{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:16:11Z","timestamp":1753272971340,"version":"3.37.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["97850925 - SFB 854 Project A01","ME-1365\/7-2  ME-1365\/9-2","LI-1031\/4-1"],"award-info":[{"award-number":["97850925 - SFB 854 Project A01","ME-1365\/7-2  ME-1365\/9-2","LI-1031\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["97850925 - SFB 854 Project B26N","GRK 2408 Project 7","GRK 2408 Project 8"],"award-info":[{"award-number":["97850925 - SFB 854 Project B26N","GRK 2408 Project 7","GRK 2408 Project 8"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saxony-Anhalt and the European Structural and Investment Funds","award":["ZS\/2016\/08\/80645"],"award-info":[{"award-number":["ZS\/2016\/08\/80645"]}]},{"DOI":"10.13039\/501100012320","name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012320","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In end-stage renal disease, a high cardiovascular risk profile and endothelial damage prevails. The heparin-binding growth factor midkine stimulates neo-angiogenesis in ischemic diseases, coordinates neutrophil influx, and raises blood pressure through stimulated angiotensin synthesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We determined changes of midkine serum levels during hemodialysis sessions under the assumption that endothelial cell-derived midkine is released. Periprocedural differences (\u2206midkine) were calculated and correlated with cardiovacular biomarkers and fluid status (clinical assessment, V. cava collapse, comet tail phenomenon), cardiovascular morbidities, mortality rates. Blood was collected before and after dialysis from hemodialysis patients (<jats:italic>n<\/jats:italic>\u2009=\u2009171; diabetes: <jats:italic>n<\/jats:italic>\u2009=\u200970; hypervolemia: <jats:italic>n<\/jats:italic>\u2009=\u200983; both: <jats:italic>n<\/jats:italic>\u2009=\u200932).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Baseline midkine levels were\u2009~\u2009fourfold elevated compared to healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u2009100). Further, on average a tenfold rise was detected during dialysis, the extent of which was partially related to non-fractionated heparin application (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.17). Inter-individual differences were highly reproducible. Hypervolemic patients responded with a less than average rise in midkine levels during dialysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.02), this difference became more obvious with co-existing diabetes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for long dialysis-free interval) and was confirmed in an independently enrolled dialysis cohort (<jats:italic>n<\/jats:italic>\u2009=\u200988). In Kaplan Meier survival curves, low delta midkine levels correlated with cardiovascular\/overall mortality rates, similar to elevated uPAR levels, whereas other markers (NTproANP, galectin, tenascin-C) were less predictive. Following intervention with successful fluid removal in hypervolemic dialysis patients to optimize fluid homeostasis, midkine values increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002), which was not observed in patients that failed to decrease weight.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Thus, for dialysis patients inadequate periprocedural midkine upregulation is linked with hypervolemia and associates with cardiovascular events.