":1792783253250,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Next-Generation BioGreen 21 program","award":["PJ011196"],"award-info":[{"award-number":["PJ011196"]}]},{"name":"Bio-industry Technology Development Program","award":["IPET312060-05-4-HD060"],"award-info":[{"award-number":["IPET312060-05-4-HD060"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s11248-016-9996-7","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T01:51:19Z","timestamp":1478656279000},"page":"209-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Production of heterozygous alpha 1,3-galactosyltransferase (GGTA1) knock-out transgenic miniature pigs expressing human CD39"],"prefix":"10.1007","volume":"26","author":[{"given":"Kimyung","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohyun","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejong","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Woong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Il","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"9996_CR1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0093-691X(00)00390-3","volume":"54","author":"LR Abeydeera","year":"2000","unstructured":"Abeydeera LR, Wang WH, Cantley TC, Rieke A, Murphy CN, Prather RS, Day BN (2000) Development and viability of pig oocytes matured in a protein-free medium containing epidermal growth factor. Theriogenology 54:787\u2013797","journal-title":"Theriogenology"},{"key":"9996_CR2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MOT.0b013e328336ba4a","volume":"15","author":"B Aigner","year":"2010","unstructured":"Aigner B, Klymiuk N, Wolf E (2010) Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression. Curr Opin Org Transplant 15:201\u2013206","journal-title":"Curr Opin Org Transplant"},{"key":"9996_CR3","unstructured":"Ayares D (2009) Invited expert speaker: international Xenotransplantation Association Meeting, Venice, Italy. Oct 12\u201316; Ref Type: Abstract"},{"key":"9996_CR48","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/diabetes.48.10.1907","volume":"48","author":"W Bennet","year":"1999","unstructured":"Bennet W, Sundberg B, Groth CG, Brendel MD, Brandhorst D, Brandhorst H, Bretzel RG, Elgue G, Larsson R, Nilsson B, Korsgren O (1999) Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes 48(10):1907\u20131914","journal-title":"Diabetes"},{"key":"9996_CR50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/01.tp.0000275401.80187.1e","volume":"84","author":"DM Berman","year":"2007","unstructured":"Berman DM, Cabrera O, Kenyon NM, Miller J, Tam SH, Khandekar VS, Picha KM, Soderman AR, Jordan RE, Bugelski PJ, Horninger D, Lark M, Davis JE, Alejandro R, Berggren PO, Zimmerman M, O'Neil JJ, Ricordi C, Kenyon NS (2007) Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model. Transplantation 84:308\u2013315","journal-title":"Transplantation"},{"key":"9996_CR49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00125-006-0529-4","volume":"50","author":"C Beuneu","year":"2007","unstructured":"Beuneu C, Vosters O, Ling Z, Pipeleers D, Pradier O, Goldman M, Verhasselt V (2007) N-Acetylcysteine derivative inhibits procoagulant activity of human islet cells. Diabetologia 50:343\u2013347","journal-title":"Diabetologia"},{"key":"9996_CR4","unstructured":"Burdorf L, Zhang T, Stoddard T, Welty E, Avon C, Laaris A, Cheng X, Ayares D, Echeverri D, Cooper DKC, Cowan P, d\u2019Apice AJF, Csizmadia E, Robson S, Azimzadeh AM, N. PIR (2009) Pilot evaluation of Galtko, Hcd39 lungs in a xenogeneic pig lung perfusion model. IXA-late breaking oral presentations 0.3, Joint Meeting of the International Pancreas & Islet Transplant Association & International Xenotransplantation Association, Venice Italy Oct 12\u201316; Ref Type: Abstract"},{"key":"9996_CR5","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1111\/ajt.12868","volume":"14","author":"R Bottino","year":"2014","unstructured":"Bottino R, Wijkstrom M, van der Windt DJ, Hara H, Ezzelarab M, Murase N, Bertera S, He J, Phelps C, Ayares D, Cooper DK, Trucco M (2014) Pig-to-monkey islet xenotransplantation using multi-transgenic pigs. Am J Transplant 14:2275\u20132287","journal-title":"Am J Transplant"},{"key":"9996_CR6","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1038\/mtna.2011.5","volume":"1","author":"DF Carlson","year":"2012","unstructured":"Carlson DF, Fahrenkrug SC, Hackett PB (2012a) Targeting DNA with fingers and talens. Mol Ther