{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:49:25Z","timestamp":1783003765658,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:00:00Z","timestamp":1642291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"national key research and development program of china","award":["No. 2016YFE0126000"],"award-info":[{"award-number":["No. 2016YFE0126000"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11248-021-00292-5","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T00:03:06Z","timestamp":1642291386000},"page":"149-163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification, purification, and pharmacological activity analysis of Desmodus rotundus salivary plasminogen activator alpha1 (DSPA\u03b11) expressed in transgenic rabbit mammary glands"],"prefix":"10.1007","volume":"31","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minya","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9819-0073","authenticated-orcid":false,"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,16]]},"reference":[{"issue":"3","key":"292_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1385\/MB:19:3:251","volume":"19","author":"P Balbas","year":"2001","unstructured":"Balbas P (2001) Understanding the art of producing protein and nonprotein molecules in Escherichia coli. Mol Biotechnol 19(3):251\u2013267","journal-title":"Mol Biotechnol"},{"issue":"3","key":"292_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.tins.2003.12.011","volume":"27","author":"K Benchenane","year":"2004","unstructured":"Benchenane K et al (2004) Equivocal roles of tissue-type plasminogen activator in stroke-induced injury. Trends Neurosci 27(3):155\u2013160","journal-title":"Trends Neurosci"},{"issue":"17","key":"292_CR3","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1161\/01.CIR.0000163542.48611.A2","volume":"111","author":"K Benchenane","year":"2005","unstructured":"Benchenane K et al (2005) Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation 111(17):2241\u20132249","journal-title":"Circulation"},{"issue":"3","key":"292_CR4","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/0006-291X(91)91713-M","volume":"179","author":"DT Berg","year":"1991","unstructured":"Berg DT, Grinnell BW (1991) Signal and propeptide processing of human tissue plasminogen activator: activity of a pro-tPA derivative. Biochem Biophys Res Commun 179(3):1289\u20131296","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"292_CR5","first-page":"1","volume":"14","author":"Z Bosze","year":"2006","unstructured":"Bosze Z, Houdebine LM (2006) Application of rabbits in biomedical research: a review. World Rabbit Sci 14(1):1\u201314","journal-title":"World Rabbit Sci"},{"key":"292_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/978-0-387-74087-4_15","volume-title":"Bioactive components of milk","author":"Z Bosze","year":"2008","unstructured":"Bosze Z, Baranyi M, Whitelaw CBA (2008) Producing recombinant human milk proteins in the milk of livestock species. In: Bosze Z (ed) Bioactive components of milk. Springer, Berlin, pp 357\u2013393"},{"issue":"8","key":"292_CR7","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/mrd.22063","volume":"79","author":"Y Cheng","year":"2012","unstructured":"Cheng Y et al (2012) Hybrid expression cassettes consisting of a milk protein promoter and a cytomegalovirus enhancer significantly increase mammary-specific expression of human lactoferrin in transgenic mice. Mol Reprod Dev 79(8):573\u2013585","journal-title":"Mol Reprod Dev"},{"issue":"9","key":"292_CR8","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S0167-7799(03)00190-2","volume":"21","author":"MK Dyck","year":"2003","unstructured":"Dyck MK et al (2003) Making recombinant proteins in animals different systems, different applications. Trends Biotechnol 21(9):394\u2013399","journal-title":"Trends Biotechnol"},{"issue":"1","key":"292_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-0102(98)00105-9","volume":"33","author":"A Endo","year":"1999","unstructured":"Endo A et al (1999) Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus. Neurosci Res 33(1):1\u20138","journal-title":"Neurosci Res"},{"issue":"5","key":"292_CR10","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1161\/01.STR.0000217403.66996.6d","volume":"37","author":"AJ Furlan","year":"2006","unstructured":"Furlan AJ et al (2006) Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke 37(5):1227\u20131231","journal-title":"Stroke"},{"issue":"30","key":"292_CR11","doi-asserted-by":"publisher","first-page":"17947","DOI":"10.1016\/S0021-9258(19)84664-1","volume":"264","author":"SJ Gardell","year":"1989","unstructured":"Gardell SJ et al (1989a) Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. J Biol Chem 264(30):17947\u201317952","journal-title":"J Biol