{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:18:46Z","timestamp":1767903526807,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970609"],"award-info":[{"award-number":["81970609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u201cThe Belt and Road international cooperation project\u201d","award":["18410741500"],"award-info":[{"award-number":["18410741500"]}]},{"name":"\u201cinterdisciplinary program of Shanghai Jiao Tong University\u201d","award":["YG2017MS07"],"award-info":[{"award-number":["YG2017MS07"]}]},{"name":"\u201cScience and Technology Innovation Fund of Shanghai Ninth People\u2019s Hospital\u201d","award":["CK2019010"],"award-info":[{"award-number":["CK2019010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-021-03093-1","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T04:43:13Z","timestamp":1643776993000},"page":"2275-2284","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Leonurine attenuates cisplatin nephrotoxicity by suppressing the NLRP3 inflammasome, mitochondrial dysfunction, and endoplasmic reticulum stress"],"prefix":"10.1007","volume":"54","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"3093_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"S Dasari","year":"2014","unstructured":"Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364\u2013378","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3093_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nrd1691","volume":"4","author":"D Wang","year":"2005","unstructured":"Wang D, Lippard SJ (2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4(4):307\u2013320","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3093_CR3","first-page":"1","volume":"55","author":"RJ Kociba","year":"1971","unstructured":"Kociba RJ, Sleight SD (1971) Acute toxicologic and pathologic effects of cis-diamminedichloroplatinum (NSC-119875) in the male rat. Cancer Chemother Rep 55(1):1\u20138","journal-title":"Cancer Chemother Rep"},{"issue":"7","key":"3093_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/0024-3205(83)90299-0","volume":"32","author":"RS Goldstein","year":"1983","unstructured":"Goldstein RS, Mayor GH (1983) Minireview. The nephrotoxicity of cisplatin. Life Sci 32(7):685\u2013690","journal-title":"Life Sci"},{"issue":"2","key":"3093_CR5","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0002-9343(78)90825-2","volume":"65","author":"NE Madias","year":"1978","unstructured":"Madias NE, Harrington JT (1978) Platinum nephrotoxicity. Am J Med 65(2):307\u2013314","journal-title":"Am J Med"},{"issue":"9","key":"3093_CR6","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","volume":"73","author":"N Pabla","year":"2008","unstructured":"Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73(9):994\u20131007","journal-title":"Kidney Int"},{"issue":"4","key":"3093_CR7","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1681\/ASN.2013121351","volume":"26","author":"A Bajwa","year":"2015","unstructured":"Bajwa A et al (2015) Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury. J Am Soc Nephrol 26(4):908\u2013925","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"3093_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1681\/ASN.2017040381","volume":"29","author":"Y Guo","year":"2018","unstructured":"Guo Y et al (2018) MicroRNA-709 mediates acute tubular injury through effects on mitochondrial function. J Am Soc Nephrol 29(2):449\u2013461","journal-title":"J Am Soc Nephrol"},{"key":"3093_CR9","doi-asserted-by":"publisher","first-page":"118869","DOI":"10.1016\/j.lfs.2020.118869","volume":"266","author":"H Un","year":"2020","unstructured":"Un H et al (2020) Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation. Life Sci 266:118869","journal-title":"Life Sci"},{"issue":"8","key":"3093_CR10","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV et al (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19(8):477\u2013489","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"3093_CR11","doi-asserted-by":"publisher","first-page":"F396","DOI":"10.1152\/ajprenal.00420.2018","volume":"316","author":"Y Xu","year":"2019","unstructured":"Xu Y et al (2019) Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation. Am J Physiol Renal Physiol 316(2):F396\u2013F407","journal-title":"Am J Physiol Renal Physiol"},{"issue":"11","key":"3093_CR12","first-page":"3504","volume":"10","author":"X Bi","year":"2018","unstructured":"Bi X et al (2018) MnTBAP treatment ameliorates aldosterone-induced renal injury by regulating mitochondrial dysfunction and NLRP3 inflammasome signalling. Am J Transl Res 10(11):3504\u20133513","journal-title":"Am J Transl Res"},{"key":"3093_CR13","doi-asserted-by":"publisher","first-page":"105789","DOI":"10.1016\/j.jsbmb.2020.105789","volume":"206","author":"S Jiang","year":"2020","unstructured":"Jiang S et al (2020) Vitamin D\/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3\/Caspase-1\/GSDMD pyroptosis