Nucleic Acids 1:e3","journal-title":"Mol Ther Nucleic Acids"},{"key":"9996_CR7","doi-asserted-by":"crossref","first-page":"17382","DOI":"10.1073\/pnas.1211446109","volume":"109","author":"DF Carlson","year":"2012","unstructured":"Carlson DF, Tan W, Lillico SG, Stverakova D, Proudfoot C, Christian M, Voytas DF, Long CR, Whitelaw CB, Fahrenkrug SC (2012b) Efficient talen-mediated gene knockout in livestock. Proc Natl Acad Sci USA 109:17382\u201317387","journal-title":"Proc Natl Acad Sci USA"},{"key":"9996_CR8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/01.tp.0000188138.53502.de","volume":"81","author":"G Chen","year":"2006","unstructured":"Chen G, Sun H, Yang H, Kubelik D, Garcia B, Luo Y, Xiang Y, Qian A, Copeman L, Liu W, Cardella CJ, Wang W, Xiong Y, Wall W, White DJ, Zhong R (2006) The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of Hdaf transgenic porcine kidneys in baboons receiving anti-gal antibody neutralization therapy. Transplantation 81:273\u2013283","journal-title":"Transplantation"},{"key":"9996_CR9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev.med.53.082901.103900","volume":"53","author":"DK Cooper","year":"2002","unstructured":"Cooper DK, Gollackner B, Sachs DH (2002) Will the pig solve the transplantation backlog? Annu Rev Med 53:133\u2013147","journal-title":"Annu Rev Med"},{"key":"9996_CR10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/MOT.0b013e3282f63c74","volume":"13","author":"PJ Cowan","year":"2008","unstructured":"Cowan PJ, d\u2019Apice AJ (2008) The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them. Curr Opin Organ Transplant 13:178\u2013183","journal-title":"Curr Opin Organ Transplant"},{"key":"9996_CR11","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1097\/00007890-200006270-00008","volume":"69","author":"PJ Cowan","year":"2000","unstructured":"Cowan PJ, Aminian A, Barlow H, Brown AA, Chen CG, Fisicaro N, Francis DM, Goodman DJ, Han W, Kurek M, Nottle MB, Pearse MJ, Salvaris E, Shinkel TA, Stainsby GV, Stewart AB, d\u2019Apice AJ (2000) Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 69:2504\u20132515","journal-title":"Transplantation"},{"key":"9996_CR12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/01.tp.0000238721.88920.ee","volume":"82","author":"S Crikis","year":"2006","unstructured":"Crikis S, Cowan PJ, d\u2019Apice AJ (2006) Intravascular thrombosis in discordant xenotransplantation. Transplantation 82:1119\u20131123","journal-title":"Transplantation"},{"key":"9996_CR13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nbt0302-251","volume":"20","author":"Y Dai","year":"2002","unstructured":"Dai Y, Vaught TD, Boone J, Chen S-H, Phelps CJ, Ball S, Monahan JA, Jobst PM, McCreath KJ, Lamborn AE (2002) Targeted disruption of the \u03911, 3-Galactosyltransferase gene in cloned pigs. Nat Biotechnol 20:251\u2013255","journal-title":"Nat Biotechnol"},{"key":"9996_CR53","doi-asserted-by":"crossref","unstructured":"Dwyer KM, Mysore TB, Crikis S, Robson SC, Nandurkar H, Cowan PJ, D'Apice AJ (2006) The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation 82(3):428\u2013432","DOI":"10.1097\/01.tp.0000229023.38873.c0"},{"key":"9996_CR15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0167-5699(93)90261-I","volume":"14","author":"U Galili","year":"1993","unstructured":"Galili U (1993) Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol Today 14:480\u2013482","journal-title":"Immunol Today"},{"key":"9996_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0300-9084(01)01294-9","volume":"83","author":"U Galili","year":"2001","unstructured":"Galili U (2001) The \u03b1-gal epitope (Gal\u03b11-3gal\u03b21-4glcnac-R) in xenotransplantation. Biochimie 83:557\u2013563","journal-title":"Biochimie"},{"key":"9996_CR17","doi-asserted-by":"crossref","first-page":"17755","DOI":"10.1016\/S0021-9258(19)77900-9","volume":"263","author":"U Galili","year":"1988","unstructured":"Galili U, Shohet S, Kobrin E, Stults C, Macher B (1988) Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 263:17755\u201317762","journal-title":"J Biol Chem"},{"key":"9996_CR18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1681\/ASN.2006101141","volume":"18","author":"A Grenz","year":"2007","unstructured":"Grenz A, Zhang H, Eckle T, Mittelbronn M, Wehrmann M, K\u00f6hle C, Kloor D, Thompson LF, Osswald H, Eltzschig HK (2007) Protective role of ecto-5\u2032-nucleotidase (Cd73) in renal ischemia. J Am