{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:42:43Z","timestamp":1793396563866,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s11255-020-02756-9","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T14:21:50Z","timestamp":1610374910000},"page":"2081-2088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in the role and mechanism of zonulin pathway in kidney diseases"],"prefix":"10.1007","volume":"53","author":[{"given":"Jie","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-171X","authenticated-orcid":false,"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"2756_CR1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029314","author":"A Buckley","year":"2018","unstructured":"Buckley A, Turner JR (2018) Cell biology of tight junction barrier regulation and mucosal disease. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a029314","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2756_CR2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1749-6632.2000.tb05244.x","volume":"915","author":"A Fasano","year":"2000","unstructured":"Fasano A (2000) Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. Ann N Y Acad Sci 915:214\u2013222. https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb05244.x","journal-title":"Ann N Y Acad Sci"},{"issue":"39","key":"2756_CR3","doi-asserted-by":"publisher","first-page":"16799","DOI":"10.1073\/pnas.0906773106","volume":"106","author":"A Tripathi","year":"2009","unstructured":"Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yang S, Arrietta MC, Meddings JB, Fasano A (2009) Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci USA 106(39):16799\u201316804. https:\/\/doi.org\/10.1073\/pnas.0906773106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2756_CR4","doi-asserted-by":"publisher","first-page":"G910","DOI":"10.1152\/ajpgi.2001.280.5.G910","volume":"280","author":"F Hollande","year":"2001","unstructured":"Hollande F, Blanc EM, Bali JP, Whitehead RH, Pelegrin A, Baldwin GS, Choquet A (2001) HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line. Am J Physiol Gastrointest Liver Physiol 280(5):G910-921. https:\/\/doi.org\/10.1152\/ajpgi.2001.280.5.G910","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"2756_CR5","first-page":"2782","volume":"43","author":"ML Jin","year":"2002","unstructured":"Jin ML, Barron E, He S, Ryan SJ, Hinton DR (2002) Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophth Vis Sci 43(8):2782\u20132790","journal-title":"Invest Ophth Vis Sci"},{"issue":"1","key":"2756_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1152\/physrev.00003.2008","volume":"91","author":"A Fasano","year":"2011","unstructured":"Fasano A (2011) Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 91(1):151\u2013175. https:\/\/doi.org\/10.1152\/physrev.00003.2008","journal-title":"Physiol Rev"},{"issue":"1","key":"2756_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1053\/gast.2003.1240275","volume":"124","author":"R El Asmar","year":"2003","unstructured":"El Asmar R, Panigrahi P, Bamford P, Bert I, Not T, Coppa GV, Catassi C, Fasano A (2003) Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure (vol 123, pg 1607, 2002). Gastroenterology 124(1):275\u2013275","journal-title":"Gastroenterology"},{"issue":"24","key":"2756_CR8","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","volume":"113","author":"WL Wang","year":"2000","unstructured":"Wang WL, Uzzau S, Goldblum SE, Fasano A (2000) Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 113(24):4435\u20134440","journal-title":"J Cell Sci"},{"issue":"1","key":"2756_CR9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1046\/j.1471-4159.2000.0740320.x","volume":"74","author":"R Lu","year":"2000","unstructured":"Lu R, Wang W, Uzzau S, Vigorito R, Zielke HR, Fasano A (2000) Affinity purification and partial characterization of the zonulin\/zonula occludens toxin (Zot) receptor from human brain. J Neurochem 74(1):320\u2013326. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0740320.x","journal-title":"J Neurochem"},{"key":"2756_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/srep29142","author":"CW Li","year":"2016","unstructured":"Li CW, Gao M, Zhang W, Chen CY, Zhou FY, Hu ZX, Zeng CY (2016) Zonulin regulates intestinal permeability and facilitates enteric bacteria permeation in coronary artery disease. Sci Rep UK. https:\/\/doi.org\/10.1038\/srep29142","journal-title":"Sci Rep UK"},{"issue":"6","key":"2756_CR11","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/annrheumdis-2016-210000","volume":"76","author":"F Ciccia","year":"2017","unstructured":"Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G (2017) Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann Rheum Dis 76(6):1123\u20131132. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210000","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2756_CR12","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/gut.52.2.218","volume":"52","author":"MG Clemente","year":"2003","unstructured":"Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Musu MP, Di Pierro MR, Drago S, Congia M, Fasano A (2003) Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 52(2):218\u2013223. https:\/\/doi.org\/10.1136\/gut.52.2.218","journal-title":"Gut"},{"issue":"4","key":"2756_CR13","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/gut.2005.086637","volume":"56","author":"MV Barone","year":"2007","unstructured":"Barone MV, Gimigliano A, Castoria G, Paolella G, Maurano F, Paparo F, Maglio M, Mineo A, Miele E, Nanayakkara M, Troncone R, Auricchio S (2007) Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease. Gut 56(4):480\u2013488. https:\/\/doi.org\/10.1136\/gut.2005.086637","journal-title":"Gut"},{"issue":"1","key":"2756_CR14","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","volume":"135","author":"KM Lammers","year":"2008","unstructured":"Lammers KM, Lu RL, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A (2008) Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 135(1):194\u2013204. https:\/\/doi.org\/10.1053\/j.gastro.2008.03.023","journal-title":"Gastroenterology"},{"issue":"1\u20133","key":"2756_CR15","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000321848","volume":"31","author":"E Ritz","year":"2011","unstructured":"Ritz E (2011) Intestinal-renal syndrome: mirage or reality? Blood Purif 31(1\u20133):70\u201376. https:\/\/doi.org\/10.1159\/000321848","journal-title":"Blood Purif"},{"issue":"2","key":"2756_CR16","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/ki.2012.345","volume":"83","author":"ND Vaziri","year":"2013","unstructured":"Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, DeSantis TZ, Ni ZM, Nguyen TH, Andersen GL (2013) Chronic kidney disease alters intestinal microbial flora. Kidney Int 83(2):308\u2013315. https:\/\/doi.org\/10.1038\/ki.2012.345","journal-title":"Kidney Int"},{"issue":"1","key":"2756_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000345969","volume":"37","author":"ND Vaziri","year":"2013","unstructured":"Vaziri ND, Yuan J, Norris K (2013) Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease. Am J Nephrol 37(1):1\u20136. https:\/\/doi.org\/10.1159\/000345969","journal-title":"Am J Nephrol"},{"issue":"3","key":"2756_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/ndt\/gfy172","volume":"34","author":"J Yang","year":"2019","unstructured":"Yang J, Lim SY, Ko YS, Lee HY, Oh SW, Kim MG, Cho WY, Jo SK (2019) Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease. Nephrol Dial Transpl 34(3):419\u2013428. https:\/\/doi.org\/10.1093\/ndt\/gfy172","journal-title":"Nephrol Dial Transpl"},{"issue":"8008","key":"2756_CR19","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/s0140-6736(77)92603-4","volume":"1","author":"DH Sandberg","year":"1977","unstructured":"Sandberg DH, Bernstein CW, McIntosh RM, Carr R, Strauss J (1977) Severe steroid-responsive nephrosis associated with hypersensitivity. Lancet 1(8008):388\u2013391. https:\/\/doi.org\/10.1016\/s0140-6736(77)92603-4","journal-title":"Lancet"},{"key":"2756_CR20","first-page":"S147","volume":"27","author":"G Lagrue","year":"1989","unstructured":"Lagrue G, Laurent J, Rostoker G (1989) Food allergy and idiopathic nephrotic syndrome. Kidney Int Suppl 27:S147-151","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"2756_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000184448","volume":"47","author":"J Laurent","year":"1987","unstructured":"Laurent J, Rostoker G, Robeva R, Bruneau C, Lagrue G (1987) Is adult idiopathic nephrotic syndrome food allergy? Value Oligoantigenic Diets Nephron 47(1):7\u201311. https:\/\/doi.org\/10.1159\/000184448","journal-title":"Value Oligoantigenic Diets Nephron"},{"key":"2756_CR22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4528","author":"KV Lemley","year":"2016","unstructured":"Lemley KV, Faul