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A randomized complete-block design with a 2\u2009\u00d7\u20092 factorial arrangement compared weaning strategies (WS: EW at 150 d lactation\/80 d gestation vs. CW at 240 d lactation\/170 d gestation) and dam parities (DP: multiparous [MP] vs. secundiparous [SP]). Carcass and meat quality data were analyzed considering the dams as experimental unit by using the Mixed procedure, considering the WS and DP as fixed effect, and their interaction. There was interaction between WS\u00d7DP (\n                    <jats:italic>P\u2009&lt;<\/jats:italic>\n                    \u20090.01) for hindquarter fat trim where EW-MP and CW-MP carcasses required more trim fat than EW-SP. EW bulls tended to reduce drip loss (\n                    <jats:italic>P\u2009=<\/jats:italic>\n                    \u20090.07), tended to increased pistola hindquarter (% of carcass;\n                    <jats:italic>P\u2009=<\/jats:italic>\n                    \u20090.09), while significantly raising ultimate carcass pH (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.04) versus CW. An untarget\n                    <jats:sup>1<\/jats:sup>\n                    H NMR-based metabolomic approach was applied to detect metabolic changes. Pathway analysis of differentially abundant metabolites revealed the upregulation of betaine and glycerolipid metabolism, methylhistidine metabolism for WS and homocysteine degradation, phosphatidylethanolamine synthesis and selenoamino acid metabolism for DP. Offspring of MP dams had heavier cold carcasses (\n                    <jats:italic>P\u2009=<\/jats:italic>\n                    \u20090.03), greater Forequarter, brisket, shank (\n                    <jats:italic>P\u2009&lt;<\/jats:italic>\n                    \u20090.03), smaller pistola hindquarter and top sirloin cap (\n                    <jats:italic>P\u2009\u2264<\/jats:italic>\n                    \u20090.05) than those of SP. These results indicate that WS and DP induce metabolomic shifts favoring muscular hypertrophy and one-carbon metabolism, which may enhance muscularity without impairing meat quality.\n                  <\/jats:p>","DOI":"10.1007\/s11250-026-05237-w","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:15:09Z","timestamp":1785845709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early weaning in pregnant cows as a fetal programming strategy alters the muscle metabotype and carcass traits in Nelore cattle"],"prefix":"10.1007","volume":"58","author":[{"given":"Matheus Sousa","family":"de Paula Carlis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Abitante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Kan","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Robertson","family":"Dahlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara Regina Brand\u00e3o","family":"C\u00f4nsolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alberto","family":"Colnago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Maria Marins","family":"Ocampos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n Dar\u00edo","family":"Ram\u00edrez-Zamudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Maloso","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Luz","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Henrique","family":"de Almeida Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlindo Saran","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Pugliesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Leme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4961-3866","authenticated-orcid":false,"given":"Rodrigo Silva","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"5237_CR1","first-page":"757","volume":"65","author":"H Abe","year":"2000","unstructured":"Abe H (2000) Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle. 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