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Transgenic mice of CAG-loxp-Laz-loxp T antigen were established. T-antigen expression was specifically activated in gastroenterological target cells with a LacZ deletion using a cre-loxp system. Gastric poorly-differentiated carcinoma was observed in T antigen-activated mice using K19-cre (stem-like cells) and PGC-cre (chief cells), but not Atp4b-cre (parietal cells) or Capn8-cre (pit cells) mice. Spontaneous hepatocellular and colorectal cancers developed in Alb-cre (hepatocytes)\/T antigen and villin-cre (intestinal cells)\/T antigen transgenic mice respectively. Gastric, colorectal, and breast cancers were observed in PGC-cre\/T antigen mice. Pancreatic insulinoma and ductal adenocarcinoma, gastric adenoma, and duodenal cancer were detected in Pdx1-cre\/T antigen mice. Alternative splicing of T antigen mRNA occurred in all target organs of these transgenic mice. Our findings suggest that JCPyV T antigen might contribute to gastroenterological carcinogenesis with respect to cell specificity. Such spontaneous tumor models provide good tools for investigating the oncogenic roles of T antigen in cancers of the digestive system.<\/jats:p>","DOI":"10.1007\/s11248-023-00352-y","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T08:02:08Z","timestamp":1685347328000},"page":"305-319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells"],"prefix":"10.1007","volume":"32","author":[{"given":"Hua-chuan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-zhi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-jing","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-guo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"352_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neo.2014.12.006","volume":"17","author":"TM Albury","year":"2015","unstructured":"Albury TM, Pandey V, Gitto SB, Dominguez L, Spinel LP, Talarchek J, Klein-Szanto AJ, Testa JR, Altomare DA (2015) Constitutively active Akt1 cooperates with KRas (G12D) to accelerate in vivo pancreatic tumor onset and progression. 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All methods were performed in accordance with the relevant guidelines and regulations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent was obtained from all study participants and\/or their legal guardian(s).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate statement"}}]}}