{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:43:30Z","timestamp":1792669410022,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK104718"],"award-info":[{"award-number":["DK104718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11255-018-1860-7","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T06:08:23Z","timestamp":1523513303000},"page":"1123-1130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Diversity of the midstream urine microbiome in adults with chronic kidney disease"],"prefix":"10.1007","volume":"50","author":[{"given":"Holly","family":"Kramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Kuffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystal","family":"Thomas-White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Vellanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Leehey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod K.","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Brubaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Flanigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Koval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Zilliox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"issue":"9","key":"1860_CR1","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00192-013-2325-2","volume":"25","author":"L Brubaker","year":"2014","unstructured":"Brubaker L, Nager CW, Richter HE et al (2014) Urinary bacteria in adult women with urgency urinary incontinence. Int Urogynecol J 25(9):1179\u20131184","journal-title":"Int Urogynecol J"},{"issue":"3","key":"1860_CR2","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1128\/JCM.02876-13","volume":"52","author":"E Hilt","year":"2014","unstructured":"Hilt E, McKnley K, Pearce M et al (2014) Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol 52(3):871\u2013876","journal-title":"J Clin Microbiol"},{"issue":"12","key":"1860_CR3","doi-asserted-by":"publisher","first-page":"e114185","DOI":"10.1371\/journal.pone.0114185","volume":"9","author":"V Nienhouse","year":"2014","unstructured":"Nienhouse V, Gao X, Dong Q et al (2014) Interplay between bladder microbiota and urinary antimicrobial peptides: mechanisms for human urinary tract infection risk and symptom severity. PLoS ONE 9(12):e114185","journal-title":"PLoS ONE"},{"issue":"4","key":"1860_CR4","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1128\/JCM.05852-11","volume":"50","author":"AJ Wolfe","year":"2012","unstructured":"Wolfe AJ, Toh E, Shibata N et al (2012) Evidence of uncultivated bacteria in the adult female bladder. J Clin Microbiol 50(4):1376\u20131383","journal-title":"J Clin Microbiol"},{"issue":"2","key":"1860_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.21037\/atm.2016.11.62","volume":"5","author":"L Brubaker","year":"2017","unstructured":"Brubaker L, Wolfe AJ (2017) The female urinary microbiota, urinary health and common urinary disorders. Ann Transl Med 5(2):34","journal-title":"Ann Transl Med"},{"key":"1860_CR6","unstructured":"Wolfe AJ, Brubaker L (2015) \u201cSterile urine\u201d and the presence of bacteria. European Urology Published online March 13, 2015"},{"issue":"Spec No","key":"1860_CR7","first-page":"93","volume":"43","author":"JD Oliver","year":"2005","unstructured":"Oliver JD (2005) The viable but nonculturable state in bacteria. J Microbiol 43(Spec No):93\u2013100","journal-title":"J Microbiol"},{"issue":"5","key":"1860_CR8","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1128\/JCM.00044-16","volume":"54","author":"TK Price","year":"2016","unstructured":"Price TK, Dune T, Hilt EE et al (2016) The clinical urine culture: enhanced techniques improve detection of clinically relevant microorganisms. J Clin Microbiol 54(5):1216\u20131222","journal-title":"J Clin Microbiol"},{"key":"1860_CR9","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1471-2180-11-244","volume":"11","author":"H Siddiqui","year":"2011","unstructured":"Siddiqui H, Nederbragt AJ, Lagesen K, Jeansson SL, Jakobsen KS (2011) Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons. BMC Microbiol 11:244","journal-title":"BMC Microbiol"},{"key":"1860_CR10","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/1479-5876-10-174","volume":"10","author":"DE Fouts","year":"2012","unstructured":"Fouts DE, Pieper R, Szpakowski S et al (2012) Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury. J Transl Med 10:174","journal-title":"J Transl Med"},{"issue":"2","key":"1860_CR11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nrurol.2016.262","volume":"14","author":"L Brubaker","year":"2017","unstructured":"Brubaker L, Wolfe AJ (2017) Microbiota in 2016: associating infection and incontinence with the female urinary microbiota. Nat Rev Urol 14(2):72\u201374","journal-title":"Nat Rev