{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:27:51Z","timestamp":1783488471437,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["N\/ST\/MN\/17\/003\/2211"],"award-info":[{"award-number":["N\/ST\/MN\/17\/003\/2211"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["N\/ST\/MN\/17\/001\/2211"],"award-info":[{"award-number":["N\/ST\/MN\/17\/001\/2211"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s11255-018-02064-3","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T15:25:21Z","timestamp":1546961121000},"page":"491-502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease"],"prefix":"10.1007","volume":"51","author":[{"given":"Tomasz W.","family":"Kaminski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Karbowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Znorko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian L.","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mysliwiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"2064_CR1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1046\/j.1523-1755.1999.00273.x","volume":"55","author":"J Zimmermann","year":"1999","unstructured":"Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C (1999) Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 55:648\u2013658. \n                    https:\/\/doi.org\/10.1046\/j.1523-1755.1999.00273.x","journal-title":"Kidney Int"},{"key":"2064_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5527\/wjn.v2.i2.31","volume":"2","author":"HF Tbahriti","year":"2013","unstructured":"Tbahriti HF, Meknassi D, Moussaoui R, Messaoudi A, Zemour L, Kaddous A et al (2013) Inflammatory status in chronic renal failure: the role of homocysteinemia and pro-inflammatory cytokines. World J Nephrol 2:31\u201337. \n                    https:\/\/doi.org\/10.5527\/wjn.v2.i2.31","journal-title":"World J Nephrol"},{"key":"2064_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.gpb.2016.12.003","volume":"15","author":"J Brooks","year":"2017","unstructured":"Brooks J, Watson A, Korcsmaros T (2017) Omics approaches to identify potential biomarkers of inflammatory diseases in the focal adhesion complex. Genomics Proteom Bioinform 15:101\u2013109. \n                    https:\/\/doi.org\/10.1016\/j.gpb.2016.12.003","journal-title":"Genomics Proteom Bioinform"},{"key":"2064_CR4","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2215\/CJN.10441015","volume":"11","author":"J Sun","year":"2016","unstructured":"Sun J, Axelsson J, Machowska A, Heimburger O, Barany P, Lindholm B et al (2016) Biomarkers of cardiovascular disease and mortality risk in patients with advanced CKD. Clin J Am Soc Nephrol 11:1163\u20131172. \n                    https:\/\/doi.org\/10.2215\/CJN.10441015","journal-title":"Clin J Am Soc Nephrol"},{"key":"2064_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1743-7075-9-36","volume":"9","author":"AD Slee","year":"2012","unstructured":"Slee AD (2012) Exploring metabolic dysfunction in chronic kidney disease. Nutr Metab (Lond) 9:36. \n                    https:\/\/doi.org\/10.1186\/1743-7075-9-36","journal-title":"Nutr Metab (Lond)"},{"key":"2064_CR6","first-page":"624632","volume":"30","author":"T Kaminski","year":"2017","unstructured":"Kaminski T, Michalowska M, Pawlak D (2017) Aryl hydrocarbon receptor (AhR) and its endogenous agonist\u2014indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw 30:624\u2013632","journal-title":"Postepy Hig Med Dosw"},{"issue":"1","key":"2064_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12882-017-0457-1","volume":"18","author":"TW Kaminski","year":"2017","unstructured":"Kaminski TW, Pawlak K, Karbowska M, My\u015bliwiec M, Pawlak D (2017) Indoxyl sulfate - the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease. BMC Nephrol 18(1):35. \n                    https:\/\/doi.org\/10.1186\/s12882-017-0457-1","journal-title":"BMC Nephrol"},{"key":"2064_CR8","doi-asserted-by":"publisher","first-page":"e005022","DOI":"10.1161\/JAHA.116.005022","volume":"6","author":"S Hung","year":"2017","unstructured":"Hung S, Kuo K, Wu C, Tarng D (2017) Indoxyl sulfate: a novel cardiovascular risk factor in chronic kidney disease. J Am Heart Assoc 6:e005022. \n                    https:\/\/doi.org\/10.1161\/JAHA.116.005022","journal-title":"J Am Heart Assoc"},{"key":"2064_CR9","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3389\/fphys.2018.01623","volume":"9","author":"M