{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:44:35Z","timestamp":1790376275715,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA169172"],"award-info":[{"award-number":["R01 CA169172"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s11255-015-1145-3","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T04:54:06Z","timestamp":1446440046000},"page":"73-77","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metastatic renal cell carcinoma without evidence of a renal primary"],"prefix":"10.1007","volume":"48","author":[{"given":"Corey","family":"Costantino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George V.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus V.","family":"Coakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Troxell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"1145_CR1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1046\/j.1464-410X.2003.04237.x","volume":"91","author":"WK Lau","year":"2003","unstructured":"Lau WK, Zincke H, Lohse CM, Cheville JC, Weaver AL, Blute ML (2003) Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review. BJU Int 91:775\u2013779. doi: 10.1046\/j.1464-410X.2003.04237.x","journal-title":"BJU Int"},{"key":"1145_CR2","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.3892\/ol.2015.2915","volume":"9","author":"H \u00d6zturk","year":"2015","unstructured":"\u00d6zturk H (2015) Bilateral synchronous adrenal metastases of renal cell carcinoma: a case report and review of the literature. Oncol Lett 9:1897\u20131901. doi: 10.3892\/ol.2015.2915","journal-title":"Oncol Lett"},{"issue":"12","key":"1145_CR3","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0090-4295(78)90303-5","volume":"1978","author":"PB Marcus","year":"1978","unstructured":"Marcus PB, Kemp CB (1978) Ectopic renal cell carcinoma: pathologist\u2019s problem. Urology 1978(12):453\u2013457. doi: 10.1016\/0090-4295(78)90303-5","journal-title":"Urology"},{"key":"1145_CR4","unstructured":"MacLennan GT, Cheng L (2008) Neoplasms of the Kidney. In: Bostwick DG, Cheng L (eds) Urologic surgical pathology. 2nd edn, Mosby Elesvier, Maryland Heights, p 83"},{"key":"1145_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1477-7819-8-18","volume":"8","author":"M Wayne","year":"2010","unstructured":"Wayne M, Wang W, Bratcher J, Cumani B, Kasmin F, Cooperman A (2010) Renal cell cancer without a renal primary. World J Surg Oncol 8:18. doi: 10.1186\/1477-7819-8-18","journal-title":"World J Surg Oncol"},{"key":"1145_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1440-1827.2011.02780.x","volume":"62","author":"T Terada","year":"2012","unstructured":"Terada T (2012) Extra-renal clear cell renal cell carcinoma probably arising from mesodermal embryonic remnants. Pathol Int 62:291\u2013293. doi: 10.1111\/j.1440-1827.2011.02780.x","journal-title":"Pathol Int"},{"key":"1145_CR7","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.4081\/rt.2014.5037","volume":"6","author":"AG Abdou","year":"2014","unstructured":"Abdou AG, Kandil M, Elshakhs S, El-Dien MS, Abdallah R (2014) Renal cell carcinoma with rhabdoid and sarcomatoid features presented as a metastatic thigh mass with an unusual immunohistochemical profile. Rare Tumors 6:5037. doi: 10.4081\/rt.2014.50378","journal-title":"Rare Tumors"},{"key":"1145_CR8","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3171\/2014.6.SPINE13448","volume":"21","author":"RF Heary","year":"2014","unstructured":"Heary RF, Agarwal N, Barrese JC, Barry MT, Baisre A (2014) Metastatic renal cell carcinoma, with a radiographically occult primary tumor, presenting in the operative site of a thoracic meningioma: long-term follow-up. J Neurosurg Spine 21:628\u2013633. doi: 10.3171\/2014.6.SPINE13448","journal-title":"J Neurosurg Spine"},{"key":"1145_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1442-2042.2011.02904.x","volume":"19","author":"MT Johnson","year":"2012","unstructured":"Johnson MT, Bahnson RR, Zynger DL (2012) Metastatic clear cell renal cell carcinoma to the adrenal gland without an identifiable primary tumor. Int J Urol 19:92\u201393. doi: 10.1111\/j.1442-2042.2011.02904.x","journal-title":"Int J Urol"},{"key":"1145_CR10","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00428-015-1732-9","volume":"466","author":"H Li","year":"2015","unstructured":"Li H, Hes O, MacLennan GT, Eastwood DC, Iczkowski KA (2015) Immunohistochemical distinction of metastases of renal cell carcinoma to the adrenal from primary adrenal nodules, including oncocytic tumor. Vichows Arch 466:581\u2013588. doi: 10.1007\/s00428-015-1732-9","journal-title":"Vichows Arch"},{"key":"1145_CR11","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/PAS.0b013e3182152629","volume":"35","author":"AR Sangoi","year":"2011","unstructured":"Sangoi AR, Fujiwara M, West RB, Montgomery KD, Bonventre JV, Higgins JP, Rouse RV, Gokden N, McKenney JK (2011) Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases. Am J Surg Pathol 35:678\u2013686. doi: 10.1097\/PAS.0b013e3182152629","journal-title":"Am J Surg Pathol"},{"key":"1145_CR12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5858\/2010-0478-RAR.1","volume":"135","author":"LD Truong","year":"2011","unstructured":"Truong LD, Shen SS (2011) Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med 135:92\u2013109","journal-title":"Arch Pathol Lab Med"},{"key":"1145_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrc3844","volume":"15","author":"L Gossage","year":"2015","unstructured":"Gossage L, Eisen T, Maher E (2015) VHL, the story of a tumour suppressor gene. Nat Rev Cancer 15:55\u201364. doi: 10.1038\/nrc3844","journal-title":"Nat Rev Cancer"},{"key":"1145_CR14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.hoc.2011.04.004","volume":"25","author":"L Li","year":"2011","unstructured":"Li L, Kaelin WG (2011) New insights into the biology of renal cell carcinoma. Hematol Oncol Clin North Am 25:667\u2013686. doi: 10.1016\/j.hoc.2011.04.004","journal-title":"Hematol Oncol Clin North Am"},{"issue":"7456","key":"1145_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature12222","volume":"499","author":"The Cancer Genome Atlas Research Network","year":"2013","unstructured":"The Cancer Genome Atlas Research Network (2013) Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499(7456):43\u201349. doi: 10.1038\/nature12222","journal-title":"Nature"},{"key":"1145_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401\u2013404. doi: 10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov"},{"issue":"269","key":"1145_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):11. doi: 10.1126\/scisignal.2004088","journal-title":"Sci Signal"},{"key":"1145_CR18","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nrc2763","volume":"9","author":"CJ Brown","year":"2009","unstructured":"Brown CJ, Lain S, Verma CS (2009) Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer 9:862\u2013873","journal-title":"Nat Rev Cancer"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1145-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-015-1145-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1145-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-015-1145-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T23:42:08Z","timestamp":1653435728000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-015-1145-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["1145"],"URL":"https:\/\/doi.org\/10.1007\/s11255-015-1145-3","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]},"assertion":[{"value":"21 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Ryan has received consulting fees from Pfizer. The other authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}