pathway. J Steroid Biochem Mol Biol 206:105789","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3093_CR14","doi-asserted-by":"publisher","first-page":"110521","DOI":"10.1016\/j.biopha.2020.110521","volume":"130","author":"SK Yang","year":"2020","unstructured":"Yang SK et al (2020) Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway. Biomed Pharmacother 130:110521","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3093_CR15","doi-asserted-by":"publisher","first-page":"111488","DOI":"10.1016\/j.yexcr.2019.07.001","volume":"383","author":"S Li","year":"2019","unstructured":"Li S et al (2019) NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation. Exp Cell Res 383(1):111488","journal-title":"Exp Cell Res"},{"key":"3093_CR16","doi-asserted-by":"publisher","first-page":"152487","DOI":"10.1016\/j.tox.2020.152487","volume":"440","author":"H Gao","year":"2020","unstructured":"Gao H et al (2020) Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4\/NF-kappaB\/NLRP3 signaling pathway. Toxicology 440:152487","journal-title":"Toxicology"},{"issue":"11","key":"3093_CR17","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nrneph.2017.129","volume":"13","author":"AV Cybulsky","year":"2017","unstructured":"Cybulsky AV (2017) Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nat Rev Nephrol 13(11):681\u2013696","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"3093_CR18","doi-asserted-by":"publisher","first-page":"e00211","DOI":"10.1002\/prp2.211","volume":"4","author":"F Foufelle","year":"2016","unstructured":"Foufelle F, Fromenty B (2016) Role of endoplasmic reticulum stress in drug-induced toxicity. Pharmacol Res Perspect 4(1):e00211","journal-title":"Pharmacol Res Perspect"},{"issue":"7","key":"3093_CR19","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1681\/ASN.2004090768","volume":"16","author":"H Liu","year":"2005","unstructured":"Liu H, Baliga R (2005) Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis. J Am Soc Nephrol 16(7):1985\u20131992","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3093_CR20","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/toxsci\/kfm152","volume":"99","author":"M Peyrou","year":"2007","unstructured":"Peyrou M et al (2007) Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci 99(1):346\u2013353","journal-title":"Toxicol Sci"},{"issue":"1","key":"3093_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.atherosclerosis.2012.06.066","volume":"224","author":"Y Zhang","year":"2012","unstructured":"Zhang Y et al (2012) SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways. Atherosclerosis 224(1):43\u201350","journal-title":"Atherosclerosis"},{"key":"3093_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.fitote.2014.06.005","volume":"97","author":"D Xu","year":"2014","unstructured":"Xu D et al (2014) Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-kappaB signaling pathway. Fitoterapia 97:148\u2013155","journal-title":"Fitoterapia"},{"issue":"2","key":"3093_CR23","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.intimp.2015.02.023","volume":"25","author":"H Cheng","year":"2015","unstructured":"Cheng H et al (2015) Leonurine ameliorates kidney fibrosis via suppressing TGF-beta and NF-kappaB signaling pathway in UUO mice. Int Immunopharmacol 25(2):406\u2013415","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"3093_CR24","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1080\/10715762.2018.1500021","volume":"52","author":"X Liu","year":"2018","unstructured":"Liu X et al (2018) Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress. Free Radic Res 52(9):952\u2013960","journal-title":"Free Radic Res"},{"key":"3093_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.05.010","volume":"351","author":"Y Liu","year":"2018","unstructured":"Liu Y et al (2018) Inhibition of COX-2\/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. Toxicol Appl Pharmacol 351:1\u201311","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4 Pt 2","key":"3093_CR26","first-page":"F700","volume":"270","author":"W Lieberthal","year":"1996","unstructured":"Lieberthal W et al (1996) Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis. Am J Physiol 270(4 Pt 2):F700\u2013F708","journal-title":"Am J Physiol"},{"issue":"4","key":"3093_CR27","doi-asserted-by":"publisher","first-page":"F610","DOI":"10.1152\/ajprenal.00101.2003","volume":"285","author":"G Ramesh","year":"2003","unstructured":"Ramesh G, Reeves WB (2003) TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Am J Physiol Renal Physiol 285(4):F610\u2013F618","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"3093_CR28","doi-asserted-by":"publisher","first-page":"F371","DOI":"10.1152\/ajprenal.00154.2004","volume":"288","author":"L Cilenti","year":"2005","unstructured":"Cilenti L et al (2005) Omi\/HtrA2 protease mediates cisplatin-induced cell death in renal cells. Am J Physiol Renal Physiol 