Karbowska","year":"2018","unstructured":"Karbowska M, Kaminski TW, Znorko B, Domaniewski T, Misztal T, Rusak T et al (2018) Indoxyl sulfate promotes arterial thrombosis in rat model via increased levels of complex TF\/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 and SIRT3. Front Physiol 9:1623. \n                    https:\/\/doi.org\/10.3389\/fphys.2018.01623","journal-title":"Front Physiol"},{"key":"2064_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1053\/j.jrn.2010.10.020","volume":"21","author":"A Adijiang","year":"2011","unstructured":"Adijiang A, Shimizu H, Higuchi Y, Nishijima F, Niwa T (2011) Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats. J Ren Nutr 21:105\u2013109. \n                    https:\/\/doi.org\/10.1053\/j.jrn.2010.10.020","journal-title":"J Ren Nutr"},{"key":"2064_CR11","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.lfs.2013.05.008","volume":"92","author":"M Yisireyili","year":"2013","unstructured":"Yisireyili M, Shimizu H, Saito S, Enomoto A, Nishijima F, Niwa T (2013) Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats. Life Sci 92:1180\u20131185. \n                    https:\/\/doi.org\/10.1016\/j.lfs.2013.05.008","journal-title":"Life Sci"},{"key":"2064_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1053\/j.ackd.2014.12.001","volume":"22","author":"E Judd","year":"2015","unstructured":"Judd E, Calhoun DA (2015) Management of hypertension in CKD: beyond the guidelines. Adv Chronic Kidney Dis 22:116\u2013122. \n                    https:\/\/doi.org\/10.1053\/j.ackd.2014.12.001","journal-title":"Adv Chronic Kidney Dis"},{"key":"2064_CR13","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1111\/j.1523-1755.2005.09304.x","volume":"93","author":"F Locatelli","year":"2005","unstructured":"Locatelli F, Del Vecchio L, Pozzoni P, D\u2019Amico M, Andrulli S (2005) Is it the agent or the blood pressure level that matters for renal and vascular protection in chronic nephropathies? Kidney Int Suppl 93:S15\u2013S19. \n                    https:\/\/doi.org\/10.1111\/j.1523-1755.2005.09304.x","journal-title":"Kidney Int Suppl"},{"key":"2064_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","volume":"7","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group","year":"2017","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group (2017) KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease\u2013mineral and bone disorder (CKD-MBD). Kidney Int Suppl 7:1\u201359. \n                    https:\/\/doi.org\/10.1016\/j.kisu.2017.04.001","journal-title":"Kidney Int Suppl"},{"key":"2064_CR15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/chromsci\/bms103","volume":"51","author":"M Al Za\u2019abi","year":"2013","unstructured":"Al Za\u2019abi M, Ali B, Al Toubi M (2013) HPLC-fluorescence method for measurement of the uremic toxin indoxyl sulfate in plasma. J Chromatogr Sci 51:40\u201343. \n                    https:\/\/doi.org\/10.1093\/chromsci\/bms103","journal-title":"J Chromatogr Sci"},{"key":"2064_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9070229","author":"M Karbowska","year":"2017","unstructured":"Karbowska M, Kaminski TW, Marcinczyk N, Misztal T, Rusak T, Smyk L, Pawlak D (2017) The uremic toxin indoxyl sulfate accelerates thrombotic response after vascular injury in animal models. Toxins (Basel). \n                    https:\/\/doi.org\/10.3390\/toxins9070229","journal-title":"Toxins (Basel)"},{"key":"2064_CR17","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"PK Whelton","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C et al (2018) 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71:1269\u20131324. \n                    https:\/\/doi.org\/10.1161\/HYP.0000000000000066","journal-title":"Hypertension"},{"key":"2064_CR18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.010","author":"MR Weir","year":"2018","unstructured":"Weir MR, Lakkis JI, Jaar B, Rocco MV, Choi MJ, Mattrix-Kramer H et al (2018) Use of renin-angiotensin system blockade in advanced ckd: An NKF-KDOQI controversies report. Am J Kidney. \n                    https:\/\/doi.org\/10.1053\/j.ajkd.2018.06.010","journal-title":"Am J Kidney"},{"key":"2064_CR19","doi-asserted-by":"publisher","first-page":"e009992","DOI":"10.1161\/JAHA.118.009992","volume":"7","author":"E