{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:50:10Z","timestamp":1773100210904,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s11255-019-02073-w","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T12:15:34Z","timestamp":1554984934000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients"],"prefix":"10.1007","volume":"51","author":[{"given":"Sonoo","family":"Mizuiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuomi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoka","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Tanji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Shigemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"2073_CR1","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.kint.2017.05.032","volume":"92","author":"N Hamano","year":"2017","unstructured":"Hamano N, Komaba H, Fukagawa M (2017) Magnesium as a new player in CKD: too little is as bad as too much? Kidney Int 92:1034\u20131036","journal-title":"Kidney Int"},{"key":"2073_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1159\/000485700","volume":"196","author":"Y Sakaguchi","year":"2018","unstructured":"Sakaguchi Y, Hamano T, Isaka Y (2018) Magnesium in hemodialysis patients: a new understanding of the old problem. Contrib Nephrol 196:58\u201363","journal-title":"Contrib Nephrol"},{"key":"2073_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1053\/j.ajkd.2015.01.029","volume":"66","author":"M Alhosaini","year":"2015","unstructured":"Alhosaini M, Leehey DJ (2015) Magnesium and dialysis: the neglected cation. Am J Kidney Dis 66:523\u2013531","journal-title":"Am J Kidney Dis"},{"key":"2073_CR4","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/sdi.12613","volume":"30","author":"PS Misra","year":"2017","unstructured":"Misra PS, Nessim SJ (2017) Clinical aspects of magnesium physiology in patients on dialysis. Semin Dial 30:438\u2013445","journal-title":"Semin Dial"},{"key":"2073_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1161\/HYPERTENSIONAHA.110.152058","volume":"56","author":"AC Montezano","year":"2010","unstructured":"Montezano AC, Zimmerman D, Yusuf H, Burger D, Chignalia AZ, Wadhera V, van Leeuwen FN, Touyz RM (2010) Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension 56:453\u2013462","journal-title":"Hypertension"},{"key":"2073_CR6","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1681\/ASN.2012030240","volume":"23","author":"A Pasch","year":"2012","unstructured":"Pasch A, Farese S, Gr\u00e4ber S, Wald J, Richtering W, Floege J, Jahnen-Dechent W (2012) Nanoparticle-based test measures overall propensity for calcification in serum. J Am Soc Nephrol 23:1744\u20131752","journal-title":"J Am Soc Nephrol"},{"key":"2073_CR7","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.kint.2017.04.011","volume":"92","author":"JM Diaz-Tocados","year":"2017","unstructured":"Diaz-Tocados JM, Peralta-Ramirez A, Rodr\u00edguez-Ortiz ME et al (2017) Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats. Kidney Int 92:1084\u20131099","journal-title":"Kidney Int"},{"key":"2073_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/ki.2013.327","volume":"85","author":"Y Sakaguchi","year":"2014","unstructured":"Sakaguchi Y, Fujii N, Shoji T, Hayashi T, Rakugi H, Isaka Y (2014) Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis. Kidney Int 85:174\u2013181","journal-title":"Kidney Int"},{"key":"2073_CR9","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1053\/j.ajkd.2015.06.014","volume":"66","author":"E Lacson Jr","year":"2015","unstructured":"Lacson E Jr, Wang W, Ma L, Passlick-Deetjen J (2015) Serum magnesium and mortality in hemodialysis patients in the United States: a cohort study. Am J Kidney Dis 66:1056\u20131066","journal-title":"Am J Kidney Dis"},{"key":"2073_CR10","doi-asserted-by":"publisher","first-page":"E926","DOI":"10.3390\/nu9090926","volume":"9","author":"C Schmaderer","year":"2017","unstructured":"Schmaderer C, Braunisch MC, Suttmann Y, Lorenz G, Pham D, Haller B, Angermann S, Matschkal J, Renders L, Baumann M, Braun JR, Heemann U, K\u00fcchle C (2017) Reduced mortality in maintenance haemodialysis patients on high versus low