{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:40Z","timestamp":1790948080127,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T00:00:00Z","timestamp":1462579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"national key Technology R&D Program","award":["2011BA10B08"],"award-info":[{"award-number":["2011BA10B08"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s11255-016-1291-2","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T11:28:46Z","timestamp":1462620526000},"page":"1313-1319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aberrant activation of Wnt pathways in arteries associates with vascular calcification in chronic kidney disease"],"prefix":"10.1007","volume":"48","author":[{"given":"Jingyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,7]]},"reference":[{"key":"1291_CR1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B et al (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260\u2013272","journal-title":"Lancet"},{"key":"1291_CR2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","volume":"382","author":"RT Gansevoort","year":"2013","unstructured":"Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJ, Mann JF et al (2013) Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 382:339\u2013352","journal-title":"Lancet"},{"key":"1291_CR3","first-page":"542","volume":"123","author":"LD Quarles","year":"2013","unstructured":"Quarles LD (2013) Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new. J Clin Investig 123:542\u2013543","journal-title":"J Clin Investig"},{"key":"1291_CR4","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/ki.2011.24","volume":"79121","author":"K Hruska","year":"2011","unstructured":"Hruska K, Mathew S, Lund R, Fang Y, Sugatani T (2011) Cardiovascular risk factors in chronic kidney disease: does phosphate qualify? Kidney Int 79121:S9\u2013S13","journal-title":"Kidney Int"},{"key":"1291_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ki.2012.69","volume":"82","author":"PA Torres","year":"2012","unstructured":"Torres PA, De Broe M (2012) Calcium-sensing receptor, calcimimetics, and cardiovascular calcifications in chronic kidney disease. Kidney Int 82:19\u201325","journal-title":"Kidney Int"},{"key":"1291_CR6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.kint.2015.12.004","volume":"89","author":"TB Drueke","year":"2016","unstructured":"Drueke TB, Massy ZA (2016) Changing bone patterns with progression of chronic kidney disease. Kidney Int 89:289\u2013302","journal-title":"Kidney Int"},{"key":"1291_CR7","doi-asserted-by":"crossref","first-page":"F891","DOI":"10.1152\/ajprenal.00163.2014","volume":"307","author":"NJ Paloian","year":"2014","unstructured":"Paloian NJ, Giachelli CM (2014) A current understanding of vascular calcification in CKD. Am J Physiol Ren Physiol 307:F891\u2013F900","journal-title":"Am J Physiol Ren Physiol"},{"key":"1291_CR8","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2008070692","volume":"20","author":"M Mizobuchi","year":"2009","unstructured":"Mizobuchi M, Towler D, Slatopolsky E (2009) Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol JASN 20:1453\u20131464","journal-title":"J Am Soc Nephrol JASN"},{"key":"1291_CR9","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1681\/ASN.2013080818","volume":"25","author":"Y Fang","year":"2014","unstructured":"Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC et al (2014) CKD-induced wingless\/integration inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol JASN 25:1760\u20131773","journal-title":"J Am Soc Nephrol JASN"},{"key":"1291_CR10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ki.2013.271","volume":"85","author":"Y Fang","year":"2014","unstructured":"Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA (2014) Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int 85:142\u2013150","journal-title":"Kidney Int"},{"key":"1291_CR11","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1517\/14656566.2013.852183","volume":"14","author":"M Sonikian","year":"2013","unstructured":"Sonikian M, Papachristou E, Goumenos DS (2013) Optimal use of phosphate binders in chronic kidney disease. Expert Opin Pharmacother 14:2521\u20132532","journal-title":"Expert Opin Pharmacother"},{"key":"1291_CR12","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","volume":"149","author":"H Clevers","year":"2012","unstructured":"Clevers H, Nusse R (2012) Wnt\/beta-catenin signaling and disease. Cell 149:1192\u20131205","journal-title":"Cell"},{"key":"1291_CR13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.yexcr.2012.12.023","volume":"319","author":"M