Ku","year":"2018","unstructured":"Ku E, McCulloch CE, Vittinghoff E, Lin F, Johansen KL (2018) Use of antihypertensive agents and association with risk of adverse outcomes in chronic kidney disease: focus on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. J Am Heart Assoc 7:e009992. \n                    https:\/\/doi.org\/10.1161\/JAHA.118.009992","journal-title":"J Am Heart Assoc"},{"key":"2064_CR20","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2215\/CJN.03980609","volume":"4","author":"FC Barreto","year":"2009","unstructured":"Barreto FC, Barreto DV, Liabeuf S, Meert N, Glorieux G, Temmar M (2009) Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 4:1551\u20131558. \n                    https:\/\/doi.org\/10.2215\/CJN.03980609","journal-title":"Clin J Am Soc Nephrol"},{"key":"2064_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00125-017-4537-3","volume":"61","author":"G Mancia","year":"2018","unstructured":"Mancia G, Grassi G (2018) Blood pressure targets in type 2 diabetes. Evidence against or in favour of an aggressive approach. Diabetologia 61:517\u2013525. \n                    https:\/\/doi.org\/10.1007\/s00125-017-4537-3","journal-title":"Diabetologia"},{"key":"2064_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0384-7","author":"DE Le","year":"2013","unstructured":"Le DE, Pascotto M, Leong-Poi H, Sari I, Micari A, Kaul S (2013) Anti-inflammatory and pro-angiogenic effects of beta blockers in a canine model of chronic ischemic cardiomyopathy: comparison between carvedilol and metoprolol. Basic Res Cardiol. \n                    https:\/\/doi.org\/10.1007\/s00395-013-0384-7","journal-title":"Basic Res Cardiol"},{"key":"2064_CR23","doi-asserted-by":"publisher","first-page":"e111952","DOI":"10.1371\/journal.pone.0111952","volume":"9","author":"KE Kortekaas","year":"2014","unstructured":"Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF et al (2014) ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm. PLoS ONE 9:e111952. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0111952","journal-title":"PLoS ONE"},{"key":"2064_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3109\/10641960903254414","volume":"32","author":"H Komoda","year":"2010","unstructured":"Komoda H, Inoue T, Node K (2010) Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker. Clin Exp Hypertens 32:121\u2013128. \n                    https:\/\/doi.org\/10.3109\/10641960903254414","journal-title":"Clin Exp Hypertens"},{"key":"2064_CR25","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1177\/1535370217693114","volume":"242","author":"J Bartosiewicz","year":"2017","unstructured":"Bartosiewicz J, Kaminski T, Pawlak K, Karbowska M, Tankiewicz-Kwedlo A, Pawlak D (2017) The activation of the kynurenine pathway in a rat model with renovascular hypertension. Exp Biol Med (Maywood) 242:750\u2013761. \n                    https:\/\/doi.org\/10.1177\/1535370217693114","journal-title":"Exp Biol Med (Maywood)"},{"key":"2064_CR26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1743-7075-8-45","volume":"8","author":"SH Ardiansyah","year":"2011","unstructured":"Ardiansyah SH, Inagawa Y, Koseki T, Komai M (2011) Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats. Nutr Metab (Lond) 8:45. \n                    https:\/\/doi.org\/10.1186\/1743-7075-8-45","journal-title":"Nutr Metab (Lond)"},{"key":"2064_CR27","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/toxins9040114","volume":"9","author":"E Castillo-Rodr\u00edguez","year":"2017","unstructured":"Castillo-Rodr\u00edguez E, Pizarro-S\u00e1nchez S, Sanz AB, Ramos AM, Sanchez-Nino MD, Martin-Cleary C et al (2017) Inflammatory cytokines as uremic toxins: \u201cNi Son Todos Los Que Estan, Ni Estan Todos Los Que Son. Toxins 9:114. \n                    https:\/\/doi.org\/10.3390\/toxins9040114","journal-title":"Toxins"},{"key":"2064_CR28","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1681\/ASN.2013101062","volume":"25","author":"R Vanholder","year":"2014","unstructured":"Vanholder R, Schepers E, Pletinck A, Nagler EV, Glorieux G (2014) The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. J Am Soc Nephrol 25:1897\u20131907. \n                    https:\/\/doi.org\/10.1681\/ASN.2013101062","journal-title":"J Am Soc Nephrol"},{"key":"2064_CR29","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4103\/0971-5916.166582","volume":"142","author":"DY