Soc Nephrol 18:833\u2013845","journal-title":"J Am Soc Nephrol"},{"key":"9996_CR19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1399-3089.2006.00319.x","volume":"13","author":"H Hara","year":"2006","unstructured":"Hara H, Ezzelarab M, Rood PP, Lin YJ, Busch J, Ibrahim Z, Zhu X, Ball S, Ayares D, Zeevi A, Awwad M, Cooper DK (2006) Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans. Xenotransplantation 13:357\u2013365","journal-title":"Xenotransplantation"},{"key":"9996_CR20","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.1106422108","volume":"108","author":"J Hauschild","year":"2011","unstructured":"Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, Niemann H (2011) Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci USA 108:12013\u201312017","journal-title":"Proc Natl Acad Sci USA"},{"key":"9996_CR21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1008934912555","volume":"9","author":"LM Houdebine","year":"2000","unstructured":"Houdebine LM (2000) Transgenic animal bioreactors. Transgenic Res 9:305\u2013320","journal-title":"Transgenic Res"},{"key":"9996_CR22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/A:1008909908180","volume":"8","author":"LM Houdebine","year":"1999","unstructured":"Houdebine LM, Attal J (1999) Internal ribosome entry sites (Iress): reality and use. Transgenic Res 8:157\u2013177","journal-title":"Transgenic Res"},{"key":"9996_CR51","doi-asserted-by":"crossref","unstructured":"Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, Felldin M, K\u00e4llen R, Salmela K, Tibell A, Tufveson G, Ekdahl KN, Elgue G, Korsgren O, Nilsson B (2005) Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 54:1755\u20131762","DOI":"10.2337\/diabetes.54.6.1755"},{"key":"9996_CR23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4142\/jvs.2016.17.1.89","volume":"17","author":"JT Kang","year":"2016","unstructured":"Kang JT, Kwon DK, Park AR, Lee EJ, Yun YJ, Ji DY, Lee K, Park KW (2016) Production of alpha 1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology. J Vet Sci 17:89\u201396","journal-title":"J Vet Sci"},{"key":"9996_CR24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/A:1006963809894","volume":"15","author":"A Katayama","year":"1998","unstructured":"Katayama A, Ogawa H, Kadomatsu K, Kurosawa N, Kobayashi T, Kaneda N, Uchimura K, Yokoyama I, Muramatsu T, Takagi H (1998) Porcine \u0391-1, 3-galactosyltransferase: full length cdna cloning, genomic organization, and analysis of splicing variants. Glycoconj J 15:583\u2013589","journal-title":"Glycoconj J"},{"key":"9996_CR25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbadis.2005.03.008","volume":"1741","author":"Z Khalpey","year":"2005","unstructured":"Khalpey Z, Yuen AH, Kalsi KK, Kochan Z, Karbowska J, Slominska EM, Forni M, Macherini M, Bacci ML, Batten P (2005) Loss of ecto-5\u2032 nucleotidase from porcine endothelial cells after exposure to human blood: implications for xenotransplantation. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1741:191\u2013198","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"9996_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/mrd.21127","volume":"77","author":"N Klymiuk","year":"2010","unstructured":"Klymiuk N, Aigner B, Brem G, Wolf E (2010) Genetic modification of pigs as organ donors for xenotransplantation. Mol Reprod Dev 77:209\u2013221","journal-title":"Mol Reprod Dev"},{"key":"9996_CR27","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1073\/pnas.0307819101","volume":"101","author":"D Kolber-Simonds","year":"2004","unstructured":"Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, Betthauser J, Carter DB, Greenstein JL, Hao Y, Im GS, Liu Z, Mell GD, Murphy CN, Park KW, Rieke A, Ryan DJ, Sachs DH, Forsberg EJ, Prather RS, Hawley RJ (2004) Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A 101:7335\u20137340","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9996_CR52","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2567.2011.03496.x","volume":"134","author":"T Koshika","year":"2011","unstructured":"Koshika T, Phelps C, Fang J, Lee SE, Fujita M, Ayares D, Cooper DK, Hara H (2011) Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules. Immunology 134:386\u2013397","journal-title":"Immunology"},{"key":"9996_CR28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm1171","volume":"11","author":"K Kuwaki","year":"2005","unstructured":"Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK (2005) Heart transplantation in baboons using alpha 1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 11:29\u201331","journal-title":"Nat Med"},{"key":"9996_CR29","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1068228","volume":"295","author":"L Lai","year":"2002","unstructured":"Lai L, Kolber-Simonds D, Park K-W, Cheong H-T, Greenstein JL, Im G-S, Samuel M, Bonk A, Rieke A, Day BN (2002) Production of \u0391-1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295:1089\u20131092","journal-title":"Science"},{"key":"9996_CR30","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.jss.2012.06.035","volume":"181","author":"P Li","year":"2013","unstructured":"Li P, Estrada JL, Burlak C, Tector AJ (2013) Biallelic knockout of the alpha-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases. J Surg Res 181:e39\u2013e45","journal-title":"J Surg Res"},{"key":"9996_CR31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/xen.12131","volume":"22","author":"P Li","year":"2015","unstructured":"Li P, Estrada JL, Burlak C, Montgomery J, Butler JR, Santos RM, Wang ZY, Paris LL, Blankenship RL, Downey SM, Tector M, Tector AJ (2015) Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide rna and carbohydrate selection. Xenotransplantation 22:20\u201331","journal-title":"Xenotransplantation"},{"key":"9996_CR32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.trim.2008.10.008","volume":"21","author":"CC Lin","year":"2009","unstructured":"Lin CC, Cooper DK, Dorling A (2009) Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol 21:75\u201380","journal-title":"Transpl Immunol"},{"key":"9996_CR54","doi-asserted-by":"crossref","unstructured":"Lin CC, Ezzelarab M, Hara H, Long C, Lin CW, Dorling A, Cooper DKC (2010) Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells. J Thromb Haemost 8(9):2001\u20132010","DOI":"10.1111\/j.1538-7836.2010.03950.x"},{"key":"9996_CR33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10545-012-9475-0","volume":"35","author":"Y Luo","year":"2012","unstructured":"Luo Y, Lin L, Bolund L, Jensen TG, Sorensen CB (2012) Genetically modified pigs for biomedical research. J Inherit Metab Dis 35:695\u2013713","journal-title":"J Inherit Metab Dis"},{"key":"9996_CR34","doi-asserted-by":"crossref","first-page":"39310","DOI":"10.1074\/jbc.M104359200","volume":"276","author":"S Miyagawa","year":"2001","unstructured":"Miyagawa S, Murakami H, Takahagi Y, Nakai R, Yamada M, Murase A, Koyota S, Koma M, Matsunami K, Fukuta D (2001) Remodeling of the major pig xenoantigen by n-acetylglucosaminyltransferase III in transgenic pig. J Biol Chem 276:39310\u201339319","journal-title":"J Biol Chem"},{"key":"9996_CR35","doi-asserted-by":"crossref","unstructured":"Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, Hoyt RF, Eckhaus M, Pierson Iii RN, Belli AJ, Wolf E, Klymiuk N, Phelps C, Reimann KA, Ayares D, Horvath KA (2016) Chimeric 2c10r4 Anti-Cd40 antibody therapy is critical for long-term survival of GTKO.Hcd46.Htbm pig-to-primate cardiac xenograft. Nat Commun 7:11138","DOI":"10.1038\/ncomms11138"},{"key":"9996_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-016-9934-8","author":"H Niemann","year":"2016","unstructured":"Niemann H, Petersen B (2016) The production of multi-transgenic pigs: update and perspectives for xenotransplantation. Transgenic Res. doi: 10.1007\/s11248-016-9934-8","journal-title":"Transgenic Res"},{"key":"9996_CR37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1095\/biolreprod66.4.1001","volume":"66","author":"K-W Park","year":"2002","unstructured":"Park K-W, Lai L, Cheong H-T, Cabot R, Sun Q-Y, Wu G, Rucker EB, Durtschi D, Bonk A, Samuel M (2002) Mosaic gene expression in nuclear transfer-derived embryos and the production of cloned transgenic pigs from ear-derived fibroblasts. Biol Reprod 66:1001\u20131005","journal-title":"Biol Reprod"},{"key":"9996_CR38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1078942","volume":"299","author":"CJ Phelps","year":"2003","unstructured":"Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, Ball S, Specht SM, Polejaeva IA, Monahan JA, Jobst PM, Sharma SB, Lamborn AE, Garst AS, Moore M, Demetris AJ, Rudert WA, Bottino R, Bertera S, Trucco M, Starzl TE, Dai Y, Ayares DL (2003) Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299:411\u2013414","journal-title":"Science"},{"key":"9996_CR39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1600-065X.2003.00090.x","volume":"196","author":"PN