Reis","year":"2013","unstructured":"Reis M, Liebner S (2013) Wnt signaling in the vasculature. Exp Cell Res 319:1317\u20131323","journal-title":"Exp Cell Res"},{"key":"1291_CR14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2741\/4214","volume":"19","author":"Y Wang","year":"2014","unstructured":"Wang Y, Li YP, Paulson C, Shao JZ, Zhang X, Wu M et al (2014) Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci 19:379\u2013407","journal-title":"Front Biosci"},{"key":"1291_CR15","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1172\/JCI24140","volume":"115","author":"JS Shao","year":"2005","unstructured":"Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA (2005) Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Investig 115:1210\u20131220","journal-title":"J Clin Investig"},{"key":"1291_CR16","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/jbmr.1630","volume":"27","author":"Y Sabbagh","year":"2012","unstructured":"Sabbagh Y, Graciolli FG, O\u2019Brien S, Tang W, dos Reis LM, Ryan S et al (2012) Repression of osteocyte Wnt\/beta-catenin signaling is an early event in the progression of renal osteodystrophy. J Bone Miner Res 27:1757\u20131772","journal-title":"J Bone Miner Res"},{"key":"1291_CR17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000370250","volume":"41","author":"L Yao","year":"2015","unstructured":"Yao L, Sun YT, Sun W, Xu TH, Ren C, Fan X et al (2015) High phosphorus level leads to aortic calcification via beta-catenin in chronic kidney disease. Am J Nephrol 41:28\u201336","journal-title":"Am J Nephrol"},{"key":"1291_CR18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2215\/CJN.01760506","volume":"2","author":"ML Gross","year":"2007","unstructured":"Gross ML, Meyer HP, Ziebart H, Rieger P, Wenzel U, Amann K et al (2007) Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients. Clin J Am Soc Nephrol CJASN 2:121\u2013134","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"1291_CR19","doi-asserted-by":"crossref","first-page":"F1302","DOI":"10.1152\/ajprenal.00114.2014","volume":"307","author":"S Soriano","year":"2014","unstructured":"Soriano S, Carmona A, Trivino F, Rodriguez M, Alvarez-Benito M, Martin-Malo A et al (2014) Endothelial damage and vascular calcification in patients with chronic kidney disease. Am J Physiol Ren Physiol 307:F1302\u2013F1311","journal-title":"Am J Physiol Ren Physiol"},{"key":"1291_CR20","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","volume":"351","author":"AS Go","year":"2004","unstructured":"Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351:1296\u20131305","journal-title":"N Engl J Med"},{"key":"1291_CR21","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1161\/CIRCULATIONAHA.107.743161","volume":"117","author":"LL Demer","year":"2008","unstructured":"Demer LL, Tintut Y (2008) Vascular calcification: pathobiology of a multifaceted disease. Circulation 117:2938\u20132948","journal-title":"Circulation"},{"key":"1291_CR22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/08860220701395010","volume":"29","author":"S Patsalas","year":"2007","unstructured":"Patsalas S, Eleftheriadis T, Spaia S, Theodoroglou H, Antoniadi G, Liakopoulos V et al (2007) Thirty-month follow-up of coronary artery calcification in hemodialysis patients: different roles for inflammation and abnormal calcium-phosphorous metabolism? Ren Fail 29:623\u2013629","journal-title":"Ren Fail"},{"key":"1291_CR23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/138161209787354230","volume":"15","author":"C Antoniades","year":"2009","unstructured":"Antoniades C, Antonopoulos AS, Bendall JK, Channon KM (2009) Targeting redox signaling in the vascular wall: from basic science to clinical practice. Curr Pharm Des 15:329\u2013342","journal-title":"Curr Pharm Des"},{"key":"1291_CR24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCRESAHA.110.234914","volume":"109","author":"CM Shanahan","year":"2011","unstructured":"Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM (2011) Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109:697\u2013711","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"1291_CR25","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S0140-6736(15)60325-7","volume":"385","author":"KK Stevens","year":"2015","unstructured":"Stevens KK, Patel RK, Mark PB, Delles C, Jardine AG (2015) Phosphate as a cardiovascular risk factor: effects on vascular and endothelial function. Lancet 385(Suppl 1):S10","journal-title":"Lancet"},{"key":"1291_CR26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejphar.2015.05.023","volume":"763","author":"W