{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:29:21Z","timestamp":1792290561267,"version":"4.4.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006432","name":"Terumo BCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006432","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic plasma exchange (TPE) is either performed using a highly permeable filter with standard multifunctional renal replacement equipment (mTPE) or a centrifugation device (cTPE). Although both techniques are well established in clinical practice, performance of these two modes of TPE was never compared in a prospective randomized fashion. Thus we aimed to compare two commercially available therapeutic apheresis systems: mTPE (Octonova with Plasmaflo filter) and cTPE (Spectra Optia apheresis system).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-one patients (age 51.6\u00a0\u00b1\u00a013.5\u00a0years; 10 F\/11 M; BMI 25.1\u00a0\u00b1\u00a05.0\u00a0kg\/m<jats:sup>2<\/jats:sup>) were enrolled in this randomized, prospective, paired, crossover study performed in the Hannover Medical School, Germany. First treatment (either mTPE or cTPE) was chosen by an online randomization list. The primary endpoints were plasma removal efficiency with 1.2\u00d7\u00a0of the total plasma volume exchanged. Secondary endpoints were total amount of plasma substances removed, such as IgG and fibrinogen. Further, the treatment effect on platelet count and complications were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite a comparable volume of the processed plasma, mTPE treatment time was 10.5\u00a0% longer than cTPE treatment time (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), resulting in a 10\u00a0% lower plasma removal rate of the mTPE treatment. Both treatments were comparable in terms of decrease in median (IQR) IgG [pre-mTPE 5.34 (3.48\u20138.37), post-mTPE 1.96 (1.43\u20132.84) g\/L; pre-cTPE 5.88 (3.42\u20138.84), post-cTPE 1.89 (1.21\u20133.52) g\/L]. Also the median (IQR) amount of IgG removed in mTPE [13.14 (7.42\u201316.10) g] was not different from the cTPE treatment [9.30 (6.26\u201315.69) g]. This was also true for IgM removal. Platelet loss during mTPE was nearly twice as much as with cTPE (15\u00a0\u00b1\u00a09 versus 7\u00a0\u00b1\u00a09\u00a0%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the centrifugal procedures were conducted using flow rates that could easily be obtained using peripheral access, plasma removal efficiency was significantly higher and treatment time was significantly lower in cTPE as compared to mTPE. Despite this lower treatment time, the decline in markers of procedure efficacy was comparable. Especially in centers performing many procedures per year, cTPE in contrast to mTPE can reduce treatment time without compromising treatment efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11255-015-1137-3","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T06:01:00Z","timestamp":1446530460000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Membrane versus centrifuge-based therapeutic plasma exchange: a randomized prospective crossover study"],"prefix":"10.1007","volume":"48","author":[{"given":"Carsten","family":"Hafer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Golla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Gericke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Beutel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard M. W.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stef","family":"De Reys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T.","family":"Kielstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"1137_CR1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0022-3565(25)08256-4","volume":"5","author":"JL Abel","year":"1914","unstructured":"Abel JL, Rowntree LG, Turner BB (1914) Plasma removal with return of corpuscles (plasmaphaeresis). J Pharmacol Exp Ther 5:625\u2013641","journal-title":"J Pharmacol Exp Ther"},{"key":"1137_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/jca.2920010405","volume":"1","author":"M Fosburg","year":"1983","unstructured":"Fosburg M, Dolan M, Propper R, Wolfe L, Kevy S (1983) Intensive plasma exchange in small and critically ill pediatric patients: techniques and clinical outcome. J Clin Apher 1:215\u2013224","journal-title":"J Clin Apher"},{"key":"1137_CR3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/039139888400700106","volume":"7","author":"HJ Gurland","year":"1984","unstructured":"Gurland HJ, Lysaght MJ, Samtleben W, Schmidt B (1984) A comparison of centrifugal and membrane-based apheresis formats. Int J Artif Organs 7:35\u201338","journal-title":"Int J Artif Organs"},{"key":"1137_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2253-14-24","volume":"14","author":"J Hadem","year":"2014","unstructured":"Hadem J, Hafer C, Schneider AS, Wiesner O, Beutel G, Fuehner T, Welte T, Hoeper MM, Kielstein JT (2014) Therapeutic plasma exchange as rescue therapy in severe sepsis and septic shock: retrospective observational single-centre study of 23 patients. BMC Anesthesiol 14:24","journal-title":"BMC Anesthesiol"},{"key":"1137_CR5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.healun.2014.09.019","volume":"34","author":"F Ius","year":"2015","unstructured":"Ius F, Sommer W, Tudorache I, Kuhn C, Avsar M, Siemeni T, Salman J, Hallensleben M, Kieneke D, Greer M, Gottlieb J, Kielstein JT, Boethig