{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:19:55Z","timestamp":1791508795914,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-022-03116-5","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T12:03:59Z","timestamp":1643630639000},"page":"2255-2261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperuricemia is associated with secondary hyperparathyroidism in patients with chronic kidney disease"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-2294","authenticated-orcid":false,"given":"Tiago Emanuel M.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-6082","authenticated-orcid":false,"given":"Julia C.","family":"Lauar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0446","authenticated-orcid":false,"given":"Mariana L. R.","family":"Innecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-2095","authenticated-orcid":false,"given":"Venceslau A.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-2127","authenticated-orcid":false,"given":"Rosa M. A.","family":"Moys\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-041X","authenticated-orcid":false,"given":"Rosilene M.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"4","key":"3116_CR1","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s00380-013-0396-0","volume":"29","author":"T Miyaoka","year":"2014","unstructured":"Miyaoka T, Mochizuki T, Takei T, Tsuchiya K, Nitta K (2014) Serum uric acid levels and long-term outcomes in chronic kidney disease. Heart Vessel 29(4):504\u2013512. https:\/\/doi.org\/10.1007\/s00380-013-0396-0","journal-title":"Heart Vessel"},{"issue":"6","key":"3116_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218510","volume":"14","author":"HJ Jeon","year":"2019","unstructured":"Jeon HJ, Oh J, Shin DH (2019) Urate-lowering agents for asymptomatic hyperuricemia in stage 3\u20134 chronic kidney disease: controversial role of kidney function. PLoS ONE 14(6):e0218510. https:\/\/doi.org\/10.1371\/journal.pone.0218510","journal-title":"PLoS ONE"},{"key":"3116_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009460.pub2","author":"AL Sampson","year":"2017","unstructured":"Sampson AL, Singer RF, Walters GD (2017) Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD009460.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"26","key":"3116_CR4","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1056\/NEJMoa1916624","volume":"382","author":"A Doria","year":"2020","unstructured":"Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M (2020) Group PS serum urate lowering with allopurinol and kidney function in type 1 diabetes. N Engl J Med 382(26):2493\u20132503. https:\/\/doi.org\/10.1056\/NEJMoa1916624","journal-title":"N Engl J Med"},{"issue":"26","key":"3116_CR5","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1056\/NEJMoa1915833","volume":"382","author":"SV Badve","year":"2020","unstructured":"Badve SV, Pascoe EM, Tiku A, Boudville N, Brown FG, Cass A, Clarke P, Dalbeth N, Day RO, de Zoysa JR, Douglas B, Faull R, Harris DC, Hawley CM, Jones GRD, Kanellis J, Palmer SC, Perkovic V, Rangan GK, Reidlinger D, Robison L, Walker RJ, Walters G, Johnson DW, Investigators C-FS (2020) Effects of allopurinol on the progression of chronic kidney disease. N Engl J Med 382(26):2504\u20132513. https:\/\/doi.org\/10.1056\/NEJMoa1915833","journal-title":"N Engl J Med"},{"issue":"3","key":"3116_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/met.2015.0099","volume":"14","author":"R Alemzadeh","year":"2016","unstructured":"Alemzadeh R, Kichler J (2016) Uric acid-induced Inflammation is mediated by the parathyroid hormone:25-hydroxyvitamin D ratio in obese adolescents. Metab Syndr Relat Disord 14(3):167\u2013174. https:\/\/doi.org\/10.1089\/met.2015.0099","journal-title":"Metab Syndr Relat Disord"},{"issue":"2","key":"3116_CR7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/1756-185X.13740","volume":"23","author":"B Ponvilawan","year":"2020","unstructured":"Ponvilawan B, Charoenngam N, Ungprasert P (2020) Primary hyperparathyroidism is associated with a higher level of serum uric acid: a