{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:10:44Z","timestamp":1781629844039,"version":"3.54.5"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Anim Health Prod"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alpha-lipoic acid (\u03b1-LA) is a potent antioxidant with potential to enhance ruminant health and productivity, yet its effects in late-pregnant ewes are not well defined. This study evaluated \u03b1-LA supplementation (600\u00a0mg\/day) from 60 days prepartum to 8 weeks postpartum on blood biochemistry, immunity, colostrum and milk composition, microbiological quality, and lamb performance in Egyptian ewes. Thirty ewes were randomly allocated to control or \u03b1-LA groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915). On day one postpartum, \u03b1-LA ewes had higher serum albumin (2.87 vs. 2.45\u00a0g\/dL), globulin (2.76 vs. 2.58\u00a0g\/dL), total protein (5.64 vs. 5.04\u00a0g\/dL), and total antioxidant capacity (29.97 vs. 28.19 mM\/L;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.01). Elevated immunoglobulin A persisted at 4 weeks (80.20 vs. 73.40 ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Lambs from supplemented ewes showed greater IgA (135.40 vs. 89.00 ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), glutathione peroxidase (29.16 vs. 20.51 U\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), TAC (56.48 vs. 31.80 mM\/L;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and higher birth (4.52 vs. 3.84\u00a0kg) and weaning weights (7.39 vs. 6.00\u00a0kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Colostrum from \u03b1-LA ewes contained more fat (16.75 vs. 7.98%), protein (8.91 vs. 6.66%), and total immunoglobulins (21.47 vs. 5.84;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), while both colostrum and milk had reduced bacterial counts and prevalence of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella spp<\/jats:italic>\n                    ., and\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    . In conclusion, periparturient \u03b1-LA supplementation improved maternal immunity, antioxidant capacity, colostrum and milk quality, and lamb growth. Further research should determine optimal dosing, assess long-term impacts on milk yield, and explore its integration into mastitis control programs.\n                  <\/jats:p>","DOI":"10.1007\/s11250-025-04831-8","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T13:54:28Z","timestamp":1768226068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periparturient alpha-lipoic acid supplementation improves ewe antioxidant status, colostrum quality, and lamb growth"],"prefix":"10.1007","volume":"58","author":[{"given":"Mohammed Hamed","family":"Eldawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad Mohammed","family":"Elken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail Abdelraouf","family":"Elnady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa A. E.","family":"Asfour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Shaimaa N.","family":"Mehany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Gamal","family":"Rashad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haney","family":"Samir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam R.","family":"El-Sherbiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-2338","authenticated-orcid":false,"given":"Nadia Hamdi","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"4831_CR1","doi-asserted-by":"publisher","unstructured":"Abdelnaby EA, Fathi M, Salem NY et al (2024) Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged baladi bucks. BMC Vet Res 20. https:\/\/doi.org\/10.1186\/s12917-024-04134-4","DOI":"10.1186\/s12917-024-04134-4"},{"key":"4831_CR2","doi-asserted-by":"publisher","unstructured":"Aver\u00f3s X, Granado-Tajada I, Arranz J et al (2022) Pre-partum supplementation with polyunsaturated fatty acids on colostrum characteristics and lamb immunity and behavior after a mild post-weaning aversive handling period. Animals 12. https:\/\/doi.org\/10.3390\/ani12141780","DOI":"10.3390\/ani12141780"},{"key":"4831_CR3","doi-asserted-by":"publisher","unstructured":"Barrientos G, Schuman ML, Landa MS et al (2024) Therapeutic effect of alpha lipoic acid in a rat preclinical model of preeclampsia: focus on maternal signs, fetal growth and placental function. Antioxidants 