{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:09:25Z","timestamp":1790741365455,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade De S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Anim Health Prod"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Zinc oxide nanoparticles (N-ZnO) represent a promising alternative for zinc (Zn) supplementation, since their reduced size provides greater bioavailability and better integration into the body. Furthermore, this characteristic becomes particularly relevant during periods of increased metabolic stress, such as the transition phase. Thus, the objective was to evaluate the effects of N-ZnO supplementation in Santa In\u00eas sheep during the peripartum period. Thirty-three ewes with an average body weight of 43.3\u2009\u00b1\u20092.05\u00a0kg were, distributed into three experimental groups: control group (CON), without supplementation, receiving only\n                    <jats:italic>Cynodon<\/jats:italic>\n                    spp. hay; and groups supplemented with 300\u00a0mg\/animal\/day of N-ZnO (40\u00a0nm) and zinc oxide microparticles (M-ZnO). The supplementation was administered orally in capsules daily from late pregnancy until weaning. The results showed no significant differences (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05) in body weight, egg count per gram of feces (EPG), and in most of the hematological, biochemical, and immunological parameters evaluated. However, differences (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) were observed in monocyte counts and albumin levels, with higher means in the N-ZnO group, showing differences compared with the M-ZnO group, while the CON group maintained intermediate values. The N-ZnO group showed differences compared to the M-ZnO group, while the CON group maintained intermediate values. Regarding antioxidant activity, a significant effect (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) was observed on the enzymes Superoxidase dismutase (SOD), Glutathione peroxidase (GPx), Catalase (Cat), and on the total antioxidant status (ORAC) of the sheep supplemented with N-ZnO. It is concluded that N-ZnO supplementation improved the antioxidant response, with no signs of intoxication, using a dose of 300\u00a0mg during the period of greatest oxidative stress.\n                  <\/jats:p>","DOI":"10.1007\/s11250-026-05156-w","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:16:20Z","timestamp":1781496980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of zinc oxide nanoparticle supplementation in Santa In\u00eas ewes during the transition period"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8916-6825","authenticated-orcid":false,"given":"Willinton Hernan Pinchao","family":"Pinchao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique de Brito","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Rodriguez","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele Rossini","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Ant\u00f4nio","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Gon\u00e7alves Santos","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Morita","family":"Katiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete Aparecida de Nadai","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus Oliveira","family":"Mena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar Cristiano","family":"Bassetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia Alexandre de","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Francisco Talamini do","family":"Amarante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Louvandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"7","key":"5156_CR1","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.3390\/ani11071916","volume":"11","author":"SA