288(2):F371\u2013F379","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"3093_CR29","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1681\/ASN.V134858","volume":"13","author":"MS Park","year":"2002","unstructured":"Park MS et al (2002) Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 13(4):858\u2013865","journal-title":"J Am Soc Nephrol"},{"issue":"29","key":"3093_CR30","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1038\/sj.onc.1209440","volume":"25","author":"M Jiang","year":"2006","unstructured":"Jiang M et al (2006) Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25(29):4056\u20134066","journal-title":"Oncogene"},{"issue":"1","key":"3093_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/sj.ki.5002256","volume":"72","author":"Q Wei","year":"2007","unstructured":"Wei Q et al (2007) The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int 72(1):53\u201362","journal-title":"Kidney Int"},{"issue":"9","key":"3093_CR32","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1681\/ASN.2006080896","volume":"18","author":"X Yin","year":"2007","unstructured":"Yin X et al (2007) Induction of renal endonuclease G by cisplatin is reduced in DNase I-deficient mice. J Am Soc Nephrol 18(9):2544\u20132553","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3093_CR33","doi-asserted-by":"publisher","first-page":"F1140","DOI":"10.1152\/ajprenal.00262.2004","volume":"287","author":"M Jiang","year":"2004","unstructured":"Jiang M et al (2004) Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. Am J Physiol Renal Physiol 287(6):F1140\u2013F1147","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"3093_CR34","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1046\/j.1523-1755.2001.00026.x","volume":"60","author":"GP Kaushal","year":"2001","unstructured":"Kaushal GP et al (2001) Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int 60(5):1726\u20131736","journal-title":"Kidney Int"},{"issue":"6","key":"3093_CR35","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1111\/j.1523-1755.2005.00739.x","volume":"68","author":"KK Nagothu","year":"2005","unstructured":"Nagothu KK et al (2005) Fibrate prevents cisplatin-induced proximal tubule cell death. Kidney Int 68(6):2680\u20132693","journal-title":"Kidney Int"},{"issue":"19","key":"3093_CR36","doi-asserted-by":"publisher","first-page":"19948","DOI":"10.1074\/jbc.M313629200","volume":"279","author":"J Wang","year":"2004","unstructured":"Wang J et al (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279(19):19948\u201319954","journal-title":"J Biol Chem"},{"issue":"3","key":"3093_CR37","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0272-6386(97)90212-2","volume":"29","author":"R Baliga","year":"1997","unstructured":"Baliga R et al (1997) Oxidant mechanisms in toxic acute renal failure. Am J Kidney Dis 29(3):465\u2013477","journal-title":"Am J Kidney Dis"},{"issue":"47","key":"3093_CR38","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","volume":"22","author":"ZH Siddik","year":"2003","unstructured":"Siddik ZH (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22(47):7265\u20137279","journal-title":"Oncogene"},{"issue":"5","key":"3093_CR39","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1046\/j.1523-1755.2003.00908.x","volume":"63","author":"H Liu","year":"2003","unstructured":"Liu H, Baliga R (2003) Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int 63(5):1687\u20131696","journal-title":"Kidney Int"},{"issue":"2","key":"3093_CR40","first-page":"638","volume":"280","author":"M Kruidering","year":"1997","unstructured":"Kruidering M et al (1997) Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther 280(2):638\u2013649","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"3093_CR41","doi-asserted-by":"publisher","first-page":"F572","DOI":"10.1152\/ajprenal.00190.2003","volume":"286","author":"S Li","year":"2004","unstructured":"Li S et al (2004) PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. Am J Physiol Renal Physiol 286(3):F572\u2013F580","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"3093_CR42","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/j.1523-1755.2002.kid553.x","volume":"62","author":"D Portilla","year":"2002","unstructured":"Portilla D et al (2002) Alterations of PPARalpha and its coactivator PGC-1 in cisplatin-induced acute renal failure. Kidney Int 62(4):1208\u20131218","journal-title":"Kidney Int"},{"issue":"5","key":"3093_CR43","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1172\/JCI37829","volume":"119","author":"C Brooks","year":"2009","unstructured":"Brooks C et al (2009) Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119(5):1275\u20131285","journal-title":"J Clin Invest"},{"issue":"3","key":"3093_CR44","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ng0398-231","volume":"18","author":"NG Larsson","year":"1998","unstructured":"Larsson NG et al (1998) Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 