13. https:\/\/doi.org\/10.3390\/antiox13060730","DOI":"10.3390\/antiox13060730"},{"key":"4831_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1159\/000459586","volume":"12","author":"A Belfield","year":"1971","unstructured":"Belfield A, Goldberg DM (1971) Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme 12:561\u2013573. https:\/\/doi.org\/10.1159\/000459586","journal-title":"Enzyme"},{"key":"4831_CR5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1071\/EA96014","volume":"37","author":"R Bencini","year":"1997","unstructured":"Bencini R, Pulina G (1997) The quality of sheep milk: a review. Aust J Exp Agric 37:485\u2013504. https:\/\/doi.org\/10.1071\/EA96014","journal-title":"Aust J Exp Agric"},{"key":"4831_CR6","first-page":"144","volume":"18","author":"R Bencini","year":"1990","unstructured":"Bencini R, Purvis IW (1990) The yield and composition of milk from Merino sheep. Proc Australian Soc Anim Prod 18:144\u2013147","journal-title":"Proc Australian Soc Anim Prod"},{"key":"4831_CR7","doi-asserted-by":"crossref","unstructured":"Bruckner GK (2009) The role of the world organization for animal health (OIE) to facilitate the international trade in animals and animal products: policy and trade issues. Onderstepoort J Vet Res","DOI":"10.4102\/ojvr.v76i1.78"},{"key":"4831_CR8","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1159\/000480217","volume":"42","author":"P Chang","year":"2017","unstructured":"Chang P, Liu J, Yu Y et al (2017) Alpha-Lipoic acid suppresses extracellular Histone-Induced release of the infammatory mediator tumor necrosis Factor-\u03b1 by macrophages. Cell Physiol Biochem 42:2559\u20132568. https:\/\/doi.org\/10.1159\/000480217","journal-title":"Cell Physiol Biochem"},{"key":"4831_CR9","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.3390\/nu15092193","volume":"15","author":"N Chen","year":"2023","unstructured":"Chen N, Zeng R, Xu C et al (2023) Low serum creatinine levels in early pregnancy are associated with a higher incidence of postpartum abnormal glucose metabolism among women with gestational diabetes mellitus: A retrospective cohort study. Nutrients 15:2193. https:\/\/doi.org\/10.3390\/nu15092193","journal-title":"Nutrients"},{"key":"4831_CR10","doi-asserted-by":"publisher","unstructured":"\u00c7olako\u011flu HE, Yazl\u0131k MO, \u00c7olako\u011flu E\u00c7 et al (2021) Oxidative stress in cows according to calving season: passive calf immunity and its relationship with colostrum quality. Pol J Vet Sci 225\u2013233. https:\/\/doi.org\/10.24425\/pjvs.2021.137657","DOI":"10.24425\/pjvs.2021.137657"},{"key":"4831_CR11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nclimate1633","volume":"3","author":"A Dai","year":"2013","unstructured":"Dai A (2013) Increasing drought under global warming in observations and models. Nat Clim Chang 3:52\u201358. https:\/\/doi.org\/10.1038\/nclimate1633","journal-title":"Nat Clim Chang"},{"key":"4831_CR29","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.5433\/1679-0359.2015v36n3p1397","volume":"36","author":"PM do Nascimento","year":"2015","unstructured":"do Nascimento PM, Morgado AA, Nunes GR et al (2015) Metabolismo oxidativo e perfil bioqu\u00edmico de ovelhas Santa in\u00eas no per\u00edodo periparto: Efeito Da suplementa\u00e7\u00e3o parenteral com vitamina E. Semin Cienc Agrar 36:1397. https:\/\/doi.org\/10.5433\/1679-0359.2015v36n3p1397","journal-title":"Semin Cienc Agrar"},{"key":"4831_CR12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","volume":"31","author":"BT Doumas","year":"1971","unstructured":"Doumas BT, Watson WA, Biggs HG (1971) Albumin standards and the measurement of serum albumin with Bromcresol green. Clin Chim Acta 31:87\u201396. https:\/\/doi.org\/10.1016\/0009-8981(71)90365-2","journal-title":"Clin Chim Acta"},{"key":"4831_CR13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/microorganisms13020394","volume":"13","author":"H Du","year":"2025","unstructured":"Du H, Li K, Guo W et al (2025) Roughage sources during late gestation and lactation alter Metabolism, immune function and rumen microbiota in Ewes and their offsprings. Microorganisms 13:394. https:\/\/doi.org\/10.3390\/microorganisms13020394","journal-title":"Microorganisms"},{"key":"4831_CR14","doi-asserted-by":"publisher","first-page":"515","DOI":"10.21608\/ejnf.2020.148160","volume":"23","author":"T