{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:43:26Z","timestamp":1785527006982,"version":"3.56.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trop Anim Health Prod"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s11250-026-05204-5","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:44:04Z","timestamp":1783529044000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo anthelmintic efficacy, hematobiochemical and antioxidant effects of Swertia chirata in Barbari goats naturally infected with Haemonchus contortus"],"prefix":"10.1007","volume":"58","author":[{"family":"Ramakant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Kumar","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem Sagar","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbind","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devesh Kumar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-5002","authenticated-orcid":false,"given":"Amit Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"issue":"10","key":"5204_CR1","first-page":"643","volume":"3","author":"A Abakar","year":"2004","unstructured":"Abakar A, Osman A (2004) Haematological and biochemical changes following concurrent infections with coccidia and Haemonchus contortus in desert lambs. J Anim Vet Adv 3(10):643\u2013647","journal-title":"J Anim Vet Adv"},{"key":"5204_CR2","doi-asserted-by":"crossref","unstructured":"Aebi H (1984) Catalase in vitro. In: Packer L, editor. Methods in Enzymology. Vol. 105. New York: Academic Press. pp. 121-126","DOI":"10.1016\/S0076-6879(84)05016-3"},{"issue":"1","key":"5204_CR4","first-page":"357","volume":"48","author":"RT Alam","year":"2020","unstructured":"Alam RT, Hassanen EA, El-Mandrawy SA (2020) Heamonchus contortus infection in Sheep and Goats: alterations in haematological, biochemical, immunological, trace element and oxidative stress markers. J Appl Vet Sci 48(1):357\u2013364","journal-title":"J Appl Vet Sci"},{"issue":"5\u2013s","key":"5204_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.22270\/jddt.v8i5-s.1957","volume":"8","author":"A Aleem","year":"2018","unstructured":"Aleem A, Kabir H (2018) Review of Swertia chirata as traditional uses to its Phytochemistry and pharmacological activity. JDDT 8(5\u2013s):73\u201378","journal-title":"JDDT"},{"issue":"1\u20132","key":"5204_CR9","first-page":"1","volume":"30","author":"M Arora","year":"2009","unstructured":"Arora M, Sahni YP, Gautam V, Singh A (2009) Evaluation of in vivo anthelmintic efficacy of Swertia chirata (Chirayata) against Gastrointestinal Nematodiasis in Goats. JDRAS 30(1\u20132):1\u20138","journal-title":"JDRAS"},{"issue":"1","key":"5204_CR10","first-page":"55","volume":"17","author":"M Ashfaque","year":"2016","unstructured":"Ashfaque M, Khan SA, Fakhruddin Chahar A, Tanwar RK (2016) Haemato biochemical changes in goats suffering from helminth parasites infestation. Vet Pract 17(1):55\u201356","journal-title":"Vet Pract"},{"issue":"1","key":"5204_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.25130\/tjps.v26i1.92","volume":"26","author":"SJ Aziz","year":"2021","unstructured":"Aziz SJ, Mahmoud OI (2021) Measurement of hematological and biochemical parameters in sheep infected with intestinal protozoa and helminthes. Tikrit J Pure Sci 26(1):8\u201311","journal-title":"Tikrit J Pure Sci"},{"key":"5204_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1017\/S1357729800053388","volume":"76","author":"RL Baker","year":"2003","unstructured":"Baker RL, Nagda S, Rodriguez-Zas SL, Southey BR, Audho JO, Aduda EO, Thorpe W (2003) Resistance and resilience to gastro-intestinal nematode parasites and relationships with productivity of Red Maasai, Dorper and Red Maasai x Dorper crossbred lambs in the sub-humid tropics. Anim Sci 76:119\u2013136","journal-title":"Anim Sci"},{"key":"5204_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0076-6879(99)99005-5","volume":"299","author":"EFI Benzie","year":"1999","unstructured":"Benzie EFI, Strain JJ (1999) Ferric reducing\/antioxidant power