Abdelnour","year":"2021","unstructured":"Abdelnour SA, Alagawany M, Hashem NM, Farag MR, Alghamdi ES, Hassan FU, Bilal RM, Elnesr SS, Dawood MAO, Nagadi SA et al (2021) Nanominerals: Fabrication methods, benefits and hazards, and their applications in ruminants with special reference to selenium and zinc nanoparticles. Animals 11(7):1916. https:\/\/doi.org\/10.3390\/ani11071916","journal-title":"Animals"},{"issue":"3","key":"5156_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/1745039X.2019.1690389","volume":"74","author":"M Abdollahi","year":"2020","unstructured":"Abdollahi M, Rezaei J, Fazaeli H (2020) Performance, rumen fermentation, blood minerals, leukocyte and antioxidant capacity of young Holstein calves receiving high-surface ZnO instead of common ZnO. Arch Anim Nutr 74(3):189\u2013205. https:\/\/doi.org\/10.1080\/1745039X.2019.1690389","journal-title":"Arch Anim Nutr"},{"issue":"1","key":"5156_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/antiox8010020","volume":"8","author":"A Abuelo","year":"2019","unstructured":"Abuelo A, Hern\u00e1ndez J, Benedito JL, Castillo C (2019) Redox biology in transition periods of dairy cattle: Role in the health of periparturient and neonatal animals. Antioxidants 8(1):20. https:\/\/doi.org\/10.3390\/antiox8010020","journal-title":"Antioxidants"},{"issue":"1","key":"5156_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2527\/tas2016.0010","volume":"1","author":"A Ademi","year":"2017","unstructured":"Ademi A, Bernhoft A, Govasmark E, Bytyqi H, Sivertsen T (2017) Singh B.R. Selenium and other mineral concentrations in feed and sheep\u2019s blood in Kosovo. Transl Anim Sci 1(1):97\u2013107. https:\/\/doi.org\/10.2527\/tas2016.0010","journal-title":"Transl Anim Sci"},{"key":"5156_CR5","volume-title":"Official methods of analysis of AOAC International. v. 1: Agricultural chemicals, contaminants, drugs","author":"AOAC International","year":"2005","unstructured":"AOAC International (2005) Official methods of analysis of AOAC International. v. 1: Agricultural chemicals, contaminants, drugs, 18th edn. AOAC International, Gaithersburg, MD","edition":"18"},{"key":"5156_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.exppara.2015.01.010","volume":"151\u2013152","author":"MD Baldissera","year":"2015","unstructured":"Baldissera MD, Pivoto FL, Bottari NB, Tonin AA, Machado G, Aires AR, Rocha JF, Pelinson LP, Dalenogare DP, Schetinger MR et al (2015) Effect of zinc supplementation on ecto-adenosine deaminase activity in lambs infected by Haemonchus contortus: highlights on acute phase of disease. Exp Parasitol 151\u2013152:34\u201338. https:\/\/doi.org\/10.1016\/j.exppara.2015.01.010","journal-title":"Exp Parasitol"},{"issue":"3","key":"5156_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","volume":"25","author":"GJ Burton","year":"2011","unstructured":"Burton GJ, Jauniaux E (2011) Oxidative stress. Best Pract. Res Clin Obstet Gynaecol 25(3):287\u2013299. https:\/\/doi.org\/10.1016\/j.bpobgyn.2010.10.016","journal-title":"Res Clin Obstet Gynaecol"},{"issue":"3\u20134","key":"5156_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/s0304-4017(99)00070-9","volume":"84","author":"RL Coop","year":"1999","unstructured":"Coop RL, Kyriazakis I (1999) Nutrition\u2013parasite interaction. Vet Parasitol 84(3\u20134):187\u2013204. https:\/\/doi.org\/10.1016\/s0304-4017(99)00070-9","journal-title":"Vet Parasitol"},{"issue":"34","key":"5156_CR9","doi-asserted-by":"publisher","first-page":"24085","DOI":"10.1074\/jbc.R600011200","volume":"281","author":"RJ Cousins","year":"2006","unstructured":"Cousins RJ, Liuzzi JP, Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281(34):24085\u201324089. https:\/\/doi.org\/10.1074\/jbc.R600011200","journal-title":"J Biol Chem"},{"issue":"3","key":"5156_CR10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1515\/ap-2018-0067","volume":"63","author":"B