Kamath","year":"2015","unstructured":"Kamath DY, Xavier D, Sigamani A, Pais P (2015) High sensitivity C-reactive protein (hsCRP) and cardiovascular disease: an Indian perspective. Indian J Med Res 142:261\u2013268. \n                    https:\/\/doi.org\/10.4103\/0971-5916.166582","journal-title":"Indian J Med Res"},{"key":"2064_CR30","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.5551\/jat.33530","volume":"23","author":"S Kubo","year":"2016","unstructured":"Kubo S, Kitamura A, Imano H, Cui R, Yamagagishi K, Umesawa M et al (2016) Serum albumin and high-sensitivity C-reactive protein are independent risk factors of chronic kidney disease in middle-aged Japanese individuals: the circulatory risk in communities study. J Atheroscler Thromb 23:1089\u20131098. \n                    https:\/\/doi.org\/10.5551\/jat.33530","journal-title":"J Atheroscler Thromb"},{"key":"2064_CR31","doi-asserted-by":"publisher","first-page":"e002073","DOI":"10.1161\/JAHA.115.002073","volume":"4","author":"MC Jim\u00e9nez","year":"2015","unstructured":"Jim\u00e9nez MC, Rexrode KM, Glynn RJ, Ridker PM, Gaziano JM, Sesso HD (2015) Association between high-sensitivity C-reactive protein and total stroke by hypertensive status among men. J Am Heart Assoc 4:e002073. \n                    https:\/\/doi.org\/10.1161\/JAHA.115.002073","journal-title":"J Am Heart Assoc"},{"key":"2064_CR32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","volume":"5","author":"G Arango Duque","year":"2014","unstructured":"Arango Duque G, Descoteaux A (2014) Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol 5:491. \n                    https:\/\/doi.org\/10.3389\/fimmu.2014.00491","journal-title":"Front Immunol"},{"key":"2064_CR33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1161\/HYPERTENSIONAHA.114.03863","volume":"64","author":"J Zhang","year":"2014","unstructured":"Zhang J, Patel MB, Griffiths R, Mao A, Song Y, Karlovich NS et al (2014) TNF-alpha produced in the kidney contributes to angiotensin II-dependent hypertension. Hypertension 64:1275\u20131281. \n                    https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03863","journal-title":"Hypertension"},{"key":"2064_CR34","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fphar.2017.00370","volume":"8","author":"S Adesso","year":"2017","unstructured":"Adesso S, Magnus T, Cuzzocrea S, Campolo M, Rissiek B, Paciello O et al (2017) Indoxyl sulfate affects glial function increasing oxidative stress and neuroinflammation in chronic kidney disease: interaction between astrocytes and microglia. Front Pharmacol 8:370. \n                    https:\/\/doi.org\/10.3389\/fphar.2017.00370","journal-title":"Front Pharmacol"},{"key":"2064_CR35","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/fimmu.2017.00405","volume":"8","author":"H Su","year":"2017","unstructured":"Su H, Lei CT, Zhang C (2017) Interleukin-6 signaling pathway and its role in kidney disease: an update. Front Immunol 8:405. \n                    https:\/\/doi.org\/10.3389\/fimmu.2017.00405","journal-title":"Front Immunol"},{"key":"2064_CR36","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cyto.2015.06.018","volume":"76","author":"M Jasiewicz","year":"2015","unstructured":"Jasiewicz M, Knapp M, Waszkiewicz E, Ptaszynska-Kopczynska K, Szpakowicz A, Sobkowicz B et al (2015) Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage. Cytokine 76:187\u2013192. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2015.06.018","journal-title":"Cytokine"},{"key":"2064_CR37","doi-asserted-by":"publisher","first-page":"232","DOI":"10.2215\/CJN.07000714","volume":"10","author":"B Spoto","year":"2015","unstructured":"Spoto B, Mattace-Raso F, Sijbrands E, Leonardis D, Testa A, Pisano A et al (2015) Association of IL-6 and a functional polymorphism in the IL-6 Gene with cardiovascular events in patients with CKD. Clin J Am Soc Nephrol 10:232\u2013240. \n                    https:\/\/doi.org\/10.2215\/CJN.07000714","journal-title":"Clin J Am Soc Nephrol"},{"key":"2064_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000365217","volume":"128","author":"Y Adelibieke","year":"2014","unstructured":"Adelibieke Y, Yisireyili M, Ng HY, Saito S, Nishijima F, Niwa T (2014) Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR\/NF-\u03baB