Chem"},{"issue":"12","key":"292_CR12","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1182\/blood.V76.12.2560.2560","volume":"76","author":"SJ Gardell","year":"1990","unstructured":"Gardell SJ et al (1990) Vampire bat salivary plasminogen activator is quiescent in human plasma in the absence of fibrin unlike human tissue plasminogen activator. Blood 76(12):2560\u20132564","journal-title":"Blood"},{"issue":"1","key":"292_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/glycob\/7.1.67","volume":"7","author":"M Gohlke","year":"1997","unstructured":"Gohlke M et al (1997) Analysis of site-specific N-glycosylation of recombinant Desmodus rotundus salivary plasminogen activator rDSPA-alpha-1 expressed in Chinese hamster ovary cells. Glycobiology 7(1):67\u201377","journal-title":"Glycobiology"},{"issue":"6","key":"292_CR14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.amjmed.2015.11.033","volume":"129","author":"V Gurewich","year":"2016","unstructured":"Gurewich V (2016) Thrombolysis: a critical first-line therapy with an unfulfilled potential. Am J Med 129(6):573\u2013575","journal-title":"Am J Med"},{"issue":"4","key":"292_CR15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1160\/TH05-03-0164","volume":"94","author":"T Harada","year":"2005","unstructured":"Harada T et al (2005) Tissue plasminogen activator extravasated through the cerebral vessels: evaluation using a rat thromboembolic stroke model. Thromb Haemost 94(4):791\u2013796","journal-title":"Thromb Haemost"},{"issue":"8","key":"292_CR16","doi-asserted-by":"publisher","first-page":"e0201788","DOI":"10.1371\/journal.pone.0201788","volume":"13","author":"Z He","year":"2018","unstructured":"He Z et al (2018) A novel recombinant human plasminogen activator: efficient expression and hereditary stability in transgenic goats and in vitro thrombolytic bioactivity in the milk of transgenic goats. PLoS One. 13(8):e0201788","journal-title":"PLoS One."},{"issue":"4","key":"292_CR17","first-page":"2269","volume":"42","author":"Z He","year":"2018","unstructured":"He Z et al (2018) Efficient increase of the novel recombinant human plasminogen activator expression level and stability through the use of homozygote transgenic rabbits. Int J Mol Med 42(4):2269\u20132275","journal-title":"Int J Mol Med"},{"issue":"5\u20136","key":"292_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0268-9499(96)80007-5","volume":"10","author":"M Hildebrand","year":"1996","unstructured":"Hildebrand M et al (1996) Pharmacokinetics of the novel plasminogen activator Desmodus rotundus plasminogen activator in animals and extrapolation to man. Fibrinolysis 10(5\u20136):269\u2013276","journal-title":"Fibrinolysis"},{"issue":"1","key":"292_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.20506\/rst.37.1.2746","volume":"37","author":"LM Houdebine","year":"2018","unstructured":"Houdebine LM (2018) Production of pharmaceutical proteins by transgenic animals. Revue Scientifique Et Technique-Office International Des Epizooties 37(1):131\u2013139","journal-title":"Revue Scientifique Et Technique-Office International Des Epizooties"},{"issue":"17","key":"292_CR20","doi-asserted-by":"publisher","first-page":"5254","DOI":"10.1016\/j.jprot.2012.06.034","volume":"75","author":"HK Jindal","year":"2012","unstructured":"Jindal HK et al (2012) Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes. J Proteomics 75(17):5254\u20135265","journal-title":"J Proteomics"},{"issue":"9","key":"292_CR21","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/01.WCB.0000137868.50767.E8","volume":"24","author":"J Kaur","year":"2004","unstructured":"Kaur J et al (2004) The neurotoxicity of tissue plasminogen activator. J Cereb Blood Flow Metab 24(9):945\u2013963","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"292_CR22","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1134\/S0003683813090020","volume":"49","author":"YM Khodarovich","year":"2013","unstructured":"Khodarovich YM et al (2013) Expression of eukaryotic recombinant proteins and deriving them from the milk of transgenic animals. Appl Biochem Microbiol 49(9):711\u2013722","journal-title":"Appl Biochem Microbiol"},{"issue":"2","key":"292_CR23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0378-1119(91)90155-5","volume":"105","author":"J Kratzschmar","year":"1991","unstructured":"Kratzschmar J et al (1991) The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: cloning and expression. Gene 105(2):229\u2013237","journal-title":"Gene"},{"issue":"2","key":"292_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0378-1119(92)90526-U","volume":"116","author":"J Kratzschmar","year":"1992","unstructured":"Kratzschmar J et al (1992) High-level secretion of the four salivary plasminogen activators from the vampire bat Desmodus rotundus by stably transfected baby hamster kidney cells. Gene 