Esmaeilnejad","year":"2018","unstructured":"Esmaeilnejad B, Razavi SM, Asri-Rezaei S, Farhadi M (2018) Assessment of oxidative\/nitrosative stress biomarkers and DNA damage in Haemonchus contortus, following exposure to zinc oxide nanoparticles. Acta Parasitol 63(3):563\u2013571. https:\/\/doi.org\/10.1515\/ap-2018-0067","journal-title":"Acta Parasitol"},{"issue":"3","key":"5156_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.livsci.2011.12.007","volume":"144","author":"A Fadayifar","year":"2012","unstructured":"Fadayifar A, Asadi A, Bahari AA, Rafiee H (2012) Improvement in lamb performance on barley-based diet supplemented with zinc. Livest Sci 144(3):285\u2013289. https:\/\/doi.org\/10.1016\/j.livsci.2011.12.007","journal-title":"Livest Sci"},{"issue":"8","key":"5156_CR12","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.3923\/pjn.2009.1164.1166","volume":"8","author":"M Feng","year":"2009","unstructured":"Feng M, Wang ZS, Zhou AG, Ai DW (2009) The effects of different sizes of nanometer zinc oxide on the proliferation and cell integrity of mice duodenum-epithelial cells in primary culture. Pak J Nutr 8(8):1164\u20131166","journal-title":"Pak J Nutr"},{"issue":"Suppl 1","key":"5156_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1590\/S0100-736X2013001300013","volume":"33","author":"JH Fonteque","year":"2013","unstructured":"Fonteque JH, Nogueira CEW, Kohayagawa A, Lopes STA, Gon\u00e7alves RC, Ribeiro LAO (2013) Leucograma e metabolismo oxidativo de neutr\u00f3filos em cabras da ra\u00e7a Saanen nos per\u00edodos de gesta\u00e7\u00e3o, parto e p\u00f3s-parto. Pesq Vet Bras 33(Suppl 1):63\u201370. https:\/\/doi.org\/10.1590\/S0100-736X2013001300013","journal-title":"Pesq Vet Bras"},{"key":"5156_CR14","doi-asserted-by":"publisher","unstructured":"Gatti BS, Moreira CFF, Moreira LGC, Nogueira FB, Salvador GT, Antonelo DS et al (2025) Kinetics of 65Zn in sheep supplemented with micro- and nanoparticles of zinc oxide. Biological Trace Element Research. Advance online publication. https:\/\/doi.org\/10.1007\/s12011-025-04710-1","DOI":"10.1007\/s12011-025-04710-1"},{"issue":"3","key":"5156_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.5713\/ajas.2005.439","volume":"18","author":"TK Goswami","year":"2005","unstructured":"Goswami TK, Bhar R, Gulati BR, Jadhav SE, Srivastava RN (2005) Role of dietary zinc as a nutritional immunomodulator. Asian-Australas J Anim Sci 18(3):439\u2013452. https:\/\/doi.org\/10.5713\/ajas.2005.439","journal-title":"Asian-Australas J Anim Sci"},{"issue":"11","key":"5156_CR16","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1039\/C6SC01695A","volume":"7","author":"KB Handing","year":"2016","unstructured":"Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Garman EF (2016) Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins. Chem Sci 7(11):6635\u20136648. https:\/\/doi.org\/10.1039\/C6SC01695A","journal-title":"Chem Sci"},{"key":"5156_CR63","doi-asserted-by":"publisher","unstructured":"Hassan S, Hassan FU, Rehman MS (2020) Nano-particles of trace minerals in poultry nutrition: potential applicationsand future prospects. Biol Trace Elem Res 195:591\u2013612. https:\/\/doi.org\/10.1007\/s12011-019-01862-9","DOI":"10.1007\/s12011-019-01862-9"},{"issue":"2","key":"5156_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.cvfa.2011.02.004","volume":"27","author":"TH Herdt","year":"2011","unstructured":"Herdt TH, Hoff B (2011) The use of blood analysis to evaluate trace mineral status in ruminant livestock. Vet Clin North Am Food Anim Pract 27(2):255\u2013283. https:\/\/doi.org\/10.1016\/j.cvfa.2011.02.004","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"9","key":"5156_CR18","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.2460\/ajvr.1992.53.09.1524","volume":"53","author":"M