{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:57:14Z","timestamp":1793105834504,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s11255-018-2002-y","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T03:18:11Z","timestamp":1539573491000},"page":"2289-2297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Significant association of anti-platelet factor 4\/heparin antibody with cardiovascular disease in hemodialysis patients: a longitudinal 7-year study"],"prefix":"10.1007","volume":"50","author":[{"given":"Chi-Chu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsang-Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-6377","authenticated-orcid":false,"given":"Chien-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Feng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"issue":"2","key":"2002_CR1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1093\/ndt\/gfh544","volume":"20","author":"M Haase","year":"2005","unstructured":"Haase M, Bellomo R, Rocktaeschel J, Ziemer S, Kiesewetter H, Morgera S et al (2005) Use of fondaparinux (ARIXTRA) in a dialysis patient with symptomatic heparin-induced thrombocytopaenia Type II. Nephrol Dial Transplant 20(2):444\u2013446","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"2002_CR2","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1182\/blood-2008-02-078014","volume":"112","author":"JG Kelton","year":"2008","unstructured":"Kelton JG, Warkentin TE (2008) Heparin-induced thrombocytopenia: a historical perspective. Blood 112(7):2607\u20132616","journal-title":"Blood"},{"issue":"6","key":"2002_CR3","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1111\/j.1538-7836.2012.04734.x","volume":"10","author":"JF Arthur","year":"2012","unstructured":"Arthur JF, Qiao J, Shen Y, Davis AK, Dunne E, Berndt MC et al (2012) ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways. J Thromb Haemost 10(6):1133\u20131141","journal-title":"J Thromb Haemost"},{"issue":"7","key":"2002_CR4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1042\/CS20120309","volume":"124","author":"D Burger","year":"2013","unstructured":"Burger D, Schock S, Thompson CS, Montezano AC, Hakim AM, Touyz RM (2013) Microparticles: biomarkers and beyond. Clin Sci (Lond) 124(7):423\u2013441","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"2002_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0008-6363(03)00367-5","volume":"59","author":"MJ VanWijk","year":"2003","unstructured":"VanWijk MJ, VanBavel E, Sturk A, Nieuwland R (2003) Microparticles in cardiovascular diseases. Cardiovasc Res 59(2):277\u2013287","journal-title":"Cardiovasc Res"},{"issue":"2","key":"2002_CR6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1161\/01.HYP.0000231507.00962.b5","volume":"48","author":"CM Boulanger","year":"2006","unstructured":"Boulanger CM, Amabile N, Tedgui A (2006) Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease. Hypertension 48(2):180\u2013186","journal-title":"Hypertension"},{"issue":"11","key":"2002_CR7","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1681\/ASN.2005050535","volume":"16","author":"N Amabile","year":"2005","unstructured":"Amabile N, Guerin AP, Leroyer A, Mallat Z, Nguyen C, Boddaert J et al (2005) Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol 16(11):3381\u20133388","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"2002_CR8","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jacc.2006.10.053","volume":"49","author":"AS Leroyer","year":"2007","unstructured":"Leroyer AS, Isobe H, Leseche G, Castier Y, Wassef M, Mallat Z et al (2007) Cellular origins and thrombogenic activity of microparticles isolated from human atherosclerotic plaques. J Am Coll Cardiol 49(7):772\u2013777","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"2002_CR9","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1161\/CIRCRESAHA.110.233163","volume":"109","author":"PE Rautou","year":"2011","unstructured":"Rautou PE, Vion AC, Amabile N, Chironi G, Simon A, Tedgui A et al (2011) Microparticles, vascular function, and atherothrombosis. Circ Res 109(5):593\u2013606","journal-title":"Circ Res"},{"issue":"2","key":"2002_CR10","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1053\/j.ajkd.2009.03.012","volume":"54","author":"A Davenport","year":"2009","unstructured":"Davenport A (2009) Antibodies to heparin-platelet factor 4 complex: pathogenesis, epidemiology, and management of heparin-induced thrombocytopenia in hemodialysis. Am J Kidney Dis 54(2):361\u2013374","journal-title":"Am J Kidney Dis"},{"issue":"13","key":"2002_CR11","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1056\/NEJMoa041031","volume":"351","author":"AS Go","year":"2004","unstructured":"Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296\u20131305","journal-title":"N Engl J Med"},{"issue":"1","key":"2002_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/1076029612436676","volume":"19","author":"T Matsuo","year":"2013","unstructured":"Matsuo T, Wanaka K, Walenga JM (2013) Evaluation of circuit and AV fistula clotting and detection of anti-PF4\/heparin complex antibodies in hemodialysis patients suspected of having heparin-induced thrombocytopenia. Clin Appl Thromb Hemost 19(1):73\u201378","journal-title":"Clin Appl Thromb Hemost"},{"issue":"8","key":"2002_CR13","doi-asserted-by":"publisher","first-page":"995","DOI":"10.4065\/80.8.995","volume":"80","author":"L PenaVega de la","year":"2005","unstructured":"Pena de la