116(2):281\u2013284","journal-title":"Gene"},{"issue":"2","key":"292_CR25","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1161\/01.STR.0000049764.49162.76","volume":"34","author":"GT Liberatore","year":"2003","unstructured":"Liberatore GT et al (2003) Vampire bat salivary plasminogen activator (desmoteplase). Stroke 34(2):537\u2013543","journal-title":"Stroke"},{"issue":"4","key":"292_CR26","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.theriogenology.2010.10.018","volume":"75","author":"TA Lin","year":"2011","unstructured":"Lin TA et al (2011) Open-pulled straw vitrification differentiates cryotolerance of in vitro cultured rabbit embryos at the eight-cell stage. Theriogenology 75(4):760\u2013768","journal-title":"Theriogenology"},{"issue":"1","key":"292_CR27","first-page":"48","volume":"39","author":"G Lippi","year":"2013","unstructured":"Lippi G, Mattiuzzi C, Favaloro EJ (2013) Novel and emerging therapies: thrombus-targeted fibrinolysis. Semin Thromb Hemost 39(1):48\u201358","journal-title":"Semin Thromb Hemost"},{"issue":"6","key":"292_CR28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/jcbfm.2008.14","volume":"28","author":"JP Lopez-Atalaya","year":"2008","unstructured":"Lopez-Atalaya JP et al (2008) Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity. J Cereb Blood Flow Metab 28(6):1212\u20131221","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"292_CR29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.32607\/20758251-2013-5-1-33-46","volume":"5","author":"OG Maksimenko","year":"2013","unstructured":"Maksimenko OG et al (2013) Use of transgenic animals in biotechnology: prospects and problems. Acta Nat 5(1):33\u201346","journal-title":"Acta Nat"},{"issue":"Suppl 2","key":"292_CR30","first-page":"S17","volume":"3","author":"K Ouriel","year":"2002","unstructured":"Ouriel K (2002) Comparison of safety and efficacy of the various thrombolytic agents. Rev Cardiovasc Med 3(Suppl 2):S17-24","journal-title":"Rev Cardiovasc Med"},{"issue":"6","key":"292_CR31","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1517\/13543784.2014.911285","volume":"23","author":"R Patel","year":"2014","unstructured":"Patel R, Ispoglou S, Apostolakis S (2014) Desmoteplase as a potential treatment for cerebral ischaemia. Expert Opin Investig Drugs 23(6):865\u2013873","journal-title":"Expert Opin Investig Drugs"},{"key":"292_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0168-1656(94)00146-4","volume":"39","author":"T Petri","year":"1995","unstructured":"Petri T et al (1995) Production of vampire bat plasminogen activator DSPA 1 in CHO and insect cells. J Biotechnol 39:75","journal-title":"J Biotechnol"},{"issue":"1","key":"292_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0168-1656(94)00146-4","volume":"39","author":"T Petri","year":"1995","unstructured":"Petri T et al (1995) Production of vampire bat plasminogen activator DSPA alpha-1 in CHO and insect cells. J Biotechnol 39(1):75\u201383","journal-title":"J Biotechnol"},{"issue":"2","key":"292_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0378-1119(92)90129-D","volume":"121","author":"B Roberts","year":"1992","unstructured":"Roberts B et al (1992) Cloning of the goat \u03b2-casein-encoding gene and expression in transgenic mice. Gene 121(2):255\u2013262","journal-title":"Gene"},{"issue":"12","key":"292_CR35","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1016\/j.ultrasmedbio.2015.07.007","volume":"41","author":"FC Roessler","year":"2015","unstructured":"Roessler FC et al (2015) In vitro examination of the thrombolytic efficacy of desmoteplase and therapeutic ultrasound compared with rt-PA. Ultrasound Med Biol 41(12):3233\u20133240","journal-title":"Ultrasound Med Biol"},{"issue":"3\u20134","key":"292_CR36","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000449386","volume":"53","author":"FC Roessler","year":"2016","unstructured":"Roessler FC et al (2016) Clot formation in the presence of acetylsalicylic acid leads to increased lysis rates regardless of the chosen thrombolysis strategy. J Vasc Res 53(3\u20134):128\u2013137","journal-title":"J Vasc Res"},{"issue":"7","key":"292_CR37","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/bit.20410","volume":"89","author":"A Schiermeyer","year":"2005","unstructured":"Schiermeyer A et al (2005a) Production of Desmodus rotundus salivary plasminogen activator alpha 1 (DSPA alpha 1) in tobacco is hampered by proteolysis. Biotechnol Bioeng 89(7):848\u2013858","journal-title":"Biotechnol Bioeng"},{"issue":"7","key":"292_CR38","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/bit.20410","volume":"89","author":"A Schiermeyer","year":"2005","unstructured":"Schiermeyer A et al (2005b) Production of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAalpha1) in tobacco is hampered by proteolysis. Biotechnol Bioeng 