Hoedemaker","year":"1992","unstructured":"Hoedemaker M, Lund LA, Wagner WC (1992) Function of neutrophils and chemoattractant properties of fetal placental tissue during the last month of pregnancy in cows. Am J Vet Res 53(9):1524\u20131529","journal-title":"Am J Vet Res"},{"key":"5156_CR19","doi-asserted-by":"publisher","first-page":"106170","DOI":"10.1016\/j.smallrumres.2020.106170","volume":"191","author":"SF Hosseini-Vardanjani","year":"2020","unstructured":"Hosseini-Vardanjani SF, Rezaei J, Karimi-Dehkordi S, Rouzbehan Y (2020) Effect of feeding nano-ZnO on performance, rumen fermentation, leukocytes, antioxidant capacity, blood serum enzymes and minerals of ewes. Small Rumin Res 191:106170. https:\/\/doi.org\/10.1016\/j.smallrumres.2020.106170","journal-title":"Small Rumin Res"},{"key":"5156_CR20","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1038\/srep03081","volume":"3","author":"T Iwase","year":"2013","unstructured":"Iwase T, Tajima A, Sugimoto S, Okuda K, Hironaka I, Kamata Y et al (2013) A simple assay for measuring catalase activity: A visual approach. Sci Rep 3:3081. https:\/\/doi.org\/10.1038\/srep03081","journal-title":"Sci Rep"},{"issue":"2","key":"5156_CR21","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3390\/nu13020692","volume":"13","author":"M Jouanne","year":"2021","unstructured":"Jouanne M, Oddoux S, Lain\u00e9 F, Kerdelhu\u00e9 B (2021) Nutrient requirements during pregnancy and lactation. Nutrients 13(2):692. https:\/\/doi.org\/10.3390\/nu13020692","journal-title":"Nutrients"},{"key":"5156_CR22","doi-asserted-by":"publisher","DOI":"10.1201\/b18198","volume-title":"Trace elements in abiotic and biotic environments","author":"A Kabata-Pendias","year":"2015","unstructured":"Kabata-Pendias A, Szteke B (2015) Trace elements in abiotic and biotic environments. CRC, Boca Raton, FL. https:\/\/doi.org\/10.1201\/b18198"},{"issue":"2","key":"5156_CR23","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s12011-019-1631-6","volume":"191","author":"R Kachuee","year":"2019","unstructured":"Kachuee R, Moeini MM, Souri M, Cheraghi S (2019) Effects of sodium selenite, L-selenomethionine, and selenium nanoparticles during late pregnancy on selenium, zinc, copper, and iron concentrations in Khalkhali goats and their kids. Biol Trace Elem Res 191(2):389\u2013402. https:\/\/doi.org\/10.1007\/s12011-019-1631-6","journal-title":"Biol Trace Elem Res"},{"key":"5156_CR24","volume-title":"Clinical biochemistry of domestic animals","author":"JJ Kaneko","year":"2008","unstructured":"Kaneko JJ, Harvey JW, Bruss ML (2008) Clinical biochemistry of domestic animals, 6th edn. Academic, San Diego, CA","edition":"6"},{"issue":"9","key":"5156_CR25","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.2527\/1995.7392721x","volume":"73","author":"EB Kegley","year":"1995","unstructured":"Kegley EB, Spears JW (1995) Immune response, glucose metabolism, and performance of stressed feeder calves fed inorganic or organic chromium. J Anim Sci 73(9):2721\u20132726. https:\/\/doi.org\/10.2527\/1995.7392721x","journal-title":"J Anim Sci"},{"key":"5156_CR26","doi-asserted-by":"publisher","first-page":"1387950","DOI":"10.3389\/fimmu.2024.1387950","volume":"15","author":"KW Kesler","year":"2024","unstructured":"Kesler KW, Abuelo A (2024) Zinc about it \u2013 zinc and calf immunity. Front Immunol 15:1387950. https:\/\/doi.org\/10.3389\/fimmu.2024.1387950","journal-title":"Front Immunol"},{"key":"5156_CR27","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.3390\/ma7042833","volume":"7","author":"A Ko\u0142odziejczak-Radzimska","year":"2014","unstructured":"Ko\u0142odziejczak-Radzimska A, Jesionowski T (2014) Zinc oxide \u2013 from synthesis to application: a review. Materials 7:2833\u20132881. https:\/\/doi.org\/10.3390\/ma7042833","journal-title":"Materials"},{"issue":"3","key":"5156_CR28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s40011-021-01212-7","volume":"91","author":"S