Vega L, Miller RS, Benda MM, Grill DE, Johnson MG, McCarthy JT et al (2005) Association of heparin-dependent antibodies and adverse outcomes in hemodialysis patients: a population-based study. Mayo Clin Proc 80(8):995\u20131000","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"2002_CR14","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.thromres.2006.09.014","volume":"120","author":"M Carrier","year":"2007","unstructured":"Carrier M, Knoll GA, Kovacs MJ, Moore JC, Fergusson D, Rodger MA (2007) The prevalence of antibodies to the platelet factor 4-heparin complex and association with access thrombosis in patients on chronic hemodialysis. Thromb Res 120(2):215\u2013220","journal-title":"Thromb Res"},{"issue":"3","key":"2002_CR15","first-page":"498","volume":"100","author":"LM Asmis","year":"2008","unstructured":"Asmis LM, Segal JB, Plantinga LC, Fink NE, Kerman JS, Kickler TS et al (2008) Heparin-induced antibodies and cardiovascular risk in patients on dialysis. Thromb Haemost 100(3):498\u2013504","journal-title":"Thromb Haemost"},{"issue":"4","key":"2002_CR16","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1681\/ASN.2005050615","volume":"17","author":"P Roy-Chaudhury","year":"2006","unstructured":"Roy-Chaudhury P, Sukhatme VP, Cheung AK (2006) Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint. J Am Soc Nephrol 17(4):1112\u20131127","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2002_CR17","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1681\/ASN.2005090958","volume":"17","author":"K Yasuda","year":"2006","unstructured":"Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y et al (2006) Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. J Am Soc Nephrol 17(8):2322\u20132332","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2002_CR18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1681\/ASN.V781169","volume":"7","author":"S Marchi De","year":"1996","unstructured":"De Marchi S, Falleti E, Giacomello R, Stel G, Cecchin E, Sepiacci G et al (1996) Risk factors for vascular disease and arteriovenous fistula dysfunction in hemodialysis patients. J Am Soc Nephrol 7(8):1169\u20131177","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"2002_CR19","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s10157-011-0555-5","volume":"16","author":"YF Tsai","year":"2012","unstructured":"Tsai YF, Chen CA, Kuo C, Lin KC (2012) Anti-PF4\/heparin antibodies are associated with arteriovenous fistula thrombosis in non-diabetic hemodialysis patients. Clin Exp Nephrol 16(2):300\u2013305","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"2002_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/ajh.10032","volume":"69","author":"SI O\u2019Shea","year":"2002","unstructured":"O\u2019Shea SI, Sands JJ, Nudo SA, Ortel TL (2002) Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis. Am J Hematol 69(1):72\u201373","journal-title":"Am J Hematol"},{"issue":"12 Suppl","key":"2002_CR21","first-page":"S16","volume":"9","author":"RN Foley","year":"1998","unstructured":"Foley RN, Parfrey PS, Sarnak MJ (1998) Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 9(12 Suppl):S16\u2013S23","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"2002_CR22","doi-asserted-by":"publisher","first-page":"874","DOI":"10.2215\/CJN.01170209","volume":"5","author":"V Krane","year":"2010","unstructured":"Krane V, Berger M, Lilienthal J, Winkler K, Schambeck C, Wanner C (2010) Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes. Clin J Am Soc Nephrol 5(5):874\u2013881","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"2002_CR23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1053\/j.ajkd.2011.07.016","volume":"59","author":"A Power","year":"2012","unstructured":"Power A, Chan K, Singh SK, Taube D, Duncan N (2012) Appraising stroke risk in maintenance hemodialysis patients: a large single-center cohort study. Am J Kidney Dis 59(2):249\u2013257","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"2002_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/sj.ki.5002631","volume":"73","author":"M Carrier","year":"2008","unstructured":"Carrier M, Rodger MA, Fergusson D, Doucette S, Kovacs MJ, Moore J et al (2008) Increased mortality in hemodialysis patients having specific antibodies to the platelet factor 4-heparin complex. Kidney Int 73(2):213\u2013219","journal-title":"Kidney Int"},{"issue":"4","key":"2002_CR25","doi-asserted-by":"publisher","first-page":"e62239","DOI":"10.1371\/journal.pone.0062239","volume":"8","author":"D Zhao","year":"2013","unstructured":"Zhao D, Sun X, Yao L, Lin H, Li J, Zhao J et al (2013) The clinical significance and risk factors of anti-platelet factor 4\/heparin antibody on maintenance hemodialysis patients: a two-year prospective follow-up. PLoS ONE 8(4):e62239","journal-title":"PLoS ONE"},{"issue":"3","key":"2002_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/ijlh.12474","volume":"38","author":"J Du","year":"2016","unstructured":"Du J, Wang Q, He B, Liu P, Chen JY, Quan H et al (2016) Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke. Int J Lab Hematol 38(3):233\u2013239","journal-title":"Int J Lab Hematol"},{"issue":"12","key":"2002_CR27","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1007\/s10072-014-1850-1","volume":"35","author":"JW Li","year":"2014","unstructured":"Li JW, Xu C, Xiao YB (2014) Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis. Neurol Sci 35(12):1877\u20131882","journal-title":"Neurol