{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:45:45Z","timestamp":1792075545050,"version":"4.4.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11248-024-00423-8","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T16:54:05Z","timestamp":1736268845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring genetic mapping and co-expression patterns to illuminate significance of Tbx20 in cardiac biology"],"prefix":"10.1007","volume":"34","author":[{"given":"Dezhong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanquan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"423_CR1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.96173","author":"DG Ashbrook","year":"2021","unstructured":"Ashbrook DG, Lu Lu (2021) Recombinant inbred mice as models for experimental precision medicine and biology. Preclin Animal Model Med. https:\/\/doi.org\/10.5772\/intechopen.96173","journal-title":"Preclin Animal Model Med."},{"issue":"3","key":"423_CR2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cels.2020.12.002","volume":"12","author":"DG Ashbrook","year":"2021","unstructured":"Ashbrook DG et al (2021) A platform for experimental precision medicine: the extended BXD mouse family. Cell Syst 12(3):235\u2013247","journal-title":"Cell Syst"},{"issue":"1","key":"423_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","volume":"20","author":"G Ashrafi","year":"2013","unstructured":"Ashrafi G, Schwarz T (2013) The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 20(1):31\u201342","journal-title":"Cell Death Differ"},{"issue":"1","key":"423_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statistical Soc Series B (Methodological). 57(1):289\u2013300","journal-title":"J R Statistical Soc Series B (Methodological)."},{"issue":"11","key":"423_CR5","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","volume":"120","author":"JM Bravo-San Pedro","year":"2017","unstructured":"Bravo-San Pedro JM, Kroemer G, Galluzzi L (2017) Autophagy and mitophagy in cardiovascular disease. Circulation Res 120(11):1812\u20131824","journal-title":"Circulation Res"},{"key":"423_CR6","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00246-014-1073-5","volume":"36","author":"J Chen","year":"2015","unstructured":"Chen J et al (2015) Association of TBX20 gene polymorphism with congenital heart disease in Han Chinese neonates. Pediatr Cardiol 36:737\u2013742","journal-title":"Pediatr Cardiol"},{"key":"423_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.638542","volume":"9","author":"Y Chen","year":"2021","unstructured":"Chen Y et al (2021) The role of Tbx20 in cardiovascular development and function. Front Cell Develop Biol 9:638542","journal-title":"Front Cell Develop Biol"},{"issue":"5","key":"423_CR8","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nn0504-485","volume":"7","author":"EJ Chesler","year":"2004","unstructured":"Chesler EJ et al (2004) WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nat Neurosci 7(5):485\u2013486","journal-title":"Nat Neurosci"},{"issue":"2","key":"423_CR9","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.sbi.2006.03.006","volume":"16","author":"R Craig","year":"2006","unstructured":"Craig R, Woodhead JL (2006) Structure and function of myosin filaments. Curr Opin Struct Biol 16(2):204\u2013212","journal-title":"Curr Opin Struct Biol"},{"key":"423_CR10","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00018-012-1131-1","volume":"70","author":"J England","year":"2013","unstructured":"England J, Loughna S (2013) Heavy and light roles: myosin in the morphogenesis of the heart. Cell Mol Life Sci 70:1221\u20131239","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"423_CR11","doi-asserted-by":"publisher","first-page":"815","DOI":"10.7150\/ijbs.20052","volume":"13","author":"M Farhan","year":"2017","unstructured":"Farhan M et al (2017) FOXO signaling pathways as therapeutic targets in cancer. Int J Biol Sci 13(7):815","journal-title":"Int J Biol Sci"},{"issue":"1","key":"423_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1152\/physiolgenomics.00066.2021","volume":"54","author":"Q Gu","year":"2022","unstructured":"Gu Q et al (2022) Systems genetics analysis defines importance of TMEM43\/LUMA for cardiac-and metabolic-related pathways. Physiol Genomics 54(1):22\u201335","journal-title":"Physiol Genomics"},{"issue":"1","key":"423_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087294","volume":"9","author":"Y Guo","year":"2014","unstructured":"Guo Y et al (2014) Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus laevis. PLoS ONE 9(1):e87294","journal-title":"PLoS ONE"},{"issue":"1","key":"423_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1146\/annurev.bi.53.070184.000343","volume":"53","author":"WF Harrington","year":"1984","unstructured":"Harrington WF, Rodgers ME (1984) Myosin. Annu Rev Biochem 