Kumar","year":"2021","unstructured":"Kumar S, Mehra UR, Singh P, Verma AK, Singh SK (2021) Comparing efficacy of nano zinc on performance, nutrient utilization, immune and antioxidant status in Hariana cattle. Proc Natl Acad Sci India B Biol Sci 91(3):707\u2013713. https:\/\/doi.org\/10.1007\/s40011-021-01212-7","journal-title":"Proc Natl Acad Sci India B Biol Sci"},{"issue":"5","key":"5156_CR29","doi-asserted-by":"publisher","first-page":"e0233350","DOI":"10.1371\/journal.pone.0233350","volume":"15","author":"N Laur","year":"2020","unstructured":"Laur N, Bode L, Degen C, Knoll R, Heitland P, Wiegand U (2020) ICP-MS trace element analysis in serum and whole blood. PLoS ONE 15(5):e0233350. https:\/\/doi.org\/10.1371\/journal.pone.0233350","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"5156_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0304-4017(94)00755-J","volume":"60","author":"SE Leland","year":"1995","unstructured":"Leland SE (1995) Monospecific nematode infections of donor calves with Cooperia punctata. Vet Parasitol 60(1\u20132):111\u2013118. https:\/\/doi.org\/10.1016\/0304-4017(94)00755-J","journal-title":"Vet Parasitol"},{"issue":"3","key":"5156_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0019-2791(65)90004-2","volume":"2","author":"G Mancini","year":"1965","unstructured":"Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2(3):235\u2013254. https:\/\/doi.org\/10.1016\/0019-2791(65)90004-2","journal-title":"Immunochemistry"},{"issue":"2","key":"5156_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/antiox6020024","volume":"6","author":"DN Marreiro","year":"2017","unstructured":"Marreiro DN, Cruz KJC, Morais JBS, Beserra JB, Severo JS, De Oliveira ARS (2017) Zinc and oxidative stress: Current mechanisms. Antioxidants 6(2):24. https:\/\/doi.org\/10.3390\/antiox6020024","journal-title":"Antioxidants"},{"issue":"10","key":"5156_CR33","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.3390\/ijms18102222","volume":"18","author":"M Maywald","year":"2017","unstructured":"Maywald M, Wessels I, Rink L (2017) Zinc signals and immunity. Int J Mol Sci 18(10):2222. https:\/\/doi.org\/10.3390\/ijms18102222","journal-title":"Int J Mol Sci"},{"key":"5156_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.foodchem.2015.02.087","volume":"181","author":"PS Melo","year":"2015","unstructured":"Melo PS, Bergamaschi KB, Tiveron AP, Massarioli AP, Oldoni TLC, Zanus MC et al (2015) Winery by-products: Extraction optimization, phenolic composition and cytotoxic evaluation to act as a new source of scavenging of reactive oxygen species. Food Chem 181:160\u2013169. https:\/\/doi.org\/10.1016\/j.foodchem.2015.02.087","journal-title":"Food Chem"},{"key":"5156_CR35","doi-asserted-by":"publisher","unstructured":"Mena MO, Moellmann VM, Bassetto CC, Lins JG, Fernandes MA, Moreira GR et al (2025) Effects of zinc oxide nanoparticle supplementation in young sheep naturally infected with gastrointestinal nematodes. Vet Parasitol Reg Stud Rep 64:101340. https:\/\/doi.org\/10.1016\/j.vprsr.2025.101340","DOI":"10.1016\/j.vprsr.2025.101340"},{"issue":"6","key":"5156_CR36","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1093\/jaoac\/85.6.1217","volume":"85","author":"DR Mertens","year":"2002","unstructured":"Mertens DR, Allen M, Carmany J, Clegg J, Davidowicz A, Drouches M et al (2002) Gravimetric determination of amylase-treated neutral detergent fiber in feeds with refluxing in beakers or crucibles: Collaborative study. J AOAC Int 85(6):1217\u20131240. https:\/\/doi.org\/10.1093\/jaoac\/85.6.1217","journal-title":"J AOAC Int"},{"key":"5156_CR37","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jtemb.2018.05.002","volume":"49","author":"S Meyer","year":"2018","unstructured":"Meyer