Urol"},{"issue":"5","key":"1860_CR12","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/GCO.0000000000000298","volume":"28","author":"L Brubaker","year":"2016","unstructured":"Brubaker L, Wolfe A (2016) The urinary microbiota: a paradigm shift for bladder disorders? Curr Opin Obstet Gynecol 28(5):407\u2013412","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"5","key":"1860_CR13","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00192-015-2847-x","volume":"27","author":"KJ Thomas-White","year":"2016","unstructured":"Thomas-White KJ, Hilt EE, Fok C et al (2016) Incontinence medication response relates to the female urinary microbiota. Int Urogynecol J 27(5):723\u2013733","journal-title":"Int Urogynecol J"},{"issue":"4","key":"1860_CR14","doi-asserted-by":"publisher","first-page":"e01283-14","DOI":"10.1128\/mBio.01283-14","volume":"5","author":"MM Pearce","year":"2014","unstructured":"Pearce MM, Hilt EE, Rosenfeld AB et al (2014) The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. MBio 5(4):e01283-14","journal-title":"MBio"},{"issue":"1","key":"1860_CR15","doi-asserted-by":"publisher","first-page":"55.e1","DOI":"10.1016\/j.ajog.2016.07.049","volume":"216","author":"KJ Thomas-White","year":"2017","unstructured":"Thomas-White KJ, Kliethermes S, Rickey L et al (2017) Evaluation of the urinary microbiota of women with uncomplicated stress urinary incontinence. Am J Obstet Gynecol 216(1):55.e1\u201355.e16","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1860_CR16","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.chom.2017.02.012","volume":"21","author":"D Gevers","year":"2017","unstructured":"Gevers D, Kugathasan S, Knights D, Kostic AD, Knight R, Xavier RJ (2017) A microbiome foundation for the study of Crohn\u2019s disease. Cell Host Microbe 21(3):301\u2013304","journal-title":"Cell Host Microbe"},{"issue":"3","key":"1860_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","volume":"15","author":"D Gevers","year":"2014","unstructured":"Gevers D, Kugathasan S, Denson LA et al (2014) The treatment-naive microbiome in new-onset Crohn\u2019s disease. Cell Host Microbe 15(3):382\u2013392","journal-title":"Cell Host Microbe"},{"issue":"18","key":"1860_CR18","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1056\/NEJMoa043802","volume":"353","author":"DN Fredricks","year":"2005","unstructured":"Fredricks DN, Fiedler TL, Marrazzo JM (2005) Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 353(18):1899\u20131911","journal-title":"N Engl J Med"},{"issue":"10","key":"1860_CR19","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1681\/ASN.2015070830","volume":"27","author":"S Ghirotto","year":"2016","unstructured":"Ghirotto S, Tassi F, Barbujani G et al (2016) The uromodulin gene locus shows evidence of pathogen adaptation through human evolution. J Am Soc Nephrol 27(10):2983\u20132996","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1860_CR20","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.juro.2009.01.014","volume":"181","author":"HS Raffi","year":"2009","unstructured":"Raffi HS, Bates JM Jr, Laszik Z, Kumar S (2009) Tamm-horsfall protein protects against urinary tract infection by proteus mirabilis. J Urol 181(5):2332\u20132338","journal-title":"J Urol"},{"issue":"4","key":"1860_CR21","doi-asserted-by":"publisher","first-page":"F795","DOI":"10.1152\/ajprenal.00357.2003","volume":"286","author":"L Mo","year":"2004","unstructured":"Mo L, Zhu XH, Huang HY, Shapiro E, Hasty DL, Wu XR (2004) Ablation of the Tamm\u2013Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol 286(4):F795\u2013F802","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"1860_CR22","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1523-1755.2004.00452.x","volume":"65","author":"JM Bates","year":"2004","unstructured":"Bates JM, Raffi HM, Prasadan K et al (2004) Tamm\u2013Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 65(3):791\u2013797","journal-title":"Kidney Int"},{"issue":"7","key":"1860_CR23","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1681\/ASN.2014010117","volume":"25","author":"HJ Anders","year":"2014","unstructured":"Anders HJ, Schaefer L (2014) Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis. J Am Soc Nephrol 25(7):1387\u20131400","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"1860_CR24","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s11255-016-1304-1","volume":"48","author":"M Patel","year":"2016","unstructured":"Patel M, Vellanki K, Leehey DJ et al (2016) Urinary incontinence and diuretic avoidance among adults with chronic kidney disease. Int Urol Nephrol 48(8):1321\u20131326","journal-title":"Int Urol Nephrol"},{"issue":"9","key":"1860_CR25","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604\u2013612","journal-title":"Ann