El-Rayes","year":"2020","unstructured":"El-Rayes T (2020) Assessment of the effect of \u0391-Lipoic acid supplementation to the diet with different dietary energy levels on broiler performance and atioxidants status. Egypt J Nutr Feeds 23:515\u2013526. https:\/\/doi.org\/10.21608\/ejnf.2020.148160","journal-title":"Egypt J Nutr Feeds"},{"key":"4831_CR15","doi-asserted-by":"publisher","unstructured":"Farooq U, Ahmed S, Liu G et al (2024) Biochemical properties of sheep colostrum and its potential benefits for lamb survival: a review. Anim Biotechnol 35. https:\/\/doi.org\/10.1080\/10495398.2024.2320726","DOI":"10.1080\/10495398.2024.2320726"},{"key":"4831_CR16","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.3168\/jds.2024-25279","volume":"108","author":"J Gao","year":"2025","unstructured":"Gao J, Marins TN, Calix JOS et al (2025) Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving. J Dairy Sci 108:2090\u20132110. https:\/\/doi.org\/10.3168\/jds.2024-25279","journal-title":"J Dairy Sci"},{"key":"4831_CR17","doi-asserted-by":"publisher","unstructured":"Grayczyk JP, Alonzo F (2019) Staphylococcus aureus lipoic acid synthesis limits macrophage reactive oxygen and nitrogen species production to promote survival during infection. Infect Immun 87. https:\/\/doi.org\/10.1128\/IAI.00344-19","DOI":"10.1128\/IAI.00344-19"},{"key":"4831_CR18","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/clinchem\/21.7.844","volume":"21","author":"PD Henry","year":"1975","unstructured":"Henry PD, Roberts R, Sobel BE (1975) Rapid separation of plasma creatine kinase isoenzymes by batch adsorption on glass beads. Clin Chem 21:844\u2013849. https:\/\/doi.org\/10.1093\/clinchem\/21.7.844","journal-title":"Clin Chem"},{"key":"4831_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.29393\/CHJAA39-17DRMP60017","volume":"39","author":"M Huerta-Jim\u00e9nez","year":"2023","unstructured":"Huerta-Jim\u00e9nez M, Ortega-Cerrilla ME, Herrera-Haro JG et al (2023) Digestibility, rumen Fermentation, rumen Microbiota, and lipid peroxidation in sheep supplemented with lipoic acid. Chil J Agricultural Anim Sci 39:198\u2013209. https:\/\/doi.org\/10.29393\/CHJAA39-17DRMP60017","journal-title":"Chil J Agricultural Anim Sci"},{"key":"4831_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/metabo13020149","volume":"13","author":"X Ji","year":"2023","unstructured":"Ji X, Liu N, Wang Y et al (2023) Pregnancy toxemia in ewes: A review of molecular metabolic mechanisms and management strategies. Metabolites 13:149. https:\/\/doi.org\/10.3390\/metabo13020149","journal-title":"Metabolites"},{"key":"4831_CR21","first-page":"201","volume-title":"Clinical biochemistry of domestic animals","author":"JJ Kaneko","year":"2008","unstructured":"Kaneko JJ, Harvey JW, Bruss ML (2008) Clinical biochemistry of domestic animals, 6th edn. Academic, San Diego, USA, pp 201\u2013257","edition":"6"},{"key":"4831_CR22","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.22092\/ARI.2022.359922.2515","volume":"78","author":"MM Khames","year":"2023","unstructured":"Khames MM, Shareef SO, Abdulealah IM (2023) Clinical and biochemical study of pregnancy toxemia in Iraqi Ewes. Arch Razi Inst 78:1131\u20131139. https:\/\/doi.org\/10.22092\/ARI.2022.359922.2515","journal-title":"Arch Razi Inst"},{"key":"4831_CR23","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/jcp.54.5.356","volume":"54","author":"D Koracevic","year":"2001","unstructured":"Koracevic D, Koracevic G, Djordjevic V et al (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54:356\u2013361. https:\/\/doi.org\/10.1136\/jcp.54.5.356","journal-title":"J Clin Pathol"},{"key":"4831_CR24","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s10753-014-9957-3","volume":"38","author":"G Li","year":"2015","unstructured":"Li G, Fu J, Zhao Y et al (2015) Alpha-Lipoic acid exerts Anti-Inflammatory effects on Lipopolysaccharide-Stimulated rat mesangial cells via Inhibition of nuclear factor kappa B (NF-\u03baB) signaling pathway. Inflammation 38:510\u2013519. https:\/\/doi.org\/10.1007\/s10753-014-9957-3","journal-title":"Inflammation"},{"key":"4831_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.fsi.2022.05.029","volume":"126","author":"M Li","year":"2022","unstructured":"Li M, Kong Y, Lai Y et al (2022) The effects of dietary supplementation of \u03b1-lipoic acid on the growth performance, antioxidant