pathway. Nephron Exp Nephrol 128:1\u20138. \n                    https:\/\/doi.org\/10.1159\/000365217","journal-title":"Nephron Exp Nephrol"},{"key":"2064_CR39","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1161\/hq0901.094280","volume":"21","author":"DJ Brull","year":"2001","unstructured":"Brull DJ, Montgomery HE, Sanders J, Dhamrait S, Luong L, Rumley A et al (2001) Interleukin-6 gene \u2212\u2009174g> c and \u2212\u2009572g> c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 21:1458\u20131463. \n                    https:\/\/doi.org\/10.1016\/j.atherosclerosis.2004.01.019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2064_CR40","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1111\/j.1538-7836.2006.02125.x","volume":"4","author":"P Cirillo","year":"2006","unstructured":"Cirillo P, Pacileo M, DE Rosa S, Calabr\u00f2 P, Gargiulo A, Angri V (2006) Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells. J Thromb Haemost 4:2248\u20132255. \n                    https:\/\/doi.org\/10.1111\/j.1538-7836.2006.02125.x","journal-title":"J Thromb Haemost"},{"key":"2064_CR41","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.amjcard.2003.11.035","volume":"93","author":"P Avanzas","year":"2004","unstructured":"Avanzas P, Arroyo-Espliguero R, Cosin-Sales J, Quiles J, Zouridakis E, Kaski JC (2004) Prognostic value of neopterin levels in treated patients with hypertension and chest pain but without obstructive coronary artery disease. Am J Cardiol 93:627\u2013629. \n                    https:\/\/doi.org\/10.1016\/j.amjcard.2003.11.035","journal-title":"Am J Cardiol"},{"key":"2064_CR42","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/10715762.2017.1296575","volume":"51","author":"S Chu","year":"2017","unstructured":"Chu S, Mao X, Guo H, Wang L, Li Z, Zhang Y (2017) Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA\/ROCK signaling in 5\/6 nephrectomized rats. Free Radic Res 51:237\u2013252. \n                    https:\/\/doi.org\/10.1080\/10715762.2017.1296575","journal-title":"Free Radic Res"},{"key":"2064_CR43","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.clinbiochem.2005.02.009","volume":"38","author":"K Pawlak","year":"2005","unstructured":"Pawlak K, Pawlak D, Mysliwiec M (2005) Cu\/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease. Clin Biochem 38:700\u2013705. \n                    https:\/\/doi.org\/10.1016\/j.clinbiochem.2005.02.009","journal-title":"Clin Biochem"},{"key":"2064_CR44","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1016\/j.febslet.2010.04.046","volume":"584","author":"Y Miyamoto","year":"2010","unstructured":"Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H (2010) The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions. FEBS Lett 584:2816\u20132820. \n                    https:\/\/doi.org\/10.1016\/j.febslet.2010.04.046","journal-title":"FEBS Lett"},{"key":"2064_CR45","doi-asserted-by":"publisher","first-page":"16977","DOI":"10.1074\/jbc.M116.740092","volume":"291","author":"M Yu","year":"2016","unstructured":"Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X et al (2016) Inhibition of macrophage CD36 expression and cellular oxidized low density lipoprotein (oxLDL) accumulation by tamoxifen: a peroxisome proliferator-activated receptor (PPAR)\u03b3-dependent mechanism. J Biol Chem 291:16977\u201316989. \n                    https:\/\/doi.org\/10.1074\/jbc.M116.740092","journal-title":"J Biol Chem"},{"key":"2064_CR46","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1042\/CS20030152","volume":"105","author":"J Frosteg\u00e5rd","year":"2003","unstructured":"Frosteg\u00e5rd J, Wu R, Lemne C, Thulin T, Witztum JL, de Faire U (2003) Circulating oxidized low-density lipoprotein is increased in hypertension. Clin Sci (Lond) 105:615\u2013620. \n                    https:\/\/doi.org\/10.1042\/CS20030152","journal-title":"Clin Sci (Lond)"},{"key":"2064_CR47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1161\/01.ATV.16.2.222","volume":"16","author":"M Mironova","year":"1996","unstructured":"Mironova M, Virella G, Lopes-Virella MF (1996) Isolation and characterization of human antioxidized LDL autoantibodies. Arterioscler Thromb Vasc Biol 16:222\u2013229","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2064_CR48","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.atherosclerosis.2012.07.011","volume":"224","author":"K