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-022-03141-4","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T17:02:55Z","timestamp":1645722175000},"page":"2407-2420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-6941","authenticated-orcid":false,"given":"Sabine","family":"Brandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Kreutze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Hempel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"Gorny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian G.","family":"Scurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia L.","family":"\u015ealaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie M.","family":"Bode-B\u00f6ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Girndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berend","family":"Isermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Lindquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"issue":"12","key":"3141_CR1","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1182\/blood-2013-06-510875","volume":"123","author":"LT Weckbach","year":"2014","unstructured":"Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Muller-Hocker J, Deindl E, Sperandio M, Walzog B (2014) The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11\/CD18). Blood 123(12):1887\u20131896. https:\/\/doi.org\/10.1182\/blood-2013-06-510875","journal-title":"Blood"},{"key":"3141_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw083","author":"DL Salaru","year":"2016","unstructured":"Salaru DL, Arsenescu-Georgescu C, Chatzikyrkou C, Karagiannis J, Fischer A, Mertens PR (2016) Midkine, a heparin-binding growth factor, and its roles in atherogenesis and inflammatory kidney diseases. Nephrol Dial Transpl. https:\/\/doi.org\/10.1093\/ndt\/gfw083","journal-title":"Nephrol Dial Transpl"},{"issue":"1","key":"3141_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ndt\/gfr652","volume":"27","author":"T Kosugi","year":"2012","unstructured":"Kosugi T, Sato W (2012) Midkine and the kidney: health and diseases. Nephrol Dial Transpl 27(1):16\u201321. https:\/\/doi.org\/10.1093\/ndt\/gfr652","journal-title":"Nephrol Dial Transpl"},{"issue":"12","key":"3141_CR4","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1038\/s41591-020-1073-3","volume":"26","author":"D Cerezo-Wallis","year":"2020","unstructured":"Cerezo-Wallis D, Contreras-Alcalde M, Troule K, Catena X, Mucientes C, Calvo TG, Canon E, Tejedo C, Pennacchi PC, Hogan S, Kolblinger P, Tejero H, Chen AX, Ibarz N, Grana-Castro O, Martinez L, Munoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gomez-Lopez G, Al-Shahrour F, Rabadan R, Levesque MP, Olmeda D, Soengas MS (2020) Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat Med 26(12):1865\u20131877. https:\/\/doi.org\/10.1038\/s41591-020-1073-3","journal-title":"Nat Med"},{"issue":"6","key":"3141_CR5","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1172\/JCI37249","volume":"119","author":"A Hobo","year":"2009","unstructured":"Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K (2009) The growth factor midkine regulates the renin-angiotensin system in mice. J Clin Investig 119(6):1616\u20131625. https:\/\/doi.org\/10.1172\/JCI37249","journal-title":"J Clin Investig"},{"issue":"1","key":"3141_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/ndt\/gfp464","volume":"25","author":"J Floege","year":"2010","unstructured":"Floege J, Uhlig S (2010) Kidney calling lung and call back: how organs talk to each other. Nephrol Dial Transpl 25(1):32\u201334. https:\/\/doi.org\/10.1093\/ndt\/gfp464","journal-title":"Nephrol Dial Transpl"},{"issue":"16","key":"3141_CR7","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1161\/CIRCULATIONAHA.106.632273","volume":"114","author":"M Horiba","year":"2006","unstructured":"Horiba M, Kadomatsu K, Yasui K, Lee JK, Takenaka H, Sumida A, Kamiya K, Chen S, Sakuma S, Muramatsu T, Kodama I (2006) Midkine plays a protective role against cardiac ischemia\/reperfusion injury through a reduction of apoptotic reaction. Circulation 114(16):1713\u20131720. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.632273","journal-title":"Circulation"},{"issue":"1","key":"3141_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/cvr\/cvp386","volume":"86","author":"A Sumida","year":"2010","unstructured":"Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I (2010) Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction. Cardiovasc Res 86(1):113\u2013121. https:\/\/doi.org\/10.1093\/cvr\/cvp386","journal-title":"Cardiovasc Res"},{"issue":"2","key":"3141_CR9","doi-asserted-by":"publisher","first-page":"H462","DOI":"10.1152\/ajpheart.00733.2008","volume":"296","author":"H Takenaka","year":"2009","unstructured":"Takenaka H, Horiba M, Ishiguro H, Sumida A, Hojo M, Usui A, Akita T, Sakuma S, Ueda Y, Kodama I, Kadomatsu K (2009) Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. Am J Physiol Heart Circ Physiol 296(2):H462-469. https:\/\/doi.org\/10.1152\/ajpheart.00733.