{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:08:19Z","timestamp":1790050099784,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004172","name":"Mersin \u00dcniversitesi","doi-asserted-by":"publisher","award":["BAP-TF (GG) 2009-8 TU"],"award-info":[{"award-number":["BAP-TF (GG) 2009-8 TU"]}],"id":[{"id":"10.13039\/501100004172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11255-018-1859-0","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T09:49:49Z","timestamp":1523440189000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Determination of NF-\u03baB and RANKL levels in peripheral blood osteoclast precursor cells in chronic kidney disease patients"],"prefix":"10.1007","volume":"50","author":[{"given":"G\u00fclcan","family":"G\u00fcne\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-0944","authenticated-orcid":false,"given":"Nil","family":"Do\u011fruer \u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u00e7in","family":"Eskandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kiykim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"B\u00f6lgen \u00c7imen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclhan","family":"Temel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Burak Y.","family":"\u00c7imen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"issue":"1","key":"1859_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/0886022X.2016.1244077","volume":"39","author":"G D\u2019Onofrio","year":"2017","unstructured":"D\u2019Onofrio G, Simeoni M, Rizza P, Caroleo M, Capria M, Mazzitello G, Sacco T, Mazzuca E, Panzino MT, Cerantonio A, Segura-Garcia C, Andreucci M, De Fazio P, Fuiano G (2017) Quality of life, clinical outcome, personality and coping in chronic hemodialysis patients. Ren Fail 39(1):45\u201353. https:\/\/doi.org\/10.1080\/0886022X.2016.1244077","journal-title":"Ren Fail"},{"key":"1859_CR2","first-page":"1761","volume-title":"Harrison\u2019s principles of internal medicine","author":"M Bargman","year":"2008","unstructured":"Bargman M, Skorecki K (2008) Chronic Kidney Disease. In: Fauci S, Kasper L, Braunwald E, Hauser K, Longo B, Jameson F (eds) Harrison\u2019s principles of internal medicine, 17th edn. Mv Graw Hill, New York, pp 1761\u20131771","edition":"17"},{"issue":"2","key":"1859_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.pop.2008.01.008","volume":"35","author":"R Thomas","year":"2008","unstructured":"Thomas R, Kanso A, Sedor JR (2008) Chronic kidney disease and its complications. Prim Care 35(2):329\u2013344. https:\/\/doi.org\/10.1016\/j.pop.2008.01.008","journal-title":"Prim Care"},{"issue":"9889","key":"1859_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","volume":"382","author":"RT Gansevoort","year":"2013","unstructured":"Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJ, Mann JF, Matsushita K, Wen CP (2013) Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 382(9889):339\u2013352. https:\/\/doi.org\/10.1016\/s0140-6736(13)60595-4","journal-title":"Lancet"},{"issue":"2","key":"1859_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11255-004-4653-0","volume":"37","author":"I Galea","year":"2005","unstructured":"Galea I, Farrugia E (2005) Biochemical indices of renal osteodystrophy in dialysis patients on the island of Malta. Int Urol Nephrol 37(2):335\u2013340. https:\/\/doi.org\/10.1007\/s11255-004-4653-0","journal-title":"Int Urol Nephrol"},{"key":"1859_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bone.2016.03.017","volume":"87","author":"CM Zheng","year":"2016","unstructured":"Zheng CM, Zheng JQ, Wu CC, Lu CL, Shyu JF, Yung-Ho H, Wu MY, Chiu IJ, Wang YH, Lin YF, Lu KC (2016) Bone loss in chronic kidney disease: quantity or quality? Bone 87:57\u201370. https:\/\/doi.org\/10.1016\/j.bone.2016.03.017","journal-title":"Bone"},{"key":"1859_CR7","doi-asserted-by":"publisher","first-page":"R152","DOI":"10.1186\/ar2046","volume":"8","author":"Y Komano","year":"2006","unstructured":"Komano Y, Nanki T, Hayashida K, Taniguchi K, Miyasaka N (2006) Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. Arthritis Res Ther 8:R152. https:\/\/doi.org\/10.1186\/ar2046","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"1859_CR8","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1084\/jem.190.12.1741","volume":"190","author":"F Arai","year":"1999","unstructured":"Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T (1999) Commitment and differentiation of osteoclast precursor cells by the sequential expression of C-Fms and receptor activator of nuclear factor \u03bab (Rank) receptors. J Exp Med 190(12):1741\u20131754","journal-title":"J Exp Med"},{"issue":"31","key":"1859_CR9","doi-asserted-by":"publisher","first-page":"31889","DOI":"10.18632\/oncotarget.5575","volume":"6","author":"E Pivetta","year":"2015","unstructured":"Pivetta E, Wassermann B, Bulian P, Steffan A, Colombatti A, Polesel J, Spessotto P (2015) Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender. Oncotarget 6(31):31889\u201331900. https:\/\/doi.org\/10.18632\/oncotarget.5575","journal-title":"Oncotarget"},{"issue":"1","key":"1859_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12178-009-9046-7","volume":"2","author":"HL Wright","year":"2009","unstructured":"Wright HL, McCarthy HS, Middleton J, Marshall MJ (2009) RANK, RANKL and osteoprotegerin in bone biology and disease. Curr Rev Musculoskelet Med 2(1):56\u201364. https:\/\/doi.org\/10.1007\/s12178-009-9046-7","journal-title":"Curr Rev Musculoskelet Med"},{"key":"1859_CR11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","volume":"473","author":"BF Boyce","year":"2008","unstructured":"Boyce BF, Xing L (2008) Functions of RANKL\/RANK\/OPG in bone modeling and remodeling. Arch Biochem Biophys 473:139\u2013146. https:\/\/doi.org\/10.1016\/j.abb.2008.03.018","journal-title":"Arch Biochem Biophys"},{"issue":"11","key":"1859_CR12","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1177\/039139880402701103","volume":"27","author":"GB Spasovski","year":"2004","unstructured":"Spasovski GB (2004) Bone biopsy as a diagnostic tool in the assessment of renal osteodystrophy. Int J Artif Organs 27(11):918\u2013923","journal-title":"Int J Artif Organs"},{"key":"1859_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/nep.13017","volume":"22","author":"T Diamond","year":"2017","unstructured":"Diamond T, Elder GJ (2017) Is there a practical role for bone biopsy in chronic kidney disease? Nephrology (Carlton) 22:22\u201326. https:\/\/doi.org\/10.1111\/nep.13017","journal-title":"Nephrology (Carlton)"},{"key":"1859_CR14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2478\/v10042-009-0035-x","volume":"47","author":"K Klejna","year":"2009","unstructured":"Klejna K, Naumnik B, Gasowska K, My\u015bliwiec M (2009) OPG\/RANK\/RANKL signaling system and its significance in nephrology. Folia Histochem Cytobiol 47:199\u2013206. https:\/\/doi.org\/10.2478\/v10042-009-0035-x","journal-title":"Folia Histochem Cytobiol"},{"key":"1859_CR15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1515\/CCLM.2007.306","volume":"45","author":"M Shaarawy","year":"2007","unstructured":"Shaarawy M, Fathy SA, Mehany NL, Hindy OW (2007) Circulating levels of osteoprotegerin and receptor activator of NF-kappaB ligand in patients with chronic renal failure. Clin Chem Lab Med 45:498\u2013503. https:\/\/doi.org\/10.1515\/CCLM.2007.306","journal-title":"Clin Chem Lab Med"},{"key":"1859_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1093\/ndt\/gfh672","volume":"20","author":"I Avbersek-Luznik","year":"2005","unstructured":"Avbersek-Luznik I, Balon BP, Rus I, Marc J (2005) Increased bone resorption in HD patients: is it caused by elevated RANKL synthesis? Nephrol Dial Transpl 20:566\u2013570. https:\/\/doi.org\/10.1093\/ndt\/gfh672","journal-title":"Nephrol Dial Transpl"},{"key":"1859_CR17","doi-asserted-by":"publisher","first-page":"652","DOI":"10.5414\/CNP71652","volume":"71","author":"A Fahrleitner-Pammer","year":"2009","unstructured":"Fahrleitner-Pammer A, Dobnig H, Dimai HP, Holzer H, Benesch T, Borchhardt K, Cejka D, Haas M (2009) The effect of RANKL and OPG on bone mineral density in pre-dialysis chronic renal failure. Clin Nephrol 71:652\u2013659","journal-title":"Clin Nephrol"},{"key":"1859_CR18","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1093\/ndt\/gfl034","volume":"21","author":"M Albalate","year":"2006","unstructured":"Albalate M, de la Piedra C, Fern\u00e1ndez C, Lefort M, Santana H, Hernando P, Hern\u00e1ndez J, Caramelo C (2006) Association between phosphate removal and markers of bone turnover in haemodialysis patients. Nephrol Dial Transpl 21:1626\u20131632. https:\/\/doi.org\/10.1093\/ndt\/gfl034","journal-title":"Nephrol Dial Transpl"},{"key":"1859_CR19","unstructured":"EPI CKD Calculator. http:\/\/www.MDRD.com\/ . Accessed 26 June 2010"},{"issue":"2","key":"1859_CR20","first-page":"A57","volume":"3","author":"AC Schoolwerth","year":"2006","unstructured":"Schoolwerth AC, Engelgau MM, Rufo KH, Vinicor F, Hostetter TH, Chianchiano D, McClellan WM, Warnock DG (2006) Chronic kidney disease: a public health problem that needs a public health action plan. Prev Chronic Dis 3(2):A57","journal-title":"Prev Chronic Dis"},{"issue":"Suppl 5","key":"1859_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/ndt\/15.suppl_5.8","volume":"15","author":"MA Ferreira","year":"2000","unstructured":"Ferreira MA (2000) Diagnosis of renal osteodystrophy: when and how to use biochemical markers and non-invasive methods; when bone biopsy is needed. Nephrol Dial Transpl 15(Suppl 5):8\u201314","journal-title":"Nephrol Dial Transpl"},{"issue":"Suppl 4","key":"1859_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/ndt\/10.supp4.19","volume":"10","author":"NA Hamdy","year":"1995","unstructured":"Hamdy NA (1995) The need to treat predialysis patients. Nephrol Dial Transpl 10(Suppl 4):19\u201322. https:\/\/doi.org\/10.1093\/ndt\/10.supp4.19","journal-title":"Nephrol Dial Transpl"},{"issue":"Suppl 2","key":"1859_CR23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/089686089901902S65","volume":"19","author":"SK Shin","year":"1999","unstructured":"Shin SK, Kim DH, Kim HS, Shin KT, Ma KA, Kim SJ, Kwak YS, Ha SK, Sherrard DJ (1999) Renal osteodystrophy in pre-dialysis patients: ethnic difference? Perit Dial Int 19(Suppl 2):402\u2013407","journal-title":"Perit Dial Int"},{"key":"1859_CR24","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1210\/jcem-67-5-876","volume":"67","author":"TO Pitt","year":"1988","unstructured":"Pitt TO, Piraino BH, Mitro R, Chen TC, Segre GV, Greenberg A, Puschett JB (1988) Hyperparathyroidism and 1,25 dihydroksyvitamin D deficiency in mild moderate and severe renal failure. J Clin Endocrinol Metab 67:876\u2013881","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"1859_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1471-2369-12-53","volume":"5","author":"A Mart\u00ednez-Castelao","year":"2011","unstructured":"Mart\u00ednez-Castelao A, G\u00f3rriz JL, Portol\u00e9s JM, De Alvaro F, Cases A, Lu\u00f1o J, Navarro-Gonz\u00e1lez JF, Montes R, De la Cruz-Troca JJ, Natarajan A, Batlle D (2011) Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in spain: the MERENA observational cohort study. BMC Nephrol 5(12):53. https:\/\/doi.org\/10.1186\/1471-2369-12-53","journal-title":"BMC Nephrol"},{"key":"1859_CR26","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/j.1440-1797.2011.01481.x","volume":"16","author":"JQ Jiang","year":"2011","unstructured":"Jiang JQ, Lin S, Xu PC, Zheng ZF, Jia JY (2011) Serum osteoprotegerin measurement for early diagnosis of chronic kidney disease-mineral and bone disorder. Nephrology (Carlton) 16:588\u2013594. https:\/\/doi.org\/10.1111\/j.1440-1797.2011.01481.x","journal-title":"Nephrology (Carlton)"},{"key":"1859_CR27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ki.2008.543","volume":"111","author":"AM Ramos","year":"2008","unstructured":"Ramos AM, Albalate M, V\u00e1zquez S, Caramelo C, Egido J, Ortiz A (2008) Hyperphosphatemia and hyperparathyroidism in incident chronic kidney disease patients. Kidney Int Suppl 