Rocha","year":"2003","unstructured":"Rocha PN, Plumb TJ, Crowley SD, Coffman TM (2003) Effector mechanisms in transplant rejection. Immunol Rev 196:51\u201364","journal-title":"Immunol Rev"},{"key":"9996_CR40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-9525(98)01689-8","volume":"15","author":"JM Sedivy","year":"1999","unstructured":"Sedivy JM, Dutriaux A (1999) Gene targeting and somatic cell genetics: a rebirth or a coming of age? Trends Genet 15:88\u201390","journal-title":"Trends Genet"},{"key":"9996_CR41","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2353\/ajpath.2008.070672","volume":"172","author":"A Shimizu","year":"2008","unstructured":"Shimizu A, Hisashi Y, Kuwaki K, Tseng YL, Dor FJ, Houser SL, Robson SC, Schuurman HJ, Cooper DK, Sachs DH, Yamada K, Colvin RB (2008) Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha 1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol 172:1471\u20131481","journal-title":"Am J Pathol"},{"key":"9996_CR42","unstructured":"Le Bas-Bernardet S, Tillou X, Poirier N, Dilek N, Leroux S, Chatelais M, Devalli\u00e8re J, Charreau B, Minault D, Hervouet J, Cowan PJ, NottIe NMB, Robson SC, d\u2019Apice AJF, Galli C, Cozzi E, Soulillou JP, G. B (2009) First xenotransplantation of Gal Ko Cd55, Cd59, Cd39, Ht transgenic pig kidneys in baboons. IXA-late breaking oral presentations 0.3, Joint Meeting of the International Pancreas & Islet Transplant Association & International Xenotransplantation Association, Venice Italy Oct 12\u201316; Ref Type: Abstract"},{"key":"9996_CR43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ki.2008.135","volume":"74","author":"B Sprangers","year":"2008","unstructured":"Sprangers B, Waer M, Billiau AD (2008) Xenotransplantation: Where are we in 2008? Kidney Int 74:14\u201321","journal-title":"Kidney Int"},{"key":"9996_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00182319","volume":"41","author":"KM Strahan","year":"1995","unstructured":"Strahan KM, Gu F, Preece AF, Gustavsson I, Andersson L, Gustafsson K (1995) Cdna Sequence and chromosome localization of pig \u03911, 3 galactosyltransferase. Immunogenetics 41:101\u2013105","journal-title":"Immunogenetics"},{"key":"9996_CR45","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1172\/JCI0215337","volume":"110","author":"K Synnestvedt","year":"2002","unstructured":"Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP (2002) Ecto-5\u2032-nucleotidase (Cd73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Investig 110:993\u20131002","journal-title":"J Clin Investig"},{"key":"9996_CR46","first-page":"107","volume":"20","author":"HC Tai","year":"2007","unstructured":"Tai HC, Ezzelarab M, Hara H, Ayares D, Cooper DK (2007) Progress in xenotransplantation following the introduction of gene-knockout technology. Transpl Int 20:107\u2013117","journal-title":"Transpl Int"},{"key":"9996_CR55","doi-asserted-by":"crossref","unstructured":"van der Windt DJ, Marigliano M, He J, Votyakova TV, Echeverri GJ, Ekser B, Ayares D, Lakkis FG, Cooper DKC, Trucco M, Bottino R (2012) Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell Transplant 21(8):1791\u20131802","DOI":"10.3727\/096368912X653011"},{"key":"9996_CR56","doi-asserted-by":"crossref","unstructured":"Wheeler DG, Joseph ME, Mahamud SD, Aurand WL, Mohler PJ, Pompili VJ, Dwyer KM, Nottle MB, Harrison SJ, d'Apice AJF, Robson SC, Cowan PJ, Gumina RJ (2012) Transgenic swine: expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol 52(5):958\u2013961","DOI":"10.1016\/j.yjmcc.2012.01.002"},{"key":"9996_CR47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.thromres.2007.05.022","volume":"121","author":"B Zhang","year":"2008","unstructured":"Zhang B, Zhang A, Zhao Y (2008) Platelet aggregation and thrombosis in xenotransplantation between pigs and humans. Thromb Res 121:433\u2013441","journal-title":"Thromb Res"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-016-9996-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-016-9996-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-016-9996-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T18:22:23Z","timestamp":1657650143000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-016-9996-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9996"],"URL":"https:\/\/doi.org\/10.1007\/s11248-016-9996-7","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]}}}