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Clinical parameters were selected using LASSO regression, and a multivariate logistic regression model based on netrin-1 was established, and then a nomogram of BPS\/IC prevalence was constructed. The nomogram was evaluated using calibration curves, the C-index, and decision curve analysis (DCA). Finally, the model was validated using an internal validation method.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The area under the curve for the ability of netrin-1 to independently predict BPS\/IC diagnosis was 0.858 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a sensitivity of 85% and specificity of 82%. The predicted nomogram included three variables: age, CD3\u2009+\u2009\/CD4\u2009+\u2009T lymphocyte ratio, and netrin-1. The C-index of this nomogram was 0.882, and the predicted values were highly consistent with the actual results in the calibration curve. In addition, the internally validated C-index of 0.870 confirms the high reliability of the model. DCA results show that the net patient benefit of the netrin-1 combined with other clinical parameters was higher than that of the single netrin-1 model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Netrin-1 can be used as a diagnostic marker for BPS\/IC and is associated with pain. The nomogram constructed by combining netrin-1 and clinical parameters was able to predict BPS\/IC with great accuracy. In addition, Netrin-1 may also serve as a novel therapeutic target for BPS\/IC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-021-03084-2","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T04:18:41Z","timestamp":1639369121000},"page":"469-477","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A nomogram for bladder pain syndrome\/interstitial cystitis based on netrin-1"],"prefix":"10.1007","volume":"54","author":[{"given":"Xiaojie","family":"Ang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0293-9295","authenticated-orcid":false,"given":"Weiguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"issue":"Suppl 1","key":"3084_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/iju.13969","volume":"26","author":"Y Akiyama","year":"2019","unstructured":"Akiyama Y, Hanno P (2019) Phenotyping of interstitial cystitis\/bladder pain syndrome. 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