Pawlak","year":"2012","unstructured":"Pawlak K, Mysliwiec M, Pawlak D (2012) Oxidized LDL to autoantibodies against oxLDL ratio - the new biomarker associated with carotid atherosclerosis and cardiovascular complications in dialyzed patients. Atherosclerosis 224:252\u2013257","journal-title":"Atherosclerosis"},{"key":"2064_CR49","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1038\/s41598-017-03130-z","volume":"7","author":"HY Kim","year":"2017","unstructured":"Kim HY, Yoo TH, Hwang Y, Lee GH, Kim B, Jang J (2017) Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD). Sci Rep 7:3057. \n                    https:\/\/doi.org\/10.1038\/s41598-017-03130-z","journal-title":"Sci Rep"},{"key":"2064_CR50","doi-asserted-by":"publisher","first-page":"565568","DOI":"10.1016\/S0272-6386(97)90339-5","volume":"29","author":"P B\u00e1r\u00e1ny","year":"1997","unstructured":"B\u00e1r\u00e1ny P, Divino Filho JC, Bergstr\u00f6m J (1997) High C-reactive protein is a strong predictor of resistance to erythropoietin in hemodialysis patients. Am J Kidney Dis 29:565\u2013568","journal-title":"Am J Kidney Dis"},{"key":"2064_CR51","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1093\/ndt\/gfn109","volume":"23","author":"M Chonchol","year":"2008","unstructured":"Chonchol M, Lippi G, Montagnana M, Muggeo M, Targher G (2008) Association of inflammation with anaemia in patients with chronic kidney disease not requiring chronic dialysis. Nephrol Dial Transplant 23:2879\u20132883. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfn109","journal-title":"Nephrol Dial Transplant"},{"key":"2064_CR52","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/ndt\/gfx252","volume":"33","author":"H Hamano","year":"2017","unstructured":"Hamano H, Ikeda Y, Watanabe H, Horinouchi Y, Izawa-Ishizawa Y, Imanishi M et al (2017) The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease. Nephrol Dial Transplant 33:586\u2013597. \n                    https:\/\/doi.org\/10.1093\/ndt\/gfx252","journal-title":"Nephrol Dial Transplant"},{"key":"2064_CR53","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12882-017-0668-5","volume":"18","author":"S Bataille","year":"2017","unstructured":"Bataille S, Pelletier M, Sall\u00e9e M, Berland Y, McKay N, Duval A et al (2017) Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients. BMC Nephrol 18:251. \n                    https:\/\/doi.org\/10.1186\/s12882-017-0668-5","journal-title":"BMC Nephrol"},{"key":"2064_CR54","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","volume":"387","author":"A Lopez","year":"2016","unstructured":"Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L (2016) Iron deficiency anaemia. Lancet 387:907\u2013916. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(15)60865-0","journal-title":"Lancet"},{"key":"2064_CR55","doi-asserted-by":"publisher","first-page":"366","DOI":"10.7150\/ijms.5.366","volume":"5","author":"NR Shah","year":"2008","unstructured":"Shah NR, Dumler F (2008) Hypoalbuminaemia\u2014a marker of cardiovascular disease in patients with chronic kidney disease stages II\u2013IV. Int J Med Sci 5:366\u2013370","journal-title":"Int J Med Sci"},{"key":"2064_CR56","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1046\/j.1523-1755.1999.00422.x","volume":"55","author":"P Stenvinkel","year":"1999","unstructured":"Stenvinkel P, Heimb\u00fcrger O, Paultre F, Diczfalusy U, Wang T, Berglund L (1999) Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55:1899\u20131911. \n                    https:\/\/doi.org\/10.1046\/j.1523-1755.1999.00422.x","journal-title":"Kidney Int"},{"key":"2064_CR57","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.2147\/TCRM.S120012","volume":"12","author":"JY Huang","year":"2016","unstructured":"Huang JY, Hsu CW, Yang CW, Hung CC, Huang WH (2016) Role of anuria in the relationship between indoxyl sulfate and anemia in peritoneal dialysis patients. Ther Clin Risk Manag 12:1797\u20131803. \n                    https:\/\/doi.org\/10.2147\/TCRM.S120012","journal-title":"Ther Clin Risk Manag"},{"key":"2064_CR58","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.0894-0959.2004.17603.x","volume":"17","author":"BR Don","year":"2004","unstructured":"Don BR, Kaysen G (2004) Serum albumin: relationship to inflammation and