capacity, immune response, and disease resistance of Northern snakehead, Channa Argus. Fish Shellfish Immunol 126:57\u201372. https:\/\/doi.org\/10.1016\/j.fsi.2022.05.029","journal-title":"Fish Shellfish Immunol"},{"key":"4831_CR26","doi-asserted-by":"publisher","first-page":"116009","DOI":"10.1016\/j.anifeedsci.2024.116009","volume":"313","author":"M Li","year":"2024","unstructured":"Li M, Zhang Y, Yuan X et al (2024) Effects of alpha-lipoic acid on the growth performance and serum biochemical index values of puppies. Anim Feed Sci Technol 313:116009. https:\/\/doi.org\/10.1016\/j.anifeedsci.2024.116009","journal-title":"Anim Feed Sci Technol"},{"key":"4831_CR27","doi-asserted-by":"publisher","unstructured":"Luo Y, Ju N, Chang J et al (2022) Dietary \u03b1-lipoic acid supplementation improves postmortem color stability of the lamb muscles through changing muscle fiber types and antioxidative status. Meat Sci 193. https:\/\/doi.org\/10.1016\/j.meatsci.2022.108945","DOI":"10.1016\/j.meatsci.2022.108945"},{"key":"4831_CR28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10911-014-9328-6","volume":"19","author":"JR Middleton","year":"2014","unstructured":"Middleton JR, Saeman A, Fox LK et al (2014) The National mastitis council: a global organization for mastitis control and milk quality, 50 years and beyond. J Mammary Gland Biol Neoplasia 19:241\u2013251. https:\/\/doi.org\/10.1007\/s10911-014-9328-6","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"4831_CR30","doi-asserted-by":"publisher","first-page":"80","DOI":"10.30704\/http-www-jivs-net.1335313","volume":"7","author":"C \u00d6vet","year":"2023","unstructured":"\u00d6vet C (2023) Colostrum induced passive immune transfer in lambs. J Istanbul Veterinary Sci 7:80\u201388. https:\/\/doi.org\/10.30704\/http-www-jivs-net.1335313","journal-title":"J Istanbul Veterinary Sci"},{"key":"4831_CR31","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158\u2013169","journal-title":"J Lab Clin Med"},{"key":"4831_CR32","volume-title":"Veterinary microbiology and microbial disease","author":"PJ Quinn","year":"2011","unstructured":"Quinn PJ, Markey BK, Leonard FC et al (2011) Veterinary microbiology and microbial disease, 2nd edn. Wiley-Blackwell, Oxford, UK","edition":"2"},{"key":"4831_CR33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56\u201363. https:\/\/doi.org\/10.1093\/ajcp\/28.1.56","journal-title":"Am J Clin Pathol"},{"key":"4831_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/jas\/skz258.866","volume":"97","author":"C Robles","year":"2019","unstructured":"Robles C, Davalos LG, Mora O et al (2019) PSXIV-19 effect of alpha-lipoic acid on productive parameters and ruminal VFA profile in sheep. J Anim Sci 97:437\u2013438. https:\/\/doi.org\/10.1093\/jas\/skz258.866","journal-title":"J Anim Sci"},{"key":"4831_CR35","doi-asserted-by":"publisher","unstructured":"Robles-Rodr\u00edguez C, Gonz\u00e1lez-D\u00e1valos L, Dom\u00ednguez-Hern\u00e1ndez Y et al (2022) Effect of alpha-lipoic acid on productive parameters and ruminal VFA profile in sheep. Asian Res J Agric 9\u201318. https:\/\/doi.org\/10.9734\/arja\/2022\/v15i330157","DOI":"10.9734\/arja\/2022\/v15i330157"},{"key":"4831_CR36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/jpen.1422","volume":"43","author":"J Sun","year":"2019","unstructured":"Sun J, Li Y, Pan X et al (2019) Human milk fortification with bovine colostrum is superior to Formula-Based fortifiers to prevent gut Dysfunction, necrotizing Enterocolitis, and systemic infection in preterm pigs. J Parenter Enter Nutr 43:252\u2013262. https:\/\/doi.org\/10.1002\/jpen.1422","journal-title":"J Parenter Enter Nutr"},{"key":"4831_CR37","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/antiox13101228","volume":"13","author":"F Superti","year":"2024","unstructured":"Superti F, Russo R (2024) Alpha-Lipoic acid: biological mechanisms and health benefits. Antioxidants 13:1228. https:\/\/doi.org\/10.3390\/antiox13101228","journal-title":"Antioxidants"},{"key":"4831_CR38","doi-asserted-by":"publisher","first-page":"E305","DOI":"10.21037\/jtd.2016.03.62","volume":"8","author":"C Thongprayoon","year":"2016","unstructured":"Thongprayoon C, Cheungpasitporn W, Kashani K (2016) Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients. J Thorac Dis 8:E305\u2013E311. https:\/\/doi.org\/10.21037\/jtd.2016.03.62","journal-title":"J