Sci"},{"issue":"3","key":"2002_CR28","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ahj.2008.05.016","volume":"156","author":"RN Foley","year":"2008","unstructured":"Foley RN, Collins AJ, Ishani A, Kalra PA (2008) Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 156(3):556\u2013563","journal-title":"Am Heart J"},{"issue":"9","key":"2002_CR29","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1161\/STROKEAHA.116.013195","volume":"47","author":"S Yamada","year":"2016","unstructured":"Yamada S, Tsuruya K, Taniguchi M, Tokumoto M, Fujisaki K, Hirakata H et al (2016) Association between serum phosphate levels and stroke risk in patients undergoing hemodialysis: the Q-Cohort Study. Stroke 47(9):2189\u20132196","journal-title":"Stroke"},{"issue":"5","key":"2002_CR30","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.2215\/CJN.09961110","volume":"6","author":"T Shoji","year":"2011","unstructured":"Shoji T, Masakane I, Watanabe Y, Iseki K, Tsubakihara Y (2011) Elevated non-high-density lipoprotein cholesterol (non-HDL-C) predicts atherosclerotic cardiovascular events in hemodialysis patients. Clin J Am Soc Nephrol 6(5):1112\u20131120","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"2002_CR31","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S0272-6386(12)80672-X","volume":"24","author":"P Goldwasser","year":"1994","unstructured":"Goldwasser P, Avram MM, Collier JT, Michel MA, Gusik SA, Mittman N (1994) Correlates of vascular access occlusion in hemodialysis. Am J Kidney Dis 24(5):785\u2013794","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"2002_CR32","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1053\/j.ajkd.2005.01.004","volume":"45","author":"F Mallamaci","year":"2005","unstructured":"Mallamaci F, Bonanno G, Seminara G, Rapisarda F, Fatuzzo P, Candela V et al (2005) Hyperhomocysteinemia and arteriovenous fistula thrombosis in hemodialysis patients. Am J Kidney Dis 45(4):702\u2013707","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"2002_CR33","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1681\/ASN.V661613","volume":"6","author":"FC Prischl","year":"1995","unstructured":"Prischl FC, Kirchgatterer A, Brandstatter E, Wallner M, Baldinger C, Roithinger FX et al (1995) Parameters of prognostic relevance to the patency of vascular access in hemodialysis patients. J Am Soc Nephrol 6(6):1613\u20131618","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"2002_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1159\/000132388","volume":"26","author":"A Kirkpantur","year":"2008","unstructured":"Kirkpantur A, Arici M, Altun B, Yilmaz MI, Cil B, Aki T et al (2008) Association of serum lipid profile and arteriovenous fistula thrombosis in maintenance hemodialysis patients. Blood Purif 26(4):322\u2013332","journal-title":"Blood Purif"},{"issue":"2","key":"2002_CR35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/112972980700800208","volume":"8","author":"AR Serati","year":"2007","unstructured":"Serati AR, Roozbeh J, Sagheb MM (2007) Serum LDL levels are a major prognostic factor for arteriovenous fistula thrombosis (AVFT) in hemodialysis patients. J Vasc Access 8(2):109\u2013114","journal-title":"J Vasc Access"},{"issue":"7","key":"2002_CR36","doi-asserted-by":"publisher","first-page":"e0159963","DOI":"10.1371\/journal.pone.0159963","volume":"11","author":"SK Morton","year":"2016","unstructured":"Morton SK, Rodriguez AJ, Morris DR, Bhandari AP, Moxon JV, Golledge J (2016) A systematic review and meta-analysis of circulating biomarkers associated with failure of arteriovenous fistulae for haemodialysis. PLoS ONE 11(7):e0159963","journal-title":"PLoS ONE"},{"key":"2002_CR37","doi-asserted-by":"publisher","first-page":"649652","DOI":"10.1155\/2014\/649652","volume":"2014","author":"JJ Naoum","year":"2014","unstructured":"Naoum JJ, Chamoun NR, Patel MS, Street TK, Haydar M, Bismuth J et al (2014) Elevated heparin-induced antibodies are more common in diabetic patients with vascular disease. Thrombosis 2014:649652","journal-title":"Thrombosis"},{"issue":"1","key":"2002_CR38","first-page":"38","volume":"31","author":"J-H Ryu","year":"2012","unstructured":"Ryu J-H, Lim S-Y, Ryu D-R, Kang D-H, Choi KB, Kim S-J (2012) Association between vascular access failure and microparticles in hemodialysis patients. Clin J Am Soc Nephrol 31(1):38\u201347","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"2002_CR39","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/ndt\/gfm055","volume":"22","author":"CA Hutchison","year":"2007","unstructured":"Hutchison CA, Dasgupta I (2007) National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population. Nephrol Dial Transplant 22(6):1680\u20131684","journal-title":"Nephrol Dial Transplant"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-018-2002-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-2002-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-018-2002-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:11:30Z","timestamp":1662250290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-018-2002-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2002"],"URL":"https:\/\/doi.org\/10.1007\/s11255-018-2002-y","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"assertion":[{"value":"18 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by Institutional Ethics Committee of Tainan Sinlau Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}