S, Weber M, Hermann S, Heitland P, Sabine H (2018) Development, validation and application of an ICP-MS\/MS method to quantify minerals and (ultra-)trace elements in human serum. J Trace Elem Med Biol 49:157\u2013163. https:\/\/doi.org\/10.1016\/j.jtemb.2018.05.002","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"5156_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s40011-019-01099-0","volume":"90","author":"SH Mir","year":"2020","unstructured":"Mir SH, Dar PA, Dar SA, Wani MA, Ganai AM (2020) Zinc in ruminants: Metabolism and homeostasis. Proc Natl Acad Sci India B Biol Sci 90(1):9\u201319. https:\/\/doi.org\/10.1007\/s40011-019-01099-0","journal-title":"Proc Natl Acad Sci India B Biol Sci"},{"issue":"4","key":"5156_CR39","doi-asserted-by":"publisher","first-page":"571","DOI":"10.21608\/ejvs.2023.282041","volume":"54","author":"C Mira","year":"2023","unstructured":"Mira C, Kaidi R, Berramdane T, Dekkiche S, Bouzebda Z (2023) Hematological and biochemical blood parameters during pregnancy in Algerian Rembi ewes. Egypt J Vet Sci 54(4):571\u2013577. https:\/\/doi.org\/10.21608\/ejvs.2023.282041","journal-title":"Egypt J Vet Sci"},{"issue":"3","key":"5156_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.21608\/ejsgs.2017.26308","volume":"12","author":"AH Mohamed","year":"2017","unstructured":"Mohamed AH, Khalil MM, El-Nour HHA, Shaaban MA (2017) Impact of nano-zinc oxide supplementation on productive performance and some biochemical parameters of ewes and offspring. Egypt J Sheep Goat Sci 12(3):49\u201364. https:\/\/doi.org\/10.21608\/ejsgs.2017.26308","journal-title":"Egypt J Sheep Goat Sci"},{"key":"5156_CR41","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cimid.2018.11.001","volume":"62","author":"DB Moretti","year":"2019","unstructured":"Moretti DB, Polizel DM, Da Silva CJA, Sampaio IBM (2019) Effect of maternal cottonseed feed on the immune and antioxidant status of Santa Ines lambs. Comp Immunol Microbiol Infect Dis 62:58\u201363. https:\/\/doi.org\/10.1016\/j.cimid.2018.11.001","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"3","key":"5156_CR42","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.5433\/1679-0359.2015v36n3p1397","volume":"36","author":"PM Nascimento","year":"2015","unstructured":"Nascimento PM, Morgado AA, Nunes GR, Nikolaus JP, Weigel RA, Lima AS, Sucupira MCA (2015) Oxidative metabolism and biochemistry profile of Santa Ines sheep in periparturition: effect of parenteral vitamin E. Semina: Cienc Agrar 36(3):1397\u20131408. https:\/\/doi.org\/10.5433\/1679-0359.2015v36n3p1397","journal-title":"Semina: Cienc Agrar"},{"key":"5156_CR43","unstructured":"National Science and Technology Council (NSTC) (2004) National nanotechnology initiative: Strategic plan. https:\/\/www.nano.gov\/sites\/default\/files\/pub_resource\/nni_strategic_plan_2004.pdf"},{"issue":"8","key":"5156_CR44","doi-asserted-by":"publisher","first-page":"801","DOI":"10.14202\/vetworld.2016.801-805","volume":"9","author":"MF Nawito","year":"2016","unstructured":"Nawito MF, Kandil OM, Ahmed WM, Al-Khalaf AN (2016) Impact of pregnancy and nutrition on oxidant\/antioxidant balance in sheep and goats reared in South Sinai. Egypt Vet World 9(8):801\u2013805. https:\/\/doi.org\/10.14202\/vetworld.2016.801-805","journal-title":"Egypt Vet World"},{"key":"5156_CR45","doi-asserted-by":"publisher","DOI":"10.17226\/11654","volume-title":"Nutrient requirements of small ruminants: Sheep, goats, cervids, and new world camelids","author":"NRC","year":"2007","unstructured":"NRC (2007) Nutrient requirements of small ruminants: Sheep, goats, cervids, and new world camelids. National Academies, Washington, DC. https:\/\/doi.org\/10.17226\/11654"},{"issue":"1","key":"5156_CR46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12576-017-0571-7","volume":"68","author":"J Olechnowicz","year":"2018","unstructured":"Olechnowicz J, Szulc P, Szczesny E, Skowronska B, Chojnowska S (2018) Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci 68(1):19\u201331. https:\/\/doi.org\/10.1007\/s12576-017-0571-7","journal-title":"J Physiol Sci"},{"issue":"9","key":"5156_CR47","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.freeradbiomed.2012.08.568","volume":"53","author":"PI Oteiza","year":"2012","unstructured":"Oteiza PI (2012) Zinc and the modulation of redox homeostasis. Free Radic Biol Med 53(9):1748\u20131759. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.08.568","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"5156_CR48","doi-asserted-by":"publisher","first-page":"3791","DOI":"10.1007\/s12011-023-03712-0","volume":"201","author":"P Pandey","year":"2023","unstructured":"Pandey P, Yadav R, Singh VK, Yadav S, Singh RP (2023) The dietary supplementation of copper and zinc nanoparticles improves health condition of young dairy calves by reducing the incidence of diarrhoea and boosting immune function and antioxidant activity. Biol Trace Elem Res 201(8):3791\u20133803. https:\/\/doi.org\/10.1007\/s12011-023-03712-0","journal-title":"Biol Trace Elem Res"},{"key":"5156_CR50","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3923\/ijds.2010.253.263","volume":"5","author":"AF Park","year":"2010","unstructured":"Park AF, Shirley JE, Titgemeyer EC, Cochran RC, DeFrain JM, Wickersham EE, Johnson DE (2010) Characterization of plasma metabolites in Holstein dairy cows during the periparturient period. Int J Dairy Sci 5:253\u2013263. https:\/\/doi.org\/10.3923\/ijds.2010.253.263","journal-title":"Int J Dairy Sci"},{"issue":"1","key":"5156_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s12011-020-02129-0","volume":"197","author":"A Patra","year":"2020","unstructured":"Patra A, Lalhriatpuii M (2020) Progress and prospect of essential mineral nanoparticles in poultry nutrition and feeding\u2014A review. Biol Trace Elem Res 197(1):233\u2013253. https:\/\/doi.org\/10.1007\/s12011-020-02129-0","journal-title":"Biol Trace Elem Res"},{"key":"5156_CR51","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1079\/PAVSNNR202116007","volume":"16","author":"JLE Robles","year":"2021","unstructured":"Robles JLE, Araujo RC, Junior MMC, Costa NA (2021) Zinc supplementation in ruminant diets: Efficacy, safety, and formulation. CAB Rev 16:7. https:\/\/doi.org\/10.1079\/PAVSNNR202116007","journal-title":"CAB Rev"},{"issue":"7","key":"5156_CR52","doi-asserted-by":"publisher","first-page":"805","DOI":"10.56093\/ijans.v88i7.81461","volume":"88","author":"KK Singh","year":"2018","unstructured":"Singh KK, Maity SB, Maity A (2018) Effect of nano zinc oxide on zinc bioavailability and blood biochemical changes in pre-ruminant lambs. Indian J Anim Sci 88(7):805\u2013807","journal-title":"Indian J Anim Sci"},{"issue":"3","key":"5156_CR56","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.aninu.2016.07.003","volume":"2","author":"PS Swain","year":"2016","unstructured":"Swain PS, Rao SBN, Rajendran D, Dominic G, Selvaraju S (2016) Nano zinc, an alternative to conventional zinc as animal feed supplement: A review. Anim Nutr 2(3):134\u2013141. https:\/\/doi.org\/10.1016\/j.aninu.2016.07.003","journal-title":"Anim Nutr"},{"issue":"3","key":"5156_CR55","doi-asserted-by":"publisher","first-page":"297","DOI":"10.5958\/0974-181X.2018.00028.8","volume":"18","author":"PS Swain","year":"2018","unstructured":"Swain PS, Rajendran D, Rao SBN, Dominic G (2018) Effect of supplementation of nano zinc on rumen fermentation and fiber degradability in goats. Anim Nutr Feed Tech 18(3):297\u2013309","journal-title":"Anim Nutr Feed Tech"},{"key":"5156_CR53","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.96013","volume-title":"Advances in poultry nutrition research","author":"PS