Intern Med"},{"issue":"6","key":"1860_CR26","doi-asserted-by":"publisher","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"AS Levey","year":"1999","unstructured":"Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130(6):461\u2013470","journal-title":"Ann Intern Med"},{"key":"1860_CR27","unstructured":"National Center for Health Statistics 2013\u20132014 National Health and Nutrition Examination Survey (NHANES). Kidney Inventory Questionnaire. Centers for disease control and prevention. \n                    http:\/\/www.cdc.gov\/nchs\/data\/nhanes\/nhanes_13_14\/KIQ_CAPI_H.pdf\n                    \n                  . August 6, 2015. Cited September 2014"},{"issue":"3","key":"1860_CR28","doi-asserted-by":"publisher","first-page":"e33865","DOI":"10.1371\/journal.pone.0033865","volume":"7","author":"S Yuan","year":"2012","unstructured":"Yuan S, Cohen DB, Ravel J, Abdo Z, Forney LJ (2012) Evaluation of methods for the extraction and purification of DNA from the human microbiome. PLoS ONE 7(3):e33865","journal-title":"PLoS ONE"},{"issue":"3","key":"1860_CR29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ismej.2012.102","volume":"7","author":"PD Schloss","year":"2013","unstructured":"Schloss PD (2013) Secondary structure improves OTU assignments of 16S rRNA gene sequences. ISME J 7(3):457\u2013460","journal-title":"ISME J"},{"issue":"16","key":"1860_CR30","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","volume":"73","author":"Q Wang","year":"2007","unstructured":"Wang Q, Garrity GM, Tiedje JM, Cole JR (2007) Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73(16):5261\u20135267","journal-title":"Appl Environ Microbiol"},{"key":"1860_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fcimb.2016.00078","volume":"6","author":"L Karstens","year":"2016","unstructured":"Karstens L, Asquith M, Davin S et al (2016) Does the urinary microbiome play a role in urgency urinary incontinence and its severity? Front Cell Infect Microbiol 6:78","journal-title":"Front Cell Infect Microbiol"},{"key":"1860_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/1471-2180-12-205","volume":"12","author":"H Siddiqui","year":"2012","unstructured":"Siddiqui H, Lagesen K, Nederbragt AJ, Jeansson SL, Jakobsen KS (2012) Alterations of microbiota in urine from women with interstitial cystitis. BMC Microbiol 12:205","journal-title":"BMC Microbiol"},{"issue":"3","key":"1860_CR33","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/AOG.0000000000001892","volume":"129","author":"MG Abernethy","year":"2017","unstructured":"Abernethy MG, Rosenfeld A, White JR, Mueller MG, Lewicky-Gaupp C, Kenton K (2017) Urinary microbiome and cytokine levels in women with interstitial cystitis. Obstet Gynecol 129(3):500\u2013506","journal-title":"Obstet Gynecol"},{"key":"1860_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fcimb.2013.00041","volume":"3","author":"DA Lewis","year":"2013","unstructured":"Lewis DA, Brown R, Williams J et al (2013) The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Front Cell Infect Microbiol 3:41","journal-title":"Front Cell Infect Microbiol"},{"issue":"5","key":"1860_CR35","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ki.2015.192","volume":"88","author":"PS Garimella","year":"2015","unstructured":"Garimella PS, Biggs ML, Katz R et al (2015) Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults. Kidney Int 88(5):1126\u20131134","journal-title":"Kidney Int"},{"issue":"5","key":"1860_CR36","doi-asserted-by":"publisher","first-page":"e19709","DOI":"10.1371\/journal.pone.0019709","volume":"6","author":"Q Dong","year":"2011","unstructured":"Dong Q, Nelson DE, Toh E et al (2011) The microbial communities in male first catch urine are highly similar to those in paired urethral swab specimens. PLoS ONE 6(5):e19709","journal-title":"PLoS ONE"},{"issue":"11","key":"1860_CR37","doi-asserted-by":"publisher","first-page":"e14116","DOI":"10.1371\/journal.pone.0014116","volume":"5","author":"DE Nelson","year":"2010","unstructured":"Nelson DE, Van Der Pol B, Dong Q et al (2010) Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection. PLoS ONE 5(11):e14116","journal-title":"PLoS ONE"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-018-1860-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-1860-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-1860-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:43:30Z","timestamp":1589417010000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-018-1860-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1860"],"URL":"https:\/\/doi.org\/10.1007\/s11255-018-1860-7","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,12]]},"assertion":[{"value":"29 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}