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Further, prior research has shown that Golli\u2013myelin basic protein is necessary for myelination and neuronal maturation during central nervous system development. In this study, we established Golli\u2013myelin basic protein-floxed mice to elucidate the cell-type-specific effects of Golli\u2013myelin basic protein knockout through the generation of conditional knockout mice (\n                    <jats:italic>Golli<\/jats:italic>\n                    \u2013\n                    <jats:italic>myelin basic proteins<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>; E3CreN<\/jats:italic>\n                    ), in which Golli\u2013myelin basic proteins were specifically deleted in cerebellar granule neurons, where Golli\u2013myelin basic proteins are expressed abundantly in wild-type mice. To investigate the role of Golli\u2013myelin basic proteins in cerebellar granule neurons, we further performed histopathological analyses of these mice, with results indicating no morphological changes or degeneration of the major cellular components of the cerebellum. Furthermore, behavioral analysis showed that\n                    <jats:italic>Golli<\/jats:italic>\n                    \u2013\n                    <jats:italic>myelin basic proteins<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>; E3CreN<\/jats:italic>\n                    mice were healthy and did not display any abnormal behavior. These results suggest that the loss of Golli\u2013myelin basic proteins in cerebellar granule neurons does not lead to cerebellar perturbations or behavioral abnormalities. This mouse model could therefore be employed to analyze the effect of Golli\u2013myelin basic protein deletion in specific cell types of the central nervous system, such as other neuronal cells and oligodendrocytes, or in lymphocytes of the immune system.\n                  <\/jats:p>","DOI":"10.1007\/s11248-024-00382-0","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:02:17Z","timestamp":1714392137000},"page":"99-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP"],"prefix":"10.1007","volume":"33","author":[{"given":"Haruko","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuto","family":"Kakuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Oohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Shimogori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Ikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Nukina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"382_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fnana.2017.00022","volume":"11","author":"P Afshar","year":"2017","unstructured":"Afshar P, Ashtari N, Jiao X, Rahimi-Balaei M, Zhang X, Yaganeh B, Del Bigio MR, Kong J, Marzban H (2017) Overexpression of human SOD1 leads to discrete defects in the cerebellar architecture in the mouse. 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