Matthijs Blankesteijn","year":"2015","unstructured":"Matthijs Blankesteijn W, Hermans KC (2015) Wnt signaling in atherosclerosis. Eur J Pharmacol 763:122\u2013130","journal-title":"Eur J Pharmacol"},{"key":"1291_CR27","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tem.2012.06.001","volume":"23","author":"K Marinou","year":"2012","unstructured":"Marinou K, Christodoulides C, Antoniades C, Koutsilieris M (2012) Wnt signaling in cardiovascular physiology. Trends Endocrinol Metab TEM 23:628\u2013636","journal-title":"Trends Endocrinol Metab TEM"},{"key":"1291_CR28","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","volume":"109","author":"KI Bostrom","year":"2011","unstructured":"Bostrom KI, Rajamannan NM, Towler DA (2011) The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ Res 109:564\u2013577","journal-title":"Circ Res"},{"key":"1291_CR29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1196\/annals.1402.075","volume":"1117","author":"JS Shao","year":"2007","unstructured":"Shao JS, Aly ZA, Lai CF, Cheng SL, Cai J, Huang E et al (2007) Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification. Ann N Y Acad Sci 1117:40\u201350","journal-title":"Ann N Y Acad Sci"},{"key":"1291_CR30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1196\/annals.1346.036","volume":"1068","author":"DA Towler","year":"2006","unstructured":"Towler DA, Shao JS, Cheng SL, Pingsterhaus JM, Loewy AP (2006) Osteogenic regulation of vascular calcification. Ann N Y Acad Sci 1068:327\u2013333","journal-title":"Ann N Y Acad Sci"},{"key":"1291_CR31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/MOL.0b013e32834aa701","volume":"22","author":"A Tsaousi","year":"2011","unstructured":"Tsaousi A, Mill C, George SJ (2011) The Wnt pathways in vascular disease: lessons from vascular development. Curr Opin Lipidol 22:350\u2013357","journal-title":"Curr Opin Lipidol"},{"key":"1291_CR32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cellsig.2016.02.011","volume":"28","author":"DM DiRenzo","year":"2016","unstructured":"DiRenzo DM, Chaudhary MA, Shi X, Franco SR, Zent J, Wang K et al (2016) A crosstalk between TGF-beta\/Smad3 and Wnt\/beta-catenin pathways promotes vascular smooth muscle cell proliferation. Cell Signal 28:498\u2013505","journal-title":"Cell Signal"},{"key":"1291_CR33","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.yexcr.2011.03.022","volume":"317","author":"KT Noh","year":"2011","unstructured":"Noh KT, Park YM, Cho SG, Choi EJ (2011) GSK-3beta-induced ASK1 stabilization is crucial in LPS-induced endotoxin shock. Exp Cell Res 317:1663\u20131668","journal-title":"Exp Cell Res"},{"key":"1291_CR34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00011-013-0697-x","volume":"63","author":"R Malgor","year":"2014","unstructured":"Malgor R, Bhatt PM, Connolly BA, Jacoby DL, Feldmann KJ, Silver MJ et al (2014) Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions. Inflamm Res 63:277\u2013285","journal-title":"Inflamm Res"},{"key":"1291_CR35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.atherosclerosis.2014.08.027","volume":"237","author":"PM Bhatt","year":"2014","unstructured":"Bhatt PM, Malgor R (2014) Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders. Atherosclerosis 237:155\u2013162","journal-title":"Atherosclerosis"},{"key":"1291_CR36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2007.10.166","volume":"365","author":"CW Cheng","year":"2008","unstructured":"Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS (2008) Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun 365:285\u2013290","journal-title":"Biochem Biophys Res Commun"},{"key":"1291_CR37","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.1000181","volume":"185","author":"J Kim","year":"2010","unstructured":"Kim J, Kim J, Kim DW, Ha Y, Ihm MH, Kim H et al (2010) Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol 185:1274\u20131282","journal-title":"J Immunol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-016-1291-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-016-1291-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-016-1291-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T08:02:10Z","timestamp":1559376130000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-016-1291-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,7]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1291"],"URL":"https:\/\/doi.org\/10.1007\/s11255-016-1291-2","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,7]]}}}