assay: Direct measurement of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant and ascorbic acid concentration. Methods Enzymol 299:15\u201327","journal-title":"Methods Enzymol"},{"key":"5204_CR16","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.ijpara.2009.03.002","volume":"39","author":"NJ Bott","year":"2009","unstructured":"Bott NJ, Campbell EB, Bevridge I, Chilton NB, Ress D, Hunt PW, Gasser RB (2009) A combined microscopic-molecular method for the diagnosis of strongylid infections in sheep. Int J Parasitol 39:1277\u20131287","journal-title":"Int J Parasitol"},{"issue":"1\u20132","key":"5204_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","volume":"44","author":"GC Coles","year":"1992","unstructured":"Coles GC, Bauer C, Borgsteede FHM, Greets S, Klei TR, Taylor MA, Waller PJ (1992) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol 44(1\u20132):35\u201344","journal-title":"Vet Parasitol"},{"issue":"3","key":"5204_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3923\/pjbs.2013.101.111","volume":"16","author":"K Dhama","year":"2013","unstructured":"Dhama K, Chakraborty S, Mahima, Wani MY, Verma AK, Deb R, Tiwari R, Kapoor S (2013) Novel and emerging therapies safeguarding health of humans and their companion animals: A review. Pak J Biol Sci 16(3):101\u2013111","journal-title":"Pak J Biol Sci"},{"issue":"3","key":"5204_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.22271\/veterinary.2024.v9.i3f.1442","volume":"9","author":"VV Dhoot","year":"2024","unstructured":"Dhoot VV, Bhojne GR, Dhoot VM, Panchbhai CG, Somkuwar AP, Raghuwanshi DS, Jadhav SG, Game YG (2024) Anthelmintic evaluation of Carica papaya against gastrointestinal nematodes in goats. Int J Vet Sci Anim Hus 9(3):401\u2013404","journal-title":"Int J Vet Sci Anim Hus"},{"issue":"6","key":"5204_CR24","first-page":"4775","volume":"18","author":"S Du","year":"2018","unstructured":"Du S, Liu H, Lei T, Xie X, Wang H, He X, Tong R, Wang Y (2018) Mangiferin: An effective therapeutic agent against several disorders (Review). Mol Med Rep 18(6):4775\u20134786","journal-title":"Mol Med Rep"},{"issue":"3","key":"5204_CR25","first-page":"128487","volume":"5","author":"B Dutta","year":"2016","unstructured":"Dutta B, Konch K, Rahman T, Upadhyaya N, Pathak DC, Samuli SM, Phangchoo CV, Begum SA (2016) Occurrence and pathology of Haemonchus contortus infection in Goats. J Entomol Zool Stud 5(3):128487","journal-title":"J Entomol Zool Stud"},{"key":"5204_CR27","first-page":"1","volume-title":"Free Radicals in Biology and Medicine","author":"B Halliwell","year":"1999","unstructured":"Halliwell B, Gutteridge JMC (1999) Free Radicals in Biology and Medicine, 3rd edn. Oxford University Press, Oxford, pp 1\u201325","edition":"3"},{"key":"5204_CR28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.fitote.2006.05.010","volume":"77","author":"Z Iqbal","year":"2006","unstructured":"Iqbal Z, Lateef M, Khan MN, Jabbar A, Akhtar MS (2006) Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep. Fitoterapia 77:463\u2013465","journal-title":"Fitoterapia"},{"issue":"1\u20132","key":"5204_CR29","first-page":"56","volume":"8","author":"S Jain","year":"2009","unstructured":"Jain S, Sahni YP (2009) Anthelmintic activity of Swertia chirata seeds against gastrointestinal endoparasitic infestation in goats. J Vet Pharmacol Ther 8(1\u20132):56\u201358","journal-title":"J Vet Pharmacol Ther"},{"key":"5204_CR31","doi-asserted-by":"crossref","unstructured":"Kaplan RM (2004) Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol 477\u2013481","DOI":"10.1016\/j.pt.2004.08.001"},{"key":"5204_CR34","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/bs.apar.2016.02.012","volume":"93","author":"A Kotze","year":"2016","unstructured":"Kotze A, Prichard R (2016) Chapter nine-anthelmintic resistance in Haemonchus contortus: History, mechanisms and diagnosis. Adv Parasitol 93:397\u2013428","journal-title":"Adv Parasitol"},{"issue":"4","key":"5204_CR36","doi-asserted-by":"publisher","first-page":"274","DOI":"10.31254\/phyto.2020.9411","volume":"9","author":"B