111:88\u201393. https:\/\/doi.org\/10.1038\/ki.2008.543","journal-title":"Kidney Int Suppl"},{"issue":"5","key":"1859_CR28","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00198-007-0554-2","volume":"19","author":"M Kurajoh","year":"2008","unstructured":"Kurajoh M, Inaba M, Yamada S, Imanishi Y, Tsuchida T, Ishimura E, Nishizawa Y (2008) Association of increased active PTH(1\u201384) fraction with decreased GFR and serum Ca in predialysis CR patients: modulation by serum 25-OH-D. Osteoporos Int 19(5):709\u2013716. https:\/\/doi.org\/10.1007\/s00198-007-0554-2","journal-title":"Osteoporos Int"},{"key":"1859_CR29","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.0105-2896.2005.00327.x","volume":"208","author":"S Tanaka","year":"2005","unstructured":"Tanaka S, Nakamura K, Takahasi N, Suda T (2005) Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev 208:30\u201349. https:\/\/doi.org\/10.1111\/j.0105-2896.2005.00327.x","journal-title":"Immunol Rev"},{"issue":"2","key":"1859_CR30","doi-asserted-by":"publisher","first-page":"382","DOI":"10.2478\/ams-2013-0026","volume":"58","author":"B Naumnik","year":"2013","unstructured":"Naumnik B, Klejna K, Koc-\u017b\u00f3rawska E, My\u015bliwiec M (2013) Age and gender predict OPG level and OPG\/sRANKL ratio in maintenance hemodialysis patients. Adv Med Sci 58(2):382\u2013387","journal-title":"Adv Med Sci"},{"issue":"1","key":"1859_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1744-9987.2009.00653.x","volume":"13","author":"K Doumouchtsis","year":"2009","unstructured":"Doumouchtsis K, Perrea D, Doumouchtsis S, Tziamalis M, Poulakou M, Vlachos I, Kostakis A (2009) Regulatory effect of parathyroid hormone on sRANKL-osteoprotegerin in hemodialysis patients with renal bone disease. Ther Apher Dial 13(1):49\u201355. https:\/\/doi.org\/10.1111\/j.1744-9987.2009.00653.x","journal-title":"Ther Apher Dial"},{"issue":"9","key":"1859_CR32","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/BF03350814","volume":"30","author":"KK Doumouchtsis","year":"2007","unstructured":"Doumouchtsis KK, Kostakis AI, Doumouchtsis SK, Tziamalis MP, Tsigris C, Kostaki MA, Perrea DN (2007) sRANKL\/osteoprotegerin complex and biochemical markers in a cohort of male and female hemodialysis patients. J Endocrinol Invest 30(9):762\u2013766. https:\/\/doi.org\/10.1007\/BF03350814","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"1859_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cytogfr.2008.11.007","volume":"20","author":"J Xu","year":"2009","unstructured":"Xu J, Wu HF, Ang ES, Yip K, Woloszyn M, Zheng MH, Tan RX (2009) NF-kappaB modulators in osteolytic bone diseases. Cytokine Growth Factor Rev 20(1):7\u201317. https:\/\/doi.org\/10.1016\/j.cytogfr.2008.11.007","journal-title":"Cytokine Growth Factor Rev"},{"key":"1859_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1749-6632.2009.05315.x","volume":"1192","author":"BF Boyce","year":"2010","unstructured":"Boyce BF, Yao Z, Xing L (2010) Functions of nuclear factor kappaB in bone. Ann N Y Acad Sci 1192:367\u2013375. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.05315.x","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"1859_CR35","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1080\/003130299104774","volume":"31","author":"SM Ward","year":"1999","unstructured":"Ward SM (1999) The use of flow cytometry in the diagnosis and monitoring of malignant hematological disorders. Pathology 31(4):382\u2013392","journal-title":"Pathology"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-018-1859-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-1859-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-1859-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T14:05:57Z","timestamp":1604153157000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-018-1859-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1859"],"URL":"https:\/\/doi.org\/10.1007\/s11255-018-1859-0","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"20 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}