53(1):35\u201373","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"423_CR15","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/bioinformatics\/bth464","volume":"21","author":"R Homayouni","year":"2005","unstructured":"Homayouni R et al (2005) Gene clustering by latent semantic indexing of MEDLINE abstracts. Bioinformatics 21(1):104\u2013115","journal-title":"Bioinformatics"},{"issue":"2","key":"423_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.31887\/DCNS.2017.19.2\/cjones","volume":"19","author":"C Jones","year":"2017","unstructured":"Jones C et al (2017) Oxytocin and social functioning. Dialogues Clin Neurosci 19(2):193\u2013201","journal-title":"Dialogues Clin Neurosci"},{"issue":"3\u20134","key":"423_CR17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbrc.2011.11.044","volume":"416","author":"MP Josephson","year":"2011","unstructured":"Josephson MP et al (2011) Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain. Biochem Biophys Res Commun 416(3\u20134):367\u2013371","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"423_CR18","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jmb.2009.02.006","volume":"387","author":"K Kazmierczak","year":"2009","unstructured":"Kazmierczak K et al (2009) The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction. J Mol Biol 387(3):706\u2013725","journal-title":"J Mol Biol"},{"key":"423_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ydbio.2020.11.008","volume":"470","author":"D Kula-Alwar","year":"2021","unstructured":"Kula-Alwar D et al (2021) Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle. Dev Biol 470:95\u2013107","journal-title":"Dev Biol"},{"issue":"2","key":"423_CR20","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/JOE-17-0002","volume":"233","author":"S Lee","year":"2017","unstructured":"Lee S, Dong HH (2017) FoxO integration of insulin signaling with glucose and lipid metabolism. J Endocrinol 233(2):R67","journal-title":"J Endocrinol"},{"issue":"9","key":"423_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1771","volume":"9","author":"B Li","year":"2021","unstructured":"Li B et al (2021) Genetic and functional analyses detect one pathological NFATC1 mutation in a Chinese tricuspid atresia family. Mol Genet Genomic Med 9(9):e1771","journal-title":"Mol Genet Genomic Med"},{"issue":"W1","key":"423_CR22","doi-asserted-by":"publisher","first-page":"W199","DOI":"10.1093\/nar\/gkz401","volume":"47","author":"Y Liao","year":"2019","unstructured":"Liao Y et al (2019) WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res 47(W1):W199\u2013W205","journal-title":"Nucleic Acids Res"},{"key":"423_CR23","doi-asserted-by":"publisher","first-page":"baac083","DOI":"10.1093\/database\/baac083","volume":"2022","author":"O Liska","year":"2022","unstructured":"Liska O et al (2022) TFLink: an integrated gateway to access transcription factor\u2013target gene interactions for multiple species. Database 2022:baac083","journal-title":"Database"},{"key":"423_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pbb.2013.06.011","volume":"119","author":"TM Love","year":"2014","unstructured":"Love TM (2014) Oxytocin, motivation and the role of dopamine. Pharmacol Biochem Behav 119:49\u201360","journal-title":"Pharmacol Biochem Behav"},{"issue":"7","key":"423_CR25","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41431-019-0364-y","volume":"27","author":"I Luyckx","year":"2019","unstructured":"Luyckx I et al (2019) Copy number variation analysis in bicuspid aortic valve-related aortopathy identifies TBX20 as a contributing gene. Eur J Hum Genet 27(7):1033\u20131043","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"423_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ydbio.2018.12.002","volume":"445","author":"SC Materna","year":"2019","unstructured":"Materna SC et al (2019) Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage. Dev Biol 445(2):170\u2013177","journal-title":"Dev Biol"},{"issue":"9","key":"423_CR27","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1161\/CIRCULATIONAHA.118.033939","volume":"138","author":"S Meng","year":"2018","unstructured":"Meng S et al (2018) TBX20 regulates angiogenesis through the prokineticin 2\u2013prokineticin receptor 1 pathway. Circulation 138(9):913\u2013928","journal-title":"Circulation"},{"key":"423_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11010-016-2666-5","volume":"414","author":"A Mittal","year":"2016","unstructured":"Mittal A et al (2016) Role of cardiac TBX20 in dilated cardiomyopathy. Mol Cell Biochem 414:129\u2013136","journal-title":"Mol Cell Biochem"},{"key":"423_CR29","doi-asserted-by":"crossref","unstructured":"Mulligan, M.K., et al., 2017 GeneNetwork: a toolbox for systems genetics. Systems genetics: Methods and protocols, 75\u2013120.","DOI":"10.1007\/978-1-4939-6427-7_4"},{"key":"423_CR30","doi-asserted-by":"publisher","first-page":"3494289","DOI":"10.1155\/2017\/3494289","volume":"2017","author":"G