C, Schramm K, Meyers K, Kaskel F, Dell KM, Gipson DS, Gibson K, Trachtman H (2016) The effect of a gluten-free diet in children with difficult-to-manage nephrotic syndrome. Pediatrics. https:\/\/doi.org\/10.1542\/peds.2015-4528","journal-title":"Pediatrics"},{"key":"2756_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00197","author":"H Trachtman","year":"2019","unstructured":"Trachtman H, Gipson DS, Lemley KV, Troost JP, Faul C, Morrison DJ, Vento SM, Ahn DH, Goldberg JD, Sedor J, Dell K, Schachere M, Lemley K, Whitted L, Srivastava T, Haney C, Sethna C, Grammatikopoulos K, Appel G, Toledo M, Greenbaum L, Wang C, Lee B, Adler S, Nast C, La Page J, Athavale A, Itteera M, Neu A, Boynton S, Fervenza F, Hogan M, Lieske J, Chernitskiy V, Kaskel F, Kumar N, Flynn P, Kopp J, Castro-Rubio E, Brede E, Trachtman H, Zhdanova O, Modersitzki F, Vento S, Lafayette R, Mehta K, Gadegbeku C, Johnstone D, Pfeffer Z, Cattran D, Hladunewich M, Reich H, Ling P, Romano M, Fornoni A, Barisoni L, Bidot C, Kretzler M, Gipson D, Williams A, Pitter R, Nachman P, Gibson K, Grubbs S, Froment A, Holzman L, Meyers K, Kallem K, Cerecino FJ, Sambandam K, Brown E, Johnson N, Jefferson A, Hingorani S, Tuttle K, Klepach K, Dismuke S, Cooper A, Freedman B, Lin JJ, Spainhour M, Gray S, Kretzler M, Barisoni L, Gadegbeku C, Gillespie B, Gipson D, Gizinski B, Holzman L, Mariani L, Sampson M, Song P, Troost J, Zee J, Herreshoff E, Kincaid C, Lienczewski C, Mainieri T, Williams A, Group NC (2019) Plasma zonulin levels in childhood nephrotic syndrome. Front Pediatr. https:\/\/doi.org\/10.3389\/fped.2019.00197","journal-title":"Front Pediatr"},{"issue":"3","key":"2756_CR24","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1182\/blood-2011-07-365973","volume":"119","author":"T Madhusudhan","year":"2012","unstructured":"Madhusudhan T, Wang HJ, Straub BK, Grone E, Zhou QX, Shahzad K, Muller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Grone HJ, Esmon CT, Nawroth PP, Isermann B (2012) Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood 119(3):874\u2013883. https:\/\/doi.org\/10.1182\/blood-2011-07-365973","journal-title":"Blood"},{"issue":"11","key":"2756_CR25","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1681\/Asn.2017020143","volume":"28","author":"C Schell","year":"2017","unstructured":"Schell C, Huber TB (2017) The evolving complexity of the podocyte cytoskeleton. J Am Soc Nephrol 28(11):3166\u20133174. https:\/\/doi.org\/10.1681\/Asn.2017020143","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2756_CR26","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1093\/ndt\/gfl281","volume":"21","author":"P Kotanko","year":"2006","unstructured":"Kotanko P, Carter M, Levin NW (2006) Intestinal bacterial microflora\u2014a potential source of chronic inflammation in patients with chronic kidney disease. Nephrol Dial Transpl 21(8):2057\u20132060. https:\/\/doi.org\/10.1093\/ndt\/gfl281","journal-title":"Nephrol Dial Transpl"},{"issue":"12","key":"2756_CR27","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.2215\/Cjn.03500412","volume":"7","author":"J Gupta","year":"2012","unstructured":"Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, Periera BG, Feldman HI, Kusek JW, Joffe MM, Raj DS, Investigators CS (2012) Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol 7(12):1938\u20131946. https:\/\/doi.org\/10.2215\/Cjn.03500412","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"2756_CR28","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s11255-016-1495-5","volume":"49","author":"J Ficek","year":"2017","unstructured":"Ficek J, Wyskida K, Ficek R, Wajda J, Klein D, Witkowicz J, Rotkegel S, Spiechowicz-Zaton U, Kocemba-Dyczek J, Ciepal J, Wiecek A, Olszanecka-Glinianowicz M, Chudek J (2017) Relationship between plasma levels of zonulin, bacterial lipopolysaccharides, d-lactate and markers of inflammation in haemodialysis patients. Int Urol Nephrol 49(4):717\u2013725. https:\/\/doi.org\/10.1007\/s11255-016-1495-5","journal-title":"Int Urol Nephrol"},{"issue":"4","key":"2756_CR29","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1159\/000368512","volume":"40","author":"E Lukaszyk","year":"2015","unstructured":"Lukaszyk E, Lukaszyk M, Koc-Zorawska E, Tobolczyk J, Bodzenta-Lukaszyk A, Malyszko J (2015) Iron status and inflammation in early stages of chronic kidney disease. Kidney Blood Press R 40(4):366\u2013373. https:\/\/doi.org\/10.1159\/000368512","journal-title":"Kidney