Kumsa","year":"2020","unstructured":"Kumsa B, Hagos Y (2020) Antihelmintic medicinal plants used for animals in Ethiopia: A review. J Phytopharmacol 9(4):274\u2013280","journal-title":"J Phytopharmacol"},{"key":"5204_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.vetpar.2007.06.014","volume":"148","author":"C Lans","year":"2007","unstructured":"Lans C, Turner N, Khan T, Brauer G (2007) Ethno veterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada. Vet Parasitol 148:325\u2013340","journal-title":"Vet Parasitol"},{"issue":"16","key":"5204_CR38","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3923\/pjbs.2012.754.774","volume":"15","author":"RA Mahima","year":"2012","unstructured":"Mahima RA, Deb R, Latheef SK, Samad HA, Tiwari R, Verma AK, Kumar A, Dhama K (2012) Immunomodulatory and therauptic potential of herbal, traditional \/ indigenous and ethanoveterinary medicine. Pak J Biol Sci 15(16):754\u2013774","journal-title":"Pak J Biol Sci"},{"key":"5204_CR39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469\u2013474","journal-title":"Eur J Biochem"},{"issue":"4","key":"5204_CR42","first-page":"468","volume":"54","author":"D Parmar","year":"2020","unstructured":"Parmar D, Chandra D, Prasad A, Sankar M, Nasir A, Khuswaha B, Khare R, Kaur N (2020) Efficacy of closantel against benzimidazole resistant Haemonchus contortus infection in sheep. Indian J Anim Res 54(4):468\u2013472","journal-title":"Indian J Anim Res"},{"issue":"1","key":"5204_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3923\/jbs.2014.1.19","volume":"14","author":"A Rahal","year":"2014","unstructured":"Rahal A, Mahima, Verma AK, Kumar A, Tiwari R, Kapoor S, Chakraborty S, Dhama K (2014) Phytonutrients and nutraceuticals in vegetables, and their multi-dimensional medicinal and health benefits for humans and their companion animals: A review. J Biol Sci 14(1):1\u201319","journal-title":"J Biol Sci"},{"issue":"1","key":"5204_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.56093\/ijans.v95i1.157162","volume":"95","author":"STK Ramakant","year":"2025","unstructured":"Ramakant STK, Verma K, Maurya PS, Jaiswal V, Singh A, Thakur V, Rawat S (2025) PCR based identification of different strongyle species in goats of western Uttar Pradesh, India. Indian J Anim Sci 95(1):13\u201317","journal-title":"Indian J Anim Sci"},{"issue":"6","key":"5204_CR46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.31080\/ASVS.2024.06.0881","volume":"6","author":"TK Ramakant Sarkar","year":"2024","unstructured":"Ramakant Sarkar TK, Verma AK, Maurya PS, Thakur V, Singh A, Rawat S, Chandra G, Maurya PK, Gautam S (2024a) Prevalence of gastrointestinal parasitic infections in goats in Western Uttar Pradesh, India. Acta Sci Vet Sci 6(6):17\u201327","journal-title":"Acta Sci Vet Sci"},{"issue":"6","key":"5204_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.33545\/26174693.2024.v8.i6Sa.1254","volume":"8","author":"TK Ramakant, Sarkar","year":"2024","unstructured":"Ramakant, Sarkar TK, Verma AK, Maurya PS, Thakur V, Singh A, Jaiswal V, Rawat S, Maurya PK, Gautam S (2024b) In vitro anthelmintic activity of aqueous extracts of seven medicinal plants against Haemonchus contortus in goats. Int J Adv Biochem Res 8(6):51\u201358","journal-title":"Int J Adv Biochem Res"},{"key":"5204_CR49","doi-asserted-by":"crossref","unstructured":"Roberts FHS, Sullivan PJO (1950) Methods for egg counts and larval cultures for strongyles infesting the gastrointestinal tract of cattle. Aust J Agric Res 1:99\u2013102","DOI":"10.1071\/AR9500099"},{"issue":"5","key":"5204_CR51","first-page":"1139","volume":"5","author":"M Selemon","year":"2018","unstructured":"Selemon M (2018) Review on control of Haemonchus contortus in Sheep and Goat. J Vet Med Res 5(5):1139\u20131145","journal-title":"J Vet Med Res"},{"issue":"1","key":"5204_CR53","first-page":"158","volume":"12","author":"SK Sinha","year":"2023","unstructured":"Sinha SK, Pati S, Shahi S (2023) Medicinal value of chiraita: A