Thorac Dis"},{"key":"4831_CR39","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3390\/agriculture13051035","volume":"13","author":"C T\u00f3thov\u00e1","year":"2023","unstructured":"T\u00f3thov\u00e1 C, Link R, Glembov\u00e1 V, Nagy O (2023) Evaluation of the differences in the serum protein electrophoretic pattern in precolostral serum of farm animal neonates. Agriculture 13:1035. https:\/\/doi.org\/10.3390\/agriculture13051035","journal-title":"Agriculture"},{"key":"4831_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.5194\/gmd-9-175-2016","volume":"9","author":"Y Wada","year":"2016","unstructured":"Wada Y, Fl\u00f6rke M, Hanasaki N et al (2016) Modeling global water use for the 21st century: the water futures and solutions (WFaS) initiative and its approaches. Geosci Model Dev 9:175\u2013222. https:\/\/doi.org\/10.5194\/gmd-9-175-2016","journal-title":"Geosci Model Dev"},{"key":"4831_CR41","doi-asserted-by":"publisher","unstructured":"Ward ES, Gelinas D, Dreesen E et al (2022) Clinical significance of serum albumin and implications of FcRn inhibitor treatment in IgG-mediated autoimmune disorders. Front Immunol 13. https:\/\/doi.org\/10.3389\/fimmu.2022.892534","DOI":"10.3389\/fimmu.2022.892534"},{"key":"4831_CR42","doi-asserted-by":"publisher","unstructured":"Wu H, Wang Y, Li H et al (2022) Protective effect of alkaline phosphatase supplementation on infant health. Foods 11. https:\/\/doi.org\/10.3390\/foods11091212","DOI":"10.3390\/foods11091212"},{"key":"4831_CR43","doi-asserted-by":"publisher","unstructured":"Yang X, Zhang H, Pang F et al (2023) Effects of \u03b1-lipoic acid on growth performance, antioxidant capacity, and immune function in sheep. J Anim Sci 101. https:\/\/doi.org\/10.1093\/jas\/skad092","DOI":"10.1093\/jas\/skad092"},{"key":"4831_CR44","doi-asserted-by":"publisher","unstructured":"Yao Z, Li G, Yang X et al (2024) Transcriptomic and metabolomic insight into the roles of \u03b1-lipoic acid in the antioxidant mechanisms of sheep. Agric (Switzerland) 14. https:\/\/doi.org\/10.3390\/agriculture14112055","DOI":"10.3390\/agriculture14112055"},{"key":"4831_CR45","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3906\/vet-1210-33","volume":"37","author":"\u00d6 Yilmaz","year":"2013","unstructured":"Yilmaz \u00d6, Kasikci G (2013) Factors affecting colostrum quality of Ewes and immunostimulation. Turk J Vet Anim Sci 37:390\u2013394. https:\/\/doi.org\/10.3906\/vet-1210-33","journal-title":"Turk J Vet Anim Sci"},{"key":"4831_CR47","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s11250-021-02917-7","volume":"53","author":"H Zhang","year":"2021","unstructured":"Zhang H, Yang G, Li H et al (2021) Effects of dietary supplementation with alpha-lipoic acid on apparent digestibility and serum metabolome alterations of sheep in summer. Trop Anim Health Prod 53:505. https:\/\/doi.org\/10.1007\/s11250-021-02917-7","journal-title":"Trop Anim Health Prod"},{"key":"4831_CR46","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859624000649","author":"H Zhang","year":"2024","unstructured":"Zhang H, Jiang Z, Fu T et al (2024) Effects of alpha-lipoic acid on productive performance, immunity, antioxidation and serum metabolism in Holstein cows. J Agric Sci. https:\/\/doi.org\/10.1017\/S0021859624000649","journal-title":"J Agric Sci"}],"container-title":["Tropical Animal Health and Production"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-025-04831-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11250-025-04831-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-025-04831-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:37:37Z","timestamp":1781627857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11250-025-04831-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4831"],"URL":"https:\/\/doi.org\/10.1007\/s11250-025-04831-8","relation":{},"ISSN":["0049-4747","1573-7438"],"issn-type":[{"value":"0049-4747","type":"print"},{"value":"1573-7438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"17 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethical Committee for the Use and Care of Animals at the Faculty of Agriculture, Al-Azhar University, approved and accredited the study (Approval No. AZHU6D625).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The researchers declare that there is no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}