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"3141_CR10","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1525-139X.2011.00925.x","volume":"24","author":"N Jourde-Chiche","year":"2011","unstructured":"Jourde-Chiche N, Dou L, Cerini C, Dignat-George F, Brunet P (2011) Vascular incompetence in dialysis patients\u2013protein-bound uremic toxins and endothelial dysfunction. Semin Dial 24(3):327\u2013337. https:\/\/doi.org\/10.1111\/j.1525-139X.2011.00925.x","journal-title":"Semin Dial"},{"key":"3141_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa084","author":"VK Campbell","year":"2020","unstructured":"Campbell VK, Gately RP, Krishnasamy R, Burg D, Robertson GR, Gray NA (2020) Midkine and chronic kidney disease-associated multisystem organ dysfunctions. Nephrol Dial Transpl. https:\/\/doi.org\/10.1093\/ndt\/gfaa084","journal-title":"Nephrol Dial Transpl"},{"issue":"5","key":"3141_CR12","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1093\/oxfordjournals.jbchem.a022017","volume":"123","author":"K Fujisawa","year":"1998","unstructured":"Fujisawa K, Matsumoto Y, Muramatsu H, Shinzato T, Hiramatsu K, Horie K, Cai Z, Oka H, Amano I, Muramatsu T, Maeda K (1998) Increased serum midkine levels during hemodialysis using heparin in chronic renal failure. J Biochem 123(5):864\u2013869","journal-title":"J Biochem"},{"issue":"6","key":"3141_CR13","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/jb\/mvt035","volume":"153","author":"K Kadomatsu","year":"2013","unstructured":"Kadomatsu K, Kishida S, Tsubota S (2013) The heparin-binding growth factor midkine: the biological activities and candidate receptors. J Biochem 153(6):511\u2013521. https:\/\/doi.org\/10.1093\/jb\/mvt035","journal-title":"J Biochem"},{"issue":"6","key":"3141_CR14","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.2337\/dc11-9998","volume":"34","author":"DB Sacks","year":"2011","unstructured":"Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, Lernmark A, Metzger BE, Nathan DM (2011) National academy of clinical b, evidence-based laboratory medicine committee of the american association for clinical C guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 34(6):e61-99. https:\/\/doi.org\/10.2337\/dc11-9998","journal-title":"Diabetes Care"},{"issue":"3","key":"3141_CR15","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1373\/clinchem.2005.060152","volume":"52","author":"J Martens-Lobenhoffer","year":"2006","unstructured":"Martens-Lobenhoffer J, Bode-Boger SM (2006) Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry. Clin Chem 52(3):488\u2013493. https:\/\/doi.org\/10.1373\/clinchem.2005.060152","journal-title":"Clin Chem"},{"issue":"Suppl","key":"3141_CR16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/ng1032","volume":"32","author":"J Quackenbush","year":"2002","unstructured":"Quackenbush J (2002) Microarray data normalization and transformation. Nat Genet 32(Suppl):496\u2013501. https:\/\/doi.org\/10.1038\/ng1032","journal-title":"Nat Genet"},{"issue":"2","key":"3141_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S1525-1578(10)60455-2","volume":"5","author":"C Cheadle","year":"2003","unstructured":"Cheadle C, Vawter MP, Freed WJ, Becker KG (2003) Analysis of microarray data using Z score transformation. J Mol Diagn 5(2):73\u201381. https:\/\/doi.org\/10.1016\/S1525-1578(10)60455-2","journal-title":"J Mol Diagn"},{"issue":"2","key":"3141_CR18","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.bbrc.2005.05.113","volume":"333","author":"L Ezquerra","year":"2005","unstructured":"Ezquerra L, Herradon G, Nguyen T, Silos-Santiago I, Deuel TF (2005) Midkine, a newly discovered regulator of the renin-angiotensin pathway in mouse aorta: significance of the pleiotrophin\/midkine