dialysate magnesium. A pilot study. Nutrients 9:E926","journal-title":"Nutrients"},{"key":"2073_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2013.301","volume":"85","author":"C Courivaud","year":"2014","unstructured":"Courivaud C, Davenport A (2014) Magnesium and the risk of all-cause and cardiac mortality in hemodialysis patients: agent provocateur or innocent bystander? Kidney Int 85:17\u201320","journal-title":"Kidney Int"},{"key":"2073_CR12","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","volume":"15","author":"AS Agatston","year":"1990","unstructured":"Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15:827\u2013832","journal-title":"J Am Coll Cardiol"},{"key":"2073_CR13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1159\/000366124","volume":"38","author":"P Jo\u00e3o Matias","year":"2014","unstructured":"Jo\u00e3o Matias P, Azevedo A, Laranjinha I, Navarro D, Mendes M, Ferreira C, Amaral T, Jorge C, Aires I, Gil C, Ferreira A (2014) Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients. Blood Purif 38:244\u2013252","journal-title":"Blood Purif"},{"key":"2073_CR14","doi-asserted-by":"publisher","first-page":"e0143104","DOI":"10.1371\/journal.pone.0143104","volume":"10","author":"CL RoijZuijdewijn devan","year":"2015","unstructured":"de Roij van Zuijdewijn CL, Grooteman MP, Bots ML, Blankestijn PJ, Steppan S, B\u00fcchel J, Groenwold RH, Brandenburg V, van den Dorpel MA, Ter Wee PM, Nub\u00e9 MJ, Vervloet MG (2015) Serum magnesium and sudden death in European hemodialysis patients. PLoS ONE 10:e0143104","journal-title":"PLoS ONE"},{"key":"2073_CR15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.5301\/ijao.5000611","volume":"40","author":"GN Selim","year":"2017","unstructured":"Selim GN, Spasovski G, Tozija L, Georgievska-Ismail L, Zafirova-Ivanovska B, Masin-Spasovska J, Rambabova-Busletic I, Petronijevic Z, Dzekova-Vidimliski P, Ristovska V, Pusevski V, Stojceva-Taneva O (2017) Hypomagnesemia and cause-specific mortality in hemodialysis patients: 5-year follow-up analysis. Int J Artif Organs 40:542\u2013549","journal-title":"Int J Artif Organs"},{"key":"2073_CR16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5414\/CNP68222","volume":"68","author":"E Ishimura","year":"2007","unstructured":"Ishimura E, Okuno S, Kitatani K, Tsuchida T, Yamakawa T, Shioi A, Inaba M, Nishizawa Y (2007) Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients. Clin Nephrol 68:222\u2013227","journal-title":"Clin Nephrol"},{"key":"2073_CR17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/1744-9987.12378","volume":"19","author":"I Masakane","year":"2015","unstructured":"Masakane I, Nakai S, Ogata S, Kimata N, Hanafusa N, Hamano T, Wakai K, Wada A, Nitta K (2015) An overview of regular dialysis treatment in Japan (As of 31 December 2013). Ther Apher Dial 19:540\u2013574","journal-title":"Ther Apher Dial"},{"key":"2073_CR18","first-page":"373","volume":"49","author":"JF Navarro-Gonz\u00e1lez","year":"1998","unstructured":"Navarro-Gonz\u00e1lez JF (1998) Magnesium in dialysis patients: serum levels and clinical implications. Clin Nephrol 49:373\u2013378","journal-title":"Clin Nephrol"},{"key":"2073_CR19","first-page":"240","volume":"14","author":"M Gonella","year":"1988","unstructured":"Gonella M, Ballanti P, Della Rocca C, Calabrese G, Pratesi G, Vagelli G, Mazzotta A, Bonucci E (1988) Improved bone morphology by normalizing serum magnesium in chronically hemodialyzed patients. Miner Electrolyte Metab 14:240\u2013245","journal-title":"Miner Electrolyte Metab"},{"key":"2073_CR20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1684\/mrh.2013.0344","volume":"26","author":"F Liu","year":"2013","unstructured":"Liu F, Zhang X, Qi H, Wang J, Wang M, Zhang Y, Yan H, Zhuang S (2013) Correlation of serum magnesium with cardiovascular risk factors in maintenance hemodialysis patients-a cross-sectional study. Magnes Res 26:100\u2013108","journal-title":"Magnes Res"},{"key":"2073_CR21","first-page":"112","volume":"26","author":"P Fein","year":"2010","unstructured":"Fein P, Suda V, Borawsky C, Kapupara H, Butikis A, Matza B, Chattopadhyay J, Avra MM (2010) Relationship of