Blood Press R"},{"issue":"1","key":"2756_CR30","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11255-017-1741-5","volume":"50","author":"E Lukaszyk","year":"2018","unstructured":"Lukaszyk E, Lukaszyk M, Koc-Zorawska E, Bodzenta-Lukaszyk A, Malyszko J (2018) Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease. Int Urol Nephrol 50(1):121\u2013125. https:\/\/doi.org\/10.1007\/s11255-017-1741-5","journal-title":"Int Urol Nephrol"},{"issue":"8","key":"2756_CR31","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1016\/j.transproceed.2014.09.018","volume":"46","author":"J Malyszko","year":"2014","unstructured":"Malyszko J, Koc-Zorawska E, Levin-Iaina N, Malyszko J (2014) Zonulin, iron status, and anemia in kidney transplant recipients: are they related? Transpl Proc 46(8):2644\u20132646. https:\/\/doi.org\/10.1016\/j.transproceed.2014.09.018","journal-title":"Transpl Proc"},{"key":"2756_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6090086","author":"MAI Al-Obaide","year":"2017","unstructured":"Al-Obaide MAI, Singh R, Datta P, Rewers-Felkins KA, Salguero MV, Al-Obaidi I, Kottapalli KR, Vasylyeva TL (2017) Gut microbiota-dependent trimethylamine-N-oxide and serum biomarkers in patients with T2DM and advanced CKD. J Clin Med. https:\/\/doi.org\/10.3390\/jcm6090086","journal-title":"J Clin Med"},{"issue":"2","key":"2756_CR33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2215\/Cjn.04660513","volume":"9","author":"JM Ambruzs","year":"2014","unstructured":"Ambruzs JM, Walker PD, Larsen CP (2014) The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clin J Am Soc Nephrol 9(2):265\u2013270. https:\/\/doi.org\/10.2215\/Cjn.04660513","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"2756_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.amjms.2019.11.011","volume":"359","author":"N Zhou","year":"2020","unstructured":"Zhou N, Shen Y, Fan L, Sun Q, Huang C, Hao J, Lan J, Yan H (2020) The characteristics of intestinal-barrier damage in rats With IgA nephropathy. Am J Med Sci 359(3):168\u2013176. https:\/\/doi.org\/10.1016\/j.amjms.2019.11.011","journal-title":"Am J Med Sci"},{"issue":"26","key":"2756_CR35","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.3748\/wjg.v19.i26.4137","volume":"19","author":"SN Peng","year":"2013","unstructured":"Peng SN, Zeng HH, Fu AX, Chen XW, Zhu QX (2013) Effects of rhein on intestinal epithelial tight junction in IgA nephropathy. World J Gastroenterol 19(26):4137\u20134145. https:\/\/doi.org\/10.3748\/wjg.v19.i26.4137","journal-title":"World J Gastroenterol"},{"issue":"6","key":"2756_CR36","doi-asserted-by":"publisher","first-page":"e99006","DOI":"10.1371\/journal.pone.0099006","volume":"9","author":"M De Angelis","year":"2014","unstructured":"De Angelis M, Montemurno E, Piccolo M, Vannini L, Lauriero G, Maranzano V, Gozzi G, Serrazanetti D, Dalfino G, Gobbetti M, Gesualdo L (2014) Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN). PLoS ONE 9(6):e99006. https:\/\/doi.org\/10.1371\/journal.pone.0099006","journal-title":"PLoS ONE"},{"issue":"4","key":"2756_CR37","first-page":"499","volume":"60","author":"R Coppo","year":"1989","unstructured":"Coppo R, Mazzucco G, Martina G, Roccatello D, Amore A, Novara R, Bargoni A, Piccoli G, Sena LM (1989) Gluten-induced experimental IgA glomerulopathy. Lab Invest 60(4):499\u2013506","journal-title":"Lab Invest"},{"issue":"5","key":"2756_CR38","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.semnephrol.2018.05.020","volume":"38","author":"R Coppo","year":"2018","unstructured":"Coppo R (2018) The gut-renal connection in IgA nephropathy. Semin Nephrol 38(5):504\u2013512. https:\/\/doi.org\/10.1016\/j.semnephrol.2018.05.020","journal-title":"Semin Nephrol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-020-02756-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-020-02756-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-020-02756-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T21:16:21Z","timestamp":1632518181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-020-02756-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2756"],"URL":"https:\/\/doi.org\/10.1007\/s11255-020-02756-9","relation":{},"ISSN":["0301-1623","1573-2584"],"issn-type":[{"value":"0301-1623","type":"print"},{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"11 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}