{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:14:26Z","timestamp":1761765266906},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,2,20]],"date-time":"2010-02-20T00:00:00Z","timestamp":1266624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s11255-010-9710-2","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T04:28:55Z","timestamp":1266553735000},"page":"881-887","source":"Crossref","is-referenced-by-count":13,"title":["In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: placebo-controlled, double-blind, cross-over laboratory setting"],"prefix":"10.1007","volume":"42","author":[{"given":"Ahmet","family":"G\u00f6k\u00e7e","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Demirtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikret","family":"Halis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguz","family":"Ekmekcioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,20]]},"reference":[{"key":"9710_CR1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00345-004-0486-9","volume":"23","author":"EA Jannini","year":"2005","unstructured":"Jannini EA, Lenzi A (2005) Ejaculatory disorders: epidemiology and current approaches to definition, classification and subtyping. World J Urol 23:68\u201375","journal-title":"World J Urol"},{"key":"9710_CR2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1743-6109.2006.00239.x","volume":"3","author":"S Althof","year":"2006","unstructured":"Althof S, Rosen R, Symonds T, Mundayat R, May K, Abraham L (2006) Development and validation of a new questionnaire to assess sexual satisfaction, control, and distress associated with premature ejaculation. J Sex Med 3:465\u2013475","journal-title":"J Sex Med"},{"key":"9710_CR3","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/j.1743-6109.2008.00901.x","volume":"5","author":"CG McMahon","year":"2008","unstructured":"McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, Adaikan PG, Becher E, Broderick GA, Buvat J, Dabees K, Giraldi A, Giuliano F, Hellstrom WJ, Incrocci L, Laan E, Meuleman E, Perelman MA, Rosen RC, Rowland DL, Segraves R (2008) An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 5:1590\u20131606","journal-title":"J Sex Med"},{"key":"9710_CR4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00926230390224738","volume":"29","author":"T Symonds","year":"2003","unstructured":"Symonds T, Roblin D, Hart K, Althof S (2003) How does premature ejaculation impact a man s life? J Sex Marital Ther 29:361\u2013370","journal-title":"J Sex Marital Ther"},{"key":"9710_CR5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/00926239308404371","volume":"19","author":"AJ Cooper","year":"1993","unstructured":"Cooper AJ, Cernovsky ZZ, Colussi K (1993) Some clinical and psychometric characteristics of primary and secondary premature ejaculators. J Sex Marital Ther 19:276\u2013288","journal-title":"J Sex Marital Ther"},{"key":"9710_CR6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.ijir.3900630","volume":"13","author":"IA Abdel-Hamid","year":"2001","unstructured":"Abdel-Hamid IA, El Naggar EA, El Gilany AH (2001) Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res 13:41\u201345","journal-title":"Int J Impot Res"},{"key":"9710_CR7","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1464-410X.2009.08456.x","volume":"103","author":"WW Dinsmore","year":"2009","unstructured":"Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5\u00a0min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. BJU Int 103:940\u2013949","journal-title":"BJU Int"},{"key":"9710_CR8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1046\/j.1439-0272.2002.00511.x","volume":"34","author":"MK Atikeler","year":"2002","unstructured":"Atikeler MK, Gecit I, Senol FA (2002) Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia 34:356\u2013359","journal-title":"Andrologia"},{"key":"9710_CR9","first-page":"856","volume":"53","author":"A Atan","year":"2000","unstructured":"Atan A, Basar MM, Aydoganli L (2000) Comparison of the efficacy of fluoxetine alone vs. fluoxetine plus local lidocaine ointment in the treatment of premature ejaculation. Arch Esp Urol 53:856\u2013858","journal-title":"Arch Esp