serum magnesium to body composition and inflammation in peritoneal dialysis patients. Adv Perit Dial 26:112\u2013115","journal-title":"Adv Perit Dial"},{"key":"2073_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1053\/j.ajkd.2015.05.024","volume":"66","author":"L Li","year":"2015","unstructured":"Li L, Streja E, Rhee CM, Mehrotra R, Soohoo M, Brunelli SM, Kovesdy CP, Kalantar-Zadeh K (2015) Hypomagnesemia and mortality in incident hemodialysis patients. Am J Kidney Dis 66:1047\u20131055","journal-title":"Am J Kidney Dis"},{"key":"2073_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1471-2369-15-20","volume":"15","author":"OT Browne","year":"2014","unstructured":"Browne OT, Allgar V, Bhandari S (2014) Analysis of factors predicting mortality of new patients commencing renal replacement therapy 10 years of follow-up. BMC Nephrol 15:20","journal-title":"BMC Nephrol"},{"key":"2073_CR24","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1056\/NEJMoa0706130","volume":"359","author":"OM Guti\u00e9rrez","year":"2008","unstructured":"Guti\u00e9rrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, Smith K, Lee H, Thadhani R, J\u00fcppner H, Wolf M (2008) Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 359:584\u2013592","journal-title":"N Engl J Med"},{"key":"2073_CR25","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1093\/ndt\/gfp191","volume":"24","author":"G Jean","year":"2009","unstructured":"Jean G, Terrat JC, Vanel T, Hurot JM, Lorriaux C, Mayor B, Chazot C (2009) High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients. Nephrol Dial Transplant 24:2792\u20132796","journal-title":"Nephrol Dial Transplant"},{"key":"2073_CR26","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1093\/ndt\/gfq191","volume":"25","author":"H Olauson","year":"2010","unstructured":"Olauson H, Qureshi AR, Miyamoto T, Barany P, Heimburger O, Lindholm B, Stenvinkel P, Larsson TE (2010) Relation between serum fibroblast growth factor-23 level and mortality in incident dialysis patients: are gender and cardiovascular disease confounding the relationship? Nephrol Dial Transplant 25:3033\u20133038","journal-title":"Nephrol Dial Transplant"},{"key":"2073_CR27","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s11255-008-9462-4","volume":"40","author":"F Kojima","year":"2008","unstructured":"Kojima F, Uchida K, Ogawa T, Tanaka Y, Nitta K (2008) Plasma levels of fibroblast growth factor-23 and mineral metabolism in diabetic and non-diabetic patients on chronic hemodialysis. Int Urol Nephrol 40:1067\u20131074","journal-title":"Int Urol Nephrol"},{"key":"2073_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1053\/ajkd.2001.25198","volume":"38","author":"D Shemin","year":"2001","unstructured":"Shemin D, Bostom AG, Laliberty P, Dworkin LD (2001) Residual renal function and mortality risk in hemodialysis patients. Am J Kidney Dis 38:85\u201390","journal-title":"Am J Kidney Dis"},{"key":"2073_CR29","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2215\/CJN.05520516","volume":"12","author":"MJ Lee","year":"2017","unstructured":"Lee MJ, Park JT, Park KS, Kwon YE, Oh HJ, Yoo TH, Han SH, Kim YL, Kim YS, Yang CW, Kim NH, Kang SW (2017) Prognostic value of residual urine volume, GFR by 24-hour urine collection, and eGFR in patients receiving dialysis. Clin J Am Soc Nephrol 12:426\u2013443","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-019-02073-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11255-019-02073-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-019-02073-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T02:15:43Z","timestamp":1607220943000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11255-019-02073-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["2073"],"URL":"https:\/\/doi.org\/10.1007\/s11255-019-02073-w","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"15 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All the authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The committee on human research at Ichiyokai Hospital approved the study protocol (Authorization No. 201706).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}