developmental gene family in angiotensin II signaling. Biochem Biophys Res Commun 333(2):636\u2013643. https:\/\/doi.org\/10.1016\/j.bbrc.2005.05.113","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"3141_CR19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/bph.12418","volume":"171","author":"W Sato","year":"2014","unstructured":"Sato W, Sato Y (2014) Midkine in nephrogenesis, hypertension and kidney diseases. Br J Pharmacol 171(4):879\u2013887. https:\/\/doi.org\/10.1111\/bph.12418","journal-title":"Br J Pharmacol"},{"key":"3141_CR20","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ijcard.2015.03.041","volume":"184","author":"S Botha","year":"2015","unstructured":"Botha S, Fourie CM, Schutte R, Eugen-Olsen J, Pretorius R, Schutte AE (2015) Soluble urokinase plasminogen activator receptor as a prognostic marker of all-cause and cardiovascular mortality in a black population. Int J Cardiol 184:631\u2013636. https:\/\/doi.org\/10.1016\/j.ijcard.2015.03.041","journal-title":"Int J Cardiol"},{"key":"3141_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ahj.2016.05.018","volume":"179","author":"M Obokata","year":"2016","unstructured":"Obokata M, Sunaga H, Ishida H, Ito K, Ogawa T, Ando Y, Kurabayashi M, Negishi K (2016) Independent and incremental prognostic value of novel cardiac biomarkers in chronic hemodialysis patients. Am Heart J 179:29\u201341. https:\/\/doi.org\/10.1016\/j.ahj.2016.05.018","journal-title":"Am Heart J"},{"key":"3141_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.lfs.2015.09.011","volume":"141","author":"S Ulusoy","year":"2015","unstructured":"Ulusoy S, Ozkan G, Mentese A, Guvercin B, Caner Karahan S, Yavuz A, Altay DU (2015) A new predictor of mortality in hemodialysis patients; Tenascin-C. Life Sci 141:54\u201360. https:\/\/doi.org\/10.1016\/j.lfs.2015.09.011","journal-title":"Life Sci"},{"issue":"19","key":"3141_CR23","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1056\/NEJMra0902710","volume":"363","author":"J Himmelfarb","year":"2010","unstructured":"Himmelfarb J, Ikizler TA (2010) Hemodialysis. N Engl J Med 363(19):1833\u20131845. https:\/\/doi.org\/10.1056\/NEJMra0902710","journal-title":"N Engl J Med"},{"issue":"12","key":"3141_CR24","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.2337\/dc12-0573","volume":"35","author":"SP Ramirez","year":"2012","unstructured":"Ramirez SP, McCullough KP, Thumma JR, Nelson RG, Morgenstern H, Gillespie BW, Inaba M, Jacobson SH, Vanholder R, Pisoni RL, Port FK, Robinson BM (2012) Hemoglobin A(1c) levels and mortality in the diabetic hemodialysis population: findings from the dialysis outcomes and practice patterns study (DOPPS). Diabetes Care 35(12):2527\u20132532. https:\/\/doi.org\/10.2337\/dc12-0573","journal-title":"Diabetes Care"},{"issue":"11","key":"3141_CR25","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1681\/ASN.2015080916","volume":"27","author":"LG Tereshchenko","year":"2016","unstructured":"Tereshchenko LG, Kim ED, Oehler A, Meoni LA, Ghafoori E, Rami T, Maly M, Kabir M, Hawkins L, Tomaselli GF, Lima JA, Jaar BG, Sozio SM, Estrella M, Kao WH, Parekh RS (2016) Electrophysiologic substrate and risk of mortality in incident hemodialysis. J Am Soc Nephrol 27(11):3413\u20133420. https:\/\/doi.org\/10.1681\/ASN.2015080916","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"3141_CR26","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1056\/NEJMoa1103313","volume":"365","author":"RN Foley","year":"2011","unstructured":"Foley RN, Gilbertson DT, Murray T, Collins AJ (2011) Long interdialytic interval and mortality among patients receiving hemodialysis. N Engl J Med 365(12):1099\u20131107. https:\/\/doi.org\/10.1056\/NEJMoa1103313","journal-title":"N Engl J Med"},{"issue":"4\u20135","key":"3141_CR27","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1159\/000435842","volume":"41","author":"PI Georgianos","year":"2015","unstructured":"Georgianos PI, Sarafidis PA, Sinha AD, Agarwal R (2015) Adverse effects of conventional thrice-weekly hemodialysis: is it time to avoid 3-day interdialytic intervals? Am