review. Eur Chem Bull 12(1):158\u2013162","journal-title":"Eur Chem Bull"},{"key":"5204_CR54","first-page":"763","volume-title":"Helminths, Arthropods & Protozoa of Domesticated Animals","author":"EJL Soulsby","year":"1982","unstructured":"Soulsby EJL (1982) Helminths, Arthropods & Protozoa of Domesticated Animals, 7th edn. ELBS, Bailliere Tindall, London, pp 763\u2013778","edition":"7"},{"key":"5204_CR57","volume-title":"Veterinary Parasitology","author":"GM Urquhart","year":"1996","unstructured":"Urquhart GM, Armour J, Duncan JL, Dunn AM, Jennings FW (1996) Veterinary Parasitology, 2nd edn. Blackwell Science Ltd., Oxford, UK","edition":"2"},{"issue":"04","key":"5204_CR58","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.20546\/ijcmas.2020.904.308","volume":"9","author":"M Veena","year":"2020","unstructured":"Veena M, Puttalakshmamm GC, Ananda KJ, Sengupta PP (2020) Morphological and molecular characterization of gastrointestinal nematodes in sheep. Int J Curr Microbiol App Sci 9(04):2564\u20132575","journal-title":"Int J Curr Microbiol App Sci"},{"key":"5204_CR59","doi-asserted-by":"publisher","first-page":"32101","DOI":"10.1038\/srep32101","volume":"6","author":"P Wangchuk","year":"2016","unstructured":"Wangchuk P, Giacomun PR, Pearson MS, Smout MJ, Loukas A (2016) Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Sci Rep 6:32101","journal-title":"Sci Rep"},{"key":"5204_CR60","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.vetpar.2016.08.009","volume":"228","author":"T Westers","year":"2016","unstructured":"Westers T, Bitton AJ, Menzies P, Leeuwen JV, Poljak Z, Peregrine AS (2016) Efficacy of closantel against ivermectin and fenbendazole-resistant Haemonchus spp. in sheep in Ontario, Canada. Vet parasitol 228:30\u201341","journal-title":"Vet parasitol"},{"issue":"3","key":"5204_CR61","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0304-4017(95)00806-2","volume":"58","author":"IB Wood","year":"1995","unstructured":"Wood IB, Amaral NK, Bairden K, Duncan JL, Kassai T, Malone JJB, Pankavich JA, Reinecke RK, Slocombe O, Taylor SM, Vercruysse J (1995) World Association for the Advancement of Veterinary Parasitology (WAAVP) of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, and caprine). Vet Parasitol 58(3):181\u2013213","journal-title":"Vet Parasitol"},{"key":"5204_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.smallrumres.2016.09.005","volume":"143","author":"PI Zvinorova","year":"2016","unstructured":"Zvinorova PI, Halimani TE, Muchadeyi FC, Matika O, Riggioe V, Dzama K (2016) Prevalence and risk factors of gastrointestinal parasitic infections in goats in low-input low-output farming systems in Zimbabwe. Small Rumin Res 143:75\u201383","journal-title":"Small Rumin Res"}],"container-title":["Tropical Animal Health and Production"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-026-05204-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11250-026-05204-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11250-026-05204-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:07:42Z","timestamp":1785521262000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11250-026-05204-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["5204"],"URL":"https:\/\/doi.org\/10.1007\/s11250-026-05204-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8910788\/v1","asserted-by":"object"}]},"ISSN":["0049-4747","1573-7438"],"issn-type":[{"value":"0049-4747","type":"print"},{"value":"1573-7438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"19 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was reviewed and approved by the Institutional Animal Ethics Committee of SVPUAT (IAEC\/SVPUAT\/2022\/125 dated 3 December 2022) and was carried out in accordance with CPCSEA guidelines for the care and use of experimental animals.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors provided their consent for the publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest among them.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"392"}}