systematic review and meta-analysis. Int J Rheum Dis 23(2):174\u2013180. https:\/\/doi.org\/10.1111\/1756-185X.13740","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"3116_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061159","volume":"8","author":"H Peng","year":"2013","unstructured":"Peng H, Li H, Li C, Chao X, Zhang Q, Zhang Y (2013) Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women. PLoS ONE 8(4):e61159. https:\/\/doi.org\/10.1371\/journal.pone.0061159","journal-title":"PLoS ONE"},{"issue":"1","key":"3116_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.dsx.2012.05.007","volume":"6","author":"H Yilmaz","year":"2012","unstructured":"Yilmaz H, Kaya M, Sahin M, Delibasi T (2012) Is vitamin D status a predictor glycaemic regulation and cardiac complication in type 2 diabetes mellitus patients? Diabetes Metab Syndr 6(1):28\u201331. https:\/\/doi.org\/10.1016\/j.dsx.2012.05.007","journal-title":"Diabetes Metab Syndr"},{"key":"3116_CR10","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/ki.2009.188","volume":"113","author":"Kidney disease: improving global ou","year":"2009","unstructured":"Kidney disease: improving global outcomes CKDMBDWG, (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 113:S1-130. https:\/\/doi.org\/10.1038\/ki.2009.188","journal-title":"Kidney Int Suppl"},{"issue":"4","key":"3116_CR11","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1681\/ASN.V441035","volume":"4","author":"R Vanholder","year":"1993","unstructured":"Vanholder R, Patel S, Hsu CH (1993) Effect of uric acid on plasma levels of 125(OH)2D in renal failure. J Am Soc Nephrol 4(4):1035\u20131038","journal-title":"J Am Soc Nephrol"},{"key":"3116_CR12","doi-asserted-by":"publisher","DOI":"10.1159\/000512340","author":"A Mohammed","year":"2020","unstructured":"Mohammed A, Marie MA, Abdulazim DO, Hassan M, Shaker O, Ayeldeen G, Salem MM, Sharaf El Din UA (2020) On behalf of the egyptian vascular calcification G serum urate lowering therapy using allopurinol improves serum 25 hydroxy vitamin D in Stage 3\u20135 CKD patients: a pilot study. Nephron. https:\/\/doi.org\/10.1159\/000512340","journal-title":"Nephron"},{"issue":"10","key":"3116_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205831","volume":"13","author":"ES Andrews","year":"2018","unstructured":"Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D (2018) Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; a post-hoc analysis of a randomized clinical trial. PLoS ONE 13(10):e0205831. https:\/\/doi.org\/10.1371\/journal.pone.0205831","journal-title":"PLoS ONE"},{"issue":"9","key":"3116_CR14","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1007\/s10067-018-4130-2","volume":"37","author":"Y Kim","year":"2018","unstructured":"Kim Y, Kang J, Kim GT (2018) Prevalence of hyperuricemia and its associated factors in the general korean population: an analysis of a population-based nationally representative sample. Clin Rheumatol 37(9):2529\u20132538. https:\/\/doi.org\/10.1007\/s10067-018-4130-2","journal-title":"Clin Rheumatol"},{"issue":"10","key":"3116_CR15","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1002\/art.30520","volume":"63","author":"Y Zhu","year":"2011","unstructured":"Zhu Y, Pandya BJ, Choi HK (2011) Prevalence of gout and hyperuricemia in the US general population: the national health and nutrition examination survey 2007\u20132008. Arthritis Rheum 63(10):3136\u20133141. https:\/\/doi.org\/10.1002\/art.30520","journal-title":"Arthritis Rheum"},{"issue":"1","key":"3116_CR16","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1038\/s41598-018-22570-9","volume":"8","author":"P Song","year":"2018","unstructured":"Song P, Wang H, Xia W, Chang X, Wang M, An L (2018) Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci Rep 8(1):4314. https:\/\/doi.org\/10.1038\/s41598-018-22570-9","journal-title":"Sci Rep"},{"issue":"4","key":"3116_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.rdc.2014.07.002","volume":"40","author":"LA MacFarlane","year":"2014","unstructured":"MacFarlane LA, Kim SC (2014) Gout: a review of nonmodifiable and modifiable risk factors. Rheum Dis Clin North Am 40(4):581\u2013604. https:\/\/doi.org\/10.1016\/j.rdc.2014.07.002","journal-title":"Rheum Dis Clin North Am"},{"issue":"5","key":"3116_CR18","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/annrheumdis-2011-201254","volume":"72","author":"G Trifiro","year":"2013","unstructured":"Trifiro G, Morabito P, Cavagna L, Ferrajolo C, Pecchioli S, Simonetti M, Bianchini E, Medea G, Cricelli C, Caputi AP, Mazzaglia G (2013) Epidemiology of gout and hyperuricaemia in Italy during the years 2005\u20132009: a nationwide population-based study. Ann Rheum Dis 72(5):694\u2013700. https:\/\/doi.org\/10.1136\/annrheumdis-2011-201254","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"3116_CR19","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.clnu.2010.06.009","volume":"29","author":"MD Unger","year":"2010","unstructured":"Unger MD, Cuppari L, Titan SM, Magalhaes MC, Sassaki AL, dos Reis LM, Jorgetti V, Moyses RM (2010) Vitamin D status in a sunny country: where has the sun gone? Clin Nutr 29(6):784\u2013788. https:\/\/doi.org\/10.1016\/j.clnu.2010.06.009","journal-title":"Clin Nutr"},{"issue":"1","key":"3116_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1590\/2175-8239-jbn-2019-0053","volume":"42","author":"H Machado","year":"2020","unstructured":"Machado H, Martins CSW, Jorgetti V, Elias RM, Moyses RMA (2020) Chronic kidney disease is a main confounding factor for 25-vitamin D measurement. J Bras Nefrol 42(1):94\u201398. https:\/\/doi.org\/10.1590\/2175-8239-jbn-2019-0053","journal-title":"J Bras Nefrol"},{"key":"3116_CR21","doi-asserted-by":"publisher","first-page":"14528","DOI":"10.1038\/srep14528","volume":"5","author":"A Thakkinstian","year":"2015","unstructured":"Thakkinstian A, Anothaisintawee T, Chailurkit L, Ratanachaiwong W, Yamwong S, Sritara P, Ongphiphadhanakul B (2015) Potential causal associations between vitamin D and uric acid: bidirectional mediation analysis. Sci Rep 5:14528. https:\/\/doi.org\/10.1038\/srep14528","journal-title":"Sci Rep"},{"issue":"9","key":"3116_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.2215\/CJN.07170717","volume":"12","author":"ND Toussaint","year":"2017","unstructured":"Toussaint ND, Ruderman I (2017) What is the role of vitamin D supplementation on vascular health in CKD? Clin J Am Soc Nephrol 12(9):1377\u20131379. https:\/\/doi.org\/10.2215\/CJN.07170717","journal-title":"Clin J Am Soc Nephrol"},{"issue":"Suppl 1","key":"3116_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1744-9987.2011.00920.x","volume":"15","author":"R Kaseda","year":"2011","unstructured":"Kaseda R, Hosojima M, Sato H, Saito A (2011) Role of megalin and cubilin in the metabolism of vitamin D(3). Ther Apher Dial 15(Suppl 1):14\u201317. https:\/\/doi.org\/10.1111\/j.1744-9987.2011.00920.x","journal-title":"Ther Apher Dial"},{"issue":"10","key":"3116_CR24","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1681\/ASN.V10102224","volume":"10","author":"EI Christensen","year":"1999","unstructured":"Christensen EI, Willnow TE (1999) Essential role of megalin in renal proximal tubule for vitamin homeostasis. J Am Soc Nephrol 10(10):2224\u20132236","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"3116_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000495138","volume":"5","author":"L Negrea","year":"2019","unstructured":"Negrea L (2019) Active vitamin D in chronic kidney disease: getting right back where we started from? Kidney Dis (Basel) 5(2):59\u201368. https:\/\/doi.org\/10.1159\/000495138","journal-title":"Kidney Dis (Basel)"},{"issue":"4","key":"3116_CR26","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.ecl.2017.07.001","volume":"46","author":"JW Pike","year":"2017","unstructured":"Pike JW, Christakos S (2017) Biology and mechanisms of action of the vitamin D hormone. Endocrinol Metab Clin North Am 46(4):815\u2013843. https:\/\/doi.org\/10.1016\/j.ecl.2017.07.001","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2 Suppl 