J Nephrol 41(4\u20135):400\u2013408. https:\/\/doi.org\/10.1159\/000435842","journal-title":"Am J Nephrol"},{"issue":"8","key":"3141_CR28","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1093\/ndt\/16.8.1538","volume":"16","author":"CR Tomson","year":"2001","unstructured":"Tomson CR (2001) Advising dialysis patients to restrict fluid intake without restricting sodium intake is not based on evidence and is a waste of time. Nephrol Dial Transpl 16(8):1538\u20131542","journal-title":"Nephrol Dial Transpl"},{"issue":"11","key":"3141_CR29","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1681\/ASN.2011121181","volume":"23","author":"CA Vlahu","year":"2012","unstructured":"Vlahu CA, Lemkes BA, Struijk DG, Koopman MG, Krediet RT, Vink H (2012) Damage of the endothelial glycocalyx in dialysis patients. J Am Soc Nephrol 23(11):1900\u20131908. https:\/\/doi.org\/10.1681\/ASN.2011121181","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"3141_CR30","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1039\/b100916h","volume":"19","author":"DL Rabenstein","year":"2002","unstructured":"Rabenstein DL (2002) Heparin and heparan sulfate: structure and function. Nat Prod Rep 19(3):312\u2013331","journal-title":"Nat Prod Rep"},{"issue":"6","key":"3141_CR31","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1053\/j.ajkd.2012.01.018","volume":"59","author":"S Assa","year":"2012","unstructured":"Assa S, Dasselaar JJ, Slart RH, de Jong PE, Voors AA, Tio RA, Franssen CF (2012) Comparison of cardiac positron emission tomography perfusion defects during stress induced by hemodialysis versus adenosine. Am J Kidney Dis 59(6):862\u2013864. https:\/\/doi.org\/10.1053\/j.ajkd.2012.01.018","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"3141_CR32","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1177\/089686080202200406","volume":"22","author":"CJ Konings","year":"2002","unstructured":"Konings CJ, Kooman JP, Schonck M, Dammers R, Cheriex E, Palmans Meulemans AP, Hoeks AP, van Kreel B, Gladziwa U, van der Sande FM, Leunissen KM (2002) Fluid status, blood pressure, and cardiovascular abnormalities in patients on peritoneal dialysis. Perit Dial Int: J Int Soc Perit Dial 22(4):477\u2013487","journal-title":"Perit Dial Int: J Int Soc Perit Dial"},{"issue":"4","key":"3141_CR33","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2183\/pjab.86.410","volume":"86","author":"T Muramatsu","year":"2010","unstructured":"Muramatsu T (2010) Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci 86(4):410\u2013425","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"12","key":"3141_CR34","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1111\/bph.12601","volume":"171","author":"DR Jones","year":"2014","unstructured":"Jones DR (2014) Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases. Br J Pharmacol 171(12):2925\u20132939. https:\/\/doi.org\/10.1111\/bph.12601","journal-title":"Br J Pharmacol"},{"issue":"4","key":"3141_CR35","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.cardfail.2009.12.014","volume":"16","author":"T Kitahara","year":"2010","unstructured":"Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I (2010) Serum midkine as a predictor of cardiac events in patients with chronic heart failure. J Cardiac Fail 16(4):308\u2013313. https:\/\/doi.org\/10.1016\/j.cardfail.2009.12.014","journal-title":"J Cardiac Fail"},{"issue":"4","key":"3141_CR36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s10157-016-1318-0","volume":"21","author":"H Hayashi","year":"2017","unstructured":"Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y (2017) Efficacy of urinary midkine as a biomarker in patients with acute kidney injury. Clin Exp Nephrol 21(4):597\u2013607. https:\/\/doi.org\/10.1007\/s10157-016-1318-0","journal-title":"Clin Exp Nephrol"},{"issue":"9","key":"3141_CR37","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014615","volume":"7","author":"VK Campbell","year":"2017","unstructured":"Campbell VK, Anstey CM, Gately RP, Comeau DC, Clark CJ, Noble EP, Mahadevan K, Hollett PR, Pollock AJ, Hall