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In Experiment 1, different concentrations (100, 200, and 400\u00a0\u00b5g\/mL) of RES, CUR, a combination of both (MIX), MON (12\u00a0\u00b5g\/mL), and a control group were evaluated for their ability to counteract ruminal acidosis. Acidosis was induced by incubating glucose (0.1\u00a0g\/mL) without buffer for 6\u00a0h to simulate a highly fermentable, unbuffered ruminal environment. In Experiment 2, RES (200\u00a0\u00b5g\/mL), CUR (200\u00a0\u00b5g\/mL), MIX (200\u00a0\u00b5g\/mL), and MON were compared when buffer was added, and fermentation was extended to 24\u00a0h using the same substrate as in Experiment 1. Experiment 3 examined the effect of RES (200\u00a0\u00b5g\/mL) on acidosis in vitro using corn, barley, or wheat as substrates, and compared it to MON. In Experiment 1, pH increased significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) and gas production decreased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) with the addition of RES and MIX at 200 and 400\u00a0g\/mL as well as MON at 12\u00a0\u00b5g\/mL, whereas CUR had no effect on pH (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). In Experiment 2, both RES and MON increased pH (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) and reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) lactic acid concentration. MON and RES increased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) propionic acid and reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) the acetate to propionate ratio. While MON significantly reduced total volatile fatty acid (VFA) concentrations (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) compared to the control, RES had no significant effect. In Experiment 3, when corn was used as a substrate, RES was found to significantly increase (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) pH and decrease lactic acid levels in comparison to barley or wheat. MON improved (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) propionate levels and decreased (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) the ratio of acetate to propionate. Both RES and MON did not affect the total VFA. In conclusion, RES shows promise as a natural alternative to MON for preventing rumen acidosis, particularly when corn is used as a basal diet. The findings indicate that RES can effectively increase ruminal pH and reduce lactic acid levels, which are key factors in mitigating acidosis.\n                  <\/jats:p>","DOI":"10.1007\/s11250-025-04632-z","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:31:50Z","timestamp":1758547910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resveratrol and curcumin as natural alternatives to monensin for preventing in vitro induced ruminal acidosis in buffalo bulls"],"prefix":"10.1007","volume":"57","author":[{"given":"Eman A.","family":"Elwakeel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam G.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan B.","family":"El-sawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Z.","family":"El-Zarkouny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-4106","authenticated-orcid":false,"given":"Adham A.","family":"Al-Sagheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"4632_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s12917-022-03457-4","volume":"18","author":"MG Ahmed","year":"2022","unstructured":"Ahmed MG, Al-Sagheer AA, El-Zarkouny SZ, Elwakeel EA (2022) Potential of selected plant extracts to control severe subacute ruminal acidosis in vitro as compared with Monensin. 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