18(3):231\u2013236","journal-title":"Nat Genet"},{"issue":"13","key":"3093_CR45","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2014.5994","volume":"22","author":"JM Abais","year":"2015","unstructured":"Abais JM et al (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal 22(13):1111\u20131129","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"3093_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2014.09.016","volume":"281","author":"Y Zhang","year":"2014","unstructured":"Zhang Y et al (2014) P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3. Toxicol Appl Pharmacol 281(1):1\u201310","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"3093_CR47","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1681\/ASN.2005010102","volume":"17","author":"M Liu","year":"2006","unstructured":"Liu M et al (2006) A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity. J Am Soc Nephrol 17(3):765\u2013774","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3093_CR48","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1172\/JCI200215606","volume":"110","author":"G Ramesh","year":"2002","unstructured":"Ramesh G, Reeves WB (2002) TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 110(6):835\u2013842","journal-title":"J Clin Invest"},{"issue":"1","key":"3093_CR49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1124\/jpet.107.119792","volume":"322","author":"S Faubel","year":"2007","unstructured":"Faubel S et al (2007) Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther 322(1):8\u201315","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"3093_CR50","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/ki.2008.214","volume":"74","author":"S Periyasamy-Thandavan","year":"2008","unstructured":"Periyasamy-Thandavan S et al (2008) Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74(5):631\u2013640","journal-title":"Kidney Int"},{"issue":"4","key":"3093_CR51","doi-asserted-by":"publisher","first-page":"F777","DOI":"10.1152\/ajprenal.00590.2007","volume":"294","author":"C Yang","year":"2008","unstructured":"Yang C et al (2008) Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am J Physiol Renal Physiol 294(4):F777\u2013F787","journal-title":"Am J Physiol Renal Physiol"},{"key":"3093_CR52","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1126\/scitranslmed.aay7591","volume":"12","author":"X Yu","year":"2020","unstructured":"Yu X et al (2020) Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI. Sci Transl Med 12:543","journal-title":"Sci Transl Med"},{"issue":"5","key":"3093_CR53","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","volume":"164","author":"Z Zhong","year":"2016","unstructured":"Zhong Z et al (2016) NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896\u2013910","journal-title":"Cell"},{"issue":"12","key":"3093_CR54","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1080\/15548627.2016.1235124","volume":"12","author":"J Han","year":"2016","unstructured":"Han J et al (2016) Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Autophagy 12(12):2326\u20132343","journal-title":"Autophagy"},{"key":"3093_CR55","doi-asserted-by":"crossref","first-page":"e22208","DOI":"10.1002\/jbt.22228","volume":"33","author":"X Qu","year":"2018","unstructured":"Qu X et al (2018) Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats. J Biochem Mol Toxicol 33:e22208","journal-title":"J Biochem Mol Toxicol"},{"issue":"6059","key":"3093_CR56","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334(6059):1081\u20131086","journal-title":"Science"},{"issue":"7586","key":"3093_CR57","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature17041","volume":"529","author":"M Wang","year":"2016","unstructured":"Wang M, Kaufman RJ (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529(7586):326\u2013335","journal-title":"Nature"},{"key":"3093_CR58","doi-asserted-by":"publisher","first-page":"110056","DOI":"10.1016\/j.biopha.2020.110056","volume":"126","author":"Z Huang","year":"2020","unstructured":"Huang Z et al (2020) Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis. Biomed Pharmacother 126:110056","journal-title":"Biomed Pharmacother"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-021-03093-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-021-03093-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-021-03093-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T19:13:12Z","timestamp":1700161992000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-021-03093-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["3093"],"URL":"https:\/\/doi.org\/10.1007\/s11255-021-03093-1","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]},"assertion":[{"value":"15 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the animal experiments were approved by the Animal Care Committee at Shanghai Jiao Tong University and carried out in accordance with institutional guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}