ST, Jones DR, Burg D, Gray NA (2017) Urine and serum midkine levels in an Australian chronic kidney disease clinic population: an observational study. BMJ Open 7(9):e014615. https:\/\/doi.org\/10.1136\/bmjopen-2016-014615","journal-title":"BMJ Open"},{"issue":"3","key":"3141_CR38","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s11255-012-0344-4","volume":"45","author":"DL Salaru","year":"2013","unstructured":"Salaru DL, Mertens PR (2013) Lessons from the heart and ischemic limbs: midkine as anti-inflammatory mediator for kidney diseases? Int Urol Nephrol 45(3):893\u2013897. https:\/\/doi.org\/10.1007\/s11255-012-0344-4","journal-title":"Int Urol Nephrol"},{"key":"3141_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0307-6","author":"B Aydemir","year":"2015","unstructured":"Aydemir B, Akdemir R, Vatan MB, Cinemre FB, Cinemre H, Kiziler AR, Bahtiyar N, Buyukokuroglu ME, Gurol G, Ogut S (2015) The circulating levels of selenium, zinc, midkine, some inflammatory cytokines, and angiogenic factors in mitral chordae tendineae rupture. Biol Trace Elem Res. https:\/\/doi.org\/10.1007\/s12011-015-0307-6","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"3141_CR40","first-page":"372","volume":"33","author":"DL Salaru","year":"2014","unstructured":"Salaru DL, Albert C, Konigsmark U, Brandt S, Halloul Z, Heller A, Heidecke H, Dragun D, Mertens PR (2014) Serum levels for midkine, a heparin-binding growth factor, inversely correlate with angiotensin and endothelin receptor autoantibody titers in patients with macroangiopathy. Int angiol: J Int Union Angiol 33(4):372\u2013378","journal-title":"Int angiol: J Int Union Angiol"},{"issue":"9","key":"3141_CR41","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1007\/s00726-015-2023-0","volume":"47","author":"AR Frenay","year":"2015","unstructured":"Frenay AR, van den Berg E, de Borst MH, Beckmann B, Tsikas D, Feelisch M, Navis G, Bakker SJ, van Goor H (2015) Plasma ADMA associates with all-cause mortality in renal transplant recipients. Amino Acids 47(9):1941\u20131949. https:\/\/doi.org\/10.1007\/s00726-015-2023-0","journal-title":"Amino Acids"},{"issue":"Suppl 1","key":"3141_CR42","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1097\/01.hjh.0000467383.13227.5b","volume":"33","author":"DV Vlahakos","year":"2015","unstructured":"Vlahakos DV, Dalamaga M, Marouga A, Bacharaki D, Drakou A, Dimas C (2015) 1c.09: Serum resistin as an independent biomarker associated with all-cause and cardiovascular mortality in elderly hypertensive, non-diabetic patients with chronic kidney disease (Ckd). J Hypertens 33(Suppl 1):e11-12. https:\/\/doi.org\/10.1097\/01.hjh.0000467383.13227.5b","journal-title":"J Hypertens"},{"issue":"3","key":"3141_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2174\/1573402111666150102111334","volume":"10","author":"P Dousdampanis","year":"2014","unstructured":"Dousdampanis P, Trigka K, Giannopoulos A, Fourtounas C (2014) Pathogenesis and management of intradialytic hypertension. Curr Hypertens Rev 10(3):171\u2013176","journal-title":"Curr Hypertens Rev"},{"issue":"8","key":"3141_CR44","doi-asserted-by":"publisher","first-page":"768","DOI":"10.2174\/1389201014666131226114919","volume":"14","author":"A Murasugi","year":"2013","unstructured":"Murasugi A (2013) Efficient expression and purification of recombinant therapeutic protein candidates, human midkine and pleiotrophin. Curr Pharm Biotechnol 14(8):768\u2013784","journal-title":"Curr Pharm Biotechnol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03141-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-022-03141-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03141-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:37:38Z","timestamp":1660214258000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-022-03141-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["3141"],"URL":"https:\/\/doi.org\/10.1007\/s11255-022-03141-4","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2022,2,24]]},"assertion":[{"value":"15 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}