Swain","year":"2021","unstructured":"Swain PS, Mishra SK, Pati PK, Panda N, Jena B (2021) Essential nanominerals and other nanomaterials in poultry nutrition and production. In: Patra AK (ed) Advances in poultry nutrition research. IntechOpen, London. Chapter 5 https:\/\/doi.org\/10.5772\/intechopen.96013"},{"key":"5156_CR54","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-981-97-0794-2_3","volume-title":"Feed additives and supplements for ruminants","author":"PS Swain","year":"2024","unstructured":"Swain PS, Mishra SK, Pati PK, Panda N, Jena B (2024) Nano-mineral technology in ruminant feeding: Progress and prospects. Feed additives and supplements for ruminants. Elsevier, Amsterdan pp 51\u201368"},{"key":"5156_CR57","volume-title":"Manual para diagn\u00f3stico das helmintoses de ruminantes","author":"H Ueno","year":"1998","unstructured":"Ueno H, Gon\u00e7alves PC (1998) Manual para diagn\u00f3stico das helmintoses de ruminantes. Japan International Cooperation Agency, Tokyo"},{"issue":"1","key":"5156_CR58","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cvfa.2022.11.004","volume":"39","author":"RJ Van Saun","year":"2023","unstructured":"Van Saun RJ (2023) Metabolic profiling in ruminant diagnostics. Vet. Clin. North Am. Food Anim Pract 39(1):49\u201371. https:\/\/doi.org\/10.1016\/j.cvfa.2022.11.004","journal-title":"Food Anim Pract"},{"issue":"10","key":"5156_CR59","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","volume":"74","author":"PJ Van Soest","year":"1991","unstructured":"Van Soest PJ, Robertson JB, Lewis BA (1991) Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J Dairy Sci 74(10):3583\u20133597. https:\/\/doi.org\/10.3168\/jds.S0022-0302(91)78551-2","journal-title":"J Dairy Sci"},{"issue":"12","key":"5156_CR60","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1093\/jas\/sky378","volume":"96","author":"KR VanValin","year":"2018","unstructured":"VanValin KR, McLeod KR, Klotz JL, Harmon DL, Matthews JC (2018) Influence of dietary zinc concentration and supplemental zinc source on nutrient digestibility, zinc absorption, and retention in sheep. J Anim Sci 96(12):5336\u20135344. https:\/\/doi.org\/10.1093\/jas\/sky378","journal-title":"J Anim Sci"},{"issue":"C","key":"5156_CR61","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","volume":"77","author":"Wendel","year":"1981","unstructured":"Wendel A (1981) Glutathione peroxidase. Methods Enzymol 77(C):325\u2013333. https:\/\/doi.org\/10.1016\/S0076-6879(81)77046-0","journal-title":"Methods Enzymol"},{"issue":"4","key":"5156_CR62","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00580-023-03465-4","volume":"32","author":"AO Yusuf","year":"2023","unstructured":"Yusuf AO, Sanda AJ, Abubakar H, Yusuf MK (2023) Nano zinc supplementation in ruminant livestock: Influence on physiological, immune functions and oxidative stability of West African dwarf goat bucks. Comp Clin Pathol 32(4):629\u2013643. https:\/\/doi.org\/10.1007\/s00580-023-03465-4","journal-title":"Comp Clin Pathol"}],"container-title":["Tropical Animal Health and Production"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-026-05156-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11250-026-05156-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-026-05156-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:25:13Z","timestamp":1783337113000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11250-026-05156-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5156"],"URL":"https:\/\/doi.org\/10.1007\/s11250-026-05156-w","relation":{},"ISSN":["0049-4747","1573-7438"],"issn-type":[{"value":"0049-4747","type":"print"},{"value":"1573-7438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This project was approved by the Ethics Committee on Animal Use from CENA\/USP (001\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"341"}}