nutrition. Semin Dial 17:432\u2013437. \n                    https:\/\/doi.org\/10.1111\/j.0894-0959.2004.17603.x","journal-title":"Semin Dial"},{"key":"2064_CR59","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1007\/s00204-015-1652-0","volume":"90","author":"WC Shen","year":"2016","unstructured":"Shen WC, Liang CJ, Huang TM, Liu CW, Wang SH, Young GH et al (2016) Indoxyl sulfate enhances IL-1\u03b2-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS\/MAPKs\/NF\u03baB\/AP-1 pathway. Arch Toxicol 90:2779\u20132792. \n                    https:\/\/doi.org\/10.1007\/s00204-015-1652-0","journal-title":"Arch Toxicol"},{"key":"2064_CR60","doi-asserted-by":"publisher","first-page":"960","DOI":"10.5551\/jat.34462","volume":"23","author":"S Ito","year":"2016","unstructured":"Ito S, Osaka M, Edamatsu T, Itoh Y, Yoshida M (2016) Crucial role of the aryl hydrocarbon receptor (AhR) in indoxyl sulfate-induced vascular inflammation. J Atheroscler Thromb 23:960\u2013975. \n                    https:\/\/doi.org\/10.5551\/jat.34462","journal-title":"J Atheroscler Thromb"},{"key":"2064_CR61","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1097\/00004872-199816010-00008","volume":"16","author":"MC Verhaar","year":"1998","unstructured":"Verhaar MC, Beutler JJ, Gaillard CA, Koomans HA, Fijnheer R, Rabelink TJ (1998) Progressive vascular damage in hypertension is associated with increased levels of circulating P-selectin. J Hypertens 16:45\u201350","journal-title":"J Hypertens"},{"key":"2064_CR62","first-page":"1670416708","volume":"8","author":"GY Lu","year":"2015","unstructured":"Lu GY, Xu RJ, Zhang SH, Qiao Q, Shen L, Li M et al (2015) Alteration of circulatory platelet microparticles and endothelial microparticles in patients with chronic kidney disease. Int J Clin Exp Med 8:16704\u201316708","journal-title":"Int J Clin Exp Med"},{"key":"2064_CR63","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10157-017-1413-x","volume":"22","author":"T Otsuka","year":"2018","unstructured":"Otsuka T, Kaneko Y, Sato Y, Kaseda R, Aoyagi R, Yamamoto S et al (2018) Kidney morphological parameters measured using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD. Clin Exp Nephrol 22:45\u201354. \n                    https:\/\/doi.org\/10.1007\/s10157-017-1413-x","journal-title":"Clin Exp Nephrol"},{"key":"2064_CR64","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s10157-017-1441-6","volume":"22","author":"Y Arai","year":"2018","unstructured":"Arai Y, Kanda E, Iimori S, Naito S, Noda Y, Sasaki S et al (2018) Low white blood cell count is independently associated with chronic kidney disease progression in the elderly: the CKD-ROUTE study. Clin Exp Nephrol 22:291\u2013298. \n                    https:\/\/doi.org\/10.1007\/s10157-017-1441-6","journal-title":"Clin Exp Nephrol"},{"key":"2064_CR65","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s10157-012-0728-x","volume":"17","author":"Y Solak","year":"2013","unstructured":"Solak Y, Yilmaz MI, Sonmez A, Saglam M, Cakir E, Unal HU et al (2013) Neutrophil to lymphocyte ratio independently predicts cardiovascular events in patients with chronic kidney disease. Clin Exp Nephrol 17:532\u2013540. \n                    https:\/\/doi.org\/10.1007\/s10157-012-0728-x","journal-title":"Clin Exp Nephrol"},{"key":"2064_CR66","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3109\/0886022X.2012.734429","volume":"35","author":"GU Okyay","year":"2013","unstructured":"Okyay GU, Inal S, One\u00e7 K, Er RE, Pa\u015fao\u011flu O, Pa\u015fao\u011flu H (2013) Neutrophil to lymphocyte ratio in evaluation of inflammation in patients with chronic kidney disease. Ren Fail 35:29\u201336. \n                    https:\/\/doi.org\/10.3109\/0886022X.2012.734429","journal-title":"Ren Fail"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-02064-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-018-02064-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-02064-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T19:12:48Z","timestamp":1578337968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-018-02064-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["2064"],"URL":"https:\/\/doi.org\/10.1007\/s11255-018-02064-3","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"assertion":[{"value":"26 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}