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Eighteen Soinga lambs (average initial body weight of 19\u2009\u00b1\u20091.38\u00a0kg) were allocated in a completely randomized design among three diets: sisal mucilage silage without additive (SMS); sisal mucilage silage ensiled with wheat bran (SMS-WB); and sisal mucilage silage ensiled with ground corn (SMS-GC). The experimental period lasted 60 days, after 14 days of adaptation to the diets. SMS without additives induced severe hepatic coagulative necrosis and microvesicular steatosis, alongside moderate-to-severe renal proliferative glomerulonephritis and glomerular atrophy. SMS-WB acted as a potent hepatoprotector, completely preventing macrovesicular steatosis and pericentral necrosis while down-grading microvesicular steatosis to a mild degree. In the kidneys, SMS-GC provided the most effective glomerular protection, mitigating both proliferative glomerulonephritis and glomerular atrophy to mild intensities. On the other hand, SMS-WB reduced only glomerular atrophy to a mild level, failing to contain proliferative glomerulonephritis. Renal medullary dystrophic calcification remained unaltered across all treatments (66.6%), indicating an intrinsic lesion profile of sisal mucilage ingestion. In conclusion, while sisal mucilage silage exhibits intrinsic hepatorenal toxicity in lambs, the use of moisture-absorbing additives is a viable mitigation strategy. Wheat bran serves as an effective hepatoprotector, whereas ground corn provides superior glomerular preservation. 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