89(7):848\u2013858","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"292_CR39","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1749-6632.1992.tb51639.x","volume":"667","author":"W-D Schleuning","year":"1992","unstructured":"Schleuning W-D et al (1992a) Plasmhogen activators from the saliva of Desmodus rotundus (common vampire bat): unique fibrin specificity. Ann N Y Acad Sci 667(1):395\u2013403","journal-title":"Ann N Y Acad Sci"},{"key":"292_CR40","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1749-6632.1992.tb51639.x","volume":"667","author":"WD Schleuning","year":"1992","unstructured":"Schleuning WD et al (1992b) Plasminogen activators from the saliva of Desmodus rotundus (common vampire bat): unique fibrin specificity. Ann N Y Acad Sci 667:395\u2013403","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"292_CR41","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s11033-016-4020-0","volume":"43","author":"S Song","year":"2016","unstructured":"Song S et al (2016) High-level expression of a novel recombinant human plasminogen activator (rhPA) in the milk of transgenic rabbits and its thrombolytic bioactivity in vitro. Mol Biol Rep 43(8):775\u2013783","journal-title":"Mol Biol Rep"},{"issue":"29","key":"292_CR42","doi-asserted-by":"publisher","first-page":"18292","DOI":"10.1074\/jbc.273.29.18292","volume":"273","author":"RJ Stewart","year":"1998","unstructured":"Stewart RJ, Fredenburgh JC, Weitz JI (1998) Characterization of the interactions of plasminogen and tissue and vampire bat plasminogen activators with fibrinogen, fibrin, and the complex of D-dimer noncovalently linked to fragment E. J Biol Chem 273(29):18292\u201318299","journal-title":"J Biol Chem"},{"issue":"6605","key":"292_CR43","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/384123b0","volume":"384","author":"S Strickland","year":"1996","unstructured":"Strickland S (1996) Neuronal cell death and tPA. Nature 384(6605):123\u2013124","journal-title":"Nature"},{"issue":"2","key":"292_CR44","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0958-1669(00)00199-3","volume":"12","author":"JR Swartz","year":"2001","unstructured":"Swartz JR (2001) Advances in Escherichia coli production of therapeutic proteins. Curr Opin Biotechnol 12(2):195\u2013201","journal-title":"Curr Opin Biotechnol"},{"issue":"7","key":"292_CR45","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/ajhp\/58.7.617","volume":"58","author":"LC Vermeulen","year":"2001","unstructured":"Vermeulen LC, Davis SN, Schwartz BS (2001) Alteplase activity. Am J Health Syst Pharm 58(7):617\u2013617","journal-title":"Am J Health Syst Pharm"},{"issue":"1\u20132","key":"292_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetimm.2004.11.010","volume":"105","author":"B Wagner","year":"2005","unstructured":"Wagner B et al (2005) Horse cytokine\/IgG fusion proteins\u2013mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cytokines. Vet Immunol Immunopathol 105(1\u20132):1\u201314","journal-title":"Vet Immunol Immunopathol"},{"issue":"1","key":"292_CR47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.pep.2007.09.001","volume":"57","author":"Z Wei","year":"2008","unstructured":"Wei Z et al (2008) Optimized gene synthesis, expression and purification of active salivary plasminogen activator alpha2 (DSPAalpha2) of Desmodus rotundus in Pichia pastoris. Protein Expr Purif 57(1):27\u201333","journal-title":"Protein Expr Purif"},{"issue":"1","key":"292_CR48","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/01.CIR.90.1.421","volume":"90","author":"W Witt","year":"1994","unstructured":"Witt W et al (1994) Coronary thrombolysis with Desmodus salivary plasminogen activator in dogs: fast and persistent recanalization by intravenous bolus administration. Circulation 90(1):421\u2013426","journal-title":"Circulation"},{"issue":"6","key":"292_CR49","first-page":"2057","volume":"44","author":"T Zhang","year":"2019","unstructured":"Zhang T et al (2019) The goat beta-casein\/CMV chimeric promoter drives the expression of hLF in transgenic goats produced by cell transgene microinjection. Int J Mol Med 44(6):2057\u20132064","journal-title":"Int J Mol Med"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-021-00292-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11248-021-00292-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-021-00292-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:57:38Z","timestamp":1700085458000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11248-021-00292-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,16]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["292"],"URL":"https:\/\/doi.org\/10.1007\/s11248-021-00292-5","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,16]]},"assertion":[{"value":"17 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}