D, Welte T, Haverich A, Warnecke G (2015) Preemptive treatment with therapeutic plasma exchange and rituximab for early donor-specific antibodies after lung transplantation. J Heart Lung Transplant 34:50\u201358","journal-title":"J Heart Lung Transplant"},{"key":"1137_CR6","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1093\/ndt\/gfs394","volume":"27","author":"JT Kielstein","year":"2012","unstructured":"Kielstein JT, Beutel G, Fleig S, Steinhoff J, Meyer TN, Hafer C, Kuhlmann U, Bramstedt J, Panzer U, Vischedyk M, Busch V, Ries W, Mitzner S, Mees S, Stracke S, Nurnberger J, Gerke P, Wiesner M, Sucke B, Abu-Tair M, Kribben A, Klause N, Schindler R, Merkel F, Schnatter S, Dorresteijn EM, Samuelsson O, Brunkhorst R (2012) Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry. Nephrol Dial Transplant 27:3807\u20133815","journal-title":"Nephrol Dial Transplant"},{"key":"1137_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1744-9987.2009.00716.x","volume":"14","author":"PS Malchesky","year":"2010","unstructured":"Malchesky PS, Koo AP, Skibinski CI, Hadsell AT, Rybicki LA (2010) Apheresis technologies and clinical applications: the 2007 International Apheresis Registry. Ther Apher Dial 14:52\u201373","journal-title":"Ther Apher Dial"},{"key":"1137_CR8","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/ki.1990.300","volume":"38","author":"RL Mehta","year":"1990","unstructured":"Mehta RL, McDonald BR, Aguilar MM, Ward DM (1990) Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int 38:976\u2013981","journal-title":"Kidney Int"},{"key":"1137_CR9","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/jca.20247","volume":"25","author":"C Okafor","year":"2010","unstructured":"Okafor C, Ward DM, Mokrzycki MH, Weinstein R, Clark P, Balogun RA (2010) Introduction and overview of therapeutic apheresis. J Clin Apher 25:240\u2013249","journal-title":"J Clin Apher"},{"key":"1137_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/cc9358","volume":"15","author":"HM Oudemans-van Straaten","year":"2011","unstructured":"Oudemans-van Straaten HM, Kellum JA, Bellomo R (2011) Clinical review: anticoagulation for continuous renal replacement therapy\u2013heparin or citrate? Crit Care 15:202","journal-title":"Crit Care"},{"key":"1137_CR11","doi-asserted-by":"publisher","first-page":"164","DOI":"10.5045\/kjh.2011.46.3.164","volume":"46","author":"M Schiffer","year":"2011","unstructured":"Schiffer M, Kielstein JT (2011) ABO-incompatible renal transplantation: from saline flushes to antigen-specific immunoadsorption-tools to overcome the barrier. Korean J Hematol 46:164\u2013168","journal-title":"Korean J Hematol"},{"key":"1137_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40608-015-0067-z","volume":"2","author":"JJ Schmidt","year":"2015","unstructured":"Schmidt JJ, Jahn J, Golla P, Hafer C, Kielstein JT, Kielstein H (2015) Effect of therapeutic plasma exchange on plasma levels and total removal of adipokines and inflammatory markers. BMC Obes 2:37","journal-title":"BMC Obes"},{"key":"1137_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/jca.21276","volume":"28","author":"J Schwartz","year":"2013","unstructured":"Schwartz J, Winters JL, Padmanabhan A, Balogun RA, Delaney M, Linenberger ML, Szczepiorkowski ZM, Williams ME, Wu Y, Shaz BH (2013) Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue. J Clin Apher 28:145\u2013284","journal-title":"J Clin Apher"},{"key":"1137_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/039139889501800110","volume":"18","author":"BG Stegmayr","year":"1995","unstructured":"Stegmayr BG, Jakobson S, Rydvall A, Bjorsell-Ostling E (1995) Plasma exchange in patients with acute renal failure in the course of multiorgan failure. Int J Artif Organs 18:45\u201352","journal-title":"Int J Artif Organs"},{"key":"1137_CR15","doi-asserted-by":"publisher","first-page":"e38573","DOI":"10.1371\/journal.pone.0038573","volume":"7","author":"O Tutarel","year":"2012","unstructured":"Tutarel O, Golla P, Beutel G, Bauersachs J, David S, Schmidt BM, Lichtinghagen R, Kielstein JT (2012) Therapeutic plasma exchange decreases levels of routinely used cardiac and inflammatory biomarkers. PLoS One 7:e38573","journal-title":"PLoS One"},{"key":"1137_CR16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/jca.20302","volume":"26","author":"DM Ward","year":"2011","unstructured":"Ward DM (2011) Conventional apheresis therapies: a review. J Clin Apher 26:230\u2013238","journal-title":"J Clin Apher"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1137-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-015-1137-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1137-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1137-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:17:18Z","timestamp":1748679438000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-015-1137-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["1137"],"URL":"https:\/\/doi.org\/10.1007\/s11255-015-1137-3","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]},"assertion":[{"value":"27 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"JTK received research grants from Fresenius Medical Care and Diamed as well as speaker fees from Fresenius Medical Care and Diamed. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethical Board of the Hannover Medical School (protocol # 5343). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}