Urol"},{"key":"9710_CR10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1743-6109.2006.00238.x","volume":"3","author":"MA Perelman","year":"2006","unstructured":"Perelman MA (2006) A new combination treatment for premature ejaculation: a sex therapist\u2019s perspective. J Sex Med 3:1004\u20131012","journal-title":"J Sex Med"},{"key":"9710_CR11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1743-6109.2005.20112.x","volume":"2","author":"MD Waldinger","year":"2005","unstructured":"Waldinger MD, Schweitzer DH, Olivier B (2005) On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med 2:121\u2013131","journal-title":"J Sex Med"},{"key":"9710_CR12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-5347(01)62078-0","volume":"161","author":"U Yilmaz","year":"1999","unstructured":"Yilmaz U, Tatlisen A, Turan H, Arman F, Ekmekcioglu O (1999) The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation. J Urol 161:107\u2013111","journal-title":"J Urol"},{"key":"9710_CR13","first-page":"43","volume":"17","author":"G Beretta","year":"1986","unstructured":"Beretta G, Chelo E, Fanciullacci F, Zanollo A (1986) Effect of an alpha-blocking agent (phenoxybenzamine) in the management of premature ejaculation. Acta Eur Fertil 17:43\u201345","journal-title":"Acta Eur Fertil"},{"key":"9710_CR14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s11255-005-3616-4","volume":"37","author":"MM Basar","year":"2005","unstructured":"Basar MM, Yilmaz E, Ferhat M, Basar H, Batislam E (2005) Terazosin in the treatment of premature ejaculation: a short-term follow-up. Int Urol Nephrol 37:773\u2013777","journal-title":"Int Urol Nephrol"},{"key":"9710_CR15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF02550283","volume":"30","author":"MD Balbay","year":"1998","unstructured":"Balbay MD, Yildiz M, Salvarci A, Ozsan O, Ozbek E (1998) Treatment of premature ejaculation with sertralin. Int Urol Nephrol 30:81\u201383","journal-title":"Int Urol Nephrol"},{"key":"9710_CR16","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1743-6109.2005.20351.x","volume":"2","author":"CG McMahon","year":"2005","unstructured":"McMahon CG, Stuckey BG, Andersen M, Purvis K, Koppiker N, Haughie S, Boolell M (2005) Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2:368\u2013375","journal-title":"J Sex Med"},{"key":"9710_CR17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.urology.2005.09.002","volume":"67","author":"A Atan","year":"2006","unstructured":"Atan A, Basar MM, Tuncel A, Ferhat M, Agras K, Tekdogan U (2006) Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology 67:388\u2013391","journal-title":"Urology"},{"key":"9710_CR18","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/S0022-5347(05)64174-2","volume":"168","author":"A Salonia","year":"2002","unstructured":"Salonia A, Maga T, Colombo R, Scattoni V, Briganti A, Cestari A, Guazzoni G, Rigatti P, Montorsi F (2002) A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. J Urol 168:2486\u20132489","journal-title":"J Urol"},{"key":"9710_CR19","first-page":"610","volume":"13","author":"XZ Sun","year":"2007","unstructured":"Sun XZ, Deng CH, Dai YP (2007) A clinical study of sertraline and vardenafil in the treatment of premature ejaculation complicated by erectile dysfunction. Zhonghua Nan Ke Xue 13:610\u2013612","journal-title":"Zhonghua Nan Ke Xue"},{"key":"9710_CR20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1439-0272.2008.00910.x","volume":"41","author":"MJ Mathers","year":"2009","unstructured":"Mathers MJ, Klotz T, Roth S, Lummen G, Sommer F (2009) Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: a randomised, prospective and crossover study. Andrologia 41:169\u2013175","journal-title":"Andrologia"},{"key":"9710_CR21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ijir.2009.21","volume":"21","author":"A Aversa","year":"2009","unstructured":"Aversa A, Pili M, Francomano D, Bruzziches R, Spera E, La Pera G, Spera G (2009) Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 21:221\u2013227","journal-title":"Int J Impot Res"},{"key":"9710_CR22","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1176\/ajp.151.9.1377","volume":"151","author":"MD Waldinger","year":"1994","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH (1994) Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 151:1377\u20131379","journal-title":"Am J Psychiatry"},{"key":"9710_CR23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1743-6109.2007.00443_2.x","volume":"4","author":"MD Waldinger","year":"2007","unstructured":"Waldinger MD (2007) Four measures of investigating ejaculatory performance. J Sex Med 4:520","journal-title":"J Sex Med"},{"issue":"Suppl 3","key":"9710_CR24","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1038\/sj.ijir.3900560","volume":"12","author":"AL Burnett","year":"2000","unstructured":"Burnett AL (2000) Lecture 2: nitric oxide synthase and heme oxygenase knockout mice-what have we learned? Int J Impot Res 12(Suppl 3):S42\u2013S44","journal-title":"Int J Impot Res"},{"key":"9710_CR25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm0198-084","volume":"4","author":"AL Burnett","year":"1998","unstructured":"Burnett AL, Johns DG, Kriegsfeld LJ, Klein SL, Calvin DC, Demas GE, Schramm LP, Tonegawa S, Nelson RJ, Snyder SH, Poss KD (1998) Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Nat Med 4:84\u201387","journal-title":"Nat Med"},{"key":"9710_CR26","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1073885","volume":"297","author":"WA Truitt","year":"2002","unstructured":"Truitt WA, Coolen LM (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297:1566\u20131569","journal-title":"Science"},{"key":"9710_CR27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/molehr\/gah143","volume":"11","author":"R Mancina","year":"2005","unstructured":"Mancina R, Filippi S, Marini M, Morelli A, Vignozzi L, Salonia A, Montorsi F, Mondaini N, Vannelli GB, Donati S, Lotti F, Forti G, Maggi M (2005) Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens. Mol Hum Reprod 11:107\u2013115","journal-title":"Mol Hum Reprod"},{"key":"9710_CR28","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/S0022-5347(05)65621-2","volume":"166","author":"S Uckert","year":"2001","unstructured":"Uckert S, Kuthe A, Jonas U, Stief CG (2001) Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate. J Urol 166:2484\u20132490","journal-title":"J Urol"},{"key":"9710_CR29","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/S0022-5347(06)00280-1","volume":"175","author":"I Orhan","year":"2006","unstructured":"Orhan I, Onur R, Tasdemir C, Ayar A, Kadioglu A (2006) Sildenafil citrate inhibits agonist induced contractions in isolated rat seminal vesicles. J Urol 175:2350\u20132353","journal-title":"J Urol"},{"key":"9710_CR30","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.pbb.2004.09.019","volume":"79","author":"BD Devan","year":"2004","unstructured":"Devan BD, Sierra-Mercado D Jr, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK (2004) Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol Biochem Behav 79:691\u2013699","journal-title":"Pharmacol Biochem Behav"},{"key":"9710_CR31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.urology.2004.09.012","volume":"65","author":"O Ekmekcioglu","year":"2005","unstructured":"Ekmekcioglu O, Inci M, Demirci D, Tatlisen A (2005) Effects of sildenafil citrate on ejaculation latency, detumescence time, and refractory period: placebo-controlled, double-blind, crossover laboratory setting study. Urology 65:347\u2013352","journal-title":"Urology"},{"key":"9710_CR32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.ijir.3901005","volume":"15","author":"N Mondaini","year":"2003","unstructured":"Mondaini N, Ponchietti R, Muir GH, Montorsi F, Di Loro F, Lombardi G, Rizzo M (2003) Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time. Int J Impot Res 15:225\u2013228","journal-title":"Int J Impot Res"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-010-9710-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-010-9710-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-010-9710-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T11:55:33Z","timestamp":1559390133000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-010-9710-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,20]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["9710"],"URL":"https:\/\/doi.org\/10.1007\/s11255-010-9710-2","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,20]]}}}