Murtaza","year":"2017","unstructured":"Murtaza G et al (2017) FOXO transcriptional factors and long-term living. Oxid Med Cell Longev 2017:3494289","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"423_CR31","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3892\/ijmm.2015.2077","volume":"35","author":"Y Pan","year":"2015","unstructured":"Pan Y et al (2015) TBX20 loss-of-function mutation contributes to double outlet right ventricle. Int J Mol Med 35(4):1058\u20131066","journal-title":"Int J Mol Med"},{"issue":"11","key":"423_CR32","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.7150\/ijms.21353","volume":"14","author":"X-H Qiao","year":"2017","unstructured":"Qiao X-H et al (2017) MEF2C loss-of-function mutation contributes to congenital heart defects. Int J Med Sci 14(11):1143","journal-title":"Int J Med Sci"},{"issue":"1","key":"423_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.gene.2015.06.027","volume":"569","author":"F Sheikh","year":"2015","unstructured":"Sheikh F, Lyon RC, Chen J (2015) Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease. Gene 569(1):14\u201320","journal-title":"Gene"},{"issue":"12","key":"423_CR34","doi-asserted-by":"publisher","first-page":"4640","DOI":"10.1172\/JCI59472","volume":"121","author":"T Shen","year":"2011","unstructured":"Shen T et al (2011) Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Investig 121(12):4640\u20134654","journal-title":"J Clin Investig"},{"issue":"7400","key":"423_CR35","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature11139","volume":"485","author":"K Song","year":"2012","unstructured":"Song K et al (2012) Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485(7400):599\u2013604","journal-title":"Nature"},{"issue":"2","key":"423_CR36","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0012-1606(03)00385-3","volume":"262","author":"FA Stennard","year":"2003","unstructured":"Stennard FA et al (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 262(2):206\u2013224","journal-title":"Dev Biol"},{"issue":"D1","key":"423_CR37","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D et al (2019) STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res 47(D1):D607\u2013D613","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"423_CR38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1161\/CIRCULATIONAHA.121.058655","volume":"147","author":"H Tani","year":"2023","unstructured":"Tani H et al (2023) Direct reprogramming improves cardiac function and reverses fibrosis in chronic myocardial infarction. Circulation 147(3):223\u2013238","journal-title":"Circulation"},{"key":"423_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2022.106804","volume":"114","author":"X Wang","year":"2022","unstructured":"Wang X et al (2022) A systems genetics approach delineates the role of Bcl2 in leukemia pathogenesis. Leuk Res 114:106804","journal-title":"Leuk Res"},{"issue":"8","key":"423_CR40","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrm3619","volume":"14","author":"M Xin","year":"2013","unstructured":"Xin M, Olson EN, Bassel-Duby R (2013) Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat Rev Mol Cell Biol 14(8):529\u2013541","journal-title":"Nat Rev Mol Cell Biol"},{"key":"423_CR41","first-page":"1","volume":"15","author":"X Yang","year":"2016","unstructured":"Yang X et al (2016) Relationship between TBX20 gene polymorphism and congenital heart disease. Genet Mol Res 15:1\u20139","journal-title":"Genet Mol Res"},{"issue":"8","key":"423_CR42","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1002\/ajmg.a.62871","volume":"188","author":"ZH Zeng","year":"2022","unstructured":"Zeng ZH et al (2022) Functional significance of novel variants of the MEF2C gene promoter in congenital ventricular septal defects. Am J Med Genet A 188(8):2397\u20132405","journal-title":"Am J Med Genet A"},{"issue":"2","key":"423_CR43","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1515\/cclm-2015-0328","volume":"54","author":"C-M Zhao","year":"2016","unstructured":"Zhao C-M et al (2016) TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy. Clin Chem Lab Med (CCLM) 54(2):325\u2013332","journal-title":"Clin Chem Lab Med (CCLM)"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-024-00423-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11248-024-00423-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-024-00423-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T22:03:29Z","timestamp":1736287409000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11248-024-00423-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["423"],"URL":"https:\/\/doi.org\/10.1007\/s11248-024-00423-8","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"value":"0962-8819","type":"print"},{"value":"1573-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"11 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"5"}}