2","key":"3116_CR27","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1053\/ajkd.1998.v32.pm9808140","volume":"32","author":"AS Dusso","year":"1998","unstructured":"Dusso AS, Brown AJ (1998) Mechanism of vitamin D action and its regulation. Am J Kidney Dis 32(2 Suppl 2):S13-24. https:\/\/doi.org\/10.1053\/ajkd.1998.v32.pm9808140","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"3116_CR28","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.metabol.2013.09.018","volume":"63","author":"W Chen","year":"2014","unstructured":"Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D (2014) Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism 63(1):150\u2013160. https:\/\/doi.org\/10.1016\/j.metabol.2013.09.018","journal-title":"Metabolism"},{"issue":"5390","key":"3116_CR29","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1136\/bmj.1.5390.1070","volume":"1","author":"JT Scott","year":"1964","unstructured":"Scott JT, Dixon AS, Bywaters EG (1964) Association of hyperuricaemia and gout with hyperparathyroidism. Br Med J 1(5390):1070\u20131073. https:\/\/doi.org\/10.1136\/bmj.1.5390.1070","journal-title":"Br Med J"},{"issue":"3","key":"3116_CR30","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1046\/j.1365-2796.1998.00366.x","volume":"244","author":"S Valdemarsson","year":"1998","unstructured":"Valdemarsson S, Lindblom P, Bergenfelz A (1998) Metabolic abnormalities related to cardiovascular risk in primary hyperparathyroidism: effects of surgical treatment. J Intern Med 244(3):241\u2013249. https:\/\/doi.org\/10.1046\/j.1365-2796.1998.00366.x","journal-title":"J Intern Med"},{"issue":"1","key":"3116_CR31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00198-006-0189-8","volume":"18","author":"PD Miller","year":"2007","unstructured":"Miller PD, Schwartz EN, Chen P, Misurski DA, Krege JH (2007) Teriparatide in postmenopausal women with osteoporosis and mild or moderate renal impairment. Osteoporos Int 18(1):59\u201368. https:\/\/doi.org\/10.1007\/s00198-006-0189-8","journal-title":"Osteoporos Int"},{"issue":"1","key":"3116_CR32","first-page":"48","volume":"17","author":"Y Hashimoto","year":"2007","unstructured":"Hashimoto Y, Wakayama N, Miyauchi A (2007) Therapeutic agents for disorders of bone and calcium metabolism\u2013teriparatide, parathyroid hormone (1\u201334) as a daily subcutaneous injection. Clin Calcium 17(1):48\u201355","journal-title":"Clin Calcium"},{"issue":"2","key":"3116_CR33","doi-asserted-by":"publisher","first-page":"R56","DOI":"10.1186\/ar3769","volume":"14","author":"JY Hui","year":"2012","unstructured":"Hui JY, Choi JW, Mount DB, Zhu Y, Zhang Y, Choi HK (2012) The independent association between parathyroid hormone levels and hyperuricemia: a national population study. Arthritis Res Ther 14(2):R56. https:\/\/doi.org\/10.1186\/ar3769","journal-title":"Arthritis Res Ther"},{"key":"3116_CR34","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.2147\/CIA.S90233","volume":"10","author":"KY Chin","year":"2015","unstructured":"Chin KY, Nirwana SI, Ngah WZ (2015) Significant association between parathyroid hormone and uric acid level in men. Clin Interv Aging 10:1377\u20131380. https:\/\/doi.org\/10.2147\/CIA.S90233","journal-title":"Clin Interv Aging"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03116-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-022-03116-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03116-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:35:49Z","timestamp":1660214149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-022-03116-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["3116"],"URL":"https:\/\/doi.org\/10.1007\/s11255-022-03116-5","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"11 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval for this study was obtained from *Comiss\u00e3o de \u00c9tica para an\u00e1lise de projetos de pesquisa\u2014CAPpesq (45163715.4.0000.0068).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was not obtained from subjects since was waived by the Research Ethical Board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}